Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes

Background: While aging is the main risk factor for Alzheimer´s disease (AD), emerging evidence suggests that metabolic alterations such as type 2 diabetes (T2D) are also major contributors. Indeed, several studies have described a close relationship between AD and T2D with clinical evidence showing that both diseases coexist. A hallmark pathological event in AD is amyloid-β (Aβ) deposition in the brain as either amyloid plaques or around leptomeningeal and cortical arterioles, thus constituting cerebral amyloid angiopathy (CAA). CAA is observed in 85–95% of autopsy cases with AD and it contributes to AD pathology by limiting perivascular drainage of Aβ. Methods: To further explore these alterations when AD and T2D coexist, we have used in vivo multiphoton microscopy to analyze over time the Aβ deposition in the form of plaques and CAA in a relevant model of AD (APPswe/ PS1dE9) combined with T2D (db/db). We have simultaneously assessed the effects of high-fat diet-induced prediabetes in AD mice. Since both plaques and CAA are implicated in oxidative-stress mediated vascular damage in the brain, as well as in the activation of matrix metalloproteinases (MMP), we have also analyzed oxidative stress by Amplex Red oxidation, MMP activity by DQ ™ Gelatin, and vascular functionality. Results: We found that prediabetes accelerates amyloid plaque and CAA deposition, suggesting that initial metabolic alterations may directly affect AD pathology. T2D significantly affects vascular pathology and CAA deposition, which is increased in AD-T2D mice, suggesting that T2D favors vascular accumulation of Aβ. Moreover, T2D synergistically contributes to increase CAA mediated oxidative stress and MMP activation, affecting red blood cell velocity. Conclusions: Our data support the cross-talk between metabolic disease and Aβ deposition that affects vascular integrity, ultimately contributing to AD pathology and related functional changes in the brain microvasculature.University of Cadiz Predoctoral FellowshipEuropean CommissionEuropean Commission Joint Research Centre GA 847749Programa Estatal de Generacion de Conocimiento y Fortalecimiento Cientifico y Tecnologico del Sistema de I + D + i y del Programa Estatal de I + D +i Orientada a los Retos de la Sociedad, del Plan Estatal de Investigacion Cientifica y Tecnica y de Innovaci PID2020-115499RB-I00/AEIAgencia Estatal de Investigacion (AEI) BFU 2016-75038-REuropean CommissionSpanish Government Spanish GovernmentAndalucia se mueve con Europa P20-0092

Estudio científico de los libros de coro de la abadía del sacromonte de Granada

El objetivo de esta comunicación es dar a conocer el estudio científico que se está realizando sobre el más de medio centenar de los Libros de Coro reali zados en pergamino, expresamente para esta institución, entre los ss. XVII al XX que se encuentran en la Abadía del Sacromonte en Granada. Se efectúa una pe queña introducción histórica de lo que es la Abadía y su localización. A conti nuación .se describen los libros estudiados (tipologías y características generales) y sobre todo de las miniaturas con las que están decorados algunos de ellos

Coordination Of Teachers In New Undergraduate Degrees Adapted To European Higher Education Area

The introduction of new undergraduate degrees adapted to the European Higher Education Area (EHEA) requires a coordinated effort by teachers, because the different subjects are based on a new methodology of teaching and learning. The Social Sciences School of Cuenca offers degrees in Business Administration, Law and Labor Sciences. The progressive adaptation of the undergraduate degrees at the University of Castilla-La Mancha has culminated with the introduction, in the academic year 2009-2010, of the Business Administration Degree and, beginning in academic year 2010-2011, of the Degrees in Law and in Industrial Relations and Human Resource Development, once they have all been verified by the National Agency for Quality Assessment and Accreditation (ANECA). This paper addresses opportunities for coordination among teachers that occur in the implementation of new degree of Law and Business Administration, through the joint work of teachers in different aspects of competency-based education. After the first course of the new degrees, it must articulate all coordination tools that allow teachers to conduct their work effectively and efficiently, with the aim of providing the best possible service to students. The synergies arising from this deployment will allow better planning tools in the implementation of the following degrees

¿Dónde están las mujeres? El impacto del lenguaje sexista en los folletos de Grado de la Universidad de Sevilla.

