Selbstvermarktung im Netz. Eine Gouvernementalitätsanalyse der Social Networking Site 'Facebook'

"Was machst du gerade?" - täglich beantworten diese Frage weltweit bis zu 400 Millionen Nutzer der Online-Community "Facebook". Sie stellen Familienfotos zur Schau und Videos der Party vom Vorabend. Der eigene Alltag wird andauernd öffentlich dokumentiert, von anderen begutachtet und bewertet. Carolin Wiedemann macht die ständige Selbstthematisierung in der größten Internet-Community "Facebook" zum Thema. Doch das Portal selbst fiel nicht vom Himmel, sondern ist eine Reaktion auf gesellschaftliche Entwicklungen, die es zugleich prägt. Gilt es nicht längst überall, ein andauerndes "Brand yourself" zu betreiben, eine permanente Performance des eigenen Selbst zu bieten vor einem möglichst großen Publikum? Was Foucault über die Anforderungen an das moderne Selbst schrieb - über 20 Jahre, bevor es Facebook gab - scheint dort exakt widergespiegelt: Facebook als Assessment-Center der alltäglichen Lebensführung

In den Ruinen der Repräsentation? Affekt, Agencement und das Okkurente

In the Ruins of Representation? Affect, 'Agencement' and the Occurent The article examines the concept of affect from the perspective of Spinoza, Deleuze and Guattari, and Massumi. It defines affect in strict opposition to “feeling” and “emotion” as a prepersonal rather than as a-social phenomenon circulating among (human and non-human) bodies and creating “agencies” (dynamic heterogeneous connections or assemblages). Affect and desire are understood as productive forces delineating lines of flight in infinitesimal movements of affecting and being affected that undermine establishing representation “from within” and give birth to the emergence of potential transformations. The article focuses on what theories of affect offer a conception of “aesthetic politics” (Massumi 2010) within the field of interactive art in an age of biopolitical capitalism. It also highlights the possible connections with a critique of representation

Implementation of a National Reference Laboratory for Buruli Ulcer Disease in Togo

Background: In a previous study PCR analysis of clinical samples from suspected cases of Buruli ulcer disease (BUD) from Togo and external quality assurance (EQA) for local microscopy were conducted at an external reference laboratory in Germany. The relatively poor performance of local microscopy as well as effort and time associated with shipment of PCR samples necessitated the implementation of stringent EQA measures and availability of local laboratory capacity. This study describes the approach to implementation of a national BUD reference laboratory in Togo. Methodology: Large scale outreach activities accompanied by regular training programs for health care professionals were conducted in the regions "Maritime'' and "Central,'' standard operating procedures defined all processes in participating laboratories (regional, national and external reference laboratories) as well as the interaction between laboratories and partners in the field. Microscopy was conducted at regional level and slides were subjected to EQA at national and external reference laboratories. For PCR analysis, sample pairs were collected and subjected to a dry-reagent-based IS2404-PCR (DRB-PCR) at national level and standard IS2404 PCR followed by IS2404 qPCR analysis of negative samples at the external reference laboratory. Principal Findings: The inter-laboratory concordance rates for microscopy ranged from 89% to 94%; overall, microscopy confirmed 50% of all suspected BUD cases. The inter-laboratory concordance rate for PCR was 96% with an overall PCR case confirmation rate of 78%. Compared to a previous study, the rate of BUD patients with non-ulcerative lesions increased from 37% to 50%, the mean duration of disease before clinical diagnosis decreased significantly from 182.6 to 82.1 days among patients with ulcerative lesions, and the percentage of category III lesions decreased from 30.3% to 19.2%. Conclusions: High inter-laboratory concordance rates as well as case confirmation rates of 50% (microscopy), 71% (PCR at national level), and 78% (including qPCR confirmation at external reference laboratory) suggest high standards of BUD diagnostics. The increase of non-ulcerative lesions, as well as the decrease in diagnostic delay and category III lesions, prove the effect of comprehensive EQA and training measures involving also procedures outside the laboratory

