385 research outputs found
Heavy-flavor dynamics in nucleus-nucleus collisions: from RHIC to LHC
The stochastic dynamics of c and b quarks in the fireball created in
nucleus-nucleus collisions at RHIC and LHC is studied employing a relativistic
Langevin equation, based on a picture of multiple uncorrelated random
collisions with the medium. Heavy-quark transport coefficients are evaluated
within a pQCD approach, with a proper HTL resummation of medium effects for
soft scatterings. The Langevin equation is embedded in a multi-step setup
developed to study heavy-flavor observables in pp and AA collisions, starting
from a NLO pQCD calculation of initial heavy-quark yields, complemented in the
nuclear case by shadowing corrections, k_T-broadening and nuclear geometry
effects. Then, only for AA collisions, the Langevin equation is solved
numerically in a background medium described by relativistic hydrodynamics.
Finally, the propagated heavy quarks are made hadronize and decay into
electrons. Results for the nuclear modification factor R_AA of heavy-flavor
hadrons and electrons from their semi-leptonic decays are provided, both for
RHIC and LHC beam energies.Comment: 4 pages, 2 figures (3 eps files); submitted for publication in the
proceedings of "Quark Matter 2011", 23-28 May 2011, Annecy (France
Linked 3-D modelling of megathrust earthquake-tsunami events: from subduction to tsunami run up
How does megathrust earthquake rupture govern tsunami behaviour? Recent modelling advances permit evaluation of the influence of 3-D earthquake dynamics on tsunami genesis, propagation, and coastal inundation. Here, we present and explore a virtual laboratory in which the tsunami source arises from 3-D coseismic seafloor displacements generated by a dynamic earthquake rupture model. This is achieved by linking open-source earthquake and tsunami computational models that follow discontinuous Galerkin schemes and are facilitated by highly optimized parallel algorithms and software. We present three scenarios demonstrating the flexibility and capabilities of linked modelling. In the first two scenarios, we use a dynamic earthquake source including time-dependent spontaneous failure along a 3-D planar fault surrounded by homogeneous rock and depth-dependent, near-lithostatic stresses. We investigate how slip to the trench influences tsunami behaviour by simulating one blind and one surface-breaching rupture. The blind rupture scenario exhibits distinct earthquake characteristics (lower slip, shorter rupture duration, lower stress drop, lower rupture speed), but the tsunami is similar to that from the surface-breaching rupture in run-up and length of impacted coastline. The higher tsunami-generating efficiency of the blind rupture may explain how there are differences in earthquake characteristics between the scenarios, but similarities in tsunami inundation patterns. However, the lower seafloor displacements in the blind rupture result in a smaller displaced volume of water leading to a narrower inundation corridor inland from the coast and a 15 per cent smaller inundation area overall. In the third scenario, the 3-D earthquake model is initialized using a seismo-thermo-mechanical geodynamic model simulating both subduction dynamics and seismic cycles. This ensures that the curved fault geometry, heterogeneous stresses and strength and material structure are consistent with each other and with millions of years of modelled deformation in the subduction channel. These conditions lead to a realistic rupture in terms of velocity and stress drop that is blind, but efficiently generates a tsunami. In all scenarios, comparison with the tsunamis sourced by the time-dependent seafloor displacements, using only the time-independent displacements alters tsunami temporal behaviour, resulting in later tsunami arrival at the coast, but faster coastal inundation. In the scenarios with the surface-breaching and subduction-initialized earthquakes, using the time-independent displacements also overpredicts run-up. In the future, the here presented scenarios may be useful for comparison of alternative dynamic earthquake-tsunami modelling approaches or linking choices, and can be readily developed into more complex applications to study how earthquake source dynamics influence tsunami genesis, propagation and inundation
Rethinking the patient: using Burden of Treatment Theory to understand the changing dynamics of illness
<b>Background</b> In this article we outline Burden of Treatment Theory, a new model of the relationship between sick people, their social networks, and healthcare services. Health services face the challenge of growing populations with long-term and life-limiting conditions, they have responded to this by delegating to sick people and their networks routine work aimed at managing symptoms, and at retarding - and sometimes preventing - disease progression. This is the new proactive work of patient-hood for which patients are increasingly accountable: founded on ideas about self-care, self-empowerment, and self-actualization, and on new technologies and treatment modalities which can be shifted from the clinic into the community. These place new demands on sick people, which they may experience as burdens of treatment.<p></p>
<b>Discussion</b> As the burdens accumulate some patients are overwhelmed, and the consequences are likely to be poor healthcare outcomes for individual patients, increasing strain on caregivers, and rising demand and costs of healthcare services. In the face of these challenges we need to better understand the resources that patients draw upon as they respond to the demands of both burdens of illness and burdens of treatment, and the ways that resources interact with healthcare utilization.<p></p>
<b>Summary</b> Burden of Treatment Theory is oriented to understanding how capacity for action interacts with the work that stems from healthcare. Burden of Treatment Theory is a structural model that focuses on the work that patients and their networks do. It thus helps us understand variations in healthcare utilization and adherence in different healthcare settings and clinical contexts
An Elementary Quantum Network of Single Atoms in Optical Cavities
Quantum networks are distributed quantum many-body systems with tailored
topology and controlled information exchange. They are the backbone of
distributed quantum computing architectures and quantum communication. Here we
present a prototype of such a quantum network based on single atoms embedded in
optical cavities. We show that atom-cavity systems form universal nodes capable
of sending, receiving, storing and releasing photonic quantum information.
