25 research outputs found
The Power of a Personal Testimony Booklet: Increasing Gospel Witness in Everyday Life
- Author
- Publication venue
- Scholars Crossing
- Publication date
- 01/02/2021
- Field of study
Evangelism is a key component of the Great Commission and a major responsibility for every Christ-Follower. The practice of personal evangelism, however, is frequently neglected by a majority of Christians. This project will initially examine the current state of personal evangelism in America and the scriptural expectation for all Christians to be frequent communicators of the gospel message. The ultimate purpose of this project is to demonstrate that a member of LivingStone Community Church can increase their Gospel witness in everyday life through the use of a written Personal Testimony Booklet. This pocket-sized booklet consists of two components. The first is a description of the three stages of one’s personal testimony. The second component consists of a unique presentation of the gospel message based upon that person’s spiritual journey. The goal of this thesis will shed light on the value of writing and distributing a personal testimony booklet. Practical suggestions will be offered for how to help church members develop and implement this evangelism method. Action research will primarily examine the success of this evangelism tool in increasing gospel witness in everyday life through surveys and interviews
DNA methylation signatures of aggression and closely related constructs : A meta-analysis of epigenome-wide studies across the lifespan
- Author
- Adams Mark J.
- Alemany Silvia
- Arindrarto Wibowo
- Arseneault Louise
- Bakermans-Kranenburg Marian J.
- Bartels Meike
- Baselmans Bart M. L.
- Beekman Marian
- Binder Elisabeth
- Boomsma Dorret I.
- Boomsma Dorret I.
- Bot Jan
- Campbell Archie
- Caspi Avshalom
- Chiocchetti Andreas G.
- Colins Olivier F.
- Corcoran David L.
- Corpeleijn Eva
- Czamara Darina
- Davies Gareth E.
- Deelen Joris
- Deelen Patrick
- Deelen Patrick
- Deuschle Michael
- Escaramis Georgia
- Evandt Jorunn
- Evans Kathryn L.
- Felix Janine F.
- Fernández-Rivas Aranzazu
- Frank Josef
- Franke Barbara
- Franke Lude
- Franke Lude
- Franke Lude
- Franke Lude
- Freitag Christine M.
- Gonzalez Juan R.
- Grazuleviciene Regina
- Gutzkow Kristine B.
- Hafferty Jonathan D.
- Hagenbeek Fiona A.
- Hakulinen Christian
- Hannon Eilis
- Heijmans Bastiaan T.
- Heijmans Bastiaan T.
- Heijmans Bastiaan T.
- Hervas Amaia
- Hofman Bert A.
- Hottenga Jouke J.
- Hägg Sara
- Ip Hill F.
- Isaacs Aaron
- Ismail Khadeeja
- Jan Bonder Marc
- Jan Bonder Marc
- Jansen Rick
- Jansen Rick
- Jansen Rick
- Jansen Rick
- Jarvelin Marjo-Riitta
- Jhamai P. Mila
- Jylhävä Juulia
- Kaprio Jaakko
- Keltikangas-Järvinen Liisa
- Kielbasa Szymon M.
- Klein Marieke
- Kluft Cornelis
- Konrad Kerstin
- Korhonen Tellervo
- Küpers Leanne K.
- Lahti Jari
- Lakenberg Nico
- Lehtimäki Terho
- Ligthart Lannie
- Lowry Estelle
- Luijk René
- McIntosh Andrew M.
- Mei Hailiang
- Meijer Mandy
- Mill Jonathan
- Mishra Pashupati Prasad
- Moed Matthijs
- Moffitt Terrie E.
- Morris Stewart W.
- Mulder Rosa H.
- Nooren Irene
- Ollikainen Miina
- Parmar Priyanka
- Pedersen Nancy L.
- Pool René
- Poulton Richie
- Raitakari Olli
- Relton Caroline
- Roetman Peter J.
- Räikkönen Katri
- Schalkwijk Casper G.
- Sebert Sylvain
- Send Tabea S.
- Sirignano Lea
- Slagboom P. Eline
- Snieder Harold
- Stehouwer Coen D. A.
- Strandberg Timo
- Streit Fabian
- Suchiman H. Eka D.
