Programmatic Strategy Synthesis: Resolving Nondeterminism in Probabilistic Programs

We consider imperative programs that involve both randomization and pure nondeterminism. The central question is how to find a strategy resolving the pure nondeterminism such that the so-obtained determinized program satisfies a given quantitative specification, i.e., bounds on expected outcomes such as the expected final value of a program variable or the probability to terminate in a given set of states. We show how memoryless and deterministic (MD) strategies can be obtained in a semi-automatic fashion using deductive verification techniques. For loop-free programs, the MD strategies resulting from our weakest precondition-style framework are correct by construction. This extends to loopy programs, provided the loops are equipped with suitable loop invariants - just like in program verification. We show how our technique relates to the well-studied problem of obtaining strategies in countably infinite Markov decision processes with reachability-reward objectives. Finally, we apply our technique to several case studies

Untersuchungen zur Störkopplung und Schirmdämpfung von Elektro- und Hybridfahrzeugen

In Elektro- und Hybridfahrzeugen wird das konventionelle 12 V-Bordnetz um ein Hochvoltbordnetz zur Realisierung des elektrischen Traktionssystems erweitert. Durch die Integration wird die Komplexität der Fahrzeugelektronik deutlich gesteigert und eine wesentlich höhere Spannungsebene (bis 1000 V) eingeführt. Aufgrund von funktionell bedingten, schnellen Schaltvorgängen erzeugen die neuen elektronischen Hochvoltkomponenten wie beispielsweise der leistungselektronische Umrichter oder der DC-DC-Wandler Störungen, die bisher im Kraftfahrzeug nicht auftraten. Damit diese Störsignale die fehlerfreie Funktion anderer Elektroniksysteme im Fahrzeug nicht beeinflussen, wird das gesamte Hochvoltsystem u. a. als vollständig geschirmtes System in das Fahrzeug integriert. Andernfalls bietet sich zwischen beiden koexistierenden Bordnetzen ein besonders hohes Verkopplungspotential. Im Mittelpunkt des Beitrags steht die Analyse des Störpotentials von elektrischen Antriebssystemen in elektrisch betriebenen Kraftfahrzeugen. Als Ergebnis zeigt sich, dass eine hochqualitative Schirmung des HV-Systems unabdingbar ist. Diese Schirmung kann dann durch Verlegungsoptionen beeinflusst werden. Daher soll im Beitrag u. a. gezeigt werden, wodurch die Schirmdämpfung real verlegter Leitungen abhängig ist. Es werden Erfahrungen mit verschiedenen Messverfahren vorgestellt, die mit Simulationen zu "worst case" Betrachtungen gegenübergestellt werden. Die EMV-Eigenschaften des Hochvoltsystems werden entscheidend durch die Leitungen und der dazugehörigen Kontaktierungen beeinflusst. Im Beitrag werden daher des Weiteren Ergebnisse und Erfahrungen zur messtechnischen Umsetzung der Untersuchungen, u. a. zur nominellen und realen Bestimmung der Transferimpedanz von Hochvoltleitungen vorgestellt. In den Vergleich werden dabei Einflüsse mechanischer Beanspruchung (Biegeradien), aufbau-bedingter Eigenschaften (Querschnitt, Schirmaufbau) sowie Steckverbindern einbezogen. Auf Basis der Leitungsuntersuchungen und Ergebnissen von Komponenten- sowie Fahrzeugtests steht im Fazit des Beitrages die Zusammenführung des Störpotentials zur Wirkung der Schirmung von Hochvoltleitungen bzw. kompletten Hochvoltsystemen in Elektro- und Hybridfahrzeugen

A new scenario framework for climate change research: background, process, and future directions

The scientific community is developing new global, regional, and sectoral scenarios to facilitate interdisciplinary research and assessment to explore the range of possible future climates and related physical changes that could pose risks to human and natural systems; how these changes could interact with social, economic, and environmental development pathways; the degree to which mitigation and adaptation policies can avoid and reduce risks; the costs and benefits of various policy mixes; residual impacts under alternative pathways; and the relationship of future climate change and adaptation and mitigation policy responses with sustainable development. This paper provides the background to and process of developing the conceptual framework for these scenarios, as described in the three subsequent papers in this Special Issue (Van Vuuren et al.; O’Neill et al.; Kriegler et al.). The paper also discusses research needs to further develop and apply this framework. A key goal of the current framework design and its future development is to facilitate the collaboration of climate change researchers from a broad range of perspectives and disciplines to develop policy- and decision-relevant scenarios and explore the challenges and opportunities human and natural systems could face with additional climate change

Net community production in the North Atlantic Ocean derived from Volunteer Observing Ship data

