Painlev\'e I and exact WKB: Stokes phenomenon for two-parameter transseries

For more than a century, the Painlev\'e I equation has played an important role in both physics and mathematics. Its two-parameter family of solutions was studied in many different ways, yet still leads to new surprises and discoveries. Two popular tools in these studies are the theory of isomonodromic deformation that uses the exact WKB method, and the asymptotic description of transcendents in terms of two-parameter transseries. Combining methods from both schools of thought, and following work by Takei and collaborators, we find complete, two-parameter connection formulae for solutions when they cross arbitrary Stokes lines in the complex plane. These formulae allow us to study Stokes phenomenon for the full two-parameter family of transseries solutions. In particular, we recover the exact expressions for the Stokes data that were recently found by Baldino, Schwick, Schiappa and Vega and compare our connection formulae to theirs. We also explain several ambiguities in relating transseries parameter choices to actual Painlev\'e transcendents, study the monodromy of formal solutions, and provide high-precision numerical tests of our results.Comment: 71 pages, 16 figures, 5 tables and 4 appendices. v2: Minor changes (rewrites, typos, added references

Restructuring for relevance: a paradigm shift for academic libraries

The primary purpose of this paper is to report on the development of a flexible and robust academic library structure that meets the demands of an ever changing user community and remains relevant and fit for purpose in a technology-driven age. The new structure makes provision for the delivery of new and innovative services responding to the need for a paradigm shift in 21st century academic librarianship. The move away from subject librarianship, which has been the bastion of South African academic librarianship, is significant. This paper used the exploratory method to gain new insights into library structures that have restructured for the 21st century. The exploratory study was used to gain new insights into functional librarianship. Despite the short comings of the exploratory method, the method was deemed most appropriate as UCT Libraries was not seeking definitive answers but a process that would provide opportunities to explore possibilities for subsequent processes. The move from subject librarianship to functional librarianship has given the library the opportunity to restructure. The restructured library can now offer new and/or radically expanded services to meet the demands of a 21st century academic library. The development of new and future roles and responsibilities commensurate with a robust and ‘future-driven’ structure, will consolidate the library’s role as a collaborator in the teaching and learning, and research agendas of a higher education institution. This paper will be of interest and value to library managers and staff wanting to develop a library structure that responds positively to the redefinition of the professional roles and functions of the library and to strategically position the academic library for the future. It will also be of interest to library and information science academics who may want to re-examine their curricula for the incorporation of new trends

Interface structure of SrTiO3-LaAlO3 at elevated temperatures studied in-situ by synchroton x-rays

The atomic interface structure between SrTiO3 and LaAlO3 was studied at elevated temperatures employing in situ surface x-ray diffraction. The results at 473 K indicate that the lattice distorts significantly in two ways. First, the interatomic distances between the cations across the interface become as large as 4.03(2) Å. Second, the TiO6 octahedra at the interface contract their principal axis along the surface normal considerably and the Ti displaces off center. These distortions can be ascribed to the charge inbalance introduced by the change in atomic species across the interface and to a Jahn-Teller effect. The latter distortion suggests the presence of extra electrons at the interface, which is important for understanding the electronic properties of this system

‘Waiting impulsivity’ in isolation-reared and socially-reared rats: effects of amphetamine

Background Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine. Methods Using an isolation-rearing (IR) manipulation, the present study examined the effects of IR on impulsive action and impulsive choice when also treated with doses of d-amphetamine, by employing the five-choice serial reaction time task (5-CSRTT) and a temporal discounting of reward task (TDRT), respectively. Results IR rats showed similar acquisition of the 5-CSRTT. Amphetamine increased premature responding in both groups; however, IR rats showed less responding overall. For the TDRT, IR rats revealed a greater preference for the large but delayed reward during task acquisition (i.e. were less impulsive) with a higher rate of nose poking during the delay, and exhibited a compressed dose-response function (i.e. reduced dose sensitivity) for amphetamine. Discussion Impulsive action and impulsive choice were reduced in IR rats under certain conditions, and a blunted response to d-amphetamine was found on these measures. These reductions in impulsivity contrast with locomotor hyperactivity normally shown in IR rats and the findings have implications for the utility of IR as a model of psychopathology

2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery

Authors/Task Force Members: Christa Boer (EACTA Chairperson)(Netherlands), Michael I. Meesters (Netherlands), Milan Milojevic (Netherlands), Umberto Benedetto (UK), Daniel Bolliger (Switzerland), Christian von Heymann (Germany), Anders Jeppsson (Sweden), Andreas Koster (Germany), Ruben L. Osnabrugge (Netherlands), Marco Ranucci (Italy), Hanne Berg Ravn (Denmark), Alexander B.A. Vonk (Netherlands), Alexander Wahba (Norway), Domenico Pagano (EACTS Chairperson)(UK),. Document Reviewers: Moritz W.V. Wyler von Ballmoos (USA), Mate Petricevic (Croatia), Arie Pieter Kappetein (Netherlands), Miguel Sousa-Uva (Portugal), Georg Trummer (Germany), Peter M. Rosseel (Netherlands), Michael Sander (Germany), Pascal Colson (France), Adrian Bauer (Germany)