- Suderman Matthew
- Sugden Karen
- Sunyer Jordi
- Swertz Morris A.
- Tiemeier Henning
- Tigchelaar Ettje F.
- Uitterlinden André G.
- Vafeiadi Marina
- van den Berg Leonard H.
- van der Breggen Ruud
- van der Kallen Carla J. H.
- van der Meer Dennis
- van Dijk Freerk
- van Dongen Jenny
- van Dongen Jenny
- van Duijn Cornelia M.
- van Galen Michiel
- van Galen Michiel
- van Greevenbroek Marleen M. J.
- van Heemst Diana
- van IJzendoorn Marinus H.
- van Iterson Maarten
- van Iterson Maarten
- van Meurs Joyce
- van Meurs Joyce
- van Rooij Jeroen
- van Zwet Erik. W.
- van ’t Hof Peter
- Veldink Jan H.
- Verbiest Michael
- Verkerk Marijn
- Vermaat Martijn
- Vermeiren Robert
- Vetro Agnes
- Vrijheid Martine
- Vuoksimaa Eero
- Walker Rosie M.
- Wang Yunzhang
- Wijmenga Cisca
- Witt Stephanie H.
- Zhernakova Dasha V.
- Zhernakova Dasha V.
- Zhernakova Sasha
- ’t Hoen Peter A. C.
- ’t Hoen Peter A. C.
- ’t Hoen Peter-Bram
- Publication venue
- Publication date
- 01/01/2021
- Field of study
DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide association studies (EWAS) of aggressive behavior (N = 15,324 participants). In peripheral blood samples of 14,434 participants from 18 cohorts with mean ages ranging from 7 to 68 years, 13 methylation sites were significantly associated with aggression (alpha = 1.2 x 10(-7); Bonferroni correction). In cord blood samples of 2425 children from five cohorts with aggression assessed at mean ages ranging from 4 to 7 years, 83% of these sites showed the same direction of association with childhood aggression (r = 0.74, p = 0.006) but no epigenome-wide significant sites were found. Top-sites (48 at a false discovery rate of 5% in the peripheral blood meta-analysis or in a combined meta-analysis of peripheral blood and cord blood) have been associated with chemical exposures, smoking, cognition, metabolic traits, and genetic variation (mQTLs). Three genes whose expression levels were associated with top-sites were previously linked to schizophrenia and general risk tolerance. At six CpGs, DNA methylation variation in blood mirrors variation in the brain. On average 44% (range = 3-82%) of the aggression-methylation association was explained by current and former smoking and BMI. These findings point at loci that are sensitive to chemical exposures with potential implications for neuronal functions. We hope these results to be a starting point for studies leading to applications as peripheral biomarkers and to reveal causal relationships with aggression and related traits.Peer reviewe
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Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
- Author
- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel Jakša
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
- Barnes Nicky
- Baršić Bruno
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bates Michelle
- Bauchmuller Kris
- Bean Sarah
- Beane Abigail
- Beane Abigail
- Beasley Richard
- Begin Phillipe
- Bellemare David
- Benettaib Fatna
- Benzekri Dalila
- Berdaguer Fernando Daniel
- Bergin Colin
- Berry Lindsay
- Berry Lindsay
- Berry Scott
- Berry Scott
- Bhimani Zahra
- Bhimani Zahra
- Bihari Shailesh
- Bihari Shilesh
- Binnie Alexandra
- Bion Julian
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Katie
- Birkinshaw Isobel
- Black Ethel
- Bloos Frank
- Board Jasmin
- Bone Allsion
- Bonner Stephen
- Bonten Marc
- Bonten Marc
- Borgatta Barbara
- Borrill Zoe
- Bosch Ziekenhuis Jeroen
- Boschert Catherine
- Bossard Isabelle
- Boumahni Dounia
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouwman Wietske
- Bowler Helen
- Boyd Craig
- Bracke Stephanie
- Bradbury Charlotte
- Bradbury Charlotte
- Bradley-Potts Joanne
- Brailsford Jane
- Brain Matthew
- Brant Emily
- Breen Patrick
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Browne Troy
- Brunkhorst Frank
- Brunkhorst Frank
- Budd Joanna
- Buehner Ulrike
- Buhr Heidi
- Bullman Laetitia
- Burns Karen
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler M
- Buxton Meredith
- Buxton Meredith
- Buzgau Adrian
- Byrne Deborah
- Byrne Kathleen
- Bélteczki János
- Cabreros Leilani
- Calfee Carolyn
- Callender Owen
- Campbell Andy
- Campbell Hilary
- Campbell Lewis
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmona Flores Rosario
- Carr-Knott Lisa
- Carrier François Martin
- Carrier Marc
- Cartner Brittney
- Casey Ruth
- Casey Siobhan
- Castro Ferreira Ricardo Manuel
- Cate Heidi
- Cathcart Susanne
- Cavayas Alexandros
- Cawley Kathryn
- Cazzola Federica
- Centofanti John
- Chablani Manish
- Chamara Warnapura Loku
- Chan Carmen
- Chan Charles
- Chan Peter
- Charlewood Richard
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cheng Allen C
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chudeau Nicolas
