5 research outputs found
Exploring the association between Alzheimer’s disease, oral health, microbial endocrinology and nutrition
Longitudinal monitoring of patients suggests a causal link between chronic periodontitis and the development of Alzheimer’s disease (AD). However, the explanation of how periodontitis can lead to dementia remains unclear. A working hypothesis links extrinsic inflammation as a secondary cause of AD. This hypothesis suggests a compromised oral hygiene leads to a dysbiotic oral microbiome whereby Porphyromonas gingivalis, a keystone periodontal pathogen, with its companion species, orchestrates immune subversion in the host. Brushing and chewing on teeth supported by already injured soft tissues leads to bacteraemias. As a result, a persistent systemic inflammatory response develops to periodontal pathogens. The pathogens, and the host’s inflammatory response, subsequently lead to the initiation and progression of multiple metabolic and inflammatory co-morbidities, including AD. Insufficient levels of essential micronutrients can lead to microbial dysbiosis through the growth of periodontal pathogens such as demonstrated for P. gingivalis under low hemin bioavailability. An individual’s diet also defines the consortium of microbial communities that take up residency in the oral and gastrointestinal (GI) tract microbiomes. Their imbalance can lead to behavioural changes. For example, probiotics enriched in Lactobacillus genus of bacteria, when ingested, exert some anti-inflammatory influence through common host/bacterial neurochemicals, both locally, and through sensory signalling back to the brain. Early life dietary behaviours may cause an imbalance in the host/microbial endocrinology through a dietary intake incompatible with a healthy GI tract microbiome later in life. This imbalance in host/microbial endocrinology may have a lasting impact on mental health. This observation opens up an opportunity to explore the mechanisms, which may underlie the previously detected relationship between diet, oral/GI microbial communities, to anxiety, cognition and sleep patterns. This review suggests healthy diet based interventions that together with improved life style/behavioural changes may reduce and/or delay the incidence of AD
Re: Meat, