Evaluation of a load cell model for dynamic calibration of the rotor systems research aircraft

The Rotor Systems Research Aircraft uses load cells to isolate the rotor/transmission system from the fuselage. An analytical model of the relationship between applied rotor loads and the resulting load cell measurements is derived by applying a force-and-moment balance to the isolated rotor/transmission system. The model is then used to estimate the applied loads from measured load cell data, as obtained from a ground-based shake test. Using nominal design values for the parameters, the estimation errors, for the case of lateral forcing, were shown to be on the order of the sensor measurement noise in all but the roll axis. An unmodeled external load appears to be the source of the error in this axis

Being proven wrong elicits learning in children - but only in those with higher executive function skills

This study investigated whether prompting children to generate predictions about an outcome facilitates activation of prior knowledge and improves belief revision. 51 children aged 9-12 were tested on two experimental tasks in which generating a prediction was compared to closely matched control conditions, as well as on a test of executive functions (EF). In Experiment 1, we showed that children exhibited a pupillary surprise response to events that they had predicted incorrectly, hypothesized to reflect the transient release of noradrenaline in response to cognitive conflict. However, children\u27s surprise response was not associated with better belief revision, in contrast to a previous study involving adults. Experiment 2 revealed that, while generating predictions helped children activate their prior knowledge, only those with better inhibitory control skills learned from incorrectly predicted outcomes. Together, these results suggest that good inhibitory control skills are needed for learning through cognitive conflict. Thus, generating predictions benefits learning - but only among children with sufficient EF capacities to harness surprise for revising their beliefs. (DIPF/Orig.

Mining and Visualizing Research Networks using the Artefact-Actor-Network Approach

Reinhardt, W., Wilke, A., Moi, M., Drachsler, H., & Sloep, P. B. (2012). Mining and Visualizing Research Networks using the Artefact-Actor-Network Approach. In A. Abraham (Ed.), Computational Social Networks. Mining and Visualization (pp. 233-268). Springer. Also available at http://www.springer.com/computer/communication+networks/book/978-1-4471-4053-5Virtual communities are increasingly relying on technologies and tools of the so-called Web 2.0. In the context of scientific events and topical Research Networks, researchers use Social Media as one main communication channel. This raises the question, how to monitor and analyze such Research Networks. In this chapter we argue that Artefact-Actor-Networks (AANs) serve well for modeling, storing and mining the social interactions around digital learning resources originating from various learning services. In order to deepen the model of AANs and its application to Research Networks, a relevant theoretical background as well as clues for a prototypical reference implementation are provided. This is followed by the analysis of six Research Networks and a detailed inspection of the results. Moreover, selected networks are visualized. Research Networks of the same type show similar descriptive measures while different types are not directly comparable to each other. Further, our analysis shows that narrowness of a Research Network's subject area can be predicted using the connectedness of semantic similarity networks. Finally conclusions are drawn and implications for future research are discussed

Enhanced mitochondrial superoxide scavenging does not Improve muscle insulin action in the high fat-fed mouse

Improving mitochondrial oxidant scavenging may be a viable strategy for the treatment of insulin resistance and diabetes. Mice overexpressing the mitochondrial matrix isoform of superoxide dismutase (sod2(tg) mice) and/or transgenically expressing catalase within the mitochondrial matrix (mcat(tg) mice) have increased scavenging of O2(˙-) and H2O2, respectively. Furthermore, muscle insulin action is partially preserved in high fat (HF)-fed mcat(tg) mice. The goal of the current study was to test the hypothesis that increased O2(˙-) scavenging alone or in combination with increased H2O2 scavenging (mtAO mice) enhances in vivo muscle insulin action in the HF-fed mouse. Insulin action was examined in conscious, unrestrained and unstressed wild type (WT), sod2(tg), mcat(tg) and mtAO mice using hyperinsulinemic-euglycemic clamps (insulin clamps) combined with radioactive glucose tracers following sixteen weeks of normal chow or HF (60% calories from fat) feeding. Glucose infusion rates, whole body glucose disappearance, and muscle glucose uptake during the insulin clamp were similar in chow- and HF-fed WT and sod2(tg) mice. Consistent with our previous work, HF-fed mcat(tg) mice had improved muscle insulin action, however, an additive effect was not seen in mtAO mice. Insulin-stimulated Akt phosphorylation in muscle from clamped mice was consistent with glucose flux measurements. These results demonstrate that increased O2(˙-) scavenging does not improve muscle insulin action in the HF-fed mouse alone or when coupled to increased H2O2 scavenging