- Cirstea Emanuel
- Clarey Emma
- Claridge Helen
- Clark Michele
- Clark Sarah
- Claxton Andrew
- Clermont Giles
- Cloutier Ève
- Coburn Susan
- Codreanu Daniel
- Coghlan Phoebe
- Cole Jade
- Coles Holly
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Daniel
- Collins Emma
- Collins Joanne
- Connor Jason
- Cooke Jill
- Cooper Jamie
- Cooper Melanie
- Cornell Sarah
- Cort Jon
- Courtin Laura
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craner Michelle
- Craven Thomas
- Creagh-Brown Ben
- Crisp Nikki
- Croft Maria
- Cusack Rebecca
- Cutler Sean
- Cviljevic Sabina
- Cárcel Fernández Sheila
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darreau Cédric
- Dasgin Joanne
- Davey Miriam
- Davidson Neil
- Davies Gwyneth
- Davies Louisa
- Davies Michelle
- Dawda Ashlish
- Day Christopher
- De Beaux Fiona
- De Bus Liesbet
- de Courcy-Golder Kim
- de Jager P
- de Jong Menno
- De Jong Menno
- de Jonge E
- de la Fuente Martos Carmen
- de Lima Pereira Tiago Nuno Alfaro
- de Man Angelique
- De Waele Jan
- Dearden Joy
- Dechert William
- Deelchand Vashish
- Dela Rosa Arnold
- Dell Amanda
- Demetriou Carrie
- Depante Maria Theresa
- Depuydt Pieter
- Dequin PierreFrançois
- Derde Lennie
- Derde Lennie
- Detry Michelle
- Detry Michelle
- Deye Nicolas
- Digby Stephen
- Distler Michael
- Doble Patricia
- Donnelly Adrian
- Donnison Phil
- Doran Peter
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- Driscoll Alana
- Drummond Andrew
- Duan Erick
- Duffy Eamon
- Duke Graeme
- Duncan Tracey
- Duplaix Mathilde
- Dushianthan Ahilanandan
- Dyas Sarah
- D’Aragon Frédérick
- D’Souza Ramsy
- Effelaar Evelien
- Elhassan Munzir
- Elin Hall Rebecca
- Ellis Christine
- Elmahi Einas
- Elsefi Tarek
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- Estcourt Lise
- Estensen Kristen
- Everitt Robert
- Evers Mirjam
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- Fartoukh Muriel
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- Faulkner Maria
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- Fernández de Pinedo Artaraz Ziortza
- Ferrier Janet
- Fierens Jan
- Finn André
- Finn Stephanie
- Fischer Roy
- Fitzgerald Mark
- Fitzgerald Mark
- Fletcher Simon
- Flint Neil
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- Forbes Loretta
- Forton Daniel
- Fortune Louise
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- Fowler Rob
- Fowler Robert
- Fox Claire
- Francia Federica
- Francoeur Charles
- Frey Anna
- Friedrich Hinrichs Carl
- Frohlich Stephen
- Fysh Ed
- Gallagher Linda Jude
- Ganguly Saibal
- Ganpat Radhika
- Garcia Rebecca
- Gardiner-Hill Caroline
- Garrard Hywel
- Garrard William
- Gates Simon
- Gattas David
- Gellamucho Minerva
- Gendall Emma
- Genetu Roman Mary
- Geng Wenli
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- Ghamraoui Ali
- Ghosh Alison
- Gibson Charly
- Girard Timothy
- Girijadevi Dinu
- Gledhill Lisa
- Godement Mathieu
- Golden David
- Goligher Ewan
- Gomm Linda
- Goodson Jennifer
- Goodwin Jayne
- Goossens Herman
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Gordon Anthony
- Gordon Anthony C
- Gordon Elizabeth
- Gosbell Iain
- Gould Richard
- Grecu Irina
- Green Cameron
- Green Cameron
- Gregory Jane
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- Grimmer Lisa
- Grimwade Kate
- Guilder E
- Guitton Christophe
- Hacking Danielle
- Hadebe Bernard
- Hagel Stefan
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- Hall Kathryn
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- Horvat Christopher
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- Howcroft Clare
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- Hullegie Sebastiaan
- Hullegie Sebastiaan J
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- Hulme Jonathan
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- Hunter Stephanie
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- Hutton Paula
- Innes Richard
- Ireland Jane
- Isgro Graziella
- Ivatt Helen
- Jackson Matthew
- Jackson Shane
- Jackson Susan
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- Jacquier Sophie
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- Jarczak Dominik
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- Jha Rajeev
- Jhanji Shaman
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- Johnson Rebekah
- Johnston Paul
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- Kosa Alma Gabriela
- Kotarski Viktor
- Kovács Sándor
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- Krishnamurthy Vinodh
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- Kruger Peter
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- Kumar Anand
- Kumar Nikhil
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- Kušan Ira
- KyereDiabour Thyra
- Kyeremeh Lynsey