The magnitude of marine plankton net community production (NCP) is indicative of both the biologically driven exchange of carbon dioxide between the atmosphere and the surface ocean and the export of organic carbon from the surface ocean to the ocean interior. In this study the seasonal variability in the NCP of five biogeochemical regions in the North Atlantic was determined from measurements of surface water dissolved oxygen and dissolved inorganic carbon (DIC) sampled from a Volunteer Observing Ship (VOS). The magnitude of NCP derived from dissolved oxygen measurements (NCPinline image) was consistent with previous geochemical estimates of NCP in the North Atlantic, with an average annual NCPinline image of 9.5 ± 6.5 mmol O2 m−2 d−1. Annual NCPinline image did not vary significantly over 35° of latitude and was not significantly different from NCP derived from DIC measurements (NCPDIC). The relatively simple method described here is applicable to any VOS route on which surface water dissolved oxygen concentrations can be accurately measured, thus providing estimates of NCP at higher spatial and temporal resolution than currently achieved

Ethical choices behind quantifications of fair contributions under the Paris Agreement

The Parties to the UNFCCC and Paris Agreement agreed to act on the basis of equity to protect the climate system. Equitable effort sharing is an irreducibly normative matter, yet some influential studies have sought to create quantitative indicators of equitable effort that claim to be value-neutral (despite evident biases). Many of these studies fail to clarify the ethical principles underlying their indicators, some mislabel approaches that favour wealthy nations as ‘equity approaches’ and some combine contradictory indicators into composites we call derivative benchmarks. This Perspective reviews influential climate effort-sharing assessments and presents guidelines for developing and adjudicating policy-relevant (but not ethically neutral) equity research

SARS-CoV-2 infects human engineered heart tissues and models COVID-19 myocarditis

There is ongoing debate as to whether cardiac complications of coronavirus disease-2019 (COVID-19) result from myocardial viral infection or are secondary to systemic inflammation and/or thrombosis. We provide evidence that cardiomyocytes are infected in patients with COVID-19 myocarditis and are susceptible to severe acute respiratory syndrome coronavirus 2. We establish an engineered heart tissue model of COVID-19 myocardial pathology, define mechanisms of viral pathogenesis, and demonstrate that cardiomyocyte severe acute respiratory syndrome coronavirus 2 infection results in contractile deficits, cytokine production, sarcomere disassembly, and cell death. These findings implicate direct infection of cardiomyocytes in the pathogenesis of COVID-19 myocardial pathology and provides a model system to study this emerging disease

Metabolomic Profiling in Patients with Heart Failure and Exercise Intolerance: Kynurenine as a Potential Biomarker

Aims: Metabolic and structural perturbations in skeletal muscle have been found in patients with heart failure (HF) both with preserved (HFpEF) and reduced (HFrEF) ejection fraction in association with reduced muscle endurance (RME). We aimed in the current study to create phenotypes for patients with RME and HFpEF compared to RME HFrEF according to their metabolomic profiles and to test the potential of Kynurenine (Kyn) as a marker for RME. Methods: Altogether, 18 HFrEF, 17 HFpEF, and 20 healthy controls (HC) were prospectively included in the current study. The following tests were performed on all participants: isokinetic muscle function tests, echocardiography, spiroergometry, and varied blood tests. Liquid chromatography tandem mass spectrometry was used to quantify metabolites in serum. Results: Except for aromatic and branched amino acids (AA), patients with HF showed reduced AAs compared to HC. Further perturbations were elevated concentrations of Kyn and acylcarnitines (ACs) in HFpEF and HFrEF patients ( p < 0.05). While patients with HFpEF and RME presented with reduced concentrations of ACs (long- and medium-chains), those with HFrEF and RME had distorted AAs metabolism ( p < 0.05). With an area under the curve (AUC) of 0.83, Kyn shows potential as a marker in HF and RME (specificity 70%, sensitivity 83%). In a multiple regression model consisting of short-chain-ACs, spermine, ornithine, glutamate, and Kyn, the latest was an independent predictor for RME (95% CI: −13.01, −3.30, B: −8.2 per 1 µM increase, p = 0.001). Conclusions: RME in patients with HFpEF vs. HFrEF proved to have different metabolomic profiles suggesting varied pathophysiology. Kyn might be a promising biomarker for patients with HF and RME

Catalytic decomposition of formic acid in a fixed bed reactor – an experimental and modelling study

Formic acid is one of the key components in green chemistry being involved in energy storage, production of chemical intermediates and fuel components. Therefore the knowledge of its stability is of crucial importance and a systematic study of its decomposition is needed. The kinetics of formic acid decomposition to hydrogen and carbon dioxide was investigated in a laboratory-scale fixed bed reactor at 150–225 °C and atmospheric pressure. Palladium nanoparticles deposited on porous active carbon Sibunit were used as the heterogeneous catalyst. The catalyst was characterized by nitrogen physisorption and high-resolution transmission electron microscopy. The average palladium nanoparticle size was 5–6 nm. The impacts of mass transfer resistance and formic acid dimerization were negligible under the reaction conditions. Prolonged experiments revealed that the catalyst had a good stability. Hydrogen and carbon dioxide were the absolutely dominant reaction products, whereas the amounts of carbon monoxide and water were negligible. The experimental data were described with three kinetic models: first order kinetics, two-step adsorption-reaction model and multistep adsorption-decomposition model of formic acid. The multistep model gave the best description of the data.</p