Оценка исследовательской деятельности ученых Беларуси с использованием баз данных «Web of Science»

Рассматриваются публикационная активность ученых Национальной академии наук Беларуси, степень отражения статей белорусских исследователей в базах данных «Web of Science» и сведения о цитировании работ белорусских авторов в исследованиях других ученых

Pathogenic Fungi Regulate Immunity by Inducing Neutrophilic Myeloid-Derived Suppressor Cells

Peer reviewedPublisher PD

Schema therapy for emotional dysregulation: Theoretical implication and clinical applications

The term emotional dysregulation refers to an impaired ability to regulate unwanted emotional states. Scientific evidence supports the idea that emotional dysregulation underlies several psychological disorders as, for example: personality disorders, bipolar disorder type II, interpersonal trauma, anxiety disorders, mood disorders and posttraumatic stress disorder. Emotional dysregulation may derive from early interpersonal traumas in childhood. These early traumatic events create a persistent sensitization of the central nervous system in relation to early life stressing events. For this reason, some authors suggest a common endophenotypical origin across psychopathologies. In the last 20 years, cognitive behavioral therapy has increasingly adopted an interactiveontogenetic view to explain the development of disorders associated to emotional dysregulation. Unfortunately, standard Cognitive Behavior Therapy (CBT) methods are not useful in treating emotional dysregulation. A CBT-derived new approach called Schema Therapy (ST), that integrates theory and techniques from psychodynamic and emotion focused therapy, holds the promise to fill this gap in cognitive literature. In this model, psychopathology is viewed as the interaction between the innate temperament of the child and the early experiences of deprivation or frustration of the subject\u2019s basic needs. This deprivation may lead to develop early maladaptive schemas (EMS), and maladaptive Modes. In the present paper we point out that EMSs and Modes are associated with either dysregulated emotions or with dysregulatory strategies that produce and maintain problematic emotional responses. Thanks to a special focus on the therapeutic relationship and emotion focused-experiential techniques, this approach successfully treats severe emotional dysregulation. In this paper, we make several comparisons between the main ideas of ST and the science of emotion regulation, and we present how to conceptualize pathological phenomena in terms of failed regulation and some of the ST strategies and techniques to foster successful regulation in patients

The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis

Systemic sclerosis (SSc) is a fibrotic autoimmune disease in which the genetic component plays an important role. One of the strongest SSc association signals outside the human leukocyte antigen (HLA) region corresponds to interferon (IFN) regulatory factor 5 (IRF5), a major regulator of the type I IFN pathway. In this study we aimed to evaluate whether three different haplotypic blocks within this locus, which have been shown to alter the protein function influencing systemic lupus erythematosus (SLE) susceptibility, are involved in SSc susceptibility and clinical phenotypes. For that purpose, we genotyped one representative single-nucleotide polymorphism (SNP) of each block (rs10488631, rs2004640, and rs4728142) in a total of 3,361 SSc patients and 4,012 unaffected controls of Caucasian origin from Spain, Germany, The Netherlands, Italy and United Kingdom. A meta-analysis of the allele frequencies was performed to analyse the overall effect of these IRF5 genetic variants on SSc. Allelic combination and dependency tests were also carried out. The three SNPs showed strong associations with the global disease (rs4728142: P = 1.34×10<sup>−8</sup>, OR = 1.22, CI 95% = 1.14–1.30; rs2004640: P = 4.60×10<sup>−7</sup>, OR = 0.84, CI 95% = 0.78–0.90; rs10488631: P = 7.53×10<sup>−20</sup>, OR = 1.63, CI 95% = 1.47–1.81). However, the association of rs2004640 with SSc was not independent of rs4728142 (conditioned P = 0.598). The haplotype containing the risk alleles (rs4728142*A-rs2004640*T-rs10488631*C: P = 9.04×10<sup>−22</sup>, OR = 1.75, CI 95% = 1.56–1.97) better explained the observed association (likelihood P-value = 1.48×10<sup>−4</sup>), suggesting an additive effect of the three haplotypic blocks. No statistical significance was observed in the comparisons amongst SSc patients with and without the main clinical characteristics. Our data clearly indicate that the SLE risk haplotype also influences SSc predisposition, and that this association is not sub-phenotype-specific