A Theory-Based Approach for a Modular System of Interactive Decision Aids

In web stores, a large amount of product information is easily available for consumers. This often leads to information overload on the consumer-side which decreases user-satisfaction and can cause purchase deferral. Therefore, our goal is to prevent consumers from information overload by supporting the cumbersome process of comparing and evaluating products. We propose easy to understand, interactive decision aids, called interactive information management tools such as filtering, sorting and scoring. The contribution of this paper is to (1) retrieve guidelines for designing such tools from both literature on decision behavior research and information systems, and (2) build a prototype following these guidelines. The prototype is evaluated in two usability studies

Psychoseähnliches Erleben, Depressivität und Schlafparameter bei Patienten mit Schlafapnoe-Syndrom

Psychoseähnliche Erlebnisse sind in der Bevölkerung weit verbreitet und gelten per se nicht als pathologisch. Ein gestörter Schlaf wird häufig bei Patienten mit Schizophrenie, aber auch bei Menschen mit psychoseähnlichem Erleben, beobachtet. Die Ziele der Studie waren, psychoseähnliche Symptome bei Patienten mit Schlafapnoe-Syndrom (OSA) zu bestimmen und diese über Veränderungen der Schlafparameter nachzuvollziehen. Überdies wurde die nächtliche Gedächtniskonsolidierung in Zusammenhang mit Schlafparametern untersucht. Wir verglichen Patienten mit OSA (n=42) mit gesunden Kontrollprobanden (n=33). Die Beurteilung psychoseähnlicher Erlebnisse erfolgte mit der Magical Ideation Scale (MIS) und dem Peters et al. Delusions Inventory (PDI-21). Zum Erfassen von Depressionen diente das Beck-Depressions-Inventar-II (BDI-II). Die nächtliche Gedächtniskonsolidierung der Patienten mit OSA wurde mit dem verbalen Lern- und Merkfähigkeitstest (VLMT) gemessen. In der Auswertung zeigten die Patienten mit OSA gesteigerte psychoseähnliche Erlebnisse im Sinne eines statistischen Trends im PDI-21. Zudem ließ sich eine erhöhte Depressivität der Patienten feststellen. Wichtig war auch die signifikant positive Korrelation von verlängertem REM-Schlaf mit gesteigerter Depressivität und Wahnüberzeugungen. Bei der Gedächtnisleistung ließ sich eine negative Assoziation mit dem Schweregrad der OSA nachweisen. Diese Befunde bedürfen weiterer Untersuchungen von psychoseähnlichen Erlebnissen bei verschiedenen Schlafstörungen. Bei Patienten mit OSA müssen weitere Studien zeigen, inwieweit die Reduktion der depressiven Symptomatik und Verbesserung der Gedächtnisleistung unter Therapie stattfinden kann

Direct prediction of site-specific lime requirement of arable fields using the base neutralizing capacity and a multi-sensor platform for on-the-go soil mapping

Liming agricultural fields is necessary for counteracting soil acidity and is one of the oldest operations in soil fertility management. However, the best management practice for liming in Germany only insufficiently considers within-field soil variability. Thus, a site-specific variable rate liming strategy was developed and tested on nine agricultural fields in a quaternary landscape of north-east Germany. It is based on the use of a proximal soil sensing module using potentiometric, geoelectric and optical sensors that have been found to be proxies for soil pH, texture and soil organic matter (SOM), which are the most relevant lime requirement (LR) affecting soil parameters. These were compared to laboratory LR analysis of reference soil samples using the soil’s base neutralizing capacity (BNC). Sensor data fusion utilizing stepwise multi-variate linear regression (MLR) analysis was used to predict BNC-based LR (LRBNC) for each field. The MLR models achieved high adjusted R2 values between 0.70 and 0.91 and low RMSE values from 65 to 204 kg CaCO3 ha−1. In comparison to univariate modeling, MLR models improved prediction by 3 to 27% with 9% improvement on average. The relative importance of covariates in the field-specific prediction models were quantified by computing standardized regression coefficients (SRC). The importance of covariates varied between fields, which emphasizes the necessity of a field-specific calibration of proximal sensor data. However, soil pH was the most important parameter for LR determination of the soils studied. Geostatistical semivariance analysis revealed differences between fields in the spatial variability of LRBNC. The sill-to-range ratio (SRR) was used to quantify and compare spatial LRBNC variability of the nine test fields. Finally, high resolution LR maps were generated. The BNC-based LR method also produces negative LR values for soil samples with pH values above which lime is required. Hence, the LR maps additionally provide an estimate on the quantity of chemically acidifying fertilizers that can be applied to obtain an optimal soil pH value

Base Neutralizing Capacity of Agricultural Soils in a Quaternary Landscape of North-East Germany and Its Relationship to Best Management Practices in Lime Requirement Determination

