EL BRANDING Y EL POSICIONAMIENTO EN EL RESTAURANTE POLLERÍA EDUARDO’S, TINGO MARÍA - 2021

El presenta trabajo de investigación científica tiene por finalidad conocer la relación del branding y el posicionamiento en el Restaurante Pollería Eduardo’s, Tingo María - 2021. La investigación es de tipo aplicada, asumió un en enfoque cuantitativo de muestras estadísticas, el alcance es descriptivo – correlacional y el diseño es no experimental de corte transversal, la población está conformada por dos unidades de análisis, el primero por el gerente general de la empresa y la segunda por 1235 clientes, dando como resultado una muestra de 63 clientes. Para la recolección de datos se utilizaron la técnica de la encuesta, la entrevista y la observación; como instrumento el cuestionario aplicado a los clientes, la guía de entrevista al gerente general y la guía de observación para conocer aspectos importantes de la Página web y la red social Facebook del restaurante. Los datos recopilados han sido analizados aplicando la técnica de la estadística descriptiva y se utilizó el software estadístico SPSS para analizar e interpretar la información en tablas y gráficos estadísticos. Mediante los resultados obtenidos en la presente investigación, se deduce que el Restaurante Pollería Eduardo’s, no promueve de forma correcta la cultura de marca a través de los valores empresariales y clima laboral, debido a que los clientes consideran como “regular” la aplicación de dichos indicadores dentro del restaurante. Así mismo, no se está haciendo el uso correcto de la dimensión comunicación, en el caso del marketing digital, porque los clientes solo conocen o han visitado “ocasionalmente” la página web y redes sociales del restaurante, de tal manera que todos estos inconvenientes en mención refleja que la empresa no tiene un adecuado posicionamiento en el mercado.Tesi

Malaria and soil-transmitted intestinal helminth co-infection and its effect on anemia: a meta-analysis

This study aimed to synthesize available evidence on the extent of malaria and soil-transmitted intestinal helminth (STH) co-infections in people living in endemic countries and to explore the effect of interactions between malaria and STHs on anemia. We searched relevant studies in electronic databases up to March 2013. Studies comparing malaria and STH co-infected patients with those not co-infected were included and the effect estimates were pooled using a random-effects model. We identified 30 studies for meta-analyses of which 17 were cross-sectional design. The majority of included studies (80%) were carried out in African countries. Among pregnant women, those infected with hookworm were found to have higher association with malaria infection compared with those without (summary OR: 1.36; 95% CI: 1.17-1.59; I2: 0%). Among non-pregnant adults, the summary OR of the association between anemia and the combined malaria and STH was 2.91 (1.38-6.14). The summary OR of the association between anemia and malaria alone was 1.53 (0.97-2.42), while the association between anemia and STH alone was 0.28 (0.04-1.95). There is no good evidence to support a different effect of malaria and STH on anemia. A subgroup analysis showed a higher risk of malaria infection in the primigravidae (summary OR: 1.61; 95% CI: 1.3-1.99; I2: 0%). In conclusion, the malaria-STH co-infection was variable with complex outcomes on anemi

Computational Design of Alloy Nanostructures for Optical Sensing of Hydrogen

Pd nanoalloys show great potential as hysteresis-free, reliable hydrogen sensors. Here, a multiscale modeling approach is employed to determine optimal conditions for optical hydrogen sensing using the Pd-Au-H system. Changes in hydrogen pressure translate to changes in hydrogen content and eventually the optical spectrum. At the single particle level, the shift of the plasmon peak position with hydrogen concentration (i.e., the "optical" sensitivity) is approximately constant at 180 nm/c(H) for nanodisk diameters of greater than or similar to 100 nm. For smaller particles, the optical sensitivity is negative and increases with decreasing diameter, due to the emergence of a second peak originating from coupling between a localized surface plasmon and interband transitions. In addition to tracking peak position, the onset of extinction as well as extinction at fixed wavelengths is considered. We carefully compare the simulation results with experimental data and assess the potential sources for discrepancies. Invariably, the results suggest that there is an upper bound for the optical sensitivity that cannot be overcome by engineering composition and/or geometry. While the alloy composition has a limited impact on optical sensitivity, it can strongly affect H uptake and consequently the "thermodynamic" sensitivity and the detection limit. Here, it is shown how the latter can be improved by compositional engineering and even substantially enhanced via the formation of an ordered phase that can be synthesized at higher hydrogen partial pressures

High-vacuum-compatible high-power Faraday isolators for gravitational-wave interferometers

Faraday isolators play a key role in the operation of large-scale gravitational-wave detectors. Second-generation gravitational-wave interferometers such as the Advanced Laser Interferometer Gravitational-Wave Observatory (LIGO) and Advanced Virgo will use high-average-power cw lasers (up to 200 W) requiring specially designed Faraday isolators that are immune to the effects resulting from the laser beam absorption–degraded isolation ratio, thermal lensing, and thermally induced beam steering. In this paper, we present a comprehensive study of Faraday isolators designed specifically for high-performance operation in high-power gravitational-wave interferometers

First-in-human phase 1 study of budigalimab, an anti-PD-1 inhibitor, in patients with non-small cell lung cancer and head and neck squamous cell carcinoma

