Computerized reduction of elementary reaction sets for CFD combustion modeling

Modeling of chemistry in Computational Fluid Dynamics can be the most time-consuming aspect of many applications. If the entire set of elementary reactions is to be solved, a set of stiff ordinary differential equations must be integrated. Some of the reactions take place at very high rates, requiring short time steps, while others take place more slowly and make little progress in the short time step integration

Transit Oriented Development Opportunities Among Failing Malls

Transit Oriented Development (TOD) typically follows a common construction sequence that begins with transit infrastructure, followed by changing land use designations and densities. TODs are then built around transit stations or lines. An alternative approach is to turn failing shopping malls with their large footprints into mixed-use housing, then provide or enhance transit to these redevelopment projects. This approach could result in successful TODs: housing and mixed uses at appropriate densities to support transit. This policy brief summarizes findings from the white paper which reviewed the literature and provided the rationale for such redevelopments.View the NCST Project Webpag

Discriminating Between Copers and those with Chronic Ankle Instability with Clinical Outcomes

Introduction: Chronic ankle instability (CAI) is a common consequence of lateral ankle sprains and a leading cause of post-traumatic ankle osteoarthritis. Despite a history of a lateral ankle sprain, there are some individuals (copers) who appear to have a mechanism that allows them to avoid recurrent lateral ankle sprains and giving way episodes. To date, research has identified differences in perceptual (e.g. self-assessed disability), mechanical (e.g. ligament laxity), and sensorimotor (e.g. balance) outcomes between copers and those with CAI. However, the vast majority of these outcomes are considered research and/or laboratory based and thus impractical for most clinicians to use on a daily basis. The identification of clinical tools, capable of discriminating between copers and those with CAI is the first step in developing an accurate clinical battery of tests that can be used to predict patients more likely to develop CAI after an initial lateral ankle sprain. Therefore, the purpose of this investigation was to establish the ability of clinical outcome measures to discriminate between copers and those with CAI. Methods: Participants- A total of 46 participants (21 copers and 25 with CAI) were enrolled and completed the investigation. All participants read and signed the university approved informed consent document prior to participation. All subjects were between the ages of 18-30 and participated in recreational activity for at least 90 minutes each week. Copers and those with CAI had a history of at least one moderate to severe ankle sprain that required acute care. Copers resumed all pre-injury activity without limitation and without recurrent episodes of injury/giving way for at least 12 months prior to testing and scored \u3e24 on the ankle joint functional assessment tool (AJFAT). In comparison, those with CAI had at least one recurrent sprain within 6 months of testing and scored \u3c20 on the AJFAT. Protocol: Perceptual outcomes, the Foot Ankle Ability Measure (FAAM) and FAAM Sport (FAAM-S) were completed first. These questionnaires determine a subject’s self-assessed limitations during daily and physical activities and lower scores represent greater disability. Next, mechanical adaptations were assessed via the the weight bearing lunge test (WBLT) and talar glide test. The WBLT measured ankle dorsiflexion range of motion using a modified lunge technique. Maximum dorsiflexion was defined as the furthest distance the subject’s foot could be from a wall while the subject’s knee was in contact with the wall and the subject’s heel was flat on the ground. The talar glide test measures the magnitude of the talus’ posterior glide by measuring the change in passive knee flexion, from 90°, while an examiner simultaneously pushes the talus posteriorly and pulls the foot into dorsiflexion until the point of capsular restriction. Finally, sensorimotor dysfunction was assessed with the Star Excursion Balance Test (SEBT) and isometric strength testing. The SEBT is a measure of dynamic postural control and measures the distance a subject can reach with their contralateral leg without losing their balance. Reach distance was defined as the farthest point that an individual could touch without accepting weight on their reach leg and maintaining balance through the return to a bilateral stance. Reach distance was normalized to each subject’s leg length. Using a handheld dynamometer, ankle dorsiflexion, plantar flexion, eversion, and inversion strength was assessed during 3-second maximal contractions. Strength was normalized to a subject’s body weight. Statistical Analysis: Group differences in perceptual, mechanical, and sensorimotor outcomes were assessed with independent sample t-tests. If significance was achieved, the ability of an outcome to accurately discriminate between the groups was then assessed using the area under the curve (AUC) for receiver operating characteristic (ROC) curves. A ROC curve illustrates the “trade-off” between sensitivity and specificity throughout a measure’s entire range of values. Finally, clinical meaningfulness was established by the calculation of cut-off scores and likelihood ratios for outcomes that successfully discriminated between copers and those with CAI. A traditional level of significance (=0.05) was used for all analyses. RESULTS: The CAI group had significant perceptual and sensorimotor deficits relative to the coper group. Specifically, FAAM (Coper: 99.0±2.5%, CAI: 89.2±9.5%), FAAM-S (Coper: 96.6±4.1%, CAI: 79.3±16.2%), normalized posteriomedial SEBT reach distance (Coper: 91.2±8.1%, CAI: 83.5±6.5%), and normalized dorsiflexion strength (Coper: 74.5±19.9%, CAI: 62.9±12.8%) were lower in those with CAI relative to copers. The secondary analysis revealed that the FAAM (P\u3c0.01), FAAM-S (p\u3c0.01), and posteriomedial SEBT reach distance (p\u3c0.01) accurately discriminated between copers and those with CAI. The AUC scores, cut-off scores, and likelihood ratios can be seen in the table below. No differences existed with regards to talar glide, range of motion, anterior SEBT reach, posteriolateral SEBT reach, and normalized eversion, inversion, or plantar flexion strength. Outcome Measure Category AUC Cut-off Score Likelihood Ratios (95% Confidence Intervals) Positive Negative FAAM 0.93 99% 5.05 (2.92 to 10.36) 0.05 (0.01 to 0.21) FAAM-S 0.90 88% 31.00 (4.42 to 217.67) 0.33 (0.22 to 0.51) Posteriomedial SEBT Reach 0.79 89% 2.53 (1.77 to 3.79) 0.06 (0.02 to 0.27) DISCUSSION: The results of this investigation indicate that perceptual (FAAM, FAAM-S) and some sensorimotor outcomes (posteriomedial SEBT reach distance) can discriminate between copers and those with CAI. We hypothesize that these outcome measures represent part of the mechanism that 1) allows copers to function as if uninjured and 2) is absent in individuals who develop CAI. The current results, using clinical outcome measures, support previous findings that have illustrated perceptual and sensorimotor deficits using research and/or laboratory based outcomes. Further, because a variety of the current outcomes (perceptual and sensorimotor) successfully discriminated between copers and those with CAI, groups, the current findings support the theory that the causal mechanism of CAI is multi-factorial in nature. However, the most important finding of the current investigation is that the perceptual outcomes demonstrated the greatest ability to discriminate between copers and those with CAI with accuracy point estimates ranging from 0.90-0.93. Indeed, the perceptual outcomes (as a whole) demonstrated higher AUC estimates and positive likelihood ratios, as well as lower negative likelihood ratios compared with the sensorimotor outcomes (as a whole). This finding, which supports previous results, indicates that perceptual outcomes have the greatest ability to accurately predict those who became copers after initial lateral ankle sprain. Given the magnitude of the positive and negative likelihood ratios, we believe that perception based outcomes, such as the FAAM and FAAM-S, should be used in future longitudinal research investigations designed to determine if and when, post-injury, these outcomes can predict who will develop CAI after an initial lateral ankle sprain

