L'éléphant comme vecteurd'un tourisme communautaire et durable

Ce travail de bachelor consiste à créer une offre touristique éthique et communautaire construite autour de l’éléphant. Cette offre a été élaborée de toutes pièces afin de bénéficier au maximum aux villageois du lieu d’implantation du projet. Les buts de l’offre sont multiples et visent par exemple à proposer aux visiteurs une expérience ludique et éducative, bénéficiant à la communauté locale tout en maximisant le bien être de l’éléphant. Ce nouveau produit vise par la même occasion à créer une vague de sensibilisation concernant les mauvais traitements infligés aux éléphants en Inde et ainsi pouvoir mettre en lumière et peut-être désamorcer le conflit actuel opposant l’homme à l’animal dans le district de Wayanad, situé dans l’Etat du Kerala au sud de l’Inde

Designing generic technologies in Energy Research: learning from two CEA technologies for double unknown management

International audienceThe aim of this paper is to shed light on an innovative strategy for the design of generic technologies (GTs). Research on radical innovation management, while recognizing the success of GTs, generally describes their design according to evolutionary strategies featuring multiple and uncertain trials, which would finally result in the discovery of common features between multiple applications. Building on a case study conducted on two technological development programs at the French Alternative Energies and Atomic Energy Commission (CEA), we exhibit an anomaly to this rarely discussed idea: we describe an alternative strategy that consists in intentionally designing common features that bridge the gap between a priori heterogeneous applications and a priori heterogeneous technologies. This anomaly brings three main results: 1) The usual trial-and-learning strategy is not necessarily the only strategy to design a GT; 2) beyond technological breakthrough, the value of GTs also relies on the capacity to reuse and connect existing technologies; 3) the design of GT might require sophisticated organizational patterns to be able to involve multiple technology suppliers and applications' providers

Strain superlattices and macroscale suspension of Graphene induced by corrugated substrates

We investigate the organized formation of strain, ripples and suspended features in macroscopic CVD-prepared graphene sheets transferred onto a corrugated substrate made of an ordered arrays of silica pillars of variable geometries. Depending on the aspect ratio and sharpness of the corrugated array, graphene can conformally coat the surface, partially collapse, or lay, fakir-like, fully suspended between pillars over tens of micrometers. Upon increase of pillar density, ripples in collapsed films display a transition from random oriented pleats emerging from pillars to ripples linking nearest neighboring pillars organized in domains of given orientation. Spatially-resolved Raman spectroscopy, atomic force microscopy and electronic microscopy reveal uniaxial strain domains in the transferred graphene, which are induced and controlled by the geometry. We propose a simple theoretical model to explain the transition between suspended and collapsed graphene. For the arrays with high aspect ratio pillars, graphene membranes stays suspended over macroscopic distances with minimal interaction with pillars tip apex. It offers a platform to tailor stress in graphene layers and open perspectives for electron transport and nanomechanical applications

Clinical characteristics and outcomes of patients with hepatic angiomyolipoma:A literature review

First reported in 1976, hepatic angiomyolipoma (HAML) is a rare mesenchymal liver tumor occurring mostly in middle-aged women. Diagnosis of the liver mass is often incidental on abdominal imaging due to the frequent absence of specific symptoms. Nearly 10% of HAMLs are associated with tuberous sclerosis complex. HAML contains variable proportions of blood vessels, smooth muscle cells and adipose tissue, which renders radiological diagnosis hazardous. Cells express positivity for HMB-45 and actin, thus these tumors are integrated into the group of perivascular epithelioid cell tumors. Typically, a HAML appears on magnetic resonance imaging (or computed tomography scan) as a hypervascular solid tumor with fatty areas and with washout, and can easily be misdiagnosed as other liver tumors, particularly hepatocellular carcinoma. The therapeutic strategy is not clearly defined, but surgical resection is indicated for symptomatic patients, for tumors showing an aggressive pattern (i.e., changes in size on imaging or high proliferation activity and atypical epithelioid pattern on liver biopsy), for large (> 5 cm) biopsy-proven HAML, and if doubts remain on imaging or histology. Conservative management may be justified in other conditions, since most cases follow a benign clinical course. In summary, the correct diagnosis of HAML is challenging on imaging and relies mainly on pathological findings

Simulations of galaxy formation in a Λ cold dark matter universe : I : dynamical and photometric properties of a simulated disk galaxy.

