Motivation and age revisited: The impact of outcome and process orientations on temporal focus in older and younger adults

When engaging in a task, individuals may prioritize the task’s results (i.e., the outcome), or they may focus on the task in and of itself (i.e., the process). Previous conceptualizations of outcome and process orientations have focused on population- and context-specific motives rather than people’s general proclivity toward these orientations across diverse tasks. Using a context-generalized outcome and process measure, we examined whether older adults (Mage = 72.8) and younger adults (Mage = 18.0) varied in their outcome and process orientations, and explored how these differences were related to temporal focus. The results indicated that, compared to their younger counterparts, older adults were more process oriented, and focused more on the present. Meanwhile, younger adults were more outcome oriented and focused more on the past and the future compared to older adults. Mediation analyses further revealed that older adults were more present focused due to their heightened process orientation, while younger adults were more past and future focused due to their outcome orientation. The implications of these findings in applied settings such as the workplace, health promotion, and business are discussed

A surprising lack of consequences when constraining language

Labels considered normatively appropriate for specific social identity groups change. Researchers have examined the effects of censorship and slur usage, but minimal research examines the psychological consequences of imposing new language constraints on people. Across four samples of university students (Ntotal = 997), we sought participants’ compliance in avoiding usage of numerous commonplace group labels while they wrote essays about obese people (Sample 1) or specific ethnic groups (Samples 2-4). We observed consistently high compliance rates: participants either invented novel terminology to describe the group or avoided group labels entirely. We observed a substantial absence of task discomfort, attitudinal shifts towards the group, or motivational shifts, according to Bayesian analyses. Nor did we detect negative effects of language constraint among people who saw themselves as opposed to censorship. Although free speech and respectful language remains a multifaceted social debate, our findings show that university students are willing to follow even completely contrived language directives when describing social identity groups and to do so without substantial discomfort or backlash against those groups

Pitch as a recipient, channel, and context factor affecting thought reliance and persuasion

Three experiments tested how low versus high pitch generated from sources beyond a message communicator can affect reliance on thoughts and influence recipients' attitudes. First, participants wrote positive or negative thoughts about an exam proposal (Experiments 1, 2) or their academic abilities (Experiment 3). Then, pitch from the message recipient (Experiment 1), channel (Experiment 2), or context (Experiment 3) was manipulated to be high or low. Experiment 1 showed that when participants vocally expressed their thoughts using low (vs. high) pitch, thoughts had a greater effect on attitudes toward exams. Experiment 2 revealed low (vs. high) pitch sounds from the keyboard participants used to write their thoughts produced the same effect on thought usage. Experiment 3 demonstrated that thoughts influenced attitudes more when listed while background music was low (vs. high) Pitch can influence attitudes through a meta-cognitive thought reliance process whether emerging from the recipient, channel, or context

The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data

Angiotensin-converting enzyme (ACE) is primarily localized (>90%) in various tissues and organs, most notably on the endothelium but also within parenchyma and inflammatory cells. Tissue ACE is now recognized as a key factor in cardiovascular and renal diseases. Endothelial dysfunction, in response to a number of risk factors or injury such as hypertension, diabetes mellitus, hypercholesteremia, and cigarette smoking, disrupts the balance of vasodilation and vasoconstriction, vascular smooth muscle cell growth, the inflammatory and oxidative state of the vessel wall, and is associated with activation of tissue ACE. Pathologic activation of local ACE can have deleterious effects on the heart, vasculature, and the kidneys. The imbalance resulting from increased local formation of angiotensin II and increased bradykinin degradation favors cardiovascular disease. Indeed, ACE inhibitors effectively reduce high blood pressure and exert cardio- and renoprotective actions. Recent evidence suggests that a principal target of ACE inhibitor action is at the tissue sites. Pharmacokinetic properties of various ACE inhibitors indicate that there are differences in their binding characteristics for tissue ACE. Clinical studies comparing the effects of antihypertensives (especially ACE inhibitors) on endothelial function suggest differences. More comparative experimental and clinical studies should address the significance of these drug differences and their impact on clinical events

