Study on the weight coefficient influence of surface water on the stability of open-pit dump. Comparative analysis of 6 degree seismic simulation

Taking Baorixile open-pit coal mine as an example, the regional hydrogeological conditions and the mining area hydrogeological conditions are briefly introduced. Analyzing the factors influencing the stability of open pit dump, discussing the classification and proportion of influencing factors, the numerical simulation of the influence of surface water and seismic vibrations on the stability of open-pit dump is carried out. Results show: Surface water is an important factor affecting the stability of open-pit dump, extremely sensitive to the safety factor, the influence of slope instability is similar to that of intensity 6 earthquake. The weight coefficient of surface water to slope stability is in the range of 0.4 to 0.9

Laboratory study of acoustic velocity in different types of rocks at seismic frequency band

In order to understand the characteristics of acoustic wave propagation in rocks within seismic frequency band (<100 Hz), the velocities of longitudinal and transverse waves of four different types of rocks were tested using low-frequency stress-strain method by means of the physical testing system of rock at low frequency and the experimental data of acoustic velocities of four different types of rocks at this frequency band were obtained. The experimental results showed that the acoustic velocities of four different types of rocks increased with the increase of temperature and pressure within the temperature and pressure ranges set by the experiment. The acoustic velocity of fine sandstone at 50% water saturation was smaller than that of dry sample. The acoustic velocities of four different types of rocks were different and the velocities of longitudinal waves of gritstone, fine sandstone, argillaceous siltstone and mudstone increased in turn under similar conditions and were smaller than those at ultrasonic frequency. Few of existing studies focus on the acoustic velocity at seismic frequency band, thus, further understanding of the acoustic characteristics at this seismic frequency band still requires more experimental data

The Effectiveness of Pay-It-Forward in Addressing HPV Vaccine Delay and Increasing Uptake Among 15–18-Year-Old Adolescent Girls Compared to User-Paid Vaccination: A Study Protocol for a Two-Arm Randomized Controlled Trial in China

Background Human papillomavirus (HPV) vaccination could prevent cervical and other HPV-associated cancers attributable to vaccine-associated HPV types. However, HPV vaccination coverage among women aged 9–18 years old is low in China. Common barriers include poor financial affordability, minimal public engagement, and low confidence in domestically produced HPV vaccines. Pay-it-forward offers an individual a free or subsidized service then an opportunity to voluntarily donate and/or create a postcard message to support future people. This study aims to assess the effectiveness of pay-it-forward as compared to standard-of-care self-paid vaccination to improve HPV vaccine uptake among adolescent girls aged 15–18 years, who are left out in the current pilot free HPV vaccination task force in some parts of China. Methods This is a two-arm randomized controlled trial in Chengdu, China. Eligible adolescent girls (via caregivers) will be randomly selected and recruited through four community health centers (one in the most developed urban areas, one in higher middle-income and one in lower middle-income suburban areas, and one in the least developed rural areas) using the resident registration list. A total of 320 participants will be randomized into two study arms (user-paid versus pay-it-forward vaccination) in a 1:1 ratio. The intervention assignment will be blinded to recruiters and participants using envelop concealment until the research assistants open the envelop to determine which treatment to deliver to each individual. The primary outcome of the study will be HPV vaccine uptake by administrative data. Secondary outcomes include costs, vaccine hesitancy, and the completion rates of the 3-dose HPV vaccination series. Discussion This study will investigate an innovative pay-it-forward strategy’s effectiveness and economic costs to improve HPV vaccination among 15–18-year-old adolescent girls. Study findings will have implications for increasing HPV vaccine uptake in places where HPV vaccines are provided for a fee

A Skin Lipidomics Study Reveals the Therapeutic Effects of Tanshinones in a Rat Model of Acne