- Labbe Vincent
- Laffan Mike
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- Lamontagne Francois
- Lamontagne Francois
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- Lane Janis-Best
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- Laver Russell
- Lawler Patrick
- Lawler Patrick R
- Lawless Patrick
- Lazaro Juan Martin
- Leaver Susannah
- Leblond Julie
- Lee Kelvin
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- Leparco Cécile
- Lesona Eden
- Leszkoven János
- Lewis Roger
- Lewis Roger J
- Lewis Sarah
- León López Rafael
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- Linstrum Kelsey
- Litton Ed
- Litton Edward
- Litton Edward
- Lomme Kaatje
- London Emily
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- Lorenzi Elizabeth
- Lother Sylvain
- Lowe Benjamin
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- Luis David
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- Malakoutis Salim
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- Marroquin Oscar
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- Mart Emma
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- Martin Timothy
- Martynoga Robert
- Maselli Astrid
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- Mateo López Maria Isabel
- Matsa Ramprasad
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- Maxime Virginie
- Mc Goldrick Clare
- Mc Master Moyra
- McArthur Colin
- McArthur Colin
- McAuley Daniel
- McAuley Daniel
- McAuley Danny
- McCallum Peter
- McClintock Declan
- McConnochie Rachael
- McCracken Phobe
- McCue Claire
- McCullagh Iain
- McCullough James
- McDyer John
- McGhee Christopher
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- Mouncey Paul
- Moviat M
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- Murphy Sheenagh
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- Murthy Srinivas
- Murthy Srinivas
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- Quinn Kevin
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- Reschreiter Henrik
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- Ricketts Daniel
- Rietveld Ilse
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- Ritzema Carter Jay
- Robert Alain
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- Robertson Yvonne
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- Robinson Philip
- Rochwerg Bram
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- Rodriguez Fernandez Jorge
- Roedl Kevin
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- Rowan Kathryn
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- Rowland Matthew
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- Shaw Joanne
- Shearer Audrey
- Sheffield Jonathan
- Shehabi Yahya
- Shovelton Charmaine
- Shrestha Tapaswi
- Shyamsundar Murali
- Siami Shidasp
- Silversides Jon
- Sim Malcolm
- Simmonds Catherine
- Simons Koen
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- Stanciu Delia
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- Strzelecka Anna
- Sundara Raman Ajay
- Sundaran Dhinesh
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- Szigligeti Gábor
- Szőke Viktória
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- Templeton Maie
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- van Bentum Puijk Wilma
- van Bentum-Puijk Wilma
- van Bentum-Puijk Wilma
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- van de Veerdonk Frank
- van de Veerdonk Frank
- Van Der Heyden Kym
- van der Poll Tom
- van’t Hoff Willian
- Vates Jennifer
- Vautier Sarah
- Vazquez-Grande Gloria
- Venkatesh Bala
- Venkatesh Balasubramanian
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- Verlander Mark
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- Voicu Sebastian
- Vowell Emma
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- Vuylsteke Alain
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- Walsh Tim
- Walsham James
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- Warnock Majella
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
- Weismann Dirk
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Wetherill Bill
- Whelan Ruth
- Whileman Amanda
- Whitbread Jennifer
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Wibrow Bradley
- Wigbers J
- Wilby Elizabeth
- Wild Laura
- Wild Laura
- Wilding Laura
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- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Erin
- Williams Hannah
- Williams Karen
- Williams Patricia
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James
- Wilson Karen
- Wilson Maggie
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- Wong Helen
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Đimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures
- Author
- Adams J.D. (John D.)
