1,078 research outputs found
Detailed design of a quiet high flow fan
A single stage fan was designed to demonstrate the noise abatement properties of near-sonic inlet flow and long-chord stator vanes for the reduction of both upstream and downstream propagated fan source noise. It is designed to produce a pressure ratio of 1.653:1 with an adiabatic efficiency of 83.9%. The fan has a 508 mm inlet diameter with a hub/tip ratio of 0.426 and a design tip speed of 533.4 m/sec. The design inlet specific flow rate is 219.71 kg/sec sq m and there are 10 tandem stator vanes with a combined aspect ratio of 0.54
âNot easily put into a boxâ: constructing professional identity
Researching the interplay between social work students' personal and professional identities, I found that, in talking about becoming professionals, students drew on a wide range of discourses. Three common usages of the term âprofessional identityâ are explored here: it can be thought of in relation to desired traits; it can also be used in a collective sense to convey the âidentity of the professionâ. Taking a more subjective approach, professional identity can be regarded as a process in which each individual comes to have a sense of themselves as a social worker. I argue that the variations in students' talk reflect a wide range of cultural understandings that are prevalent within the social work community and society in general, and conclude that professional identity is more complicated than adopting certain traits or values, or even demonstrating competence. The different meanings of professional identity all have something to offer, providing resources for students as they construct themselves as social workers. This is important for social work education because it acknowledges the dynamic nature of professional identity, highlights the difficult identity work which each student must undertake, and prompts us to consider how this process might best be supported
Towards large scale automated cage monitoring - Diurnal rhythm and impact of interventions on in-cage activity of C57BL/6J mice recorded 24/7 with a non-disrupting capacitive-based technique.
BACKGROUND AND AIMS: Automated recording of laboratory animal\u27s home cage behavior is receiving increasing attention since such non-intruding surveillance will aid in the unbiased understanding of animal cage behavior potentially improving animal experimental reproducibility.
MATERIAL AND METHODS: Here we investigate activity of group held female C57BL/6J mice (mus musculus) housed in standard Individually Ventilated Cages across three test-sites: Consiglio Nazionale delle Ricerche (CNR, Rome, Italy), The Jackson Laboratory (JAX, Bar Harbor, USA) and Karolinska Insititutet (KI, Stockholm, Sweden). Additionally, comparison of female and male C57BL/6J mice was done at KI. Activity was recorded using a capacitive-based sensor placed non-intrusively on the cage rack under the home cage collecting activity data every 250 msec, 24/7. The data collection was analyzed using non-parametric analysis of variance for longitudinal data comparing sites, weekdays and sex.
RESULTS: The system detected an increase in activity preceding and peaking around lights-on followed by a decrease to a rest pattern. At lights off, activity increased substantially displaying a distinct temporal variation across this period. We also documented impact on mouse activity that standard animal handling procedures have, e.g. cage-changes, and show that such procedures are stressors impacting in-cage activity. These key observations replicated across the three test-sites, however, it is also clear that, apparently minor local environmental differences generate significant behavioral variances between the sites and within sites across weeks. Comparison of gender revealed differences in activity in the response to cage-change lasting for days in male but not female mice; and apparently also impacting the response to other events such as lights-on in males. Females but not males showed a larger tendency for week-to-week variance in activity possibly reflecting estrous cycling.