Despite being a natural soil-forming process, soil acidification is a major agronomic challenge under humid climate conditions, as soil acidity influences several yield-relevant soil properties. It can be counterbalanced by the regular application of agricultural lime to maintain or re-establish soil fertility and to optimize plant growth and yield. To avoid underdose as well as overdose, lime rates need to be calculated carefully. The lime rate should be determined by the optimum soil pH (target pH) and the response of the soil to lime, which is described by the base neutralizing capacity (BNC). Several methods exist to determine the lime requirement (LR) to raise the soil pH to its optimum. They range from extremely time-consuming equilibration methods, which mimic the natural processes in the soil, to quick tests, which rely on some approximations and are designed to provide farmers with timely and cost-efficient data. Due to the higher analytical efforts, only limited information is available on the real BNC of particular soils. In the present paper, we report the BNC of 420 topsoil samples from Central Europe (north-east Germany), developed on sediments from the last ice age 10,000 years ago under Holocene conditions. These soils are predominantly sandy and low in humus, but they exhibit a huge spatial variability in soil properties on a small scale. The BNC was determined by adding various concentrations of Ca(OH)2 and fitting an exponential model to derive a titration curve for each sample. The coefficients of the BNC titration curve were well correlated with soil properties affecting soil acidity and pH buffer capacity, i.e., pH, soil texture and soil organic matter (SOM). From the BNC model, the LRs (LRBNC) were derived and compared with LRVDLUFA based on the standard protocol in Germany as established by the Association of German Agricultural Analytic and Research Institutes (VDLUFA). The LRBNC and LRVDLUFA correlated well but the LRVDLUFA were generally by approximately one order of magnitude higher. This is partly due to the VDLUFA concept to recommend a maintenance or conservation liming, even though the pH value is in the optimum range, to keep it there until the next lime application during the following rotation. Furthermore, the VDLUFA method was primarily developed from field experiments where natural soil acidification and management practices depressed the effect of lime treatment. The BNC method, on the other hand, is solely based on laboratory analysis with standardized soil samples. This indicates the demand for further research to develop a sound scientific algorithm that complements LRBNC with realistic values of annual Ca2+ removal and acidification by natural processes and N fertilization

Guidelines for precise lime management based on high-resolution soil pH, texture and SOM maps generated from proximal soil sensing data

Soil acidification is caused by natural paedogenetic processes and anthropogenic impacts but can be counteracted by regular lime application. Although sensors and applicators for variable-rate liming (VRL) exist, there are no established strategies for using these tools or helping to implement VRL in practice. Therefore, this study aimed to provide guidelines for site-specific liming based on proximal soil sensing. First, high-resolution soil maps of the liming-relevant indicators (pH, soil texture and soil organic matter content) were generated using on-the-go sensors. The soil acidity was predicted by two ion-selective antimony electrodes (RMSEpH: 0.37); the soil texture was predicted by a combination of apparent electrical resistivity measurements and natural soil-borne gamma emissions (RMSEclay: 0.046 kg kg−1); and the soil organic matter (SOM) status was predicted by a combination of red (660 nm) and near-infrared (NIR, 970 nm) optical reflection measurements (RMSESOM: 6.4 g kg−1). Second, to address the high within-field soil variability (pH varied by 2.9 units, clay content by 0.44 kg kg−1 and SOM by 5.5 g kg−1), a well-established empirical lime recommendation algorithm that represents the best management practices for liming in Germany was adapted, and the lime requirements (LRs) were determined. The generated workflow was applied to a 25.6 ha test field in north-eastern Germany, and the variable LR was compared to the conventional uniform LR. The comparison showed that under the uniform liming approach, 63% of the field would be over-fertilized by approximately 12 t of lime, 6% would receive approximately 6 t too little lime and 31% would still be adequately limed. © 2020, The Author(s)

Molecular constituents of the extracellular matrix in rat liver mounting a hepatic progenitor cell response for tissue repair