Tanshinone (TAN), a class of bioactive components in traditional Chinese medicinal plant Salvia miltiorrhiza, has antibacterial and anti-inflammatory effects, can enhance blood circulation, remove blood stasis, and promote wound healing. For these reasons it has been developed as a drug to treat acne. The purpose of this study was to evaluate the therapeutic effects of TAN in rats with oleic acid-induced acne and to explore its possible mechanisms of action through the identification of potential lipid biomarkers. In this study, a rat model of acne was established by applying 0.5 ml of 80% oleic acid to rats’ back skin. The potential metabolites and targets involved in the anti-acne effects of TAN were predicted using lipidomics. The results indicate that TAN has therapeutic efficacy for acne, as supported by the results of the histological analyses and biochemical index assays for interleukin (IL)-8, IL-6, IL-β and tumor necrosis factor alpha. The orthogonal projection of latent structure discriminant analysis score was used to analyze the lipidomic profiles between control and acne rats. Ninety-six potential biomarkers were identified in the skin samples of the acne rats. These biomarkers were mainly related to glycerophospholipid and sphingolipid metabolism, and the regulation of their dysfunction is thought to be a possible therapeutic mechanism of action of TAN on acne

Disconnection between plant–microbial nutrient limitation across forest biomes

11 páginas.- 7 figuras.- 1 tabla.- 41 referencias.- Additional supporting information can be found online in the Supporting Information section at the end of this article..- Read the free Plain Language Summary for this article on the Journal blog.Nitrogen (N) and phosphorus (P) are essential elements limiting plant–microbial growth in forest ecosystems. However, whether the pattern of plant–microbe nutrient limitation is consistent across forest biomes and the associated potential mechanisms remain largely unclear, limiting us to better understand the biogeochemical processes under future climate change. Here, we investigated patterns of plant–microbial N/P limitation in forests across a wide environmental gradient and biomes in China to explore the divergence of plant–microbial N/P limitation and the driving mechanisms. We revealed that 42.6% of the N/P limitation between plant–microbial communities was disconnected. Patterns in plant–microbial N/P limitations were consistent only for 17.7% of N and 39.7% of P. Geospatially, the inconsistency was more evident at mid-latitudes, where plants were mainly N limited and microbes were mainly P limited. Furthermore, our findings were consistent with the ecological stoichiometry of plants and microbes themselves and their requirements. Whereas plant N and P limitation was more strongly responsive to meteorological conditions and atmospheric deposition, that of microbes was more strongly responsive to soil chemistry, which exacerbated the plant–microbe N and P limitation divergence. Our work identified an important disconnection between plant and microbial N/P limitation, which should be incorporated into future Earth System Model to better predict forest biomes–climate change feedback. Read the free Plain Language Summary for this article on the Journal blog. © 2023 The Authors. Functional Ecology © 2023 British Ecological SocietyNational Natural Science Foundation of China, Grant/Award Number: 42207107; Catalan Government Grant, Grant/Award Number: SGR2017-1005; Fundación Ramón Areces grant, Grant/Award Number: CIVP20A6621; National Key Research and Development Program of China, Grant/Award Number: 2021YFD1901205; Open Fund of Key Laboratory of Agro-Ecological Processes in Subtropical Region, Chinese Academy of Sciences, Grant/Award Number: ISA2021101; Spanish Government, Grant/Award Number: PID2019-110521GB-I00 and PID2020-115770RB-I00; Strategic Priority Research Program of Chinese Academy of Sciences, Grant/Award Number: XDB40020202Peer reviewe

Influenza vaccine uptake among children and older adults in China: a secondary analysis of a quasi-experimental study.

