Cosmic rays measurements around the knee of the primary spectrum

In this contribution I will summarize and discuss some recent results about the study of the knee of the cosmic rays energy spectrum, indicating that this spectral feature is originated by astrophysical processes. I will then discuss the current experimental efforts that are giving further insights. Latest all particle spectrum measurements have shown that, between 1016eV and 1018eV, the spectrum cannot be described by a single slope power law: an hardening around 1016eV and a steepeningaround 1017eV have been observed. This last feature has been attributed, by the KASCADE-Grande experiment, to the heavy primary component, confirming that the energy of the elemental spectra change of slope increase with the mass of the primary particle

Correlations in the Ising antiferromagnet on the anisotropic kagome lattice

We study the correlation function of middle spins, i. e. of spins on intermediate sites between two adjacent parallel lattice axes, of the spatially anisotropic Ising antiferromagnet on the kagome lattice. It is given rigorously by a Toeplitz determinant. The large-distance behaviour of this correlation function is obtained by analytic methods. For shorter distances we evaluate the Toeplitz determinant numerically. The correlation function is found to vanish exactly on a line J_d(T) in the T-J (temperature vs. coupling constant) phase diagram. This disorder line divides the phase diagram into two regions. For J less than J_d(T) the correlations display the features of an unfrustrated two-dimensional Ising magnet, whereas for J greater than J_d(T) the correlations between the middle spins are seen to be strongly influenced by the short-range antiferromagnetic order that prevails among the spins of the adjacent lattice axes. While for J less than J_d(T) there is a region with ferrimagnetic long-range order, the model remains disordered for J greater than J_d(T) down to T=0.Comment: 26 pages, 9 figures, published versio

Mechanistic Link between Vitamin B12 and Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common form of dementia in the elderly population, affecting over 55 million people worldwide. Histopathological hallmarks of this multifactorial disease are an increased plaque burden and tangles in the brains of affected individuals. Several lines of evidence indicate that B12 hypovitaminosis is linked to AD. In this review, the biochemical pathways involved in AD that are affected by vitamin B12, focusing on APP processing, Aβ fibrillization, Aβ induced oxidative damage as well as tau hyperphosphorylation and tau aggregation, are summarized. Besides the mechanistic link, an overview of clinical studies utilizing vitamin B supplementation are given, and a potential link between diseases and medication resulting in a reduced vitamin B12 level and AD are discussed. Besides the disease-mediated B12 hypovitaminosis, the reduction in vitamin B12 levels caused by an increasing change in dietary preferences has been gaining in relevance. In particular, vegetarian and vegan diets are associated with vitamin B12 deficiency, and therefore might have potential implications for AD. In conclusion, our review emphasizes the important role of vitamin B12 in AD, which is particularly important, as even in industrialized countries a large proportion of the population might not be sufficiently supplied with vitamin B12

Fold and thrust partitioning in a contracting fold belt: Insights from the 1931 Mach earthquake in Baluchistan

Surface deformation associated with the 27 August 1931 earthquake near Mach in Baluchistan is quantified from spirit-leveling data and from detailed structural sections of the region interpreted from seismic reflection data constrained by numerous well logs. Mean slip on the west dipping Dezghat/Bannh fault system amounted to 1.2 m on a 42 km x 72 km thrust plane with slip locally attaining 3.2 m up dip of an inferred locking line at approximately 9 km depth. Slip also occurred at depths below the interseismic locking line. In contrast, negligible slip occurred in the 4 km near the interseismic locking line. The absence of slip here in the 4 years following the earthquake suggests that elastic energy there must either dissipate slowly in the interseismic cycle, or that a slip deficit remains, pending its release in a large future earthquake. Elastic models of the earthquake cycle in this fold and thrust belt suggest that slip on the frontal thrust fault is reduced by a factor of 2 to 8 compared to that anticipated from convergence of the hinterland, a partitioning process that is presumably responsible for thickening of the fold and thrust belt at the expense of slip on the frontal thrust. Near the latitude of Quetta, GPS measurements indicate that convergence is approximately 5 mm/yr. Hence the minimum renewal time between earthquakes with 1.2-m mean displacement should be as little as 240 years. However, when the partitioning of fold belt convergence to frontal thrust slip is taken into account the minimum renewal time may exceed 2000 years

Comparable Autoantibody Serum Levels against Amyloid- and Inflammation-Associated Proteins in Parkinson’s Disease Patients and Controls