CONCLUSIONS: These data demonstrate that home cage monitoring is scalable and run in real time, providing complementary information for animal welfare measures, experimental design and phenotype characterization
Elliptic Curves over Real Quadratic Fields are Modular
We prove that all elliptic curves defined over real quadratic fields are
modular.Comment: 38 pages. Magma scripts available as ancillary files with this arXiv
versio
De Litteris
This book is drawn from a series of annual faculty lectures at Connecticut College. The contents are Some Philosophical Remarks About Poetry, Robert W. Jordan Linguistics and Rhetoric, Eugene P. Cognon Literary Problems in Interpreting Paul\u27s Letters, Gordon P. Wiles Iris Sacred and Profane: the Philosopher as Novelist, Susan M. Woody Toward an American Epic: Four Poets, James R. Baird 1100 A.D.: A Crisis for Us?, F. Edward Cranz Of Messages and Messengers, Marijan Despalotovichttps://digitalcommons.conncoll.edu/ccbooks/1006/thumbnail.jp
Elliptic curves of large rank and small conductor
For r=6,7,...,11 we find an elliptic curve E/Q of rank at least r and the
smallest conductor known, improving on the previous records by factors ranging
from 1.0136 (for r=6) to over 100 (for r=10 and r=11). We describe our search
methods, and tabulate, for each r=5,6,...,11, the five curves of lowest
conductor, and (except for r=11) also the five of lowest absolute discriminant,
that we found.Comment: 16 pages, including tables and one .eps figure; to appear in the
Proceedings of ANTS-6 (June 2004, Burlington, VT). Revised somewhat after
comments by J.Silverman on the previous draft, and again to get the correct
page break
Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands.
BACKGROUND: The development and application of CRISPR technologies for the modification of the genome are rapidly expanding. Advances in the field describe new CRISPR components that are strategically engineered to improve the precision and reliability of CRISPR editing within the genome sequence. Genome modification using induced genome breaks that are targeted and mediated by CRISPR components leverage cellular mechanisms for repair like homology directed repair (HDR) to incorporate genomic edits with increased precision.
RESULTS: In this report, we describe the gain of methylation at typically hypomethylated CpG island (CGI) locations affected by the CRISPR-mediated incorporation of donor DNA using HDR mechanisms. With characterization of CpG methylation patterns using whole genome bisulfite sequencing, these CGI methylation disruptions trace the insertion of the donor DNA during the genomic edit. These insertions mediated by homology-directed recombination disrupt the generational methylation pattern stability of the edited CGI within the cells and their cellular lineage within the animal strain, persisting across generations. Our approach describes a statistically based workflow for indicating locations of modified CGIs and provides a mechanism for evaluating the directed modification of the methylome of the affected CGI at the CpG-level.
CONCLUSIONS: With advances in genome modification technology comes the need to detect the level and persistence of methylation change that modifications to the genomic sequence impose upon the collaterally edited methylome. Any modification of the methylome of somatic or germline cells could have implications for gene regulation mechanisms governed by the methylation patterns of CGI regions in the application of therapeutic edits of more sensitively regulated genomic regions. The method described here locates the directed modification of the mouse epigenome that persists over generations. While this observance would require supporting molecular observations such as direct sequence changes or gene expression changes, the observation of epigenetic modification provides an indicator that intentionally directed genomic edits can lead to collateral, unintentional epigenomic changes post modification with generational persistence
Management of traumatic brain injury in the nonâneurosurgical intensive care unit: a narrative review of current evidence
Each year, approximately 70 million people suffer traumatic brain injury, which has a significant physical, psychosocial and economic impact for patients and their families. It is recommended in the UK that all patients with traumatic brain injury and a Glasgow coma scale â€â8 should be transferred to a neurosurgical centre. However, many patients, especially those in whom neurosurgery is not required, are not treated in, nor transferred to, a neurosurgical centre. This review aims to provide clinicians who work in non-neurosurgical centres with a summary of contemporary studies relevant to the critical care management of patients with traumatic brain injury. A targeted literature review was undertaken that included guidelines, systematic reviews, meta-analyses, clinical trials and randomised controlled trials (published in English between 1 January 2017 and 1 July 2022). Studies involving key clinical management strategies published before this time, but which have not been updated or repeated, were also eligible for inclusion. Analysis of the topics identified during the review was then summarised. These included: fundamental critical care management approaches (including ventilation strategies, fluid management, seizure control and osmotherapy); use of processed electroencephalogram monitoring; non-invasive assessment of intracranial pressure; prognostication; and rehabilitation techniques. Through this process, we have formulated practical recommendations to guide clinical practice in non-specialist centres
