Demography and disorders of German Shepherd Dogs under primary veterinarycare in the UK

The German Shepherd Dog (GSD) has been widely used for a variety of working roles. However, concerns for the health and welfare of the GSD have been widely aired and there is evidence that breed numbers are now in decline in the UK. Accurate demographic and disorder data could assist with breeding and clinical prioritisation. The VetCompassTM Programme collects clinical data on dogs under primary veterinary care in the UK. This study included all VetCompassTM dogs under veterinary care during 2013. Demographic, mortality and clinical diagnosis data on GSDs were extracted and reported

First trimester fetal heart rate as a predictor of newborn sex

OBJECTIVE: To predict the sex of newborns using first trimester fetal heart rate (FHR). METHODS: This was a retrospective review of medical records and ultrasounds performed between 8 and 13 weeks of gestation. Continuous variables were compared using Student\u27s t-tests while categorical variables were compared using Chi-square test. RESULTS: We found no significant differences between 332 (50.7%) female and 323 (49.3%) male FHRs during the first trimester. The mean FHR for female fetuses was 167.0 +/- 9.1 bpm and for male fetuses 167.3 +/- 10.1 bpm (p = 0.62). There was no significant difference in crown rump length between female and male fetuses (4.01 +/- 1.7 versus 3.98 +/- 1.7 cm; p = 0.78) or in gestational age at birth (38.01 +/- 2.1 versus 38.08 +/- 2.1 weeks; p = 0.67). The males were significantly heavier than females (3305.3 +/- 568.3 versus 3127.5 +/- 579.8 g; p \u3c 0.0001) but there were no differences in the proportion of small for gestational age (SGA), average for gestational age (AGA) and large for gestational age (LGA) infants. CONCLUSIONS: We found no significant difference between the female and male FHR during the first trimester in contrast to the prevailing lay view of females having a faster FHR. The only statistically significant difference was that males weighed more than female newborns

OPTEC: A Cubesat for Solar Cell Calibration

A new type of small spacecraft, the cubesat, has introduced a new concept for extremely small, low-cost missions into space. Cubesats are designed to be launched as secondary payloads on other missions, and are made up of unit elements (U) of size 10 cm by 10 cm by 10 cm, with a nominal mass of no more than 1.33 kg per U. We have designed a cubesat, OPTEC (Orbital Photovoltaic Testbed Cubesat) as a low-cost testbed to demonstrate, calibrate, and test solar cell technologies in space. Size of the cubesat is 2U (10x10x20cm, and the mass 2.66 kg. The cubesat deploys from the International Space Station into Low Earth Orbit at an altitude of about 420 km. Up to two 4x8cm test solar panels can be flown, with full I-V curves and temperature measurements taken

Associations between cerebrospinal fluid biomarkers and long-term neurologic outcome in dogs with acute intervertebral disk herniation

OBJECTIVE: To examine associations between CSF biomarkers, initial neurologic dysfunction, and long-term ambulatory outcome in dogs with acute intervertebral disk herniation (IVDH). DESIGN: Prospective clinical study. ANIMALS: 54 dogs with acute thoracolumbar IVDH and 16 clinically normal dogs. PROCEDURES:For each dog, variables, including CSF myelin basic protein (MBP), lactate, calcium, glucose, and total protein concentrations; nucleated cell count; and creatine kinase (CK) and aspartate aminotransferase activities, were measured. For dogs with thoracolumbar IVDH, initial neurologic function was characterized by use of a modified Frankel score (MFS; determined on a scale of 0 to 5, where 0 represented paraplegia with no deep nociception and 5 represented paraspinal hyperesthesia only). Long-term follow-up was assessed. RESULTS: Among dogs with thoracolumbar IVDH, those with CSF CK activity ≤ 38 U/L had a 35-fold increase in the odds of long-term ambulation, compared with the odds in dogs with CSF CK activity > 38 U/L, adjusting for neurologic functioning at the evaluation. The CSF lactate, calcium, and glucose concentrations and aspartate aminotransferase activity were not predictive of long-term ambulatory outcome. Data analysis revealed that longterm functional recovery was > 98% for affected dogs, regardless of their initial MFS, when CSF CK activity was ≤ 38 U/L and MBP concentration was ≤ 3 ng/mL. CONCLUSIONS AND CLINICAL RELEVANCE: In dogs with acute thoracolumbar IVDH, CSF CK activity and MBP concentration appeared to be prognostic indicators and, along with initial MFS, can be used to predict long-term ambulatory outcome. (J Am Vet Med Assoc 2012;240:555–562)Presented as a poster at the American College of Veterinary Surgeons Symposium, Washington, DC, October 2009.American Kennel Club ACORN Grant No. 1180-Ahttp://avmajournals.avma.org/loi/javmaab201