Naturally occurring autoantibodies (NAbs) against a number of potentially disease-associated cellular proteins, including Amyloid-beta1-42 (Abeta1-42), Alpha-synuclein (Asyn), myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and S100 calcium binding protein B (S100B) have been suggested to be associated with neurodegenerative disorders, in particular Alzheimer's (AD) and Parkinson's disease (PD). Whereas the (reduced) occurrence of specific NAbs in AD is widely accepted, previous literature examining the relation of these NAb titres between PD patients and controls, as well as comparing these levels with demographic and clinical parameters in PD patients have produced inconsistent findings. We therefore aimed, in a cross-sectional approach, to determine serum titres of the above NAbs in a cohort of 93 PD patients (31 of them demented) and 194 controls. Levels were correlated with demographic and clinical variables, cerebrospinal fluid Abeta1-42, total tau and phospho-tau levels, as well as with single nucleotide polymorphisms (SNPs) of genes which either have been reported to influence the immune system, the amyloid cascade or the occurrence of PD (ApoE, GSK3B, HLA-DRA, HSPA5, SNCA, and STK39). The investigated NAb titres were neither significantly associated with the occurrence of PD, nor with demographic and clinical parameters, neurodegenerative markers or genetic variables. These results argue against a major potential of blood-borne parameters of the adaptive immune system to serve as trait or state markers in PD

Insulin-Like Growth Factor 1 (IGF-1) in Parkinson's Disease: Potential as Trait-, Progression- and Prediction Marker and Confounding Factors

Introduction Biomarkers indicating trait, progression and prediction of pathology and symptoms in Parkinson's disease (PD) often lack specificity or reliability. Investigating biomarker variance between individuals and over time and the effect of confounding factors is essential for the evaluation of biomarkers in PD, such as insulin-like growth factor 1 (IGF-1). Materials and Methods IGF-1 serum levels were investigated in up to 8 biannual visits in 37 PD patients and 22 healthy controls (HC) in the longitudinal MODEP study. IGF-1 baseline levels and annual changes in IGF-1 were compared between PD patients and HC while accounting for baseline disease duration (19 early stage: 3.5 years; 18 moderate stage: >4 years), age, sex, body mass index (BMI) and common medical factors putatively modulating IGF-1. In addition, associations of baseline IGF-1 with annual changes of motor, cognitive and depressive symptoms and medication dose were investigated. Results PD patients in moderate (130±26 ng/mL; p = .004), but not early stages (115±19, p>.1), showed significantly increased baseline IGF-1 levels compared with HC (106±24 ng/mL; p = .017). Age had a significant negative correlation with IGF-1 levels in HC (r = -.47, p = .028) and no correlation in PD patients (r = -.06, p>.1). BMI was negatively correlated in the overall group (r = -.28, p = .034). The annual changes in IGF-1 did not differ significantly between groups and were not correlated with disease duration. Baseline IGF-1 levels were not associated with annual changes of clinical parameters. Discussion Elevated IGF-1 in serum might differentiate between patients in moderate PD stages and HC. However, the value of serum IGF-1 as a trait-, progression- and prediction marker in PD is limited as IGF-1 showed large inter- and intraindividual variability and may be modulated by several confounders

All-particle cosmic ray energy spectrum measured with 26 IceTop stations

We report on a measurement of the cosmic ray energy spectrum with the IceTop air shower array, the surface component of the IceCube Neutrino Observatory at the South Pole. The data used in this analysis were taken between June and October, 2007, with 26 surface stations operational at that time, corresponding to about one third of the final array. The fiducial area used in this analysis was 0.122 km^2. The analysis investigated the energy spectrum from 1 to 100 PeV measured for three different zenith angle ranges between 0{\deg} and 46{\deg}. Because of the isotropy of cosmic rays in this energy range the spectra from all zenith angle intervals have to agree. The cosmic-ray energy spectrum was determined under different assumptions on the primary mass composition. Good agreement of spectra in the three zenith angle ranges was found for the assumption of pure proton and a simple two-component model. For zenith angles {\theta} < 30{\deg}, where the mass dependence is smallest, the knee in the cosmic ray energy spectrum was observed between 3.5 and 4.32 PeV, depending on composition assumption. Spectral indices above the knee range from -3.08 to -3.11 depending on primary mass composition assumption. Moreover, an indication of a flattening of the spectrum above 22 PeV were observed.Comment: 38 pages, 17 figure