BACKGROUND: Tissue repair in the adult mammalian liver occurs in two distinct processes, referred to as the first and second tiers of defense. We undertook to characterize the changes in molecular constituents of the extracellular matrix when hepatic progenitor cells (HPCs) respond in a second tier of defense to liver injury. RESULTS: We used transcriptional profiling on rat livers responding by a first tier (surgical removal of 70% of the liver mass (PHx protocol)) and a second tier (70% hepatectomy combined with exposure to 2-acetylaminofluorene (AAF/PHx protocol)) of defense to liver injury and compared the transcriptional signatures in untreated rat liver (control) with those from livers of day 1, day 5 and day 9 post hepatectomy in both protocols. Numerous transcripts encoding specific subunits of collagens, laminins, integrins, and various other extracellular matrix structural components were differentially up- or down-modulated (P < 0.01). The levels of a number of transcripts were significantly up-modulated, mainly in the second tier of defense (Agrn, Bgn, Fbn1, Col4a1, Col8a1, Col9a3, Lama5, Lamb1, Lamb2, Itga4, Igtb2, Itgb4, Itgb6, Nid2), and their signal intensities showed a strong or very strong correlation with Krt1-19, a well-established marker of a ductular/HPC reaction. Furthermore, a significant up-modulation and very strong correlation between the transcriptional profiles of Krt1-19 and St14 encoding matriptase, a component of a novel protease system, was found in the second tier of defense. Real-time PCR confirmed the modulation of St14 transcript levels and strong correlation to Krt-19 and also showed a significant up-modulation and strong correlation to Spint1 encoding HAI-1, a cognate inhibitor of matriptase. Immunodetection and three-dimensional reconstructions showed that laminin, Collagen1a1, agrin and nidogen1 surrounded bile ducts, proliferating cholangiocytes, and HPCs in ductular reactions regardless of the nature of defense. Similarly, matriptase and HAI-1 were expressed in cholangiocytes regardless of the tier of defense, but in the second tier of defense, a subpopulation of HPCs in ductular reactions co-expressed HAI-1 and the fetal hepatocyte marker Dlk1. CONCLUSION: Transcriptional profiling and immunodetection, including three-dimensional reconstruction, generated a detailed overview of the extracellular matrix constituents expressed in a second tier of defense to liver injury

Three-dimensional preforming via wet-laid nonwoven technology for ceramic matrix composites

In this study, a new 3D preforming method was developed using wet-laid nonwoven technology, for application in manufacturing ceramic matrix composites (CMC). For this purpose, a process setup was developed and tested on an example geometry (radome). HTS 45 carbon fibers and Nextel610 alumina fibers were used for the preforming. The resulting C/C-SiC and OXIPOL materials were mechanically characterized and the microstructure was investigated. A radome was manufactured from each material and subjected to DLR's L2K and VMK wind tunnels. The tests have been successful with the C/C-SiC and OXIPOL radome. Overall the application-oriented tests show that load-bearing components can be produced with the newly developed preform method and that they also prove themselves in the application. The knowledge gained, demonstrates the potential of the 3D wet-laid nonwoven preforming method and represents a new possibility for CMC production with complex shapes

Mechanisms of manipulation:a systematic review of the literature on immediate anatomical structural or positional changes in response to manually delivered high-velocity, low-amplitude spinal manipulation

Background: Spinal manipulation (SM) has been claimed to change anatomy, either in structure or position, and that these changes may be the cause of clinical improvements. The aim of this systematic review was to evaluate and synthesise the peer-reviewed literature on the current evidence of anatomical changes in response to SM. Methods: The review was registered with PROSPERO (CRD42022304971) and reporting was guided by the standards of the PRISMA Statement. We searched Medline, Embase, CINAHL, AMED, Cochrane Library all databases, PEDro, and the Index to Chiropractic Literature from inception to 11 March 2022 and updated on 06 June 2023. Search terms included manipulation, adjustment, chiropractic, osteopathy, spine and spine-related structures. We included primary research studies that compared outcomes with and without SM regardless of study design. Manipulation was defined as high-velocity, low-amplitude thrust delivered by hand to the spine or directly related joints. Included studies objectively measured a potential change in an anatomical structure or in position. We developed a novel list of methodological quality items in addition to a short, customized list of risk of bias (RoB) items. We used quality and RoB items together to determine whether an article was credible or not credible. We sought differences in outcomes between SM and control groups for randomised controlled trials and crossover studies, and between pre- and post-SM outcomes for other study designs. We reported, in narrative form, whether there was a change or not. Results: The search retrieved 19,572 articles and 20 of those were included for review. Study topics included vertebral position (n = 3) facet joint space (n = 5), spinal stiffness (n = 3), resting muscle thickness (n = 6), intervertebral disc pressure (n = 1), myofascial hysteresis (n = 1), and further damage to already damaged arteries (n = 1). Eight articles were considered credible. The credible articles indicated that lumbar facet joint space increased and spinal stiffness decreased but that the resting muscle thickness did not change. Conclusion: We found few studies on this topic. However, there are two promising areas for future study: facet joint space and spinal stiffness. A research strategy should be developed with funding for high quality research centres

Relative recency influences object-in-context memory

In two experiments rats received training on an object-in-context (OIC) task, in which they received preexposure to object A in context x, followed by exposure to object B in context y. In a subsequent test both A and B are presented in either context x or context y. Usually more exploration is seen of the object that has not previously been paired with the test context, an effect attributed to the ability to remember where an object was encountered. However, in the typical version of this task, object A has also been encountered less recently than object B at test. This is precisely the arrangement in tests of ‘relatively recency’ (RR), in which more remotely presented objects are explored more than objects experienced more recently. RR could contaminate performance on the OIC task, by enhancing the OIC effect when animals are tested in context y, and masking it when the test is in context x. This possibility was examined in two experiments, and evidence for superior performance in context y was obtained. The implications of this for theoretical interpretations of recognition memory and the procedures used to explore it are discussed