808 research outputs found
Rabies: an evidence-based approach to management
Human rabies in South Africa is largely due to infection with the classical rabies virus (genotype 1), with the yellow mongoose
the commonest vector except in KwaZulu-Natal, Eastern Cape, Mpumalanga and now Limpopo provinces where the dog is
predominantly responsible for most bites. Rabies is always fatal in humans but can be prevented by timeous administration of
post exposure prophylaxis( PEP). This article discusses an evidence-based approach to rabies management in South Africa. South African Family Practice Vol. 49 (7) 2007: pp. 35-4
Vacancy complexes with oversized impurities in Si and Ge
In this paper we examine the electronic and geometrical structure of
impurity-vacancy complexes in Si and Ge. Already Watkins suggested that in Si
the pairing of Sn with the vacancy produces a complex with the Sn-atom at the
bond center and the vacancy split into two half vacancies on the neighboring
sites. Within the framework of density-functional theory we use two
complementary ab initio methods, the pseudopotential plane wave (PPW) method
and the all-electron Kohn-Korringa-Rostoker (KKR) method, to investigate the
structure of vacancy complexes with 11 different sp-impurities. For the case of
Sn in Si, we confirm the split configuration and obtain good agreement with EPR
data of Watkins. In general we find that all impurities of the 5sp and 6sp
series in Si and Ge prefer the split-vacancy configuration, with an energy gain
of 0.5 to 1 eV compared to the substitutional complex. On the other hand,
impurities of the 3sp and 4sp series form a (slightly distorted) substitutional
complex. Al impurities show an exception from this rule, forming a split
complex in Si and a strongly distorted substitutional complex in Ge. We find a
strong correlation of these data with the size of the isolated impurities,
being defined via the lattice relaxations of the nearest neighbors.Comment: 8 pages, 4 bw figure
A new measurement of the properties of the rare decay K -> pi+ e+ e-
A large low-background sample of events (10300) has been collected for the
rare decay of kaons in flight K+ -> pi+ e+ e- by experiment E865 at the
Brookhaven AGS. The decay products were accepted by a broad band
high-resolution charged particle spectrometer with particle identification. The
branching ratio (2.94 +- 0.05(stat.) +- 0.13(syst.) +- 0.05(model))*10**{-7}
was determined normalizing to events from the decay chain K+ -> pi+ pi0; pi0 ->
e+ e- gamma. From the analysis of the decay distributions the vector nature of
this decay is firmly established now, and limits on scalar and tensor
contributions are deduced. From the (e+ e-) invariant mass distribution the
decay form factor f(z)=f0(1+ delta*z) (z=M(ee)**2/m(K)**2) is determined with
delta=2.14 +- 0.13 +- 0.15. Chiral QCD perturbation theory predictions for the
form factor are also tested, and terms beyond leading order O(p**4) are found
to be important.Comment: 4 pages, 5 figure
Changes in hydrodynamic, structural and geochemical properties in carbonate rock samples due to reactive transport
Reactive transport plays an important role in the development of a wide range of both anthropic and natural processes affecting geological media. To predict the consequences of reactive transport processes on structural and hydrodynamic properties of a porous media at large time and spatial scales, numerical modeling is a powerful tool. Nevertheless, such models, to be realistic, need geochemical, structural and hydrodynamic data inputs representative of the studied reservoir or material. Here, we present an experimental study coupling traditional laboratory measurements and percolation experiments in order to obtain the parameters that define rock heterogeneity, which can be altered during the percolation of a reactive fluid. In order to validate the experimental methodology and identify the role of the initial heterogeneities on the localization of the reactive transport processes, we used three different limestones with different petrophysical characteristics. We tracked the changes of geochemical, structural and hydrodynamic parameters in these samples induced by the percolation of an acid fluid by measuring, before and after the percolation experiment, petrophysical and hydrodynamic properties of the rocks.Peer ReviewedPostprint (published version
Strategic responses to global challenges: The case of European banking, 1973–2000
In applying a strategy, structure, ownership and performance (SSOP) framework to three major clearing banks (ABN AMRO, UBS, Barclays), this article debates whether the conclusions generated by Whittington and Mayer about European manufacturing industry can be applied to the financial services sector. While European integration plays a key role in determining strategy, it is clear that global factors were far more important in determining management actions, leading to significant differences in structural adaptation. The article also debates whether this has led to improved performance, given the problems experienced with both geographical dispersion and diversification, bringing into question the quality of decision-making over the long term
Atypical presentation of Crimean-Congo haemorrhagic fever: Lessons learned