The timescale of early land plant evolution

Establishing the timescale of early land plant evolution is essential for testing hypotheses on the coevolution of land plants and Earth's System. The sparseness of early land plant megafossils and stratigraphic controls on their distribution make the fossil record an unreliable guide, leaving only the molecular clock. However, the application of molecular clock methodology is challenged by the current impasse in attempts to resolve the evolutionary relationships among the living bryophytes and tracheophytes. Here, we establish a timescale for early land plant evolution that integrates over topological uncertainty by exploring the impact of competing hypotheses on bryophyte-tracheophyte relationships, among other variables, on divergence time estimation. We codify 37 fossil calibrations for Viridiplantae following best practice. We apply these calibrations in a Bayesian relaxed molecular clock analysis of a phylogenomic dataset encompassing the diversity of Embryophyta and their relatives within Viridiplantae. Topology and dataset sizes have little impact on age estimates, with greater differences among alternative clock models and calibration strategies. For all analyses, a Cambrian origin of Embryophyta is recovered with highest probability. The estimated ages for crown tracheophytes range from Late Ordovician to late Silurian. This timescale implies an early establishment of terrestrial ecosystems by land plants that is in close accord with recent estimates for the origin of terrestrial animal lineages. Biogeochemical models that are constrained by the fossil record of early land plants, or attempt to explain their impact, must consider the implications of a much earlier, middle Cambrian-Early Ordovician, origin

Using models of the ocean's mean dynamic topography to identify errors in coastal geodetic levelling

Identifying errors (blunders and systematic errors) in coastal geodetic levelling networks has often been problematic. This is because (1) mean sea level (MSL) at tide gauges cannot be directly compared to height differences from levelling because the geoid/quasigeoid and MSL are not parallel, being separated by the ocean’s mean dynamic topography (MDT) and (2) the lack of redundancy at the edge of the levelling network. This paper sets out a methodology to independently identify blunders and/or systematic errors (over long distances) in geodetic levelling using MDT models to account for the separation between the geoid/quasigeoid and MSL at tide gauges. This method is then tested in a case study using an oceanographic MDT model, MSL observations, GNSS data and a quasigeoid model. The results are significant because the errors found could not be detected by standard levelling misclosure checks alone, with supplementary data from an MDT model, with cross-validation from GNSS-quasigeoid allowing their detection. In addition, it appears that an oceanographic-only MDT is as effective as GNSS and a quasigeoid model for detecting levelling errors, which could be particularly useful for countries with coastal levelling errors in their levelling networks that cannot be identified by conventional levelling closure checks

Compact radio sources and jet-driven AGN feedback in the early Universe: Constraints from integral-field spectroscopy

