Sistematización del proceso de intervención psicosocial (Vivo Mi Barrio) en los barrios los Olivos II y La María de la Comuna III del municipio de Soacha

El presente trabajo de grado buscó, a partir de la sistematización del proceso Vivo Mi Barrio en el marco de la Práctica de Violencia Sociopolítica, comprender las dinámicas de violencia que se dan en los barrios Olivos II y La María y sus impactos en la vivencia de la comunidad, en particular de los niños, niñas y adolescentes, de los espacios públicos de estos barrios. Para ello se revisaron las concepciones de violencia propuestas por Johan Galtung, las dinámicas de poder y violencia desde la teoría de Michel Foucault, el concepto de espacio público revisado por Olga Segovia y Ricardo Jordán y la propuesta de Carol Gilligan en torno a la ética del cuidado y la moral de la responsabilidad. Se realizó un análisis de narrativas a partir de las relatorías de los talleres de Vivo Mi Barrio y de entrevistas realizadas a personas implicadas y que conocen de cerca la situación de estos barrios. Se identificaron los mecanismos a través de los cuales se ejerce la violencia en estos barrios y el impacto que estos tienen en la relación entre la comunidad, particularmente de los niños, niñas y adolescentes, y el espacio público.The present study sought, from the systematization of the process Vivo Mi Barrio from the Sistematización del proceso de intervención psicosocial Vivo Mi Barrio practice of Sociopolitical Violence, pretend to understand the dynamics of violence that take place in Olivos II and La María and its impacts on the experience of the community , particularly children and adolescents , in public spaces of these neighborhoods . Were reviewed conceptions of violence proposed by Johan Galtung, the dynamics of power and violence from the theory of Michel Foucault , the concept of public space developed by Olga Segovia and Ricardo Jordan and Carol Gilligan 's proposal regarding the ethics of care and moral of responsibility. Narrative analysis was conducted from the rapporteurs of Vivo Mi Barrio workshops and interviews with people involved in the situation of these neighborhoods . Mechanisms through which violence in these neighborhoods and the impact they have on the relationship between the community, particularly children and adolescents , and public space is exercised were identified.Psicólogo (a)Pregrad

SpeedMed: device for measuring velocity in track sports

El desarrollo de productos e investigaciones relacionadas con el mejoramiento del desempeño atlético ha sido impulsado por el apoyo económico de las crecientes industrias deportivas. Así, la construcción de un dispositivo económico y portátil que permita medir los tiempos y velocidades en deportes de pista proporcionará información adecuada para cuantificar el progreso de los deportistas relacionados e identificar los aspectos para fortalecer. Su uso podría extenderse a personas ordinarias bajo condiciones de estrés. En este trabajo se utilizaron fotoceldas para desarrollar un dispositivo capaz de medir la velocidad en los escenarios mencionados. Para esto se programó un microcontrolador que mide el intervalo de tiempo entre las interrupciones de dos haces de láser que impactan la superifcie de las fotoseldas, y luego calcula la velocidad para una distancia dada entre los sensores. Finalmente los valores se envían a una pantalla de cristal líquido (LCD) para su visualización e interpretación.Everyday, industries make use of economic resources to carry on research studies of products to improve the athletic performance of people. This is the main reason why it is believed that the development of an inexpensive and portable device capable of measuring times and speeds in track sports in general will provide useful information to study the performance of not only sportsmen, but also of ordinary people under stress situations allowing them to determine their weaknesses. In this project, two very simple sensors (photocells) are used to develop a device capable of measuring speed. A microcontroller was programmed to measure the time between the interruptions of two laser beams which lighten the surfaces of photocells, and it was also programmed to calculate velocity for a given distance. These values are sent to a Liquid Crystal Display (LCD) where they can be visualized and interpreted

Conocimientos sobre salud sexual y reproductiva en población con discapacidad auditiva: caso Barranquilla-estudio piloto 2021

