Desarrollo sustentable en la facultad de ingeniería mecánica y eléctrica

Con la finalidad de promover una nueva era de responsabilidad social en el área de Desarrollo Sustentable, se pretende socializar un sistema de contabilidad, reporte y evaluación de desempeño ambiental. Esto se puede lograr a través de diagnósticos de carga eléctrica e hidráulica en las escuelas preparatorias y en las facultades de la Institución o Empresa. Para establecer una línea base e identificar, clasificar y tipificar el estado actual de la Institución se llevaran a cabo reportes de diagnóstico que permitan sugerir acciones correctivas para disminuir el impacto sobre el medio ambiente por el uso de energía eléctrica, agua y gas. Finalmente, lo que se busca es evaluar el desempeño “ambiental” en el marco de responsabilidad social. Se trata de evaluar el desempeño ambiental de la Facultad en el contexto del cumplimiento de su responsabilidad social

Analysis and Curation of the Database of a Colo-Rectal Cancer Screening Program

Data collection in health programs databases is prone to errors that might hinder its use to identify risk indicators and to support optimal decision making in health services. This is the case, in colo-rectal cancer (CRC) screening programs, when trying to optimize the cut-off point to select the patients who will undergo a colonoscopy, especially when having insufficient offer of colonoscopies or temporary excessive demand. It is necessary therefore to establish “good practice” guidelines for data collection, management and analysis. With the aim of improving the redesign of a regional CRC screening program platform, we performed an exhaustive analysis of the data collected, proposing a set of recommendations for its correct maintenance. We also carried out the curation of the available data in order to finally have a clean source of information that would allow proper future analyses. We present here the result of such study, showing the importance of the design of the database and of the user interface to avoid redundancies keeping consistency and checking known correlations, with the final aim of providing quality data that permit to take correct decisions

Manual municipal sobre control de vertidos

El agua, como motor de desarrollo y fuente de riqueza, ha constituido uno de los pilares fundamentales para el progreso del hombre. La ordenación y gestión de los recursos hídricos, que ha sido desde siempre un objetivo prioritario para cualquier sociedad, se ha realizado históricamente bajo directrices orientadas a satisfacer la demanda en cantidades suficientes, bajo una perspectiva de política de oferta. El incremento de la oferta de agua como herramienta para el impulso económico, el mayor nivel de contaminación, irremisiblemente asociado a un mayor nivel de desarrollo, algunas características naturales (sequías prolongadas, inundaciones) y en definitiva una sobreexplotación de los recursos hídricos, han conducido a un deterioro importante de los mismos. El desarrollo de la Directiva Europea y Nacional respecto a control de vertido responsabiliza al Ayuntamiento directamente de los vertidos del municipio al exterior, y consecuentemente al Alcalde Presidente de cada Municipio. Por ello la Diputación de Sevilla, cumpliendo su labor de auxilio técnico al municipio ha encargado al Grupo TAR este manual municipal de control de vertidos para asesorar continuamente a todos los pueblos de la provincia de Sevilla, con la vocación de que sea una herramienta permanente de consulta que ayude a conseguir que la provincia lidere el cumplimiento de las normas y el desarrollo sostenible de todo su entorno. Real Decreto Legislativo 1/2001, de 20 de julio, por el que se aprueba el texto refundido de la Ley de Aguas de 1.985, junto con la nueva Directiva Marco europea para la política de agua suponen un cambio importante en los conceptos y criterios utilizados en la planificación hidrológica e introducen la calidad de las aguas y la protección de los recursos hídricos como puntos fundamentales para estructurar dicha planificación. El estado ecológico de un agua sería una expresión de la calidad de la estructura y del funcionamiento del ecosistema y cuyos criterios de clasificación (muy bueno, bueno y aceptable), en función del tipo de ecosistema acuático de que se trate, se recogen en los anexos de la directiva

The Short Form of the Fonseca Anamnestic Index for the Screening of Temporomandibular Disorders: Validity and Reliability in a Spanish-Speaking Population

The Short Form of the Fonseca Anamnestic Index (SFAI) is a simple and quick questionnaire used for screening temporomandibular disorders (TMDs). The present study aimed to validate the Spanish version of the SFAI in patients with TMDs. The study sample comprised 112 subjects (50 TMDs and 52 controls). Test–retest reliability, factorial validity, internal consistency, concurrent validity, and the SFAI’s ability to discriminate between TMDs subjects and healthy controls were analyzed using the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD protocol) as the reference. Factor analysis showed a single factor that explained 63% of the total variance. Cronbach’s alpha was 0.849. The reliability of the items measured with the Kappa index showed values from 0.767 to 0.888. Test–retest reliability was substantial (intraclass correlation coefficient = 0.837). The total SFAI score showed a significant correlation with orofacial pain, vertigo, and neck disability measurements. For a cut-off point of >10 points, the SFAI showed a sensitivity of 78% and specificity of 78.85% at differentiating between TMDs patients and healthy subjects, with an area under the curve (AUC) of 0.852. The Spanish version of the SFAI is a valid and reliable instrument for diagnosing people with TMDs and shows generally good psychometric properties

Mutational screening of newly diagnosed multiple myeloma patients by deep targeted sequencing

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The GSK3b-MAFB axis controls the pro-fibrotic gene profile of pathogenic monocyte-derived macrophages in severe COVID-19