Publisher Copyright: © 2021, The Author(s).Background: Budigalimab is a humanized, recombinant immunoglobulin G1 monoclonal antibody targeting programmed cell death protein 1 (PD-1). We present the safety, efficacy, pharmacokinetic (PK), and pharmacodynamic data from patients enrolled in the head and neck squamous cell carcinoma (HNSCC) and non-small cell lung cancer (NSCLC) expansion cohorts of the phase 1 first-in-human study of budigalimab monotherapy (NCT03000257; registered 15 December 2016). Patients and methods: Patients with recurrent/metastatic HNSCC or locally advanced/metastatic NSCLC naive to PD-1/PD-1-ligand inhibitors were enrolled; patients were not selected on the basis of oncogene driver mutations or PD-L1 status. Budigalimab was administered at 250 mg intravenously Q2W or 500 mg intravenously Q4W until disease progression/unacceptable toxicity. The primary endpoints were safety and PK; the secondary endpoint was efficacy. Exploratory endpoints included biomarker assessments. Results: In total, 81 patients were enrolled (HNSCC: N = 41 [PD-L1 positive: n = 19]; NSCLC: N = 40 [PD-L1 positive: n = 16]); median treatment duration was 72 days (range, 1–617) and 71 days (range, 1–490) for the HNSCC and NSCLC cohorts, respectively. The most frequent grade ≥ 3 treatment-emergent adverse event was anemia (HNSCC: n = 9, 22%; NSCLC: n = 5, 13%). Both dosing regimens had comparable drug exposure and increased interferon gamma-induced chemokines, monokine induced by gamma interferon, and interferon-gamma-inducible protein 10. Objective response rates were 13% (90% CI, 5.1–24.5) in the HNSCC cohort and 19% (90% CI, 9.2–32.6) in the NSCLC cohort. Median progression-free survival was 3.6 months (95% CI, 1.7–4.7) and 1.9 months (95% CI, 1.7–3.7) in the HNSCC and NSCLC cohorts. Conclusions: The safety, efficacy and biomarker profiles of budigalimab are similar to other PD-1 inhibitors. Development of budigalimab in combination with novel anticancer agents is ongoing.Peer reviewe

Atlantic Ocean Observing Networks: Cost and feasibility study

Results of a cost and feasibility study of the present and planned integrated Atlantic Ocean Observing System, including assessing the readiness and feasibility of implementation of different observing technologie

Political Economy of Climate Compatible Development: Artisanal Fisheries and Climate Change in Ghana

Interest in prospects for policy processes that contribute to development, climate change adaptation and mitigation, known as ‘climate compatible development’, has been growing in response to increasing awareness of the impacts of climate change. This paper provides insight into the complex political economy of climate compatible development in Ghana's artisanal fisheries, a sector that has received comparatively little attention in climate change literature and policy processes. It focuses on two contentious policy areas where there is potential for climate compatible development, namely the subsidized premix fuel provided to artisanal fishermen, and mangrove protection. Regarding the premix subsidy, while there is theoretical scope for a ‘triple win’ outcome by removing the subsidy to reduce incentives to unsustainable fishing and supporting alternative policies, in practice this is highly problematic. Artisanal fishermen strongly oppose removing the subsidy on the grounds that it would damage their livelihoods, and do not have the confidence that they would be appropriately compensated for any hypothetical reform. Moreover, it is argued that removing it could have negative unintended consequences if fishermen are forced into alternative livelihoods that are themselves unsustainable. There is, however, a need to make considerable improvements to the distribution of the premix fuel so that it reaches the intended beneficiaries and is not siphoned off for contraband. Meanwhile, although improved mangrove protection could have significant ‘triple‐win’ benefits, this area suffers from a lack of funding and administrative coordination across ministries and agencies, leading it to be neglected. The case studies reveal, therefore, that the major constraint to climate compatible development is institutional failing, rather than a lack of policies per se. The paper emphasizes the need to conceptualize climate compatible development as a process which is dynamic across space and time, such that potential for triple win outcomes is fluctuate to vary according to changing circumstances. It is necessary to recognize, furthermore, that pressures from a number of actors, including those at the grass roots, may demand short term improvements to current problems rather than aspiring to triple win outcomes in the long term, creating a major challenge for climate compatible development

Role of the progesterone receptor for paclitaxel resistance in primary breast cancer

Paclitaxel plays an important role in the treatment of primary breast cancer. However, a substantial proportion of patients treated with paclitaxel does not appear to derive any benefit from this therapy. We performed a prospective study using tumour cells isolated from 50 primary breast carcinomas. Sensitivity of primary tumour cells to paclitaxel was determined in a clinically relevant range of concentrations (0.85–27.2 μg ml−1 paclitaxel) using an ATP assay. Chemosensitivity data were used to study a possible association with immunohistochemically determined oestrogen and progesterone receptor (ER and PR) status, as well as histopathological parameters. Progesterone receptor (PR) mRNA expression was also determined by quantitative RT–PCR. We observed a clear association of the PR status with chemosensitivity to paclitaxel. Higher levels of immunohistochemically detected PR expression correlated with decreased chemosensitivity (P=0.008). Similarly, high levels of PR mRNA expression were associated with decreased paclitaxel chemosensitivity (P=0.007). Cells from carcinomas with T-stages 3 and 4 were less sensitive compared to stages 1 and 2 (P=0.013). Multiple regression analysis identified PR receptor status and T-stage as independent predictors of paclitaxel chemosensitivity, whereas the ER, N-stage, grading and age were not influential. In conclusion, in vitro sensitivity to paclitaxel was higher for PR-negative compared with PR-positive breast carcinoma cells. Thus, PR status should be considered as a possible factor of influence when designing new trials and chemotherapy protocols