The Stripe Fortified GCT:A new GCT design for maximizing the controllable current

In this paper we introduce a new GCT design, namely the Stripe Fortified GCT, for the purpose of maximizing the controllable current by optimizing the current flow path in the device during turn-off. The main design of the new device along with variants are introduced. The MCC performance of this novel structure is assessed with a developed two dimensional model for full wafer simulations. Our results show that this new design is a very good candidate for increasing the MCC to values more than 5000A

Annihilation of NMSSM neutralinos in the Sun and neutrino telescope limits

We investigate neutralino dark matter in the framework of NMSSM performing a scan over its parameter space and calculating neutralino capture and annihilation rates in the Sun. We discuss the prospects of searches for neutralino dark matter in neutrino experiments depending on neutralino content and its main annihilation channel. We recalculate the upper limits on neutralino-proton elastic cross sections directly from neutrino telescopes upper bounds on annihilation rates in the Sun. This procedure has advantages as compared with corresponding recalcalations from the limits on muon flux, namely, it is independent on details of the experiment and the recalculation coefficients are universal for any kind of WIMP dark matter models. We derive 90% c.l. upper limits on neutralino-proton cross sections from the results of the Baksan Underground Scintillator Telescope.Comment: 28 pages, 16 figures, accepted for publication in JCAP, references adde

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research

Mitochondria can change their shape from discrete isolated organelles to a large continuous reticulum. The cellular advantages underlying these fused networks are still incompletely understood. In this paper, we describe and compare hypotheses regarding the function of mitochondrial networks. We use mathematical and physical tools both to investigate existing hypotheses and to generate new ones, and we suggest experimental and modelling strategies. Among the novel insights we underline from this work are the possibilities that (i) selective mitophagy is not required for quality control because selective fusion is sufficient; (ii) increased connectivity may have non-linear effects on the diffusion rate of proteins; and (iii) fused networks can act to dampen biochemical fluctuations. We hope to convey to the reader that quantitative approaches can drive advances in the understanding of the physiological advantage of these morphological changes

Intensity-dependent reductions in resting blood pressure following short-term isometric exercise training

To reduce resting blood pressure, a minimum isometric exercise training (IET) intensity has been suggested, but this is not known for short-term IET programmes. We therefore compared the effects of moderate- and low-intensity IET programmes on resting blood pressure. Forty normotensive participants (22.3 ± 3.4 years; 69.5 ± 15.5 kg; 170.2 ± 8.7 cm) were randomly assigned to groups of differing training intensities [20%EMGpeak (~23%MVC, maximum voluntary contraction, or 30%EMGpeak (~34%MVC)] or control group; 3 weeks of IET at 30%EMGpeak resulted in significant reductions in resting mean arterial pressure (e.g. −3.9 ± 1.0 mmHg, P 0.05). Moreover, after pooling all female versus male participants, IET induced a 6.9-mmHg reduction in systolic blood pressure in female participants, but only a 1.5-mmHg reduction in systolic blood pressure in male participants, although the difference was not significant. An IET intensity between 20%EMGpeak and 30%EMGpeak is sufficient to elicit significant resting blood pressure reductions in a short-term training period (3 weeks). In addition, sexual dimorphism may exist in the magnitude of reductions, but further work is required to confirm this possibility, which could be important in understanding the mechanisms responsible