Prevalence, duration and risk factors for appendicular osteoarthritis in a UK dog population under primary veterinary care.

Osteoarthritis is the most common joint disease diagnosed in veterinary medicine and poses considerable challenges to canine welfare. This study aimed to investigate prevalence, duration and risk factors of appendicular osteoarthritis in dogs under primary veterinary care in the UK. The VetCompassTM programme collects clinical data on dogs attending UK primary-care veterinary practices. The study included all VetCompassTM dogs under veterinary care during 2013. Candidate osteoarthritis cases were identified using multiple search strategies. A random subset was manually evaluated against a case definition. Of 455,557 study dogs, 16,437 candidate osteoarthritis cases were identified; 6104 (37%) were manually checked and 4196 (69% of sample) were confirmed as cases. Additional data on demography, clinical signs, duration and management were extracted for confirmed cases. Estimated annual period prevalence (accounting for subsampling) of appendicular osteoarthritis was 2.5% (CI95: 2.4-2.5%) equating to around 200,000 UK affected dogs annually. Risk factors associated with osteoarthritis diagnosis included breed (e.g. Labrador, Golden Retriever), being insured, being neutered, of higher bodyweight and being older than eight years. Duration calculation trials suggest osteoarthritis affects 11.4% of affected individuals' lifespan, providing further evidence for substantial impact of osteoarthritis on canine welfare at the individual and population level

Risk Factors for Canine Osteoarthritis and Its Predisposing Arthropathies: A Systematic Review

Osteoarthritis is a common clinical and pathological end-point from a range of joint disorders, that ultimately lead to structural and functional decline of the joint with associated lameness and pain. Increasing understanding of the risk factors associated with osteoarthritis will assist in addressing the significant threat it poses to the welfare of the dog population and implementing preventive measures. Presented here, is the first comprehensive systematic review and evaluation of the literature reporting risk factors for canine osteoarthritis. This paper aimed to systematically collate, review and critically evaluate the published literature on risk factors for canine osteoarthritis and its predisposing conditions such as developmental joint dysplasias, cruciate ligament degeneration, and patellar luxation. Peer-reviewed publications were systematically searched for both osteoarthritis and predisposing arthropathies on Web of Science and PubMed following PRISMA (2009) guidelines, using pre-specified combinations of keywords. Sixty-two papers met the inclusion criteria and were evaluated and graded on reporting quality. Identified risk factors included both modifiable factors (neuter status and body weight) for which intervention can potentially affect the risk of occurrence of osteoarthritis, and unmodifiable factors (sex, breed, and age) which can be used to identify individuals most “at risk.” Osteoarthritis in dogs frequently develops from predisposing arthropathies, and therefore risk factors for these are also important to consider. Papers evaluated in this study were rated as medium to high-quality; gap analysis of the literature suggests there would be significant benefit from additional research into the interactions between and relative weighting of risk factors. There are a number of examples where research outcomes are conflicting such as age and sex; and further investigation into these factors would be beneficial to attain greater understanding of the nature of these risks. Comprehensively collating the published risk factors for osteoarthritis and its predisposing conditions offers opportunities to identify possible means for control and reduction within the population through preventative methods and control strategies. These factors are highlighted here, as well as current literature gaps where further research is warranted, to aid future research direction

A Neural-Network-Based Controller for Missed-Thrust Interplanetary Trajectory Design