Neue Rechte und Universität

Prof. Dr. Jens Schröter, Dr. Pablo Abend und Prof. Dr. Benjamin Beil sind Herausgeber der Reihe. Die Herausgeber*innen der einzelnen Hefte sind renommierte Wissenschaftler*innen aus dem In- und Ausland. AG Siegen Denken: Pablo Abend, Armin Beverungen, Marcus Burkhardt, Timo Kaerlein, Tatjana Seitz, Nadine TahaIn dieser Ausgabe der "Navigationen" sammeln wir Ressourcen gegen die Vereinnahmung der Universität durch die so genannte Neue Rechte. Auslöser für das Themenheft sind die Geschehnisse rund um ein Seminar, das im Wintersemester 2018/19 unter dem Titel „Denken und Denken lassen. Zur Philosophie und Praxis der Meinungsfreiheit“ an der Universität Siegen angeboten wurde.Das Seminar wurde von einer Vorlesungsreihe flankiert, in der „dezidiert konservative oder rechte Denker“ eine Bühne bekamen, u.a. Marc Jongen von der AfD, und der Autor Thilo Sarrazin. Ein zentrales Anliegen dieser Ausgabe ist es, die Siegener Ereignisse zu dokumentieren, wissenschaftlich aufzuarbeiten und in verschiedenen Hinsichten zu kontextualisieren: diskursstrategisch, geographisch, historisch und politisch. Hierzu versammelt das Heft Beiträge diverser Forschungsdisziplinen – explizit auch von Vertreter*innen derjenigen Disziplinen, deren Existenzrecht von Teilen der Siegener Vortragenden in Zweifel gezogen wird. Um die Diversität der betroffenen Zugänge zu repräsentieren, sind über die Medienwissenschaft hinaus Beiträge aus der Islamwissenschaft, den Gender Studies, der Linguistik und der Soziologie im Heft vertreten

Risk governance in organizations

Dieses Buch dokumentiert 10 Jahre Risk-Governance-Forschung an der Universität Siegen. In 50 Beiträgen reflektieren Forscher und Praktiker Risk Governance vor dem Hintergrund ihrer eigenen Forschungen und/oder Erfahrungen und geben jeweils einen Entwicklungsimpuls für die Zukunft der Risk Governance. Das Buch zeigt die große Bandbreite und Tiefe des Forschungsgebietes auf und diskutiert Grundannahmen, Implementierungsfragen, die Rolle der Risk Governance als Transformationsmotor, ihre Wirkung in den verschiedenen betrieblichen Funktionen, Entwicklungsperspektiven und den Beitrag der Risk Governance zu einer nachhaltigen Ausrichtung von Unternehmen.This book documents 10 years of risk governance research at the University of Siegen. In 50 contributions, researchers and practitioners reflect on risk governance against the background of their own research and/or experience and provide a development impetus for the future of risk governance. The book shows the wide range and depth of the research field and discusses basic assumptions, implementation issues, the role of risk governance as transformation engine, its impact in the various operational functions, development perspectives, and the contribution of risk governance to a sustainable orientation of companies

Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications

The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands the redirection of scientific efforts and criteria to organized research projects. The international COVID19-NMR consortium seeks to provide such new approaches by gathering scientific expertise worldwide. In particular, making available viral proteins and RNAs will pave the way to understanding the SARS-CoV-2 molecular components in detail. The research in COVID19-NMR and the resources provided through the consortium are fully disclosed to accelerate access and exploitation. NMR investigations of the viral molecular components are designated to provide the essential basis for further work, including macromolecular interaction studies and high-throughput drug screening. Here, we present the extensive catalog of a holistic SARS-CoV-2 protein preparation approach based on the consortium’s collective efforts. We provide protocols for the large-scale production of more than 80% of all SARS-CoV-2 proteins or essential parts of them. Several of the proteins were produced in more than one laboratory, demonstrating the high interoperability between NMR groups worldwide. For the majority of proteins, we can produce isotope-labeled samples of HSQC-grade. Together with several NMR chemical shift assignments made publicly available on covid19-nmr.com, we here provide highly valuable resources for the production of SARS-CoV-2 proteins in isotope-labeled form

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Open Collectivity

The article describes the concept of Open Collectivities, that forms (by denying identity and representation) a post structuralist model of resistance

Selbstvermarktung im Netz. Eine Gouvernementalitätsanalyse der Social Networking Site \u27Facebook\u27

"Was machst du gerade?" - täglich beantworten diese Frage weltweit bis zu 400 Millionen Nutzer der Online-Community "Facebook". Sie stellen Familienfotos zur Schau und Videos der Party vom Vorabend. Der eigene Alltag wird andauernd öffentlich dokumentiert, von anderen begutachtet und bewertet. Carolin Wiedemann macht die ständige Selbstthematisierung in der größten Internet-Community "Facebook" zum Thema. Doch das Portal selbst fiel nicht vom Himmel, sondern ist eine Reaktion auf gesellschaftliche Entwicklungen, die es zugleich prägt. Gilt es nicht längst überall, ein andauerndes "Brand yourself" zu betreiben, eine permanente Performance des eigenen Selbst zu bieten vor einem möglichst großen Publikum? Was Foucault über die Anforderungen an das moderne Selbst schrieb - über 20 Jahre, bevor es Facebook gab - scheint dort exakt widergespiegelt: Facebook als Assessment-Center der alltäglichen Lebensführung