A Complete Set of Firmware for the TileCal Read-Out Driver

TileCal is the hadronic tile calorimeter of the ATLAS experiment at LHC/CERN. The Read-Out Driver (ROD) is the main component of the TileCal back-end electronics. The ROD is a VME 64x 9u board with multiple programmable devices which requires a complete set of firmware. This paper describes the firmware and functionalities of all these programmable devices, especially the DSP Processing Units daughterboards where the data processing takes place

Gauge Invariant Hamiltonian Formalism for Spherically Symmetric Gravitating Shells

The dynamics of a spherically symmetric thin shell with arbitrary rest mass and surface tension interacting with a central black hole is studied. A careful investigation of all classical solutions reveals that the value of the radius of the shell and of the radial velocity as an initial datum does not determine the motion of the shell; another configuration space must, therefore, be found. A different problem is that the shell Hamiltonians used in literature are complicated functions of momenta (non-local) and they are gauge dependent. To solve these problems, the existence is proved of a gauge invariant super-Hamiltonian that is quadratic in momenta and that generates the shell equations of motion. The true Hamiltonians are shown to follow from the super-Hamiltonian by a reduction procedure including a choice of gauge and solution of constraint; one important step in the proof is a lemma stating that the true Hamiltonians are uniquely determined (up to a canonical transformation) by the equations of motion of the shell, the value of the total energy of the system, and the choice of time coordinate along the shell. As an example, the Kraus-Wilczek Hamiltonian is rederived from the super-Hamiltonian. The super-Hamiltonian coincides with that of a fictitious particle moving in a fixed two-dimensional Kruskal spacetime under the influence of two effective potentials. The pair consisting of a point of this spacetime and a unit timelike vector at the point, considered as an initial datum, determines a unique motion of the shell.Comment: Some remarks on the singularity of the vector potantial are added and some minor corrections done. Definitive version accepted in Phys. Re

Optical Buffer 1:16

This document is a manual describing the functionality and the operation of the Optical Buffer 1:16 (OB). The OB was specially designed to repeat optical signals during the TileCal Read-Out drivers (ROD) production. The data generated in one Optical Multiplexer Board (OMB) 6U prototypes were repeated with two OB in order to inject data simultaneously to four RODs

Monte Carlo Performance of the TileCal Low pT Muon Identification Algorithm

This note describes the TileCal standalone low pT muon identification algorithm (TileMuId) developed to contribute to the Level-2 trigger. This algorithm is based on the characteristic muon energy deposition inside the calorimeter. The implementation of this algorithm in the core of the Digital Signal Processors (DSPs) in the TileCal Read-Out Drivers (RODs) is also discussed in this paper. The TileMuId performance with Monte Carlo data from single muons and bb events is shown in terms of efficiencies and fraction of fakes for both a fully Level-2 version and a ROD-based version of the algorithm

Identification of circulating miRNA profiles that distinguish malignant pleural mesothelioma from lung adenocarcinoma

Accurate diagnosis of malignant pleura mesothelioma (MPM) is challenging. Differential diagnosis of MPM versus lung adenocarcinoma (AD) is particularly difficult, yet clinically important since the two neoplasias call for different treatment approaches. Circulating miRNA-profiling to identify miRNAs that can be used to distinguish MPM from AD has not been reported. We conducted a wide screening study of miRNA profiles in serum pools of MPM patients (N = 11), AD patients (N = 36), and healthy subjects (N = 45) to identify non-invasive biomarkers for differential diagnosis of MPM and AD, using deep sequencing. Sequencing detected up to 300 known miRNAs and up to 25 novel miRNAs species in the serum samples. Among known miRNAs, 7 were upregulated in MPM and 12 were upregulated in AD compared to healthy controls. Of these, eight were distinctive for AD and three were unique for MPM. Direct comparison of the miRNA profiles for MPM and AD revealed differences in miRNA levels that could be useful for differential diagnosis. No differentially expressed novel miRNAs were found. Further bioinformatics analysis indicated that three upregulated miRNAs in MPM are associated with the p38 pathway. There are unique alterations in serum miRNAs in MPM and AD compared to healthy controls, as well as differences between MPM and AD profiles. Differing miRNA levels between MPM and AD may be useful for differential diagnosis. A potential association to p38 pathway of three upregulated miRNAs in MPM was revealed