- Agel J. (Julie)
- Ahn H. (Henry)
- Ahn J. (Jaimo)
- Albers G.H.R. (G.H. Robert)
- Alexander D. (David)
- Alosky R. (Rachel)
- Amirault J.D. (J. David)
- Amundsen A. (Asgeir)
- Anand S. (Sanjeev)
- Anderson C.G. (Christopher G.)
- Anderson L.K. (Linda K.)
- Anderson S.A. (Sarah A.)
- Apostle K. (Kelly)
- Archdeacon M. (Michael)
- Arora V. (Vinod)
- Aurang K. (Kamran)
- Avram V. (Victoria)
- Axelrod T. (Terry)
- Baele J. (Joseph)
- Baker J.K. (Janell K.)
- Bannister E.R. (Evan R.)
- Bardana D. (Davide)
- Barden B.B. (Benjamin B.)
- Beckish M.L. (Michael L.)
- Bedi H. (Harvinder)
- Ben Schmidt G. (G.)
- Bhandari M. (Mohit)
- Bhatia M. (Mahesh)
- Bicknell R. (Ryan)
- Biddulph M. (Michael)
- Bielby S.A. (Shea A.)
- Biert J. (Jan)
- Blokhuis T.J. (Taco J.)
- Borch T. (Tor)
- Borsella V. (Vivian)
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- Torres E.T. (Erick T.)
- Trask K. (Kelly)
- Trenholm J.A. (J. Andrew)
- Trivedi M. (Mittal)
- Trommer A. (Axel)
- Turckan K. (Kahn)
- Tyagi V. (Vivek)
- Tynan M.C. (Martin C.)
- Ugland S. (Stein)
- Vallier H.A. (Heather A.)
- Van Der Brand I. (Igor)
- Van Der Hoeven H. (Henk)
- Van Egmond T. (Teun)
- Van Gaalen S.M. (Steven M.)
- Van Mulken J. (Jeroen)
- Van Vugt A.B. (Arie B.)
- Vang S. (Sandy)
- Verhagen R. (Ronald)
- Verhoeven B. (Bart)
- Verhofstad M.H.J. (Michiel)
- Vermeulen E.G.J. (Erik G.J.)
- Vesterhus E.B. (Elise Berg)
- Vicente M.R. (Milena R.)
- Vis H.M. (Harm) van der
- Viskontas D. (Darius)
- Visser G.A. (Gijs A.)
- Viveiros H. (Helena)
- Vogt M. (Michelle)
- Vries A.C. (Alexander) de
- Vries M.R. (Mark) de
- Vuylsteke R. (Ronald)
- Wadey V. (Veronica)
- Waes O.J.F. (Oscar) van
- Wai E.K. (Eugene K.)
- Walker J.E. (Jane E.)
- Walter S.D. (Stephen D.)
- Wang O. (Otis)
- Ward A. (Angela)
- Watson D.J. (Dylan J.)
- Watson S.T. (Scott T.)
- Weber T. (Timothy)
- Weening B. (Brad)
- Weinerman S. (Stuart)
- Weingarten P. (Peter)
- Weinrauch P. (Patrick)
- Wessel R.N. (Ronald N.)
