Gravity-driven instabilities in fibrillar colloidal gels containing a second disperse phase

Fibrillar networks are of great importance for biological systems and many industrial applications. We investigate gravity-driven instabilities in fibrilalr colloidal gels containing a second disperse phase. We use a model system containing a surfactant-stabilized oil-in-water emulsion dispersed in a gel of cellulose microfibrils in the presence of carboxymethyl cellulose. Optical scanning of the creaming emulsion containing gels along the height was used to quantify the network evolution over time. We find a remarkable correlation between the concentration of microfibrils and creaming behaviour such as initial creaming speed and final gel height. We compare this behaviour to the theoretical model of gravitational stability of poroelastic gels, which was extended to account for particle shape anisotropy and the presence of a second disperse phase. Please click Additional Files below to see the full abstract

Long-term Phanerozoic global mean sea level: Insights from strontium isotope variations and estimates of continental glaciation

Global mean sea level is a key component within the fields of climate and oceanographic modelling in the Anthropocene. Hence, an improved understanding of eustatic sea level in deep time aids in our understanding of Earth's paleoclimate and may help predict future climatological and sea level changes. However, long-term eustatic sea level reconstructions are hampered because of ambiguity in stratigraphic interpretations of the rock record and limitations in plate tectonic modelling. Hence the amplitude and timescales of Phanerozoic eustasy remains poorly constrained. A novel, independent method from stratigraphic or plate modelling methods, based on estimating the effect of plate tectonics (i.e., mid-ocean ridge spreading) from the 87Sr/86Sr record led to a long-term eustatic sea level curve, but did not include glacio-eustatic drivers. Here, we incorporate changes in sea level resulting from variations in seawater volume from continental glaciations at time steps of 1 Myr. Based on a recent compilation of global average paleotemperature derived from δ18O data, paleo-Köppen zones and paleogeographic reconstructions, we estimate ice distribution on land and continental shelf margins. Ice thickness is calibrated with a recent paleoclimate model for the late Cenozoic icehouse, yielding an average ∼1.4 km thickness for land ice, ultimately providing global ice volume estimates. Eustatic sea level variations associated with long-term glaciations (>1 Myr) reach up to ∼90 m, similar to, and is at times dominant in amplitude over plate tectonic-derived eustasy. We superimpose the long-term sea level effects of land ice on the plate tectonically driven sea level record. This results in a Tectono-Glacio-Eustatic (TGE) curvefor which we describe the main long-term (>50 Myr) and residual trends in detail

Detection and Characterization of Ignitable Liquid Residues in Forensic Fire Debris Samples by Comprehensive Two-Dimensional Gas Chromatography

This study covers an extensive experimental design that was developed for creating simulated fire debris samples under controlled conditions for the detection and identification of ignitable liquids (IL) residues. This design included 19 different substrates, 45 substrate combinations with and without ignitable liquids, and 45 different ILs from three classes (i.e., white spirit, gasoline, and lamp oil). Chemical analysis was performed with comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC×GC-TOFMS) for improved separation and compound identification. The enhanced peak capacity offered by GC×GC-TOFMS allowed the use of a target compound list in combination with a simple binary decision model to arrive at quite acceptable results with respect to IL detection (89% true positive and 7% false positive rate) and classification (100% correct white spirit, 79% correct gasoline, and 77% correct lamp oil assignment). Although these results were obtained in a limited set of laboratory controlled fire experiments including only three IL classes, this study confirms the conclusions of other studies that GC×GC-TOFMS can be a powerful tool in the challenging task of forensic fire debris analysis

Long-term Phanerozoic global mean sea level: Insights from strontium isotope variations and estimates of continental glaciation

Global mean sea level is a key component within the fields of climate and oceanographic modelling in the Anthropocene. Hence, an improved understanding of eustatic sea level in deep time aids in our understanding of Earth's paleoclimate and may help predict future climatological and sea level changes. However, long-term eustatic sea level reconstructions are hampered because of ambiguity in stratigraphic interpretations of the rock record and limitations in plate tectonic modelling. Hence the amplitude and timescales of Phanerozoic eustasy remains poorly constrained. A novel, independent method from stratigraphic or plate modelling methods, based on estimating the effect of plate tectonics (i.e., mid-ocean ridge spreading) from the 87Sr/86Sr record led to a long-term eustatic sea level curve, but did not include glacio-eustatic drivers. Here, we incorporate changes in sea level resulting from variations in seawater volume from continental glaciations at time steps of 1 Myr. Based on a recent compilation of global average paleotemperature derived from δ18O data, paleo-Köppen zones and paleogeographic reconstructions, we estimate ice distribution on land and continental shelf margins. Ice thickness is calibrated with a recent paleoclimate model for the late Cenozoic icehouse, yielding an average ∼1.4 km thickness for land ice, ultimately providing global ice volume estimates. Eustatic sea level variations associated with long-term glaciations (>1 Myr) reach up to ∼90 m, similar to, and is at times dominant in amplitude over plate tectonic-derived eustasy. We superimpose the long-term sea level effects of land ice on the plate tectonically driven sea level record. This results in a Tectono-Glacio-Eustatic (TGE) curvefor which we describe the main long-term (>50 Myr) and residual trends in detail

Adipocyte fatty acid binding protein in atherosclerotic plaques is associated with local vulnerability and is predictive for the occurrence of adverse cardiovascular events

Aims There is an increasing need for translational studies identifying molecular targets contributing to atherosclerotic plaque destabilization. Local molecular plaque markers that are related to plaque vulnerability may hold predictive value to identify patients who are at increased risk to suffer from cardiovascular events. Animal studies revealed that adipocyte fatty acid binding protein (FABP4) is associated with the progression of atherosclerosis; however, FABP4 expression studies in human atherosclerotic plaques are lacking. We investigated FABP4 expression in carotid atherosclerotic lesions in relation to plaque composition and future cardiovascular events. Methods and results Atherosclerotic plaques were obtained from 561 patients undergoing carotid endarterectomy (CEA). Plaques were analysed for the presence of macrophages, lipid core, smooth-muscle cells, collagen, calcification, and intraplaque haemorrhage. Patients were followed for 3 years after CEA. The primary outcome was defined as the composite of vascular death, vascular event, and surgical or percutaneous vascular intervention. Fatty acid binding protein levels correlated with unstable plaque characteristics and symptomatic lesions. Patients with increased FABP4 plaque levels showed a two-fold increased risk [HR = 1.99, 95% confidence interval (95% CI) (1.30-3.04)] (P = 0.005) to reach the primary outcome during follow-up. Increased FABP4 levels related to primary outcome, independent from general cardiovascular risk factors [HR 1.33, 95% CI (1.08-1.65)] (P = 0.008). Conclusion FABP4 levels in atherosclerotic lesions are associated with an unstable plaque phenotype and an increased risk for cardiovascular events during follow-up. Besides risk stratification for adverse future cardiovascular events, the outcome of the present study supports the relevance of exploring FABP4 antagonists as a potential pharmaceutical intervention to treat atherosclerotic disease progression