Numerical methods for RANSE simulations of a self-propelled fish-like body

International audienceThis paper deals with numerical simulations on a self-propelled fish-like body. Firstly, the methods used to achieve such simulations based on the solution of the Reynolds-Averaged-Navier–Stokes Equations are described: resolution of the Newton's law (parameterization, use of a description of the rotation based on a quaternion), regridding strategies linked to body motion and deformation, fluid–motion coupling methods. In the second part, realistic applications are shown. The interaction between the fluid and the body is fully solved since the evolution of the body's position is not imposed but computed. Only the imposed deformation of the shape and its interaction with the fluid produce forces on the body and, consequently, motion

Bank effects for KVLCC2

A study is presented on ship–bank interaction effects in which viscous-flow solvers are used to predict the hydrodynamic forces and moments on the ship. The ship under consideration is the KRISO Very Large Crude Carrier (KVLCC2). For this hull form, Flanders Hydraulics Research (FHR) has conducted shallow water model tests in their towing tank equipped with surface-piercing banks and a vertical quay wall. The forces and moments on the KVLCC2 model were obtained for various water depths and lateral distances to the banks. Additionally, the wave elevation was measured between the quay wall and the ship model. In this study, two different CFD codes are used to predict the loads on the KVLCC2 as a function of the water depth and lateral position in the channel. The effect of propeller suction and free surface modelling on the results is quantified. Furthermore, comparisons will be made with CFD results from literature and potential flow computations to highlight the benefits of each approach. It will be shown that with careful setup of the computations, reliable predictions of the ship–bank interaction effects can be obtained

Current status of the verification and processing system GALILEE-1 for evaluated data

International audienceThis paper describes the current status of GALILÉE-1 that is the new verification and processing system for evaluated data, developed at CEA. It consists of various components respectively dedicated to read/write the evaluated data whatever the format is, to diagnose inconsistencies in the evaluated data and to provide continuous-energy and multigroup data as well as probability tables for transport and depletion codes. All these components are written in C++ language and share the same objects. Cross-comparisons with other processing systems (NJOY, CALENDF or PREPRO) are systematically carried out at each step in order to fully master possible discrepancies. Some results of such comparisons are provided

A proper generalized decomposition approach for high-order problems

En este artículo se desarrollan dos aproximaciones distintas para la resolución de problemas de alto orden mediante métodos de descomposición propia generalizada (PGD, del inglés Proper Generalized Decomposition ). La primera está basada en el uso de técnicas de colocación y polinomios de Chebyshev, mientras que la segunda se basa en el uso de polinomios de Hermite en el marco de una formulación de Galerkin. Ambas poseen ventajas e inconvenientes, que se analizan en detalle con la ayuda de distintos problemas clásicos de validación.In this paper two different approximations for the solution of high-order problems by proper generalized decompositions (PGD) are developed. The first one is based upon the use of collocation techniques, along with Chebyshev polynomials, while the second employs Hermite polynomials in a Galerkin framework. Both approaches having pros and cons, they are studied with the help of some classical benchmark tests.Peer Reviewe

Free-Surface Viscous Flow Solution Methods for Ship Hydrodynamics

The simulation of viscous free-surface water flow is a subject that has reached a certain maturity and is nowadays used in industrial applications, like the simulation of the flow around ships. While almost all methods used are based on the Navier-Stokes equations, the discretisation methods for the water surface differ widely. Many of these highly different methods are being used with success. We review three of these methods, by describing in detail their implementation in one particular code that is being used in industrial practice. The descriptions concern the principle of the method, numerical details, and the method’s strengths and limitations. For each code, examples are given of its use. Finally, the methods are compared to determine the best field of application for each. The following surface descretisation methods are reviewed. First, surface fitting/mesh deformation in PARNASSOS, developed by MARIN; the description focuses on the efficient steady-state solution method of this code. Then surface capturing with Volume-of-Fluid in ISIS-CFD, developed by CNRS/Ecole Centrale de Nantes; the main topic of this review are the compressive flux discretisation schemes for the volume fraction that are used in this code. And fi- nally, the Level Set method in SURF, developed by NMRI; this description contains a modified formulation of the Level Set method that is optimised for ship flow computation

Evidence for the Re-Enactment of a Recently Learned Behavior during Sleepwalking

Animal studies have shown that sequenced patterns of neuronal activity may be replayed during sleep. However, the existence of such replay in humans has not yet been directly demonstrated. Here we studied patients who exhibit overt behaviors during sleep to test whether sequences of movements trained during the day may be spontaneously reenacted by the patients during sleep

Guillain-Barré syndrome during childhood: particular clinical and electrophysiological features