1 p.-4 fig.MAF and MAFB are members of the “large MAF” transcription factor family that shape the transcriptome of antiinflammatory and pro-tumoral human macrophages. We have now determined the MAF- and MAFB-dependent gene profile of M-CSF-dependent monocyte-derived macrophages (M-MØ), and found that both factors exhibit overlapping transcriptional outcomes during monocyte-to-M-MØ differentiation, but differentially affect macrophage effector functions like production of monocyte-recruiting chemokines, T-cell activation and immunosuppression. Remarkably, MAFB was found to positively regulate the expression of the genesets that define the pathogenic monocyte-derived pulmonary macrophage subsets in COVID-19, as evidenced through siRNA-mediated silencing and analysis of MAFBoverexpressing M-MØ from a Multicentric Carpotarsal Osteolysis (MCTO) patient. MAFB silencing downregulated theexpression of genes coding for biomarkers of COVID-19 severity, and genome-wide mapping of MAFB-binding elements in M-MØ identified biomarkers of COVID-19 severity (CD163, IL10, HGF and CCL2) as direct MAFB targets. Further, and in line with the GSK3b-dependent expression of MAFB, GSK3b inhibition in M-MØ significantly boosted the expression of genes that characterize pathogenic macrophage subsets in severe COVID-19, an effect that was primarily dependent on MAFB. In addition, we have demonstrated that a large number of MAFB-dependent genes, as well as GSK3b-dependent expression of MAFB genes were modulated by SARS-Cov-2 infection on human macrophages. Globally, our results demonstrate that the GSK3b-MAFB axis controls the transcriptome of pathogenic pulmonary macrophages in COVID-19,and positively regulates the expression of biomarkers for COVID-19 severity. Thus, macrophage re-programming through modulation of GSK3 -MAFB axis has potential therapeutic strategy for COVID-19 and other inflammatory diseases.This research work was also funded by the European Commission– NextGenerationEU (Regulation EU 2020/2094), through CSIC's Global Health Platform (PTI Salud Global).Peer reviewe

Recurrent dissemination of SARS-CoV-2 through the Uruguayan–Brazilian border

Uruguay is one of the few countries in the Americas that successfully contained the coronavirus disease 19 (COVID-19) epidemic during the first half of 2020. Nevertheless, the intensive human mobility across the dry border with Brazil is a major challenge for public health authorities. We aimed to investigate the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains detected in Uruguayan localities bordering Brazil as well as to measure the viral flux across this ∼1,100 km uninterrupted dry frontier. Using complete SARS-CoV-2 genomes from the Uruguayan–Brazilian bordering region and phylogeographic analyses, we inferred the virus dissemination frequency between Brazil and Uruguay and characterized local outbreak dynamics during the first months (May–July) of the pandemic. Phylogenetic analyses revealed multiple introductions of SARS-CoV-2 Brazilian lineages B.1.1.28 and B.1.1.33 into Uruguayan localities at the bordering region. The most probable sources of viral strains introduced to Uruguay were the Southeast Brazilian region and the state of Rio Grande do Sul. Some of the viral strains introduced in Uruguayan border localities between early May and mid-July were able to locally spread and originated the first outbreaks detected outside the metropolitan region. The viral lineages responsible for Uruguayan urban outbreaks were defined by a set of between four and 11 mutations (synonymous and non-synonymous) with respect to the ancestral B.1.1.28 and B.1.1.33 viruses that arose in Brazil, supporting the notion of a rapid genetic differentiation between SARS-CoV-2 subpopulations spreading in South America. Although Uruguayan borders have remained essentially closed to non-Uruguayan citizens, the inevitable flow of people across the dry border with Brazil allowed the repeated entry of the virus into Uruguay and the subsequent emergence of local outbreaks in Uruguayan border localities. Implementation of coordinated bi-national surveillance systems is crucial to achieve an efficient control of the SARS-CoV-2 spread across this kind of highly permeable borderland regions around the world

Prediction of poor outcome in clostridioides difficile infection: A multicentre external validation of the toxin B amplification cycle

Producción CientíficaClassification of patients according to their risk of poor outcomes in Clostridioides difficile infection (CDI) would enable implementation of costly new treatment options in a subset of patients at higher risk of poor outcome. In a previous study, we found that low toxin B amplification cycle thresholds (Ct) were independently associated with poor outcome CDI. Our objective was to perform a multicentre external validation of a PCR-toxin B Ct as a marker of poor outcome CDI. We carried out a multicentre study (14 hospitals) in which the characteristics and outcome of patients with CDI were evaluated. A subanalysis of the results of the amplification curve of real-time PCR gene toxin B (XpertTM C. difficile) was performed. A total of 223 patients were included. The median age was 73.0 years, 50.2% were female, and the median Charlson index was 3.0. The comparison of poor outcome and non–poor outcome CDI episodes revealed, respectively, the following results: median age (years), 77.0 vs 72.0 (p = 0.009); patients from nursing homes, 24.4% vs 10.8% (p = 0.039); median leukocytes (cells/μl), 10,740.0 vs 8795.0 (p = 0.026); and median PCR-toxin B Ct, 23.3 vs 25.4 (p = 0.004). Multivariate analysis showed that a PCR-toxin B Ct cut-off <23.5 was significantly and independently associated with poor outcome CDI (p = 0.002; OR, 3.371; 95%CI, 1.565–7.264). This variable correctly classified 68.5% of patients. The use of this microbiological marker could facilitate early selection of patients who are at higher risk of poor outcome and are more likely to benefit from newer and more costly therapeutic options