We present a detailed analysis of the dynamical and photometric properties of a disk galaxy simulated in the cold dark matter (CDM) cosmogony. The galaxy is assembled through a number of high-redshift mergers followed by a period of quiescent accretion after z1 that lead to the formation of two distinct dynamical components: a spheroid of mostly old stars and a rotationally supported disk of younger stars. The surface brightness profile is very well approximated by the superposition of an R1/4 spheroid and an exponential disk. Each photometric component contributes a similar fraction of the total luminosity of the system, although less than a quarter of the stars form after the last merger episode at z1. In the optical bands the surface brightness profile is remarkably similar to that of Sab galaxy UGC 615, but the simulated galaxy rotates significantly faster and has a declining rotation curve dominated by the spheroid near the center. The decline in circular velocity is at odds with observation and results from the high concentration of the dark matter and baryonic components, as well as from the relatively high mass-to-light ratio of the stars in the simulation. The simulated galaxy lies 1 mag off the I-band Tully-Fisher relation of late-type spirals but seems to be in reasonable agreement with Tully-Fisher data on S0 galaxies. In agreement with previous simulation work, the angular momentum of the luminous component is an order of magnitude lower than that of late-type spirals of similar rotation speed. This again reflects the dominance of the slowly rotating, dense spheroidal component, to which most discrepancies with observation may be traced. On its own, the disk component has properties rather similar to those of late-type spirals: its luminosity, its exponential scale length, and its colors are all comparable to those of galaxy disks of similar rotation speed. This suggests that a different form of feedback than adopted here is required to inhibit the efficient collapse and cooling of gas at high redshift that leads to the formation of the spheroid. Reconciling, without fine-tuning, the properties of disk galaxies with the early collapse and high merging rates characteristic of hierarchical scenarios such as CDM remains a challenging, yet so far elusive, proposition

Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine.

OBJECTIVE: Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate. The aim of this consensus is to provide support to the bedside clinician regarding the diagnosis, management and monitoring of shock. METHODS: The European Society of Intensive Care Medicine invited 12 experts to form a Task Force to update a previous consensus (Antonelli et al.: Intensive Care Med 33:575-590, 2007). The same five questions addressed in the earlier consensus were used as the outline for the literature search and review, with the aim of the Task Force to produce statements based on the available literature and evidence. These questions were: (1) What are the epidemiologic and pathophysiologic features of shock in the intensive care unit ? (2) Should we monitor preload and fluid responsiveness in shock ? (3) How and when should we monitor stroke volume or cardiac output in shock ? (4) What markers of the regional and microcirculation can be monitored, and how can cellular function be assessed in shock ? (5) What is the evidence for using hemodynamic monitoring to direct therapy in shock ? Four types of statements were used: definition, recommendation, best practice and statement of fact. RESULTS: Forty-four statements were made. The main new statements include: (1) statements on individualizing blood pressure targets; (2) statements on the assessment and prediction of fluid responsiveness; (3) statements on the use of echocardiography and hemodynamic monitoring. CONCLUSIONS: This consensus provides 44 statements that can be used at the bedside to diagnose, treat and monitor patients with shock

Pathologies related to abnormal deposits in dermatology : a physico-chemical approach

Although numerous pathologies are associated with abnormal skin deposits, these remain poorly described, as accurate characterization continues to present a challenge for dermatologists. Their submicrometer size as well as their diverse chemistry require various characterization tools. We aim to exemplify characterization of endogenous and exogenous skin deposits in some selected skin diseases using different physico-chemical techniques. We begin with a presentation of selected dis-eases associated with skin deposits. We then present those of our results which show their variety of structure, location and chemical composition, obtained with various tools: Field Emission Scanning Electron Microscopy coupled with Energy Dispersive X-ray Spectroscopy, X-ray fluorescence, vibra-tional spectroscopies, as well as techniques specific to synchrotron radiation. Our results constitute a real opportunity to improve diagnosis, and to understand the pathogenesis of many skin diseases, and opportunities for therapeutic intervention.Peer reviewe

Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids

Cadherin-23 is a component of early transient lateral links of the auditory sensory cells' hair bundle, the mechanoreceptive structure to sound. This protein also makes up the upper part of the tip links that control gating of the mechanoelectrical transduction channels. We addressed the issue of the molecular complex that anchors these links to the hair bundle F-actin core. By using surface plasmon resonance assays, we show that the cytoplasmic regions of the two cadherin-23 isoforms that do or do not contain the exon68-encoded peptide directly interact with harmonin, a submembrane PDZ (post-synaptic density, disc large, zonula occludens) domain-containing protein, with unusually high affinity. This interaction involves the harmonin Nter-PDZ1 supramodule, but not the C-terminal PDZ-binding motif of cadherin-23. We establish that cadherin-23 directly binds to the tail of myosin VIIa. Moreover, cadherin-23, harmonin and myosin VIIa can form a ternary complex, which suggests that myosin VIIa applies tension forces on hair bundle links. We also show that the cadherin-23 cytoplasmic region, harmonin and myosin VIIa interact with phospholipids on synthetic liposomes. Harmonin and the cytoplasmic region of cadherin-23, both independently and as a binary complex, can bind specifically to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), which may account for the role of this phospholipid in the adaptation of mechanoelectrical transduction in the hair bundle. The distributions of cadherin-23, harmonin, myosin VIIa and PI(4,5)P2 in the growing and mature auditory hair bundles as well as the abnormal locations of harmonin and myosin VIIa in cadherin-23 null mutant mice strongly support the functional relevance of these interactions

Scanning electron microscopy—a powerful imaging technique for the clinician

International audienc