The 2HWC HAWC Observatory Gamma Ray Catalog

We present the first catalog of TeV gamma-ray sources realized with the recently completed High Altitude Water Cherenkov Observatory (HAWC). It is the most sensitive wide field-of-view TeV telescope currently in operation, with a 1-year survey sensitivity of ~5-10% of the flux of the Crab Nebula. With an instantaneous field of view >1.5 sr and >90% duty cycle, it continuously surveys and monitors the sky for gamma ray energies between hundreds GeV and tens of TeV. HAWC is located in Mexico at a latitude of 19 degree North and was completed in March 2015. Here, we present the 2HWC catalog, which is the result of the first source search realized with the complete HAWC detector. Realized with 507 days of data and represents the most sensitive TeV survey to date for such a large fraction of the sky. A total of 39 sources were detected, with an expected contamination of 0.5 due to background fluctuation. Out of these sources, 16 are more than one degree away from any previously reported TeV source. The source list, including the position measurement, spectrum measurement, and uncertainties, is reported. Seven of the detected sources may be associated with pulsar wind nebulae, two with supernova remnants, two with blazars, and the remaining 23 have no firm identification yet.Comment: Submitted 2017/02/09 to the Astrophysical Journa

The combined impact of sauerkraut with Leuconostoc mesenteroides to enhance immunomodulatory activity in Escherichia coli-infected mice

This study investigated the combined impact of sauerkraut and Leuconostoc mesenteroides culture on immunomodulatory activity in experimental animal. The in vivo immunomodulatory activity of Escherichia coli-infected Balb-C mice was ascertained in fermented sauerkrauts [test vs. control]. Both sauerkrauts enhanced the adaptive immune response [evidenced by an increase in CD4+ CD8+ IFN-γ, TNFα] and innate immune response [represented by a decrease of CD68-IL-6]. Nev- ertheless, the in vivo immunomodulatory activity of sauerkraut combined with L. mesenteroides was higher than that shown in sauerkraut control solely

A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility

Introduction: A recent genome-wide association study (GWAS) comprising a French cohort of systemic sclerosis (SSc) reported several non-HLA single-nucleotide polymorphisms (SNPs) showing a nominal association in the discovery phase. We aimed to identify previously overlooked susceptibility variants by using a follow-up strategy.<p></p> Methods: Sixty-six non-HLA SNPs showing a P value <10-4 in the discovery phase of the French SSc GWAS were analyzed in the first step of this study, performing a meta-analysis that combined data from the two published SSc GWASs. A total of 2,921 SSc patients and 6,963 healthy controls were included in this first phase. Two SNPs, PPARG rs310746 and CHRNA9 rs6832151, were selected for genotyping in the replication cohort (1,068 SSc patients and 6,762 healthy controls) based on the results of the first step. Genotyping was performed by using TaqMan SNP genotyping assays. Results: We observed nominal associations for both PPARG rs310746 (PMH = 1.90 × 10-6, OR, 1.28) and CHRNA9 rs6832151 (PMH = 4.30 × 10-6, OR, 1.17) genetic variants with SSc in the first step of our study. In the replication phase, we observed a trend of association for PPARG rs310746 (P value = 0.066; OR, 1.17). The combined overall Mantel-Haenszel meta-analysis of all the cohorts included in the present study revealed that PPARG rs310746 remained associated with SSc with a nominal non-genome-wide significant P value (PMH = 5.00 × 10-7; OR, 1.25). No evidence of association was observed for CHRNA9 rs6832151 either in the replication phase or in the overall pooled analysis.<p></p> Conclusion: Our results suggest a role of PPARG gene in the development of SSc

The Pandora multi-algorithm approach to automated pattern recognition of cosmic-ray muon and neutrino events in the MicroBooNE detector.

The development and operation of liquid-argon time-projection chambers for neutrino physics has created a need for new approaches to pattern recognition in order to fully exploit the imaging capabilities offered by this technology. Whereas the human brain can excel at identifying features in the recorded events, it is a significant challenge to develop an automated, algorithmic solution. The Pandora Software Development Kit provides functionality to aid the design and implementation of pattern-recognition algorithms. It promotes the use of a multi-algorithm approach to pattern recognition, in which individual algorithms each address a specific task in a particular topology. Many tens of algorithms then carefully build up a picture of the event and, together, provide a robust automated pattern-recognition solution. This paper describes details of the chain of over one hundred Pandora algorithms and tools used to reconstruct cosmic-ray muon and neutrino events in the MicroBooNE detector. Metrics that assess the current pattern-recognition performance are presented for simulated MicroBooNE events, using a selection of final-state event topologies