1,085 research outputs found

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    Writing for Comprehension: How does Writing Influence Informational Reading Comprehension in the Elementary Classroom?

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    This quantitative study was conducted through a school and university partnership. Data from benchmark reading assessments and writing rubrics were gathered over five weeks in a third-grade classroom in the rural mountains of the southeastern United States. Results indicate student growth in reading comprehension and writing. Findings confirm the positive correlation between reading and writing, which suggests integrating explicit reading and writing instruction supports students’ reading comprehension. Based on these findings, we suggest ways teachers can improve reading comprehension skills, blend reading and writing instruction, and pique student interest through an informational writing unit

    Remote sensing of mesospheric dust layers using active modulation of PMWE by high-power radio waves

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    This paper presents the first study of the modulation of polar mesospheric winter echoes (PMWE) by artificial radio wave heating using computational modeling and experimental observation in different radar frequency bands. The temporal behavior of PMWE response to HF pump heating can be employed to diagnose the charged dust layer associated with mesospheric smoke particles. Specifically, the rise and fall time of radar echo strength as well as relaxation and recovery time after heater turn-on and turnoff are distinct parameters that are a function of radar frequency. The variation of PMWE strength with PMWE source region parameters such as electron-neutral collision frequency, photodetachment current, electron temperature enhancement ratio, dust density, and radius is considered. The comparison of recent PMWE measurements at 56 MHz and 224 MHz with computational results is discussed, and dust parameters in the PMWE generation regime are estimated. Predictions for HF PMWE modification and its connection to the dust charging process by free electrons is investigated. The possibility for remote sensing of dust and plasma parameters in artificially modified PMWE regions using simultaneous measurements in multiple frequency bands are discussed. © 2016. American Geophysical Union. All Rights Reserved

    First modulation of high-frequency polar mesospheric summer echoes by radio heating of the ionosphere

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    The first high-frequency (HF, 8 MHz) observations of the modulation of polar mesospheric summer echoes (PMSE) by artificial radio heating of the ionosphere are presented and compared to observations at 224 MHz and model predictions. The experiments were performed at the European Incoherent Scatter facility in northern Norway. It is shown that model results are in qualitative and partial quantitative agreement with the observations, supporting the prediction that with certain ranges of ice particle radii and concentration, PMSE at HF radar wavelengths can be enhanced by heating due to the dominance of dust charging over plasma diffusion

    Hemophilia gene therapy knowledge and perceptions: Results of an international survey

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    Background Hemophilia gene therapy is a rapidly evolving therapeutic approach in which a number of programs are approaching clinical development completion. Objective The aim of this study was to evaluate knowledge and perceptions of a variety of health care practitioners and scientists about gene therapy for hemophilia. Methods This survey study was conducted February 1 to 18, 2019. Survey participants were members of the ISTH, European Hemophilia Consortium, European Hematology Association, or European Association for Hemophilia and Allied Disorders with valid email contacts. The online survey consisted of 36 questions covering demographic information, perceptions and knowledge of gene therapy for hemophilia, and educational preferences. Survey results were summarized using descriptive statistics. Results Of the 5117 survey recipients, 201 responded from 55 countries (4% response rate). Most respondents (66%) were physicians, and 59% were physicians directly involved in the care of people with hemophilia. Among physician respondents directly involved in hemophilia care, 35% lacked the ability to explain the science of adeno-associated viral gene therapy for hemophilia, and 40% indicated limited ability or lack of comfort answering patient questions about gene therapy for hemophilia based on clinical trial results to date. Overall, 75% of survey respondents answered 10 single-answer knowledge questions correctly, 13% incorrectly, and 12% were unsure of the correct answers. Conclusions This survey highlighted knowledge gaps and educational needs related to gene therapy for hemophilia and, along with other inputs, has informed the development of "Gene Therapy in Hemophilia: An ISTH Education Initiative.

    Bifurcations in annular electroconvection with an imposed shear

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    We report an experimental study of the primary bifurcation in electrically-driven convection in a freely suspended film. A weakly conducting, submicron thick smectic liquid crystal film was supported by concentric circular electrodes. It electroconvected when a sufficiently large voltage VV was applied between its inner and outer edges. The film could sustain rapid flows and yet remain strictly two-dimensional. By rotation of the inner electrode, a circular Couette shear could be independently imposed. The control parameters were a dimensionless number R{\cal R}, analogous to the Rayleigh number, which is V2\propto V^2 and the Reynolds number Re{\cal R}e of the azimuthal shear flow. The geometrical and material properties of the film were characterized by the radius ratio α\alpha, and a Prandtl-like number P{\cal P}. Using measurements of current-voltage characteristics of a large number of films, we examined the onset of electroconvection over a broad range of α\alpha, P{\cal P} and Re{\cal R}e. We compared this data quantitatively to the results of linear stability theory. This could be done with essentially no adjustable parameters. The current-voltage data above onset were then used to infer the amplitude of electroconvection in the weakly nonlinear regime by fitting them to a steady-state amplitude equation of the Landau form. We show how the primary bifurcation can be tuned between supercritical and subcritical by changing α\alpha and Re{\cal R}e.Comment: 17 pages, 12 figures. Submitted to Phys. Rev. E. Minor changes after refereeing. See also http://mobydick.physics.utoronto.c

    Syntaxin 16 is a master recruitment factor for cytokinesis

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    Recently it was shown that both recycling endosome and endosomal sorting complex required for transport (ESCRT) components are required for cytokinesis, in which they are believed to act in a sequential manner to bring about secondary ingression and abscission, respectively. However, it is not clear how either of these complexes is targeted to the midbody and whether their delivery is coordinated. The trafficking of membrane vesicles between different intracellular organelles involves the formation of soluble N-ethylmalei­mide–sensitive factor attachment protein receptor (SNARE) complexes. Although membrane traffic is known to play an important role in cytokinesis, the contribution and identity of intracellular SNAREs to cytokinesis remain unclear. Here we demonstrate that syntaxin 16 is a key regulator of cytokinesis, as it is required for recruitment of both recycling endosome–associated Exocyst and ESCRT machinery during late telophase, and therefore that these two distinct facets of cytokinesis are inextricably linked
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