817 research outputs found

    PRM62 The Impact of Centre Selection on the Generalisability of Economic Evaluation Results from Multi-Centre Randomised Controlled Trials

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    Stability of Fine Tuned Hierarchies in Strongly Coupled Chiral Models

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    A fine tuned hierarchy between a strongly coupled high energy compositeness scale and a much lower chiral symmetry breaking scale is a requisite ingredient in many models of dynamical electroweak symmetry breaking. Using a nonperturbative continuous Wilson renormalization group equation approach, we explore the stability of such a hierarchy against quantum fluctuations.Comment: 14,PURD-TH-94-1

    On the Holomorphic Structure of a Low Energy Supersymmetric Wilson Effective Action

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    The Wilson (exact) renormalization group equations are used to determine the evolution of a general low energy N=1 supersymmetric action containing a U(1) gauge vector multiplet and a neutral chiral multiplet. The effective theory evolves towards satisfying a fixed relation where the K\"ahler potential and effective gauge coupling are obtained from a N=2 supersymmetric holomorphic prepotential.Comment: 10 pages, LaTe

    Growth performance of nursery pigs fed BIOSAF yeast, alone or in combination with an in-feed antimicrobial

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    Swine research, 2005 is known as Swine day, 2005A total of 280 pigs were used in a 28-d growth study to evaluate the effects of feeding the antimicrobial carbadox, BIOSAF (0.4%), and the combination of carbadox and BIOSAF yeast (0.15%) in nursery pig diets. Over the length of the entire trial, pigs fed the diet containing carbadox alone had greater ADG than did pigs fed the control diet or the diet containing 0.4% BIOSAF. Overall, pigs fed the diet containing both carbadox and 0.15% BIOSAF had greater ADG than did pigs fed the control diet or the diet containing 0.4% BIOSAF (P<0.04), although their growth performance did not differ from that of pigs fed carbadox alone. Antibody titers in response to routine vaccination against Mycoplasma hyopneumoniae were not affected by dietary treatment. There was no evidence that BIOSAF improved growth performance of nursery pigs, either alone or in combination with the carbadox. It is possible that the interactive effects of BIOSAF that have been reported for other in-feed antibiotics are not present when BIOSAF is combined with carbadox, or perhaps interactive effects are only observed when carbadox itself exerts a more potent stimulation of ADG in nursery pigs

    Babesia, Theileria and Anaplasma spp. infecting sable antelope, Hippotragus niger (Harris, 1838), in southern Africa

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    Some observations are recorded on blood parasites of sable antelopes. Blood smears of 124 of these antelopes from South Africa and Zimbabwe were examined and 7 were found to be positive for a Babesia sp., identified as Babesia irvinesmithi Martinaglia 1936. A total of 70 of the smears were positive for Theilerial piroplasms, while 1 smear had macroschizonts (with cytomeres) and microschizonts of a Theileria (=Cytauxzoon) sp. One blood smear was positive for an Anaplasma sp. Attempts to isolate the Babesia sp. by subinoculating blood from sable to splenectomized and intact sable and splenectomized cattle were unsuccessful. Attempts to infect sable with Babesia bovis and Babesia bigemina were likewise unsuccessful. Theilerial piroplasms reached high levels in a splenectomized sable but could not be transmitted with blood to cattle. The Anaplasma sp. was found to be infective for sheep but not for cattle.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

    Wilson Renormalization Group Analysis of Theories with Scalars and Fermions

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    The continuous block spin (Wilson) renormalization group equation governing the scale dependence of the action is constructed for theories containing scalars and fermions. A locally approximated form of this equation detailing the structure of a generalized effective potential is numerically analyzed. The role of the irrelevant operators in the nonperturbative renormalization group running is elucidated and a comparison with the 1-loop perturbative results is drawn. Focusing on the spontaneously broken phase of a model possessing a discrete symmetry forbidding an explicit fermion mass term, mass bounds on both the scalar and fermion degrees of freedom are established. The effect of the generalized Yukawa coupling on the scalar mass upper bound is emphasized.Comment: 40, PURD-TH-92-

    Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures

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    Our objective was to obtain new information on the in vitro antilymphocytic action of the cytokine synthesis inhibitor FK 506 and the purine biosynthesis inhibitors mycophenolic acid (MPA; the active moiety of RS61443) and mizoribine (MZB) when used alone or in combination. When added at the initiation of six-day human mixed lymphocyte cultures (MLC), FK 506, MPA or MZB exhibited dose-dependent inhibition of T-lymphocyte DNA synthesis. FK 506, however, was 100-fold more potent than MPA, and 10000-fold more potent than MZB. Combination of FK 506 with either MPA or MZB, each at suboptional concentrations, produced no more than additive inhibitory effects on 3H thymidine incorporation. Two-colour flow cytometric analysis of lymphocytes revealed that none of the drugs affected cell surface activation molecule expression (CD25 = IL-2R 55 kD α-chain, HLA-DR or CD71 = transferrin receptor [TR]) on allostimulated CD4+ or CD8+ cells harvested at three days of culture. By day six, however, all three agents, at levels which markedly inhibited proliferation, suppressed the expression of activation markers on both CD4+ and CD8+ cells. Also at day six, inhibition of activation molecule expression on CD4+ cells was achieved with the combination of FK 506 and either MPA or MZB at concentrations which, on their own, were ineffective. These data provide new, additional information on the in vitro antilymphocytic action of FK 506, MPA and MZB when used alone and in combination. © 1993

    Effectiveness of interventions targeting self-regulation to improve adherence to chronic disease medications: a meta-review of meta-analyses

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    Adherence to chronic disease medication regimens depends in part on successful self-regulation. However, the overall benefit of interventions targeting self-regulatory mechanisms is not well-understood. Accordingly, we conducted a meta-review of meta-analyses assessing the effect of interventions targeting self-regulation on medication adherence. For this meta-review, meta-analyses appearing between January 2006 and March 2019 were eligible if they included experimental trials that assessed the effect of an intervention targeting self-regulation on adherence to chronic disease medication. A systematic literature search of multiple databases for published and unpublished literature identified 16,001 abstracts. Twelve meta-analyses met eligibility criteria and had variable quality according to AMSTAR 2 item completion (M = 50%; range: 31–66%). Overall, meta-reviews showed small to medium effect sizes for interventions that targeted self-monitoring, provided personalised feedback on adherence, or involved complete self-management. Other interventions, such as goal setting, barrier identification and problem solving, and stress management showed little evidence of improving adherence. Only a limited number of self-regulation intervention components were able to be evaluated. Additional research is needed to advance the understanding of the efficacy of adherence interventions focussed on self-regulation by expanding the scope of self-regulation elements targeted (e.g., emotion regulation)

    Small-scale solar magnetic fields

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    As we resolve ever smaller structures in the solar atmosphere, it has become clear that magnetism is an important component of those small structures. Small-scale magnetism holds the key to many poorly understood facets of solar magnetism on all scales, such as the existence of a local dynamo, chromospheric heating, and flux emergence, to name a few. Here, we review our knowledge of small-scale photospheric fields, with particular emphasis on quiet-sun field, and discuss the implications of several results obtained recently using new instruments, as well as future prospects in this field of research.Comment: 43 pages, 18 figure
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