To investigate the impact of radio jets during the formation epoch of their massive host galaxies, we present an analysis of two massive, log(M_stel/ M_sun)~10.6 and 11.3, compact radio galaxies at z=3.5, TNJ0205+2242 and TNJ0121+1320. Their small radio sizes (R<= 10 kpc) are most likely a sign of youth. We compare their radio properties and gas dynamics with those in well extended radio galaxies at high redshift, which show strong evidence for powerful, jet-driven outflows of significant gas masses (M 10^9-10 M_sun). Our analysis combines rest-frame optical integral-field spectroscopy with existing radio imaging, CO emission line spectra, and rest-frame UV spectroscopy. [OIII]5007 line emission is compact in both galaxies and lies within the region defined by the radio lobes. For TNJ0205+2242, the Ly-alpha profile narrows significantly outside the jet radius, indicating the presence of a quiescent halo. TNJ0121+1320 has two components separated by ~10 kpc and a velocity offset of ~300 km s^-1. If motions are gravitational, this implies a dynamical mass of 2x10^11 M_sun for the more massive, radio-loud component. The dynamical mass, molecular gas mass measured from the CO line emission, and radio luminosity of these two compact radio galaxies imply that compact radio sources may well develop large-scale, energetic outflows as observed in extended radio galaxies, with the potential of removing significant fractions of the ISM from the host galaxy. The absence of luminous emission line gas extending beyond the radio emission in these sources agrees with the observed timescales and outflow rates in extended radio galaxies, and adds further evidence that the energetic, large-scale outflows observed in extended radio sources (Nesvadba et al. 2006) are indeed the result of influence of the radio jet.Comment: A&A accepte

E-government adoption: A cultural comparison

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Springer Science + Business Media, LLC 2008.E-government diffusion is an international phenomenon. This study compares e-government adoption in the U.K. to adoption in the U.S. In particular, this study seeks to determine if the same factors are salient in both countries. Several studies have explored citizen acceptance of e-government services in the U.S. However, few studies have explored this phenomenon in the U.K. To identify the similarities and differences between the U.K. and the U.S. a survey is conducted in the U.K. and the findings are compared to the literature that investigates diffusion in the U.S. This study proposes a model of e-government adoption in the U.K. based on salient factors in the U.S. A survey is administered to 260 citizens in London to assess the importance of relative advantage, trust and the digital divide on intention to use e-government. The results of binary logistic regression indicate that there are cultural differences in e-government adoption in the U.K. and the U.S. The results indicate that of the prevailing adoption constructs, relative advantage and trust are pertinent in both the U.S. and the U.K., while ICT adoption barriers such as access and skill may vary by culture. Implications for research and practice are discussed

The practical other : teleology and its development

We argue for teleology as a description of the way in which we ordinarily understand others’ intentional actions. Teleology starts from the close resemblance between the reasoning involved in understanding others’ actions and one’s own practical reasoning involved in deciding what to do. We carve out teleology’s distinctive features more sharply by comparing it to its three main competitors: theory theory, simulation theory, and rationality theory. The plausibility of teleology as our way of understanding others is underlined by developmental data in its favour

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B

Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels can be modulated by receptor-driven alterations of cyclic AMP-dependent protein kinase (PKA) activity. Here, we demonstrate that Kv channel activity is maintained by tonic activity of PKA. Whole-cell recording was used to assess the effect of manipulating PKA signalling on Kv and ATP-dependent K+ channels of rat mesenteric artery smooth muscle cells. Application of PKA inhibitors, KT5720 or H89, caused a significant inhibition of Kv currents. Tonic PKA-mediated activation of Kv appears maximal as application of isoprenaline (a β-adrenoceptor agonist) or dibutyryl-cAMP failed to enhance Kv currents. We also show that this modulation of Kv by PKA can be reversed by protein phosphatase 2B/calcineurin (PP2B). PKA-dependent inhibition of Kv by KT5720 can be abrogated by pre-treatment with the PP2B inhibitor cyclosporin A, or inclusion of a PP2B auto-inhibitory peptide in the pipette solution. Finally, we demonstrate that tonic PKA-mediated modulation of Kv requires intact caveolae. Pre-treatment of the cells with methyl-β-cyclodextrin to deplete cellular cholesterol, or adding caveolin-scaffolding domain peptide to the pipette solution to disrupt caveolae-dependent signalling each attenuated PKA-mediated modulation of the Kv current. These findings highlight a novel, caveolae-dependent, tonic modulatory role of PKA on Kv channels providing new insight into mechanisms and the potential for pharmacological manipulation of vascular tone