BACKGROUND: Influenza vaccination is the key to prevent influenza-related disease, especially among high-risk populations. However, influenza vaccine uptake in China is low. This secondary analysis of a quasi-experimental trial aimed to understand factors associated with influenza vaccine uptake among children and older people stratified by funding context. METHODS: A total of 225 children (aged 0.5-8 years) and 225 older people (aged 60 years or above) were recruited from three clinics (rural, suburban and urban) in Guangdong Province. Participants were allocated into two groups based on funding contexts: a self-paid group (N = 150, 75 children and 75 older adults) in which participants paid full price for their vaccination; and a subsidized group (N = 300, 150 children and 150 older adults) in which varying levels of financial support was provided. Univariate and multivariable logistic regressions were conducted stratified by funding contexts. RESULTS: Overall, 75.0% (225/300) of participants in the subsidized group and 36.7% (55/150) in the self-paid group got vaccinated. Older adults had lower vaccination rates than children in both funding groups, while both age groups showed much higher uptake in the subsidized group than in the self-paid group (aOR = 5.96, 95% CI: 3.77-9.42, p = 0.001). In the self-paid group, having prior influenza vaccination history of children (aOR:2.61, 95%CI: 1.06-6.42) or older people (aOR:4.76, 95%CI: 1.08-20.90) was associated with increased influenza vaccine uptake compared to those who had no prior vaccination experiences in the family. While in the subsidized group, participants who got married or lived with partners (aOR = 0.32, 0.10-0.98) had lower vaccination uptake than single ones. Trust in providers' advice (aOR = 4.95, 95%CI:1.99, 12.43), perceived effectiveness of the vaccine (aOR: 12.18, 95%CI: 5.21-28.50), and experienced influenza-like illnesses in the family in the past year (aOR = 46.52, 4.10, 533.78) were associated with higher vaccine uptake. CONCLUSIONS: Older people had suboptimal vaccine uptake compared to children in both contexts and need more attention to enhance influenza vaccination. Tailoring interventions to different vaccine funding contexts may help improve influenza vaccination: In self-paid context, motivating people to accept their first ever influenza vaccination may be a promising strategy. In subsidized context, improving public confidence in vaccine effectiveness and providers' advice would be useful

The effectiveness of pay-it-forward in addressing HPV vaccine delay and increasing uptake among 15-18-year-old adolescent girls compared to user-paid vaccination: a study protocol for a two-arm randomized controlled trial in China

BACKGROUND: Human papillomavirus (HPV) vaccination could prevent cervical and other HPV-associated cancers attributable to vaccine-associated HPV types. However, HPV vaccination coverage among women aged 9-18 years old is low in China. Common barriers include poor financial affordability, minimal public engagement, and low confidence in domestically produced HPV vaccines. Pay-it-forward offers an individual a free or subsidized service then an opportunity to voluntarily donate and/or create a postcard message to support future people. This study aims to assess the effectiveness of pay-it-forward as compared to standard-of-care self-paid vaccination to improve HPV vaccine uptake among adolescent girls aged 15-18 years, who are left out in the current pilot free HPV vaccination task force in some parts of China. METHODS: This is a two-arm randomized controlled trial in Chengdu, China. Eligible adolescent girls (via caregivers) will be randomly selected and recruited through four community health centers (one in the most developed urban areas, one in higher middle-income and one in lower middle-income suburban areas, and one in the least developed rural areas) using the resident registration list. A total of 320 participants will be randomized into two study arms (user-paid versus pay-it-forward vaccination) in a 1:1 ratio. The intervention assignment will be blinded to recruiters and participants using envelop concealment until the research assistants open the envelop to determine which treatment to deliver to each individual. The primary outcome of the study will be HPV vaccine uptake by administrative data. Secondary outcomes include costs, vaccine hesitancy, and the completion rates of the 3-dose HPV vaccination series. DISCUSSION: This study will investigate an innovative pay-it-forward strategy's effectiveness and economic costs to improve HPV vaccination among 15-18-year-old adolescent girls. Study findings will have implications for increasing HPV vaccine uptake in places where HPV vaccines are provided for a fee. TRIAL REGISTRATION: Chinese Clinical Trial Registry (ChiCTR), ChiCTR2200055542. Registered on 11 January 2022

Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies

Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of intensive research because of its crucial role in the pathogenesis of different diseases across many medical specialties. In this context, the present review in which a panel of 13 experts in immunology, dermatology, rheumatology, neurology, hematology, infectious diseases, hepatology, cardiology, ophthalmology and oncology have been involved, puts in common the mechanisms through which IL-17 is considered a molecular target for the development of novel biological therapies in these different fields. A comprehensive review of the literature and analysis of the most outstanding evidence have provided the basis for discussing the most relevant data related to IL-17A blocking agents for the treatment of different disorders, such as psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, cardiovascular disorders, non alcoholic fatty liver disease, multiple sclerosis, inflammatory bowel disease, uveitis, hematological and solid cancer. Current controversies are presented giving an opening line for future research.This work was supported by Novartis Pharmaceuticals Spain