El androcentrismo lingüístico ha sido considerado una forma simbólica de violencia machista por su capacidad de modular nuestros esquemas mentales. La Universidad de Sevilla, comprometida con la igualdad de género, ha incorporado iniciativas para la erradicación del lenguaje sexista, aunque se sigue perpetuando actualmente en la redacción de documentos dirigidos a la comunidad universitaria. El objetivo es analizar el lenguaje empleado en los folletos de Grado universitarios desde una perspectiva de género. Tras examinar ochenta y tres folletos (unificados en cinco áreas de conocimiento), se categorizaron en función de su mayor o menor compromiso con el lenguaje inclusivo. Seguidamente, se contrastó cada una de esas áreas de conocimiento con el porcentaje de alumnado matriculado desagregado por sexo. Se concluye la importante influencia que ejerce el folleto desinteresado en el lenguaje inclusivo sobre la desigualdad, más o menos significativa, en el porcentaje de alumnas y alumnos cursando esos grados.Androcentrism in language has been considered a symbolic way of violence against women because of its capacity to modulate our mental diagram. The University of Seville, committed to gender equality, has incorporated some initiatives to eradicate sexist language, although this study stand up the current use of sexist language in the documents addressed to the university community. Therefore, we are going to analyze the Degree leaflet´s language used by the Hispalense from a gender perspective. After analyzing eighty-three leaflets (from five areas of knowledge), they were categorized according to their greater or lesser commitment to inclusive language. Then, each of these areas was compared with the percentage of registered students disaggregated by sex. It’s possible to conclude that the important influence exerted by the Degree leaflet which do not care about inclusive language on inequality, more or less significant, in the number of women and men attending each Degree offer

El consumo de bebidas carbonatadas como factor de riesgo de diabetes mellitus tipo 2 en estudiantes universitarios.

El Objetivo del estudio fue determinar el efecto de la frecuencia y cantidad de consumo de bebidas carbonatadas, sobre los valores de glucosa en ayunas y tolerancia a la glucosa en un grupo de 189 estudiantes de segundo y tercer año de la carrera Doctorado en Medicina de la Universidad Evangélica de El Salvador,que representó el 75.6% del total de los estudiantes matriculados en estos niveles de la carrera. El estudio se realizó durante los meses de agosto y septiembre de 2013, cuya tipología fue de tipo descriptivo,correlacional y transversal

Influence of nanoemulsion/gum ratio on droplet size distribution, rheology and physical stability of nanoemulgels containing inulin and omega-3 fatty acids

Background: New consumer habits are forcing the food industry to develop new and healthy products. In response to this tendency, in this investigation, we obtained nanoemulgels by microfluidization containing inulin fibre and omega-3 fatty acids. First, the influence of the number of microfluidization cycles on the physical properties of the nanoemulsions was studied. Subsequently, an advanced-performance xanthan gum was added to the nanoemulsion in different nanoemulsion/xanthan ratios (1:1, 2:1, 3:1, 4:1, 1:2, and 1:3). Results: Laser diffraction, multiple light scattering, and rheology techniques were used to characterize nanoemulsions and the corresponding nanoemulgels. The nanoemulsion with the lowest Sauter mean diameter (138 nm) and the longest physical stability was obtained after three passes through a microfluidization device at a fixed pressure of 103 421 kPa. Thus, these processing conditions were always used to obtain the nanoemulsion; these were subsequently mixed with a xanthan gum solution to produce nanoemulgels that showed weak gel-like viscoelastic and shear-thinning flow behaviours. A decrease in the nanoemulsion/xanthan ratio (i.e. by an increase in the content of xanthan gum in the nanoemulgel) increased the viscoelastic moduli and the zero shear viscosity values. A rise in the droplet size was observed with aging time, probably due to flocculation. The nanoemulsion/xanthan gum mass ratio of 1:3 yielded the most stable nanoemulgel. Conclusions: This work is a contribution to the development of functional foods. It has been demonstrated that it is possible to obtain a stable nanoemulgel-based food matrix containing fibre and omega-3 fatty acids. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.Universidad de Sevilla PP2019-1329

Diseño del Sistema de Gestión de Calidad para la Reencauchadora Bandtek S.A.