Triptycene as a supramolecular additive in PTB7:PCBM blends and its influence on photovoltaic properties
We acknowledge support from EPSRC (grant number EP/L012294/1) and the European Research Council (grant number 321305). I. D. W. S. also acknowledges a Royal Society Wolfson Research Merit Award.Additives play an important role in modifying the morphology and phase separation of donor and acceptor molecules in bulk heterojunction (BHJ) solar cells. Here, we report triptycene (TPC) as a small-molecule additive for supramolecular control of phase separation and concomitant improvement of the power conversion efficiency (PCE) of PTB7 donor and fullerene acceptor-based BHJ polymer solar cells. An overall 60% improvement in PCE is observed for both PTB7:PC61BM and PTB7:PC71BM blends. The improved photovoltaic (PV) performance can be attributed to three factors: (a) TPC-induced supramolecular interactions with donor:acceptor components in the blends to realize a nanoscale phase-separated morphology; (b) an increase in the charge transfer state energy that lowers the driving force for electron transfer from donor to acceptor molecules; and (c) an increase in the charge carrier mobility. An improvement in efficiency using TPC as a supramolecular additive has also been demonstrated for other BHJ blends such as PBDB-T:PC71BM and P3HT:PCBM, implying the wide applicability of this new additive molecule. A comparison of the photostability of TPC as an additive for PTB7:PCBM solar cells to that of the widely used 1,8-diiodooctane additive shows âŒ30% higher retention of PV performance for the TPC-added solar cells after 34 h of AM 1.5G illumination. The results obtained suggest that the approach of using additives that can promote supramolecular interactions to modify the length scale of phase separation between donor and acceptor is very promising and can lead to the development of highly efficient and stable organic photovoltaics.PostprintPostprintPeer reviewe
Managing lifestyle change to reduce coronary risk: a synthesis of qualitative research on peoplesâ experiences
Background
Coronary heart disease is an incurable condition. The only approach known to slow its progression is healthy lifestyle change and concordance with cardio-protective medicines. Few people fully succeed in these daily activities so potential health improvements are not fully realised. Little is known about peoplesâ experiences of managing lifestyle change. The aim of this study was to synthesise qualitative research to explain how participants make lifestyle change after a cardiac event and explore this within the wider illness experience.
Methods
A qualitative synthesis was conducted drawing upon the principles of meta-ethnography. Qualitative studies were identified through a systematic search of 7 databases using explicit criteria. Key concepts were identified and translated across studies. Findings were discussed and diagrammed during a series of audiotaped meetings.
Results
The final synthesis is grounded in findings from 27 studies, with over 500 participants (56% male) across 8 countries. All participants experienced a change in their self-identity from what was âfamiliarâ to âunfamiliarâ. The transition process involved âfinding new limits and a life worth livingââ, âfinding support for selfâ and âfinding a new normalâ. Analyses of these concepts led to the generation of a third order construct, namely an ongoing process of âreassessing past, present and future livesâ as participants considered their changed identity. Participants experienced a strong urge to get back to ânormalâ. Support from family and friends could enable or constrain life change and lifestyle changes. Lifestyle change was but one small part of a wider âlifeâ change that occurred.
Conclusions
The final synthesis presents an interpretation, not evident in the primary studies, of a person-centred model to explain how lifestyle change is situated within âwiderâ life changes. The magnitude of individual responses to a changed health status varied. Participants experienced distress as their notion of self identity shifted and emotions that reflected the various stages of the grief process were evident in participantsâ accounts. The process of self-managing lifestyle took place through experiential learning; the level of engagement with lifestyle change reflected an individualâs unique view of the balance needed to manage ârealistic changeâ whilst leading to a life that was perceived as âworth livingâ. Findings highlight the importance of providing person centred care that aligns with both psychological and physical dimensions of recovery which are inextricably linked
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