- Wessem K.J.P. van
- Westberg J.R. (Jerald R.)
- Whatley E. (Erica)
- Whelan D.B. (Daniel B.)
- Wild L.M. (Lisa M.)
- Wille J.C. (Jan)
- Willems W.J. (Jaap)
- Wittich P. (Philippe)
- Wong I. (Ivan)
- Wood G. (Gavin)
- Worman R. (Ripley)
- Wright D.M. (David M.)
- Wyrick J. (John)
- Yach J. (Jeff)
- Yadav V. (Vineet)
- Yang S. (Steven)
- Yee A. (Albert)
- Yen D. (David)
- Yu M. (Michelle)
- Zalzal P. (Paul)
- Zamorano D.P. (David P.)
- Zellar A. (Abby)
- Zhou Q. (Qi)
- Zielinski S.M. (Stephanie)
- Zijl J.A.C. (Jacco A.C.)
- Zohman G. (Gary)
- Zomar M. (Mauri)
- Zurcher A.W. (Arthur W.)
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/05/2018
- Field of study
Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
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- Ayee Robert
- Azaiz Amine
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- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
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- Bothma Pieter
- Boudineau Michel
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- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
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- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
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- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
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- Denmade Craig
- Dent Martin
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- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
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- Donaldson Kate
- Dondrop Arjen
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- Duroux Maree
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- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
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- Eisenbeis Simone
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- van de Veerdonk Frank L.
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- Wetzold Richard
- Whileman Amanda
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- Yates David
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- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
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- Yeh S. -W.
- Yelikar A. B.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yoshioka T.
- Yu Hang
- Yu Haocun
- Yuzurihara H.
- Zadrożny A.
- Zahoor Jan Aasim
- Zanolin M.
- Zeidler Simon
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhan M.
- Zhang H.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Y.
- Zhao C.
- Zhao G.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 王谨
- 都丸 隆行
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Baier Jeremy
- Baiotti Luca
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Bartoletti A. M.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bates D. E.
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Baynard II. P. A.
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger Michał
- Belardinelli Daniele
- Bell Angus
- Benedetto V.
- Benoit William
- Bentley Joe
- Bera Sayantani
- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
- Bhardwaj Uddipta
- Bhatt R.
- Bhattacharjee Dripta
- Bhaumik Shubhagata
- Bhowmick S.
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- Bini Sophie
- Birnholtz Ofek
- Bisht A.
- Bitossi Massimiliano
- Blackburn Kent
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- Bobba F.
- Bode Nina
- Boileau Guillaume
- Boldrini Mattia
- Bolingbroke Georgia
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- Bondarescu Ruxandra
- Bondu François
- Bonilla Carrasquel Edgard
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- Yamamura S.
- Yamazaki Ryo
- Yan S.
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- Yang Yi
- Yarbrough Zach
- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuan S.
- Yuzurihara Hirotaka
- Zadrożny A.
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- Zeeshan M.
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- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barber J.
- Barish B. C.
- Barker D.
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- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Barthelmy S. D.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
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- Benedetto V.
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- C. Utina Andrei
- Cabourn Davies Gareth
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- Capocasa Eleonora
- Capote E.
- Carapella G.
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- Carpinelli Massimo
- Carter Jonathan
- Carullo Gregorio
- Casentini C.
- Castaldi G.
- Castro-Lucas S. Y.
- Caudill S.
- Cavaglia Marco
- Cavalieri Roberto
- Cella Giancarlo
- Cerdá-Durán Pablo
- Cesarini Elisabetta
- Chaibi W.
- Chalathadka Subrahmanya Shreevathsa
- Chan C.
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- Chan W. L.
- Chandra K.
- Chang I. P.
- Chang R. -J.
- Chang W.
- Chanial Pierre
- Chao Shiuh
- Chapman-Bird Christian
- Charlton E. L.
- Charlton Philip
- CHASSANDE-MOTTIN Eric
- Chastain L.
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen A.
- Chen A. H. -Y.
- Chen Dan
- Chen H.
- Chen Hsin-Yu
- Chen Junxin
- Chen K. H.
- Chen X.
- Chen Y.
