Remarkable Anticancer Activity of Triruthenium-Arene Clusters Compared to Tetraruthenium-Arene Clusters

The invitro activity of a series of ruthenium clusters, [(η6-C6H6)(η6-C6Me6)2Ru3(μ-H)3(μ3-O)][BF4], [(η6-C6H6)(η6-1,4-iPrC6H4Me)(η6-C6Me6)Ru3(μ-H)3(μ3-O)][BF4], [(η6-C6H6)4Ru4(μ-H)4][BF4]2, [(η6-C6H5Me)4Ru4(μ-H)4][BF4]2 and [(η6-C6H6)4Ru4(μ-H)3(μ-OH)][Cl]2, has been evaluated against A2780 and A2780cisR ovarian carcinoma cell lines. Both triruthenium clusters are very active compared to ruthenium compounds in general, whereas the tetraruthenium clusters do not display significant cytotoxicities. Since the triruthenium clusters are known to form supramolecular interactions with arenes and other functions, it is possible that such interactions are also important with respect to their mode of biological activity. The X-ray structure analysis of [(η6-C6H5Me)4Ru4(μ-H)4][PF6]2 is also reported. Graphical Abstract: The invitro activity of a series of ruthenium clusters has been evaluated against A2780 and A2780cisR ovarian carcinoma cell lines and their activity compared to cisplatin. The triruthenium clusters are very active, while the tetraruthenium clusters do not display significant cytotoxicitie

Post-functionalized iridium Zr-MOF as a promising recycle catalyst for the hydrogenation of aromatics

[EN] The multifunctional heterogeneous catalyst iridium–Zr-based MOF is able to effectively catalyze the hydrogenation of aromatic compounds in high yields under mild conditions. The catalyst was found to be highly active and reusable, giving similar reactivity and selectivity after at least five catalytic uses.We thank the MINECO of Spain (project MAT2011-29020-C02-02), Consolider-Ingenio 2010-(CSD-0050-MULTICAT). for financial support. A.M.R.A. thanks MINECO for the FPI program.Rasero Almansa, AM.; Corma Canós, A.; Iglesias, M.; Sánchez Alonso, F. (2014). Post-functionalized iridium Zr-MOF as a promising recycle catalyst for the hydrogenation of aromatics. Green Chemistry. 16(7):3522-3527. https://doi.org/10.1039/c4gc00581cS3522352716