An atypical case of Crimean-Congo haemorrhagic fever is presented. The diagnosis of the case in the presence of several comorbidities was complicated and illustrates the importance of maintaining a high index of suspicion for viral haemorrhagic fever in cases presenting with multisystem disease and an epidemiological history that could present opportunities for exposure to a haemorrhagic fever virus
Two-body Pion Absorption on at Threshold
It is shown that a satisfactory explanation of the ratio of the rates of the
reactions and for stopped pions is obtained
once the effect of the short range two-nucleon components of the axial charge
operator for the nuclear system is taken into account. By employing realistic
models for the nucleon-nucleon interaction in the construction of these
components of the axial charge operator, the predicted ratios agree with the
empirical value to within 10-20\%.Comment: 19, UHPHYDOR-94-
A species-wide inventory of NLR genes and alleles in Arabidopsis thaliana
Infectious disease is both a major force of selection in nature and a prime cause of yield loss in agriculture. In plants, disease resistance is often conferred by nucleotide-binding leucine-rich repeat (NLR) proteins, intracellular immune receptors that recognize pathogen proteins and their effects on the host. Consistent with extensive balancing and positive selection, NLRs are encoded by one of the most variable gene families in plants, but the true extent of intraspecific NLR diversity has been unclear. Here, we define a nearly complete species-wide pan-NLRome in Arabidopsis thaliana based on sequence enrichment and long-read sequencing. The pan-NLRome largely saturates with approximately 40 well-chosen wild strains, with half of the pan-NLRome being present in most accessions. We chart NLR architectural diversity, identify new architectures, and quantify selective forces that act on specific NLRs and NLR domains. Our study provides a blueprint for defining pan-NLRomes
The pd <--> pi+ t reaction around the Delta resonance
The pd pi+ t process has been calculated in the energy region around the
Delta-resonance with elementary production/absorption mechanisms involving one
and two nucleons. The isobar degrees of freedom have been explicitly included
in the two-nucleon mechanism via pi-- and rho-exchange diagrams. No free
parameters have been employed in the analysis since all the parameters have
been fixed in previous studies on the simpler pp pi+ d process. The
treatment of the few-nucleon dynamics entailed a Faddeev-based calculation of
the reaction, with continuum calculations for the initial p-d state and
accurate solutions of the three-nucleon bound-state equation. The integral
cross-section was found to be quite sensitive to the NN interaction employed
while the angular dependence showed less sensitivity. Approximately a 4% effect
was found for the one-body mechanism, for the three-nucleon dynamics in the p-d
channel, and for the inclusion of a large, possibly converged, number of
three-body partial states, indicating that these different aspects are of
comparable importance in the calculation of the spin-averaged observables.Comment: 40 Pages, RevTex, plus 5 PostScript figure
Rabies mortality and morbidity associated with animal bites in Africa: a case for integrated rabies disease surveillance, prevention and control: a scoping review
OBJECTIVE: The objective of this scoping review was to map the current situation and available evidence and gaps on rabies morbidity, mortality, integrated rabies surveillance programmes, and existing prevention and control strategies in Africa. METHODS: We conducted a systematic scoping review following the Joanna Briggs methodology and Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews checklist. Medline, Embase, CINAHL (EBSCOHost), Scopus, Web of Science and rabies web conferences were used to search for peer-reviewed publications between January 1946 and May 2020. Two researchers reviewed the studies and extracted data based on author (year) and region, study design and data collection duration, participants/comparators, interventions, control conditions/exposures and outcomes (rabies mortality and morbidity) and key findings/gaps/challenges. The results were reported narratively using Arksey and O'Malley's methodological framework. RESULTS: Electronic search yielded 2775 records, of which 43 studies were included. A total of 543 714 bite victims were censored through the included studies. Most of the victims were less than 15 years of age. The studies included rabies morbidity (21) and mortality (15) fluctuating in space and time across Africa depending on countries' rabies prevention and control practices (16). Others were surveillance (nine studies); surveillance and prevention (five studies); management and control (seven studies); and surveillance, prevention and control (six studies). We found challenges in rabies reporting, existing dog vaccination programmes and post-exposure prophylaxis availability or compliance. CONCLUSION: This study found challenges for dog rabies control and elimination in Africa and the need for a policy to drive the goal of zero dog-transmitted rabies to humans by 2030.This is an open-access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build on this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated and the use is non-commercial (see http://creativecommons.org/licenses/by-nc/4.0/)
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