En Colombia gran parte de la población con discapacidad auditiva experimenta barreras y marginalización en el acceso a servicios de salud y educación sexual de calidad. Los pocos estudios realizados en esta población que evalúan esta problemática han evidenciado que existe una asociación entre la marginalización, las limitaciones, y las barreras de comunicación que se presentan en las Personas con Discapacidad auditiva (PcD Auditiva), y la desinformación respecto al tema de Salud Sexual y Reproductiva (SSR) en esta población. Con la información obtenida en el presente estudio se pretende describir los conocimientos sobre SSR en PcD auditiva en el distrito de Barranquilla en el año 2021. El presente es un estudio descriptivo transversal observacional, que consistió en un corte transversal analítico de fuente primaria, en donde el muestreo fue tipo bola de nieve, y se empleó un cuestionario estandarizado para evaluar los conocimientos de la población. Se implementó un cuestionario adaptado a lengua de señas con video con intérprete certificado. El instrumento de Google se compone de 50 preguntas: 15 para perfil sociodemográfico junto con lingüística, y 35 para conocimiento de salud sexual y reproductiva, además incluyó enunciados con sus opciones de respuesta. Se realizó un análisis descriptivo de las variables cualitativas a través de frecuencia absoluta y porcentaje, y de las variables cuantitativas por medio de análisis estadístico de significancia. En una muestra de 29 personas, de las cuales el 55,2% (n=29) fueron mujeres, se observó que él 65.52% de los participantes tenían un nivel de conocimiento moderado, y solo el 34.48% un nivel de conocimientos adecuado. Ninguna de las asociaciones obtenidas presentan significancia estadística en la comparación del nivel de conocimiento y las variables sociodemográficas de interés, dado que el IC (95%) no es preciso. Respecto a las variables lingüísticas, se observó que el 81,2% de los que no tienen buenas habilidades de escritura en el idioma español presentan un nivel de conocimiento moderado, ascendiendo el porcentaje el caso de la lectura a un 81,8%. El presente estudio permitió comprobar que es posible realizar cuestionarios por metodología de auto diligenciamiento a PcD auditiva que permitan describir los conocimientos sobre SSR. Como estudio exploratorio se espera que sirva como aporte a futuras investigaciones que busquen abordar a esta población.PregradoMedic

Evaluation of the Spanish population coverage of a prospective HLA haplobank of induced pluripotent stem cells

Background: iPSC (induced pluripotent stem cells) banks of iPSC lines with homozygous HLA (human leukocyte antigen) haplotypes (haplobanks) are proposed as an affordable and off-the-shelf approach to allogeneic transplantation of iPSC derived cell therapies. Cord blood banks offer an extensive source of HLA-typed cells suitable for reprogramming to iPSC. Several initiatives worldwide have been undertaken to create national and international iPSC haplobanks that match a significant part of a population. Methods: To create an iPSC haplobank that serves the Spanish population (IPS-PANIA), we have searched the Spanish Bone Marrow Donor Registry (REDMO) to identify the most frequently estimated haplotypes. From the top ten donors identified, we estimated the population coverage using the criteria of zero mismatches in HLA-A, HLA-B, and HLA-DRB1 with different stringencies: high resolution, low resolution, and beneficial mismatch. Results: We have calculated that ten cord blood units from homozygous donors stored at the Spanish cord blood banks can provide HLA-A, HLA-B, and HLA-DRB1 matching for 28.23% of the population. Conclusion: We confirm the feasibility of using banked cord blood units to create an iPSC haplobank that will cover a significant percentage of the Spanish and international population for future advanced therapy replacement strategies

Estudos Artísticos

Nesta procura continuada de reunir escritos de artistas sobre outros criadores se reuniram neste número da Revista Croma dezasseis artigos que têm em comum a determinação interventiva e emancipada. Provoca-se o inconformismo, ensaia-se o pensamento. A intervenção advém do estatuto, do capital simbólico associado à autoria. O estatuto político da arte centra o artista e tona-o vocal. A sua perspetiva, a sua síntese, a sua fantasia, são agora meios para uma mediação junto de todos, em direção a uma transformação fundamental e construtora de um dos pontos essenciais da cultura: a arte emancipada. Com a emancipação da arte, criou-se uma nova referencialidade, um novo descentramento, um olhar exterior, um olhar do homem sobre o homem, um olhar político mediado pelas formas pensadas.info:eu-repo/semantics/publishedVersio

Novel genes and sex differences in COVID-19 severity

[EN] Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.S

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Speedmed: Device for measuring velocity in track sports

Everyday, industries make use of economic resources to carry on research studies of products to improve the athletic performance of people. This is the main reason why it is believed that the development of an inexpensive and portable device capable of measuring times and speeds in track sports in general will provide useful information to study the performance of not only sportsmen, but also of ordinary people under stress situations allowing them to determine their weaknesses. In this project, two very simple sensors (photocells) are used to develop a device capable of measuring speed. A microcontroller was programmed to measure the time between the interruptions of two laser beams which lighten the surfaces of photocells, and it was also programmed to calculate velocity for a given distance. These values are sent to a Liquid Crystal Display (LCD) where they can be visualized and interpreted.El desarrollo de productos e investigaciones relacionadas con el mejoramiento del desempeño atlético ha sido impulsado por el apoyo económico de las crecientes industrias deportivas. Así, la construcción de un dispositivo económico y portátil que permita medir los tiempos y velocidades en deportes de pista proporcionará información adecuada para cuantificar el progreso de los deportistas relacionados e identificar los aspectos para fortalecer. Su uso podría extenderse a personas ordinarias bajo condiciones de estrés. En este trabajo se utilizaron fotoceldas para desarrollar un dispositivo capaz de medir la velocidad en los escenarios mencionados. Para esto se programó un microcontrolador que mide el intervalo de tiempo entre las interrupciones de dos haces de láser que impactan la superficie de las fotoceldas, y luego calcula la velocidad para una distancia dada entre los sensores. Finalmente los valores se envían a una pantalla de cristal líquido (LCD) para su visualización e interpretación

Spatial and temporal population dynamics of male and female Aedes albopictus at a local scale in Medellín, Colombia

Abstract Background Diseases transmitted by invasive Aedes aegypti and Aedes albopictus mosquitoes are public health issues in the tropics and subtropics. Understanding the ecology of mosquito vectors is essential for the development of effective disease mitigation programs and will allow for accurate predictions of vector occurrence and abundance. Studies that examine mosquito population dynamics are typically focused on female presence or total adult captures without discriminating the temporal and spatial distribution of both sexes. Methods We collected immature and adult mosquitoes bimonthly for 2 years (2018–2019) in the Medellín Botanical Garden. Collection sites differed in proximity to buildings and nearby vegetation, and were classified by their overhead vegetation cover. We used linear mixed models (LMMs) and Spatial Analysis by Distance Indices (SADIE) to assess the spatial distribution of Ae. aegypti and Ae. albopictus. Using our Ae. albopictus captures exclusively, we assessed (1) the spatial and temporal distribution of males and females using SADIE and a generalized linear mixed model (GLMM), (2) the relationship between climatic variables/vegetation coverage and adult captures using GLMMs and LMMs, and (3) the correlation of male and female size in relation to climatic variables and vegetation coverage using LMMs. Results Spatial analysis showed that Ae. aegypti and Ae. albopictus were distributed at different locations within the surveilled area. However, Ae. albopictus was the predominant species in the park during the study period. Adult Ae. albopictus captures were positively correlated with precipitation and relative humidity, and inversely correlated with temperature and wind speed. Moreover, we observed a spatial misalignment of Ae. albopictus males and females—the majority of males were located in the high vegetation coverage sites, while females were more evenly distributed. We observed significant associations of the size of our adult Ae. albopictus captures with precipitation, temperature, and wind speed for both sexes and found that overhead vegetation cover influenced male size, but observed no effect on female size. Conclusions Our work elucidates the differential dynamics of Ae. albopictus males and females, which is pivotal to develop accurate surveillance and the successful establishment of vector control programs based on the disruption of insect reproduction. Graphic Abstrac