The missed-thrust problem is a modern challenge in the field of mission design. While some methods exist to quantify its effects, there still exists room for improvement for algorithms which can fully anticipate and plan for a realistic set of missed-thrust events. The present work investigates the use of machine learning techniques to provide a robust controller for a low-thrust spacecraft. The spacecraft’s thrust vector is provided by a neural network controller which guides the spacecraft to the target along a trajectory that is robust to missed thrust, and the controller does not need to re-optimize any trajectories if it veers off its nominal course. The algorithms used to train the controller to account for missed thrust are supervised learning and neuroevolution. Supervised learning entails showing a neural network many examples of what inputs and outputs should look like, with the network learning over time to duplicate the patterns it has seen. Neuroevolution involves testing many neural networks on a problem, and using the principles of biological evolution and survival of the fittest to produce increasingly competitive networks. Preliminary results show that a controller designed with these methods provides mixed results, but performance can be greatly boosted if the controller’s output is used as an initial guess for an optimizer. With an optimizer, the success rate ranges from around 60% to 96% depending on the problem. Additionally, this work conducts an analysis of a novel hyperbolic rendezvous strategy which was originally conceived by Dr. Buzz Aldrin. Instead of rendezvousing on the outbound leg of a hyperbolic orbit (traveling away from Earth), the spacecraft performs a rendezvous while on the inbound leg (traveling towards Earth). This allows for a relatively low ∆v abort option for the spacecraft to return to Earth if a problem arose during rendezvous. Previous work that studied hyperbolic rendezvous has always assumed rendezvous on the outbound leg because the total ∆v required (total propellant required) for the insertion alone is minimal with this strategy. However, I show that when an abort maneuver is taken into consideration, inserting on the inbound leg is both lower ∆voverall, and also provides an abort window which is up to a full day longer

Trends in length of stay for Medicare patients: 1979-87.

Hospital length of stay (LOS) declined steadily during the 1970s, then rapidly during the early years of the Medicare prospective payment system (PPS). In this article, the authors examine trends in hospital LOS for Medicare patients from 1979 through 1987 for all cases combined, for medical and surgical cases separately, and for different geographic regions. The increase in LOS for surgical cases from 1985 through 1987 represented two offsetting trends. Continuing declines in LOS for most procedures were offset by an increased shift toward complex, long LOS procedures

A NEURAL-NETWORK-BASED CONTROLLER FOR MISSED-THRUST INTERPLANETARY TRAJECTORY DESIGN

The missed-thrust problem is a modern challenge in the field of mission design. While some methods exist to quantify its effects, there still exists room for improvement for algorithms which can fully anticipate and plan for a realistic set of missed-thrust events. The present work investigates the use of machine learning techniques to provide a robust controller for a low-thrust spacecraft. The spacecraft’s thrust vector is provided by a neural network controller which guides the spacecraft to the target along a trajectory that is robust to missed thrust, and the controller does not need to re-optimize any trajectories if it veers off its nominal course. The algorithms used to train the controller to account for missed thrust are supervised learning and neuroevolution. Supervised learning entails showing a neural network many examples of what inputs and outputs should look like, with the network learning over time to duplicate the patterns it has seen. Neuroevolution involves testing many neural networks on a problem, and using the principles of biological evolution and survival of the fittest to produce increasingly competitive networks. Preliminary results show that a controller designed with these methods provides mixed results, but performance can be greatly boosted if the controller’s output is used as an initial guess for an optimizer. With an optimizer, the success rate ranges from around 60% to 96% depending on the problem. Additionally, this work conducts an analysis of a novel hyperbolic rendezvous strategy which was originally conceived by Dr. Buzz Aldrin. Instead of rendezvousing on the outbound leg of a hyperbolic orbit (traveling away from Earth), the spacecraft performs a rendezvous while on the inbound leg (traveling towards Earth). This allows for a relatively low Delta-v abort option for the spacecraft to return to Earth if a problem arose during rendezvous. Previous work that studied hyperbolic rendezvous has always assumed rendezvous on the outbound leg because the total Delta-v required (total propellant required) for the insertion alone is minimal with this strategy. However, I show that when an abort maneuver is taken into consideration, inserting on the inbound leg is both lower Delta-v overall, and also provides an abort window which is up to a full day longer.</p