Introduction Guillain–Barré syndrome (GBS) has some specific characteristics in children. Methods In this study we reviewed the clinical, laboratory, electrophysiological, and prognosis features of the 19 children diagnosed with GBS at Nantes University Hospital from 2000 to 2011. Results Gait disturbance and leg pain were the most frequent presenting symptoms. Electrophysiological examinations revealed significant abnormalities even when performed within the first week after onset. Decreased distal CMAP amplitude was noted in 89% of cases. The pattern indicated an acute inflammatory demyelinating polyneuropathy in 95% of cases and acute motor axonal neuropathy in the remaining 5%. About two-thirds of the children were treated with intravenous immunoglobulin. After >1 year of follow-up, 17 patients had complete recovery. Conclusion Gait disorder, leg pain, a high rate of distal conduction block, and a good prognosis are among the main specific features of GBS in childhood. Muscle Nerve, 48: 247–251, 201

Gene expression profiles in rat mesenteric lymph nodes upon supplementation with Conjugated Linoleic Acid during gestation and suckling

Background Diet plays a role on the development of the immune system, and polyunsaturated fatty acids can modulate the expression of a variety of genes. Human milk contains conjugated linoleic acid (CLA), a fatty acid that seems to contribute to immune development. Indeed, recent studies carried out in our group in suckling animals have shown that the immune function is enhanced after feeding them with an 80:20 isomer mix composed of c9,t11 and t10,c12 CLA. However, little work has been done on the effects of CLA on gene expression, and even less regarding immune system development in early life. Results The expression profile of mesenteric lymph nodes from animals supplemented with CLA during gestation and suckling through dam's milk (Group A) or by oral gavage (Group B), supplemented just during suckling (Group C) and control animals (Group D) was determined with the aid of the specific GeneChip® Rat Genome 230 2.0 (Affymettrix). Bioinformatics analyses were performed using the GeneSpring GX software package v10.0.2 and lead to the identification of 89 genes differentially expressed in all three dietary approaches. Generation of a biological association network evidenced several genes, such as connective tissue growth factor (Ctgf), tissue inhibitor of metalloproteinase 1 (Timp1), galanin (Gal), synaptotagmin 1 (Syt1), growth factor receptor bound protein 2 (Grb2), actin gamma 2 (Actg2) and smooth muscle alpha actin (Acta2), as highly interconnected nodes of the resulting network. Gene underexpression was confirmed by Real-Time RT-PCR. Conclusions Ctgf, Timp1, Gal and Syt1, among others, are genes modulated by CLA supplementation that may have a role on mucosal immune responses in early life

Gene expression profiles in rat mesenteric lymph nodes upon supplementation with Conjugated Linoleic Acid during gestation and suckling

Background Diet plays a role on the development of the immune system, and polyunsaturated fatty acids can modulate the expression of a variety of genes. Human milk contains conjugated linoleic acid (CLA), a fatty acid that seems to contribute to immune development. Indeed, recent studies carried out in our group in suckling animals have shown that the immune function is enhanced after feeding them with an 80:20 isomer mix composed of c9,t11 and t10,c12 CLA. However, little work has been done on the effects of CLA on gene expression, and even less regarding immune system development in early life. Results The expression profile of mesenteric lymph nodes from animals supplemented with CLA during gestation and suckling through dam's milk (Group A) or by oral gavage (Group B), supplemented just during suckling (Group C) and control animals (Group D) was determined with the aid of the specific GeneChip® Rat Genome 230 2.0 (Affymettrix). Bioinformatics analyses were performed using the GeneSpring GX software package v10.0.2 and lead to the identification of 89 genes differentially expressed in all three dietary approaches. Generation of a biological association network evidenced several genes, such as connective tissue growth factor (Ctgf), tissue inhibitor of metalloproteinase 1 (Timp1), galanin (Gal), synaptotagmin 1 (Syt1), growth factor receptor bound protein 2 (Grb2), actin gamma 2 (Actg2) and smooth muscle alpha actin (Acta2), as highly interconnected nodes of the resulting network. Gene underexpression was confirmed by Real-Time RT-PCR. Conclusions Ctgf, Timp1, Gal and Syt1, among others, are genes modulated by CLA supplementation that may have a role on mucosal immune responses in early life

Patient-derived xenograft (PDX) models in basic and translational breast cancer research

Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational preclinical research. In breast cancer, to complement the now curated collection of approximately 45 long-established human breast cancer cell lines, a newly formed consortium of academic laboratories, currently from Europe, Australia, and North America, herein summarizes data on over 500 stably transplantable PDX models representing all three clinical subtypes of breast cancer (ER+, HER2+, and "Triple-negative" (TNBC)). Many of these models are well-characterized with respect to genomic, transcriptomic, and proteomic features, metastatic behavior, and treatment response to a variety of standard-of-care and experimental therapeutics. These stably transplantable PDX lines are generally available for dissemination to laboratories conducting translational research, and contact information for each collection is provided. This review summarizes current experiences related to PDX generation across participating groups, efforts to develop data standards for annotation and dissemination of patient clinical information that does not compromise patient privacy, efforts to develop complementary data standards for annotation of PDX characteristics and biology, and progress toward "credentialing" of PDX models as surrogates to represent individual patients for use in preclinical and co-clinical translational research. In addition, this review highlights important unresolved questions, as well as current limitations, that have hampered more efficient generation of PDX lines and more rapid adoption of PDX use in translational breast cancer research