MUSE-inspired view of the quasar Q2059-360, its Lyman alpha blob, and its neighborhood

The radio-quiet quasar Q2059-360 at redshift $z=3.08$ is known to be close to a small Lyman $\alpha$ blob (LAB) and to be absorbed by a proximate damped Ly$\alpha$ (PDLA) system. Here, we present the Multi Unit Spectroscopic Explorer (MUSE) integral field spectroscopy follow-up of this quasi-stellar object (QSO). Our primary goal is to characterize this LAB in detail by mapping it both spatially and spectrally using the Ly$\alpha$ line, and by looking for high-ionization lines to constrain the emission mechanism. Combining the high sensitivity of the MUSE integral field spectrograph mounted on the Yepun telescope at ESO-VLT with the natural coronagraph provided by the PDLA, we map the LAB down to the QSO position, after robust subtraction of QSO light in the spectral domain. In addition to confirming earlier results for the small bright component of the LAB, we unveil a faint filamentary emission protruding to the south over about 80 pkpc (physical kpc); this results in a total size of about 120 pkpc. We derive the velocity field of the LAB (assuming no transfer effects) and map the Ly$\alpha$ line width. Upper limits are set to the flux of the N V $\lambda 1238-1242$, C IV $\lambda 1548-1551$, He II $\lambda 1640$, and C III] $\lambda 1548-1551$ lines. We have discovered two probable Ly$\alpha$ emitters at the same redshift as the LAB and at projected distances of 265 kpc and 207 kpc from the QSO; their Ly$\alpha$ luminosities might well be enhanced by the QSO radiation. We also find an emission line galaxy at $z=0.33$ near the line of sight to the QSO. This LAB shares the same general characteristics as the 17 others surrounding radio-quiet QSOs presented previously. However, there are indications that it may be centered on the PDLA galaxy rather than on the QSO.Comment: Accepted for publication in Astronomy & Astrophysics; 16 pages, 19 figure

Cigarette smoke extract induces a phenotypic shift in epithelial cells: involvement of HIF1α in mesenchymal transition

In COPD, matrix remodeling contributes to airflow limitation. Recent evidence suggests that next to fibroblasts, the process of epithelial-mesenchymal transition can contribute to matrix remodeling. CSE has been shown to induce EMT in lung epithelial cells, but the signaling mechanisms involved are largely unknown and subject of this study. EMT was assessed in A549 and BEAS2B cells stimulated with CSE by qPCR, Western blotting and immunofluorescence for epithelial and mesenchymal markers, as were collagen production, cell adhesion and barrier integrity as functional endpoints. Involvement of TGF-beta and HIF1 alpha signaling pathways were investigated. In addition, mouse models were used to examine the effects of CS on hypoxia signaling and of hypoxia per se on mesenchymal expression. CSE induced EMT characteristics in A549 and BEAS2B cells, evidenced by decreased expression of epithelial markers and a concomitant increase in mesenchymal marker expression after CSE exposure. Furthermore cells that underwent EMT showed increased production of collagen, decreased adhesion and disrupted barrier integrity. The induction of EMT was found to be independent of TGF-beta signaling. On the contrary, CS was able to induce hypoxic signaling in A549 and BEAS2B cells as well as in mice lung tissue. Importantly, HIF1 alpha knock-down prevented induction of mesenchymal markers, increased collagen production and decreased adhesion after CSE exposure, data that are in line with the observed induction of mesenchymal marker expression by hypoxia in vitro and in vivo. Together these data provide evidence that both bronchial and alveolar epithelial cells undergo a functional phenotypic shift in response to CSE exposure which can contribute to increased collagen deposition in COPD lungs. Moreover, HIF1 alpha signaling appears to play an important role in this process

