The economics of municipal solid waste management in tourism destinations: the case of Mallorca

El turismo es una de los sectores que ha mostrado un destacado crecimiento a nivel mundial actualmente. En relación con el estudio de los impactos negativos, la investigación sobre externalidades ha sido objeto de gran interés, sin embargo la relación entre la actividad turística y de los residuos sólidos municipales (RSM) no ha atendida profundamente. La tesis realiza importantes contribuciones en el análisis de tres aspectos de la relación entre turismo y la gestión de RSM. En primer lugar, el análisis cuantitativo del turismo como factor determinante en la generación de RSM. En segundo lugar, los retos del turismo en la gestión de RSM en destinos turísticos, con énfasis en Mallorca. En tercer lugar, el análisis teórico de incentivos a las empresas turísticas para mejorar la gestión de residuos. Finalmente, la tesis abre camino para identificar una serie de cuestiones que deben ser exploradas en futuras investigaciones

Cumplimiento de criterios médicos establecidos para las indicaciones de cesáreas en 19 Empresas Médicas en el departamento de Managua. Año 2003.

Estudio de tipo descriptivo de corte transversal realizado en 19 empresas médicas previsionales en el departamento de Managua para conocer el cumplimiento de los criterios médicos establecidos para la realización del procedimiento quirúrgico, cesáreas

Dynamics of a model of Toxoplasmosis disease in human and cat populations

AbstractA mathematical model for the transmission of Toxoplasmosis disease in human and cat populations is proposed and analyzed. We explore the dynamics of the Toxoplasmosis disease at the population level using an epidemiological type model. Discussion of the basic concepts of the Toxoplasmosis transmission dynamics on human and cat populations are presented. The cats in this model plays a role of infectious agents and host of the protozoan Toxoplasma Gondii parasite. Qualitative dynamics of the model is determined by the basic reproduction number, R0. If the threshold parameter R0<1, then the solution converges to the disease free equilibrium point. On the other hand if R0>1 the convergence is to the endemic equilibrium point. Numerical simulations of the model illustrates several different dynamics depending on the threshold parameter R0 and show the importance of this parameter

Multi-mode Flight Sliding Mode Control System for a Quadrotor

There is a wide range of applications for unmanned aerial vehicles that requires the capability of having several and robust flight controllers available. This paper presents the main framework of a multimode flight control system for a quadrotor based on the super twisting control algorithm. The design stages for the four flight control modes encompassing manual, altitude, GPS fixed and autonomous mode are presented. The stability proof for each flight mode is carried out by means of Lyapunov functions while the stability analysis for the complete system, when a transition from one mode to another occurs, is demonstrated using the switching nonlinear systems theory. The performance of the proposed framework is demonstrated in a simulation study taking into account external disturbances.ITESO, A.C.CINVESTAV-IP

Sistemas constructivos no convencionales y condiciones habitables en las viviendas del Barrio 4A, Alto Trujillo, El Porvenir, Trujillo, 2021

La problemática de las condiciones habitables deficientes y los sistemas constructivos empleados de forma inadecuada, esto vinculado a sus carentes ingresos económicos, el cual no les permite acceder a construcciones convencionales, por lo cual conlleva a la población construir con materiales de baja calidad y esto se demuestra en las malas construcciones de sus viviendas. con la finalidad de plantear una alternativa con un sistema constructivo se formuló el siguiente objetivo: Determinar el sistema constructivo no convencional de bajos costos que contribuya a mejorar las condiciones habitables de las viviendas del Barrio 4 A, Alto Trujillo, El Porvenir. Fue de enfoque cuantitativo de diseño no experimental, se desarrolló una muestra de 88 viviendas y como muestreo el método probabilístico aleatorio simple, se usó como técnicas: la encuesta, ficha de observación y entrevista, se emplearon tablas de contingencia. Los resultados mostraron, que las viviendas del sector no son completamente habitables, debido al estado y no mostrar condiciones mínimas de habitabilidad, en cuanto a área construida, resistencia, tipo de material, cantidad de ambientes y confort habitacional. Se concluye que el sistema constructivo no convencional vivienda contenedor, brinda mejores beneficios tanto de costo, tiempo de ejecución, resistencia, confort, acabados

Parque Biblioteca Interdistrital en San Juan de Miraflores, Lima Sur

El fin del presente proyecto de estudio es la propuesta arquitectónica de Parque Biblioteca Interdistrital ubicado en el distrito de San Juan de Miraflores para el cono sur de la Lima Metropolitana del Perú, en contribución al ámbito cultural, el fomento de la lectura y la investigación para sus habitantes en respuesta a la carencia o deficiencia de los resultados preliminares estudiados. Las teorías implementadas en el proyecto arquitectónico se basan en la correlación colectiva positiva entre la lectura cultural como los criterios de diseño bibliotecario y sus respectivas funciones, y los espacios libres recreacionales, como parque o áreas verdes para sus habitantes dando como resultado un reanimador urbano como plan estratégico en el desarrollo de la ciudad. El método de estudio cualitativo corresponde al diseño desarrollado bajo una programación arquitectónica y las recomendaciones obtenidas del análisis de estudio del lugar dando como resultado la fusión entre biblioteca y parque, un intermedio armonioso entre los espacios internos en visualidad con áreas verdes, mostrado en un expediente técnico, cumpliendo con el objetivo de proveer un espacio para el desarrollo cultural e integral en los residentes de su sector