Con el fin de mejorar la competitividad y asegurar la calidad del reencauche, se realiza la presente propuesta de diseño del sistema de gestión de calidad en la empresa Bandtek S.A. Se desarrolla el proyecto teniendo en cuenta el análisis de la situación actual y el planteamiento del modelo ideal que aporta al fortalecimiento de todos los procesos de la organización.Especialista en Gerencia Integral de la CalidadEspecializació

Inter-rater and intra-rater reliability of the extended TUG test in elderly participants

Background: To analyse the reliability, variance and execution time of the Extended Timed Up and Go (Extended TUG) test in three age groups of elderly participants (G1: 55–64 years; G2: 65–74 years; G3: 75–85 years). Methods: An analytical cross-sectional study of 114 recruited participants (63 women) of average age 70.17 (± 7.3) years was undertaken. Each participant performed the Extended TUG three consecutive times, with a rest break between tests of 120 s. Both the intragroup and intergroup reliability of the measurements in the Extended TUG were analysed. Results: The reliability of the Extended TUG test is excellent for the first and second decades but drops down to good for the third decade. Specifically, intragroup reliability ranged from 0.784 for G3 to 0.977 for G1 (G2 = 0.858). Intergroup reliability, compared with intragroup reliability, was slightly lower, ranging between 0.779 for G3 and 0.972 for G1 (G2 = 0.853). Conclusion: The reliability of the Extended TUG test progressively decreases with increasing age, being excellent for the younger age groups and good for the oldest age group

Image restoration a comparative study of some methods applied to color images

The present work introduces five different methods to deal with digital image restoration. Particularly deconvolution by Richardson-Lucy method, Wiener filter, deconvolution with Gaussian priors in the frequency domain, spatial domain and the use of sparse priors. The Bayesian methodology is based on the prior knowledge of some information that allows an efficient modeling of the image acquisition process. The edge preservation of objects into the image while smoothing noise is necessary for an adequate model. Thus, we use five deconvolution methods to recover images, all of the presented images are contained on TID 2008, all of them were previously degraded by Gaussian noise and convolved with a disc point spread function (PSF) making reference to a typical fluorescence microscopy degradation. The principal objective when using restoration methods in the context of image processing is to eliminate those effects caused by the excessive smoothness on the reconstruction process of an image which is rich in contours or edges and also is important to consider the process time due to an improvement in this área could lead to a faster application. A comparison between the five methods is presented for a restoration process. This collection of implemented methods has been compared using different metrics such as SNR, PSNR, SSIM and process time. The obtained results showed a satisfactory performance and the effectiveness of the proposed methods on color space

Danthron, an Anthraquinone Isolated from a Marine Fungus, Is a New Inhibitor of Angiogenesis Exhibiting Interesting Antitumor and Antioxidant Properties

The role played by a sustained angiogenesis in cancer and other diseases stimulates the interest in the search for new antiangiogenic drugs. In this manuscript, we provide evidence that 1,8- dihydroxy-9,10-anthraquinone (danthron), isolated from the fermentation broth of the marine fungus Chromolaenicola sp. (HL-114-33-R04), is a new inhibitor of angiogenesis. The results obtained with the in vivo CAM assay indicate that danthron is a potent antiangiogenic compound. In vitro studies with human umbilical endothelial cells (HUVEC) reveal that this anthraquinone inhibits certain key functions of activated endothelial cells, including proliferation, proteolytic and invasive capabilities and tube formation. In vitro studies with human breast carcinoma MDA-MB231 and fibrosarcoma HT1080 cell lines suggest a moderate antitumor and antimetastatic activity of this compound. Antioxidant properties of danthron are evidenced by the observation that it reduces the intracellular reactive oxygen species production and increases the amount of intracellular sulfhydryl groups in endothelial and tumor cells. These results support a putative role of danthron as a new antiangiogenic drug with potential application in the treatment and angioprevention of cancer and other angiogenesis-dependent diseases.Partial funding for open access charge: Universidad de Málag