Quantic Analysis of Formation of a Biomaterial of Latex, Retinol, and Chitosan for Biomedical Applications

The present work shows the quantum theoretical analysis and practical tests for the formation of a homogeneous mixture with Latex (Lx), Chitosan (Qn) and Retinol (Rl), which work as possible biomaterial for regeneration of epithelial tissue. Lx, Qn, and Rl compounds molecules were designed through Hyperchem to get the coefficient of electrostatic potential calculations. The amounts used to create the biomaterial are minimum depending on the quantities of molecules used in chemical design. A positive calculation was obtained for the reaction of these three compounds and the formation of the biomaterial in physical checking theory etc

J-PLUS: Toward a homogeneous photometric calibration using Gaia BP/RP low-resolution spectra

Aims. We present the photometric calibration of the 12 optical passbands for the Javalambre Photometric Local Universe Survey (J-PLUS) third data release (DR3) comprising 1642 pointings of two square degrees each. Methods. We selected nearly 1.5 million main sequence stars with a signal-to-noise ratio larger than ten in the 12 J-PLUS passbands and available low-resolution (R = 20–80) spectrum from the blue and red photometers (BP/RP) in Gaia DR3. We compared the synthetic photometry from BP/RP spectra with the J-PLUS instrumental magnitudes after correcting for the magnitude and color terms between both systems in order to obtain a homogeneous photometric solution for J-PLUS. To circumvent the current limitations in the absolute calibration of the BP/RP spectra, the absolute color scale was derived using the locus of 109 white dwarfs closer than 100 pc with a negligible interstellar extinction. Finally, the absolute flux scale was anchored to the Panoramic Survey Telescope and Rapid Response System (Pan-STARRS) photometry in the r band. Results. The precision of the J-PLUS photometric calibration estimated from duplicated objects observed in adjacent pointings and by comparison with the spectro-photometric standard star GD 153 is ~12 mmag in u, J0378, and J0395, and it is ~7 mmag in J0410, J0430, ɡ, J0515, r, J0660, i, J0861, and z. The estimated accuracy in the calibration along the surveyed area is better than 1% for all the passbands. Conclusions. The Gaia BP/RP spectra provide a high-quality, homogeneous photometric reference in the optical range across the full sky in spite of their current limitations as an absolute reference. The calibration method for J-PLUS DR3 reaches an absolute precision and accuracy of 1% in the 12 optical filters within an area of 3284 square degrees

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad

Acta de congresoLa conmemoración de los cien años de la Reforma Universitaria de 1918 se presentó como una ocasión propicia para debatir el rol de la historia, la teoría y la crítica en la formación y en la práctica profesional de diseñadores, arquitectos y urbanistas. En ese marco el VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad constituyó un espacio de intercambio y reflexión cuya realización ha sido posible gracias a la colaboración entre Facultades de Arquitectura, Urbanismo y Diseño de la Universidad Nacional y la Facultad de Arquitectura de la Universidad Católica de Córdoba, contando además con la activa participación de mayoría de las Facultades, Centros e Institutos de Historia de la Arquitectura del país y la región. Orientado en su convocatoria tanto a docentes como a estudiantes de Arquitectura y Diseño Industrial de todos los niveles de la FAUD-UNC promovió el debate de ideas a partir de experiencias concretas en instancias tales como mesas temáticas de carácter interdisciplinario, que adoptaron la modalidad de presentación de ponencias, entre otras actividades. En el ámbito de VIII Encuentro, desarrollado en la sede Ciudad Universitaria de Córdoba, se desplegaron numerosas posiciones sobre la enseñanza, la investigación y la formación en historia, teoría y crítica del diseño, la arquitectura y la ciudad; sumándose el aporte realizado a través de sus respectivas conferencias de Ana Clarisa Agüero, Bibiana Cicutti, Fernando Aliata y Alberto Petrina. El conjunto de ponencias que se publican en este Repositorio de la UNC son el resultado de dos intensas jornadas de exposiciones, cuyos contenidos han posibilitado actualizar viejos dilemas y promover nuevos debates. El evento recibió el apoyo de las autoridades de la FAUD-UNC, en especial de la Secretaría de Investigación y de la Biblioteca de nuestra casa, como así también de la Facultad de Arquitectura de la UCC; va para todos ellos un especial agradecimiento

Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children

Science with the Cherenkov Telescope Array

213 pages, including references and glossary. Version 2: credits and references updated, some figures updated, and author list updatedInternational audienceThe Cherenkov Telescope Array, CTA, will be the major global observatory for very high energy gamma-ray astronomy over the next decade and beyond. The scientific potential of CTA is extremely broad: from understanding the role of relativistic cosmic particles to the search for dark matter. CTA is an explorer of the extreme universe, probing environments from the immediate neighbourhood of black holes to cosmic voids on the largest scales. Covering a huge range in photon energy from 20 GeV to 300 TeV, CTA will improve on all aspects of performance with respect to current instruments. The observatory will operate arrays on sites in both hemispheres to provide full sky coverage and will hence maximize the potential for the rarest phenomena such as very nearby supernovae, gamma-ray bursts or gravitational wave transients. With 99 telescopes on the southern site and 19 telescopes on the northern site, flexible operation will be possible, with sub-arrays available for specific tasks. CTA will have important synergies with many of the new generation of major astronomical and astroparticle observatories. Multi-wavelength and multi-messenger approaches combining CTA data with those from other instruments will lead to a deeper understanding of the broad-band non-thermal properties of target sources. The CTA Observatory will be operated as an open, proposal-driven observatory, with all data available on a public archive after a pre-defined proprietary period. Scientists from institutions worldwide have combined together to form the CTA Consortium. This Consortium has prepared a proposal for a Core Programme of highly motivated observations. The programme, encompassing approximately 40% of the available observing time over the first ten years of CTA operation, is made up of individual Key Science Projects (KSPs), which are presented in this document

Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study

Background: Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours. Methods: In this retrospective, international, cross-sectional study, centres were invited to participate in June 22, 2022; each centre joining the study was asked to provide data from medical records on all surgical thyroidectomies consecutively performed from Jan 1, 2019, to Dec 31, 2021. Patients with indeterminate thyroid nodules were divided into three groups according to when they underwent surgery: from Jan 1, 2019, to Feb 29, 2020 (global prepandemic phase), from March 1, 2020, to May 31, 2021 (pandemic escalation phase), and from June 1 to Dec 31, 2021 (pandemic decrease phase). The main outcomes were, for each phase, the number of surgeries for indeterminate thyroid nodules, and in patients with a postoperative diagnosis of thyroid cancers, the occurrence of tumours larger than 10 mm, extrathyroidal extension, lymph node metastases, vascular invasion, distant metastases, and tumours at high risk of structural disease recurrence. Univariate analysis was used to compare the probability of aggressive thyroid features between the first and third study phases. The study was registered on ClinicalTrials.gov, NCT05178186. Findings: Data from 157 centres (n=49 countries) on 87 467 patients who underwent surgery for benign and malignant thyroid disease were collected, of whom 22 974 patients (18 052 [78·6%] female patients and 4922 [21·4%] male patients) received surgery for indeterminate thyroid nodules. We observed a significant reduction in surgery for indeterminate thyroid nodules during the pandemic escalation phase (median monthly surgeries per centre, 1·4 [IQR 0·6-3·4]) compared with the prepandemic phase (2·0 [0·9-3·7]; p<0·0001) and pandemic decrease phase (2·3 [1·0-5·0]; p<0·0001). Compared with the prepandemic phase, in the pandemic decrease phase we observed an increased occurrence of thyroid tumours larger than 10 mm (2554 [69·0%] of 3704 vs 1515 [71·5%] of 2119; OR 1·1 [95% CI 1·0-1·3]; p=0·042), lymph node metastases (343 [9·3%] vs 264 [12·5%]; OR 1·4 [1·2-1·7]; p=0·0001), and tumours at high risk of structural disease recurrence (203 [5·7%] of 3584 vs 155 [7·7%] of 2006; OR 1·4 [1·1-1·7]; p=0·0039). Interpretation: Our study suggests that the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic period could have led to an increased occurrence of aggressive thyroid tumours. However, other compelling hypotheses, including increased selection of patients with aggressive malignancies during this period, should be considered. We suggest that surgery for indeterminate thyroid nodules should no longer be postponed even in future instances of pandemic escalation. Funding: None

Science with the Cherenkov Telescope Array

The Cherenkov Telescope Array, CTA, will be the major global observatory forvery high energy gamma-ray astronomy over the next decade and beyond. Thescientific potential of CTA is extremely broad: from understanding the role ofrelativistic cosmic particles to the search for dark matter. CTA is an explorerof the extreme universe, probing environments from the immediate neighbourhoodof black holes to cosmic voids on the largest scales. Covering a huge range inphoton energy from 20 GeV to 300 TeV, CTA will improve on all aspects ofperformance with respect to current instruments. The observatory will operate arrays on sites in both hemispheres to providefull sky coverage and will hence maximize the potential for the rarestphenomena such as very nearby supernovae, gamma-ray bursts or gravitationalwave transients. With 99 telescopes on the southern site and 19 telescopes onthe northern site, flexible operation will be possible, with sub-arraysavailable for specific tasks. CTA will have important synergies with many ofthe new generation of major astronomical and astroparticle observatories.Multi-wavelength and multi-messenger approaches combining CTA data with thosefrom other instruments will lead to a deeper understanding of the broad-bandnon-thermal properties of target sources. The CTA Observatory will be operated as an open, proposal-driven observatory,with all data available on a public archive after a pre-defined proprietaryperiod. Scientists from institutions worldwide have combined together to formthe CTA Consortium. This Consortium has prepared a proposal for a CoreProgramme of highly motivated observations. The programme, encompassingapproximately 40% of the available observing time over the first ten years ofCTA operation, is made up of individual Key Science Projects (KSPs), which arepresented in this document