Quantum connectivity between nodes is achieved in the conceptually most
fundamental way: by the coherent exchange of a single photon. We demonstrate
the faithful transfer of an atomic quantum state and the creation of
entanglement between two identical nodes in independent laboratories. The
created nonlocal state is manipulated by local qubit rotation. This efficient
cavity-based approach to quantum networking is particularly promising as it
offers a clear perspective for scalability, thus paving the way towards
large-scale quantum networks and their applications.Comment: 8 pages, 5 figure
Meningeal lymphatic endothelial cells fulfill scavenger endothelial cell function and cooperate with microglia in waste removal from the brain
Brain lymphatic endothelial cells (BLECs) constitute a group of loosely connected endothelial cells that reside within the meningeal layer of the zebrafish brain without forming a vascular tubular system. BLECs have been shown to readily endocytose extracellular cargo molecules from the brain parenchyma, however, their functional relevance in relation to microglia remains enigmatic. We here compare their functional uptake efficiency for several macromolecules and bacterial components with microglia in a qualitative and quantitative manner in 5-day-old zebrafish embryos. We find BLECs to be significantly more effective in the uptake of proteins, polysaccharides and virus particles as compared to microglia, while larger particles like bacteria are only ingested by microglia but not by BLECs, implying a clear distribution of tasks between the two cell types in the brain area. In addition, we compare BLECs to the recently discovered scavenger endothelial cells (SECs) of the cardinal vein and find them to accept an identical set of substrate molecules. Our data identifies BLECs as the first brain-associated SEC population in vertebrates, and demonstrates that BLECs cooperate with microglia to remove particle waste from the brain.Thrombosis and Hemostasi
Politicizing vulnerability and adaptation: on the need to democratize local responses to climate impacts in developing countries
Neighborhood social capital is associated with participation in health checks of a general population: a multilevel analysis of a population-based lifestyle intervention- the Inter99 study
Building social capital through breastfeeding peer support: Insights from an evaluation of a voluntary breastfeeding peer support service in North-West England
Background:
Peer support is reported to be a key method to help build social capital in communities. To date there are no studies that describe how this can be achieved through a breastfeeding peer support service. In this paper we present findings from an evaluation of a voluntary model of breastfeeding peer support in North-West England to describe how the service was operationalized and embedded into the community. This study was undertaken from May, 2012 to May, 2013.
Methods:
Interviews (group or individual) were held with 87 participants: 24 breastfeeding women, 13 peer supporters and 50 health and community professionals. The data contained within 23 monthly monitoring reports (January, 2011 to February 2013) compiled by the voluntary peer support service were also extracted and analysed.
Results:
Thematic analysis was undertaken using social capital concepts as a theoretical lens. Key findings were identified to resonate with âbondingâ, âbridgingâ and âlinkingâ forms of social capital. These insights illuminate how the peer support service facilitates âbondsâ with its members, and within and between women who access the service; how the service âbridgesâ with individuals from different interests and backgrounds, and how âlinksâ were forged with those in authority to gain access and reach to women and to promote a breastfeeding culture. Some of the tensions highlighted within the social capital literature were also identified.
Conclusions:
Horizontal and vertical relationships forged between the peer support service and community members enabled peer support to be embedded into care pathways, helped to promote positive attitudes to breastfeeding and to disseminate knowledge and maximise reach for breastfeeding support across the community. Further effort to engage with those of different ethnic backgrounds and to resolve tensions between peer supporters and health professionals is warranted
Heavy-flavour and quarkonium production in the LHC era: from proton-proton to heavy-ion collisions
This report reviews the study of open heavy-flavour and quarkonium production
in high-energy hadronic collisions, as tools to investigate fundamental aspects
of Quantum Chromodynamics, from the proton and nucleus structure at high energy
to deconfinement and the properties of the Quark-Gluon Plasma. Emphasis is
given to the lessons learnt from LHC Run 1 results, which are reviewed in a
global picture with the results from SPS and RHIC at lower energies, as well as
to the questions to be addressed in the future. The report covers heavy flavour
and quarkonium production in proton-proton, proton-nucleus and nucleus-nucleus
collisions. This includes discussion of the effects of hot and cold strongly
interacting matter, quarkonium photo-production in nucleus-nucleus collisions
and perspectives on the study of heavy flavour and quarkonium with upgrades of
existing experiments and new experiments. The report results from the activity
of the SaporeGravis network of the I3 Hadron Physics programme of the European
Union 7th Framework Programme
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