- Chen Y. -R.
- Cheng H.
- Chessa Piero
- Chia H. Y.
- Chiadini Francesco
- Chiang C.
- Chiarini G.
- Chiba A.
- Chiba R.
- Chierici R.
- Chincarini Andrea
- Chiofalo M. L.
- Chiummo Antonino
- Chou C.
- Choudhary Sunil
- Christensen Nelson
- Chua Sheon S. Y.
- Chun Lung Chan Juno
- Chung K. W.
- Ciani Giacomo
- Ciecieląg Paweł
- Cieślar Marek
- Cifaldi M.
- Ciobanu A. A.
- Ciolfi Riccardo
- Clara F.
- Clark James
- Clarke Teagan
- Clasey Essick Reed
- Claudio Diaz Mario
- Clearwater P.
- Clesse S.
- Cleva F.
- Coccia E.
- Codazzo Elena
- Cohadon Pierre-François
- Colleoni Marta
- Collette C. G.
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- Colombo Alberto
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- Concetta Tringali Maria
- Conti Livia
- Cooper Sam
- Corbitt Thomas
- Cordero-Carrión Isabel
- Corezzi S.
- Cornish Neil
- Corsi Alessandra
- Cortese Stefano
- Costa C. A.
- Cottingham R.
- Coughlin Michael
- Couineaux A.
- Coulon J. -P.
- Countryman S. T.
- Coupechoux J. -F.
- Cousins Bryce
- Couvares Peter
- Coward D. M.
- Cowart M. J.
- Cowburn B. D.
- Coyne Dennis
- Coyne Robert
- Craig K.
- Creighton Jolien
- Creighton T. D.
- Criswell Alexander
- Crockett-Gray J. C. G.
- Croquette Michaël
- Crouch R.
- Crowder S. G.
- Cudell Jean-René
- Cullen T. J.
- Cumming Alan
- Cuoco E.
- Curyło M.
- Cusinato Marco
- D'Angelo Beatrice
- D'Antonio S.
- d'Emilio V.
- D'Onofrio Luca
- D'Urso D.
- Dabadie P.
- Dal Canton Tito
- DALL'OSSO Simone
- Danilishin Stefan
- Danzmann K.
- Darroch K. E.
- Darsow-Fromm Christian
- Dartez L. P.
- Dasgupta A.
- Datta Sayantani
- Dattilo V.
- Daumas A.
- Dave I.
- Davenport A.
- Davier M.
- Davis Derek
- Davis Michael C.
- Daw Edward
- Dax Maximilian
- De Laurentis Martina
- De Lillo Federico
- de Lluc Planas Maria
- De Marco F.
- De Matteis F.
- De Pietri Roberto
- De Rosa Rosario
- de rossi camilla
- De Simone R.
- de Souza Melo S. Assis
- Deenadayalan M.
- Degallaix Jerome
- Del Pozzo W.
- Delfavero Vera
- Dell'Aquila Daniele
- Deléglise Samuel
- Demos N.
- Dent Thomas
- Depasse Antoine
- Dhurandhar S.
- Di Fiore L.
- Di Fronzo Chiara
- di giovanni Fabrizio
- Di Giovanni M.
- Di Girolamo Tristano
- Di Michele Alessandro
- Di Renzo Francesco
- DI. PALMA Irene
- Diab R.
- Diamond P. Z.
- Diaz J. Casanueva
- Didio N. A.
- Diego Bonavena Luis
- Dietrich Tim
- Diksha D.
- Ding Jacques
- Divyajyoti
- Dmitriev Artemiy
- Doctor Zoheyr
- Dohmen E.
- Doleva P. P.
- Donahue L.
- Donovan F.
- Dooley Katherine L.
- Dooney T.
- Doravari Suresh
- Dorosh O.
- Drago Marco
- Driggers Jennifer C.
- Drori Y.
- Du H.
- Ducoin J. -G.
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- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
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- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
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- Zhang Rui
- Zhang T.
- Zhang Ya
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
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- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
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- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
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- Antier Sarah
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- Antonio Font Roda Jose
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- Armato F.
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- Wang Haoyu
- Wang J. Z.
- Wang W. H.
- Wang Z.