Mammals of the San Pedro-Mezquital River Basin, Durango-Nayarit, Mexico

The San Pedro–Mezquital River Basin is located in the southern Sierra Madre Occidental, at the Nearctic– Neotropical transition. The river traverses the Sierra through a canyon that reaches over 1000 m in depth. Based on examination of museum specimens, literature records, and our own collections, we documented the occurrence of 120 species (24.6% of the Mexican terrestrial mammals), 24 endemic to Mexico. Richness was comparable with other megadiverse areas of Mexico, and higher than any other Nearctic–Neotropical transition area, moreover species richness is likely to rise as survey continues. Contrary to expectation, distribution of mammals across the basin not only reflected the Nearctic–Neotropical divide, but a third fauna that is a mixture of tropical, temperate and desert species was identifiable at the canyon. Anthropogenic threats including damming of the river, uncontrolled cattle grazing, and pollution from domestic sources, call for effective management strategies to preserve one of the most biodiverse areas of Mexico

Matrix Nonstandard Numerical Schemes for Epidemic Models

This paper is concerned with the construction and developing of several nonstandard finite difference (NSFD) schemes in matrix form in order to obtain numerical solutions of epidemic models. In particular, we deal with a classical SIR epidemic model and a seasonal model associated with the evolution of the transmission of respiratory syncytial virus RSV in the human population. The first model is an autonomous differential equation system, and the second one is a nonautonomous one which generally is more difficult to be solved. The numerical schemes developed here can be used in other general epidemic models based on ordinary differential equations. One advantage of the developed methodology is that can be used easily by the scientific community without special knowledge. In addition, these NSFD schemes which are based on the the nonstandard finite difference methods developed by Mickens solve numerically systems describing epidemics with less computational effort. Finally, with these matrix NSFD schemes it can be exploited more easily matrix operations advantages.González Parra, GC.; Villanueva Micó, RJ.; Arenas Tawil, AJ. (2010). Matrix Nonstandard Numerical Schemes for Epidemic Models. WSEAS Transactions on Mathematics. 9(11):840-850. http://hdl.handle.net/10251/60495S84085091

The Causative and Curative Roles of Brain-Derived Neurotrophic Factor in Parkinson’s Disease

Parkinson’s disease (PD) is characterized by the activation of degenerative and inflammatory processes in brain circuits that control movement and, according to the degree of progression of the damage, can cause neuropsychological disorders such as cognitive dysfunction. Changes in gene expression profile or post-translational modifications in secretory proteins such as neurotrophic factors could define the disease progression. Brain-derived neurotrophic factor (BDNF) is relevant, because it not only participates in neuronal survival, neurotransmission, dendritic growth and cellular communication but also in disease progression. In this chapter, considering both experimental evidences and clinical reports, the authors will analyze the contribution of BDNF as one of the causes of neurodegeneration and neuroinflammation; discuss the participation of this neurotrophic factor in the development of cognitive dysfunction, and finally the scope of novel BDNF-based therapies for PD

Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell Malignancies

Background: Chimeric antigen receptor (CAR) T cells directed against CD19 (CART19) are effective in B-cell malignancies, but little is known about the molecular factors predicting clinical outcome of CART19 therapy. The increasingly recognized relevance of epigenetic changes in cancer immunology prompted us to determine the impact of the DNA methylation profiles of CART19 cells on the clinical course. Methods: We recruited 114 patients with B-cell malignancies, comprising 77 patients with acute lymphoblastic leukemia and 37 patients with non-Hodgkin lymphoma who were treated with CART19 cells. Using a comprehensive DNA methylation microarray, we determined the epigenomic changes that occur in the patient T cells upon transduction of the CAR vector. The effects of the identified DNA methylation sites on clinical response, cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, event-free survival, and overall survival were assessed. All statistical tests were 2-sided. Results: We identified 984 genomic sites with differential DNA methylation between CAR-untransduced and CAR-transduced T cells before infusion into the patient. Eighteen of these distinct epigenetic loci were associated with complete response (CR), adjusting by multiple testing. Using the sites linked to CR, an epigenetic signature, referred to hereafter as the EPICART signature, was established in the initial discovery cohort (n = 79), which was associated with CR (Fisher exact test, P < .001) and enhanced event-free survival (hazard ratio [HR] = 0.36; 95% confidence interval [CI] = 0.19 to 0.70; P = .002; log-rank P = .003) and overall survival (HR = 0.45; 95% CI = 0.20 to 0.99; P = .047; log-rank P = .04;). Most important, the EPICART profile maintained its clinical course predictive value in the validation cohort (n = 35), where it was associated with CR (Fisher exact test, P < .001) and enhanced overall survival (HR = 0.31; 95% CI = 0.11 to 0.84; P = .02; log-rank P = .02). Conclusions: We show that the DNA methylation landscape of patient CART19 cells influences the efficacy of the cellular immunotherapy treatment in patients with B-cell malignancy.Supported by CERCA Programme/Generalitat de Catalunya, Health Department PERIS #SLT/002/16/00374, AGAUR-project #2017SGR1080; MCI/AEI/ERDF project #RTI2018-094049-B-I00; ERC EPIPHARM; Cellex Foundation; “la Caixa” Foundation (LCF/PR/GN18/51140001 and LCF/PR/GN18/50310007), RF-2016–02364388, Accelerator Award—Cancer Research UK/AIRC—INCAR Associazione Italiana Ricerca per la Ricerca sul Cancro (AIRC) Project 5 × 1000 no. 9962, AIRC IG 2018 id. 21724, AIRC MFAG id. 21769 and id. 20450; MIUR (Grant PRIN 2017); and RCR-2019–23669115