The UV, Lyman α, and dark matter halo properties of high-redshift galaxies

We explore the properties of high-redshift Lyman alpha emitters (LAEs), and their link with the Lyman-break galaxy (LBG) population, using a semi-analytic model of galaxy formation that takes into account resonant scattering of Lyα photons in gas outflows. We can reasonably reproduce the abundances of LAEs and LBGs from z≈3 to 7, as well as most UV luminosity functions (LFs) of LAEs. The stronger dust attenuation for (resonant) Lyα photons compared to UV continuum photons in bright LBGs provides a natural interpretation to the increase of the LAE fraction in LBG samples, XLAE, towards fainter magnitudes. The redshift evolution of XLAE seems however very sensitive to UV magnitudes limits and equivalent width (EW) cuts. In spite of the apparent good match between the statistical properties predicted by the model and the observations, we find that the tail of the Lyα EW distribution (EW≳100 Å) cannot be explained by our model, and we need to invoke additional mechanisms. We find that LAEs and LBGs span a very similar dynamical range, but bright LAEs are ∼4times rarer than LBGs in massive haloes. Moreover, massive haloes mainly contain weak LAEs in our model, which might introduce a bias towards low-mass haloes in surveys which select sources with high-EW cuts. Overall, our results are consistent with the idea that LAEs and LBGs make a very similar galaxy population. Their apparent differences seem mainly due to EW selections, UV detection limits, and a decreasing Lyα to UV escape fraction ratio in high star formation rate galaxie

A young star-forming galaxy at z = 3.5 with an extended Ly\,α\alpha halo seen with MUSE

Spatially resolved studies of high redshift galaxies, an essential insight into galaxy formation processes, have been mostly limited to stacking or unusually bright objects. We present here the study of a typical (L$^{*}$, M$_\star$ = 6 $\times 10^9$ $M_\odot$) young lensed galaxy at $z=3.5$, observed with MUSE, for which we obtain 2D resolved spatial information of Ly$\alpha$ and, for the first time, of CIII] emission. The exceptional signal-to-noise of the data reveals UV emission and absorption lines rarely seen at these redshifts, allowing us to derive important physical properties (T$_e\sim$15600 K, n$_e\sim$300 cm$^{-3}$, covering fraction f$_c\sim0.4$) using multiple diagnostics. Inferred stellar and gas-phase metallicities point towards a low metallicity object (Z$_{\mathrm{stellar}}$ = $\sim$ 0.07 Z$_\odot$ and Z$_{\mathrm{ISM}}$ $<$ 0.16 Z$_\odot$). The Ly$\alpha$ emission extends over $\sim$10 kpc across the galaxy and presents a very uniform spectral profile, showing only a small velocity shift which is unrelated to the intrinsic kinematics of the nebular emission. The Ly$\alpha$ extension is $\sim$4 times larger than the continuum emission, and makes this object comparable to low-mass LAEs at low redshift, and more compact than the Lyman-break galaxies and Ly$\alpha$ emitters usually studied at high redshift. We model the Ly$\alpha$ line and surface brightness profile using a radiative transfer code in an expanding gas shell, finding that this model provides a good description of both observables.Comment: 19 pages, 15 figures, accepted in MNRA

Understanding the escape of LyC and Lyα photons from turbulent clouds

Understanding the escape of Lyman continuum (LyC) and Lyman alpha (Lya) photons from molecular clouds is one of the keys to constraining the reionization history of the Universe and the evolution of galaxies at high redshift. Using a set of radiation-hydrodynamic simulations with adaptive mesh refinement, we investigate how photons propagate and escape from turbulent clouds with different masses, star formation efficiencies (SFEs), and metallicities, as well as with different models of stellar spectra and supernova feedback. We find that the escape fractions in both LyC and Lya are generally increasing with time if the cloud is efficiently dispersed by radiation and supernova feedback. When the total SFE is low (1% of the cloud mass), 0.1-5% of LyC photons leave the metal-poor cloud, whereas the fractions increase to 20-70% in clouds with a 10% SFE. LyC photons escape more efficiently if gas metallicity is lower, if the upper mass limit in the stellar initial mass function is higher, if binary interactions are allowed in the evolution of stars, or if additional strong radiation pressure, such as Lya pressure, is present. As a result, the number of escaping LyC photons can easily vary by a factor of $\sim4$ on cloud scales. The escape fractions of Lya photons are systemically higher (60-80%) than those of LyC photons despite large optical depths at line centre ($\tau_0\sim10^6-10^9$). Scattering of Lya photons is already significant on cloud scales, leading to double-peaked profiles with peak separations of $v_{\rm sep}\sim400\,{\rm km\,s^{-1}}$ during the initial stage of the cloud evolution, while it becomes narrower than $v_{\rm sep} \le 150 \, {\rm km\,s^{-1}}$ in the LyC bright phase. Comparisons with observations of low-redshift galaxies suggest that Lya photons require further interactions with neutral hydrogen to reproduce their velocity offset for a given LyC escape fraction

Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study

COPD is the third leading cause of death in the world and its global burden is predicted to increase further. Even though the prevalence of COPD is well studied, only few studies examined the incidence of COPD in a prospective and standardized manner. In a prospective population-based cohort study (Rotterdam Study) enrolling subjects aged ≥45, COPD was diagnosed based on a pre-bronchodilator obstructive spirometry (FEV1/FVC < 0.70). In absence of an interpretable spirometry within the Rotterdam Study, cases were defined as having COPD diagnosed by a physician on the basis of clinical presentation and obstructive lung function measured by the general practitioner or respiratory physician. Incidence rates were calculated by dividing the number of incident cases by the total number of person years of subjects at risk. In this cohort of 14,619 participants, 1993 subjects with COPD were identified of whom 689 as prevalent ones and 1304 cases as incident ones. The overall incidence rate (IR) of COPD was 8.9/1000 person-years (PY); 95 % Confidence Interval (CI) 8.4–9.4. The IR was higher in males and in smokers. The proportion of female COPD participants without a history of smoking was 27.2 %, while this proportion was 7.3 % in males. The prevalence of COPD in the Rotterdam Study i

An extreme [OIII] emitter at z=3.2z=3.2: a low metallicity Lyman continuum source

[Abridged] We investigate the physical properties of a Lyman continuum emitter candidate at $z=3.212$ with photometric coverage from $U$ to MIPS 24$\mu$m band and VIMOS/VLT and MOSFIRE/Keck spectroscopy. Investigation of the UV spectrum confirms a direct spectroscopic detection of the Lyman continuum emission with $S/N>5$. Non-zero Ly$\alpha$ flux at the systemic redshift and high Lyman-$\alpha$ escape fraction suggest a low HI column density. The weak C and Si low-ionization absorption lines are also consistent with a low covering fraction along the line of sight. The [OIII]$\lambda\lambda4959,5007+\mathrm{H}\beta$ equivalent width is one of the largest reported for a galaxy at $z>3$ ($\mathrm{EW}([\mathrm{OIII}]\lambda\lambda4959,5007+\mathrm{H}\beta) \simeq 1600\AA$, rest-frame) and the NIR spectrum shows that this is mainly due to an extremely strong [OIII] emission. The large observed [OIII]/[OII] ratio ($>10$) and high ionization parameter are consistent with prediction from photoionization models in case of a density-bounded nebula scenario. Furthermore, the $\mathrm{EW}([\mathrm{OIII}]\lambda\lambda4959,5007+\mathrm{H}\beta)$ is comparable to recent measurements reported at $z\sim7-9$, in the reionization epoch. We also investigate the possibility of an AGN contribution to explain the ionizing emission but most of the AGN identification diagnostics suggest that stellar emission dominates instead. This source is currently the first high-$z$ example of a Lyman continuum emitter exhibiting indirect and direct evidences of a Lyman continuum leakage and having physical properties consistent with theoretical expectation from Lyman continuum emission from a density-bounded nebula.Comment: 14 pages, 11 figures, accepted for publication in A&A. Minor modifications, Figure 2 updated, Figure 9 adde

Real-life effectiveness of omalizumab in difficult-to-treat versus severe asthma: A national cohort study in Belgium

Background: Guidelines recommend omalizumab in patients with uncontrolled severe allergic asthma. We investigated real-life use of omalizumab, the proportion of patients fulfilling eligibility criteria, its costs and its effectiveness. Method: In a cohort of asthma patients initiating treatment with omalizumab in Belgium between 2010 and 2016, we investigated fulfilment of eligibility criteria (chronic use of high-dose inhaled corticosteroids (ICSs) plus long-acting β2-agonists (LABAs) and ⩾2 severe asthma exacerbations in previous year), and compared hospitalisations and systemic corticosteroid consumption in the year before and after omalizumab initiation. We computed healthcare costs in the respective time periods and compared the cost per prevented hospitalisation in patients fulfilling eligibility criteria versus those who did not. Results: Between 2010 and 2016, omalizumab treatment was initiated in 2068 patients with asthma; only 24% fulfilled the eligibility criteria, mainly due to nonadherence to high-dose ICSs + LABAs. The proportion of patients hospitalised f

The unusual NIV]-emitter galaxy GDS J033218.92-275302.7: star formation or AGN-driven winds from a massive galaxy at z=5.56

Aims: We investigate the nature of the source GDS J033218.92-275302.7at redshift ~ 5.56. Methods: The SED of the source is well sampled by 16 bands photometry, from UV-optical, near infrared and mid-infrared (MID-IR).The detection of signal in the MID-IR Spitzer/IRAC bands 5.8, 8.0 um -- where the nebular emission contribution is less effective -- suggests the presence of a Balmer break, signature of an underlying stellar population formed at earlier epochs. The optical spectrum shows a clear Lya emission line together with semi-forbidden NIV] 1483.3-1486.5 also in emission. Results: From the SED fitting and the Lya modelling it turns out that the source seems to have an evolved component with stellar mass of ~5 x10^(10) Msolar and age ~ 0.4 Gyrs, and a young component with an age of ~ 0.01 Gyrs and SFR in the range of 30-200 Msolar yr^(-1). The limits on the effective radius derived from the ACS/z850 and VLT/Ks bands indicate that this galaxy is denser than the local ones with similar mass. A relatively high nebular gas column density is favored from the Lya line modelling (NHI>=10^(21) cm^(-2)). A vigorous outflow (~ 450 km/s) has been measured from the optical spectrum,consistent with the Lya modelling. From ACS observations it turns out that the region emitting Lya photons is spatially compact and of the same order of the effective radius estimated at the ~1400A rest-frame wavelength, whose emission is dominated by the stellar continuum and/or AGN. The gas is blown out from the central region,but given the mass of the galaxy it is uncertain whether it will pollute the IGM to large distances. We argue that a burst of star formation in a dense gas environment is active (possibly containing hot and massive stars and/or a low luminosity AGN), superimposed to an already formed fraction of stellar mass (abridged).Comment: 13 pages, 9 figures (published on A&A). Here replaced with a typo fixed in the footnote of Sect. 4.2 and with four updated references. Results unchange

Ubiquitous giant Ly α\alpha nebulae around the brightest quasars at z∼3.5z\sim3.5 revealed with MUSE

Direct Ly $\alpha$ imaging of intergalactic gas at $z\sim2$ has recently revealed giant cosmological structures around quasars, e.g. the Slug Nebula (Cantalupo et al. 2014). Despite their high luminosity, the detection rate of such systems in narrow-band and spectroscopic surveys is less than 10%, possibly encoding crucial information on the distribution of gas around quasars and the quasar emission properties. In this study, we use the MUSE integral-field instrument to perform a blind survey for giant Ly $\alpha$ nebulae around 17 bright radio-quiet quasars at $3<z<4$ that does not suffer from most of the limitations of previous surveys. After data reduction and analysis performed with specifically developed tools, we found that each quasar is surrounded by giant Ly $\alpha$ nebulae with projected sizes larger than 100 physical kpc and, in some cases, extending up to 320 kpc. The circularly averaged surface brightness profiles of the nebulae appear very similar to each other despite their different morphologies and are consistent with power laws with slopes $\approx-1.8$. The similarity between the properties of all these nebulae and the Slug Nebula suggests a similar origin for all systems and that a large fraction of gas around bright quasars could be in a relatively "cold" (T$\sim$10$^4$K) and dense phase. In addition, our results imply that such gas is ubiquitous within at least 50 kpc from bright quasars at $3<z<4$ independently of the quasar emission opening angle, or extending up to 200 kpc for quasar isotropic emission.Comment: 19 pages, 9 figures, 3 Tables, accepted to Ap