- Waratkar Gaurav
- Ward R. L.
- Warner J.
- Was Michal
- Washimi Tatsuki
- Washington N. Y.
- Watarai D.
- Wayt K. E.
- Weaver B.
- Weaving C. R.
- Webster S. A.
- Weinert M.
- Weinstein Alan J.
- Weiss R.
- Weizmann Kiendrebeogo R.
- Weller C. M.
- Weller Robert
- Wellmann F.
- Wen L.
- Wette Karl
- Weßels P.
- Whelan John
- White D. D.
- Whiting Bernard F.
- Whittle Chris
- Wildberger J. B.
- Wilk O. S.
- Wilken Dennis
- Willetts K.
- Williams Daniel
- Williams Michael J.
- Williams N. S.
- Willis Joshua
- Willke Benno
- Wils Milan
- Wipf C. C.
- Woan Graham
- Woehler J.
- Wofford Jared
- Wolfe N. E.
- Won Lee Hyung
- Won Seo Jin
- Wong D.
- Wong Henry T.
- Wright J. L.
- Wright Mick
- Wu Chien-Ming
- Wu David S.
- Wu Hsun-Chung
- Wysocki Daniel
- Xiao Liting
- Xu Victoria
- Xu Yumeng
- Yaala M. Ben
- Yadav Nikesh
- Yakovlev Alexey
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto M.
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yan T.
- Yang F.
- Yang Fengwei
- Yang Kate Z.
- Yang L. -C.
- Yang Yi
- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Lessening Organ dysfunction with VITamin C (LOVIT): Protocol for a randomized controlled trial
- Author
- Adhikari Neill
- annane djillali
- Arabi Yaseen M.
- Archambault Patrick Michel
- Battista Marie Claude
- Belley-Côté Émilie Prudence
- Bolduc Brigitte
- Carbonneau Élaine
- Carr Anitra C.
- Chassé Michaël
- Clarke France J.
- Cohen Dian N.
- Cook Deborah J.
- D'Aragon Frédérick
- Day Andrew G.
- Deblois Estel
- Drouin Christine
- Guyatt Gordon Henry M.
- Heyland Daren Keith
- Hunt Miranda
- Iazzetta John J.
- Kanji Salmaan
- Lamontagne François C.
- Lebrasseur Martine
- Lellouche François
- Lizotte Patricia
- Marinoff Nicole
- Maslove David M.
- Masse Marie Hélène
- McGuinness Shay
- Millen Tina
- Ménard Julie
- Parke Rachael L.
- Pinto Ruxandra L.
- Porteous Rebecca
- Rochwerg Bram
- Sprague Sheila A.
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Walker Scott E.
- Watpool Irene
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
International audienceBackground: Sepsis is a health problem of global importance; treatments focus on controlling infection and supporting failing organs. Recent clinical research suggests that intravenous vitamin C may decrease mortality in sepsis. We have designed a randomized controlled trial (RCT) to ascertain the effect of vitamin C on the composite endpoint of death or persistent organ dysfunction at 28 days in patients with sepsis. Methods: LOVIT (Lessening Organ dysfunction with VITamin C) is a multicenter, parallel-group, blinded (participants, clinicians, study personnel, Steering Committee members, data analysts), superiority RCT (minimum n = 800). Eligible patients have sepsis as the diagnosis for admission to the intensive care unit (ICU) and are receiving vasopressors. Those admitted to the ICU for more than 24 h are excluded. Eligible patients are randomized to high-dose intravenous vitamin C (50 mg/kg every 6 h for 96 h) or placebo. The primary outcome is a composite of death or persistent organ dysfunction (need for vasopressors, invasive mechanical ventilation, or new and persisting renal replacement therapy) at day 28. Secondary outcomes include persistent organ dysfunction-free days to day 28, mortality and health-related quality of life at 6 months, biomarkers of dysoxia, inflammation, infection, endothelial function, and adverse effects (hemolysis, acute kidney injury, and hypoglycemia). Six subgroup analyses are planned. Discussion: This RCT will provide evidence of the effect of high-dose intravenous vitamin C on patient-important outcomes in patients with sepsis. Trial registration: clinicaltrials.gov, NCT03680274, first posted 21 September 2018