Super-Aggregations of Krill and Humpback Whales in Wilhelmina Bay, Antarctic Peninsula

Ecological relationships of krill and whales have not been explored in the Western Antarctic Peninsula (WAP), and have only rarely been studied elsewhere in the Southern Ocean. In the austral autumn we observed an extremely high density (5.1 whales per km2) of humpback whales (Megaptera novaeangliae) feeding on a super-aggregation of Antarctic krill (Euphausia superba) in Wilhelmina Bay. The krill biomass was approximately 2 million tons, distributed over an area of 100 km2 at densities of up to 2000 individuals m−3; reports of such ‘super-aggregations’ of krill have been absent in the scientific literature for >20 years. Retentive circulation patterns in the Bay entrained phytoplankton and meso-zooplankton that were grazed by the krill. Tagged whales rested during daylight hours and fed intensively throughout the night as krill migrated toward the surface. We infer that the previously unstudied WAP embayments are important foraging areas for whales during autumn and, furthermore, that meso-scale variation in the distribution of whales and their prey are important features of this system. Recent decreases in the abundance of Antarctic krill around the WAP have been linked to reductions in sea ice, mediated by rapid climate change in this area. At the same time, baleen whale populations in the Southern Ocean, which feed primarily on krill, are recovering from past exploitation. Consideration of these features and the effects of climate change on krill dynamics are critical to managing both krill harvests and the recovery of baleen whales in the Southern Ocean

Search for charged massive long-lived particles with the D0 detector

We search for charged massive long-lived particles using 1.1 fb$^{-1}$ of data collected by the D0 detector at the Fermilab Tevatron $p\bar{p}$ Collider. Time-of-flight information is used to search for pair produced long-lived tau sleptons, gaugino-like charginos, and higgsino-like charginos. We find no evidence of a signal and set 95% C.L. cross section upper limits for staus, which vary from 0.31pb to 0.04pb for stau masses between 60 GeV and 300 GeV. We also set lower mass limits of 206 GeV (171 GeV) for pair produced charged gauginos (higgsinos).Comment: To be submitted to Phys. Rev. Letters, V2: updated the figures and references, V3: final version submitted to PRL and changes in title and abstracts from "stable" to "long-lived

Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy

Background A reliable system for grading operative difficulty of laparoscopic cholecystectomy would standardise description of findings and reporting of outcomes. The aim of this study was to validate a difficulty grading system (Nassar scale), testing its applicability and consistency in two large prospective datasets. Methods Patient and disease-related variables and 30-day outcomes were identified in two prospective cholecystectomy databases: the multi-centre prospective cohort of 8820 patients from the recent CholeS Study and the single-surgeon series containing 4089 patients. Operative data and patient outcomes were correlated with Nassar operative difficultly scale, using Kendall’s tau for dichotomous variables, or Jonckheere–Terpstra tests for continuous variables. A ROC curve analysis was performed, to quantify the predictive accuracy of the scale for each outcome, with continuous outcomes dichotomised, prior to analysis. Results A higher operative difficulty grade was consistently associated with worse outcomes for the patients in both the reference and CholeS cohorts. The median length of stay increased from 0 to 4 days, and the 30-day complication rate from 7.6 to 24.4% as the difficulty grade increased from 1 to 4/5 (both p < 0.001). In the CholeS cohort, a higher difficulty grade was found to be most strongly associated with conversion to open and 30-day mortality (AUROC = 0.903, 0.822, respectively). On multivariable analysis, the Nassar operative difficultly scale was found to be a significant independent predictor of operative duration, conversion to open surgery, 30-day complications and 30-day reintervention (all p < 0.001). Conclusion We have shown that an operative difficulty scale can standardise the description of operative findings by multiple grades of surgeons to facilitate audit, training assessment and research. It provides a tool for reporting operative findings, disease severity and technical difficulty and can be utilised in future research to reliably compare outcomes according to case mix and intra-operative difficulty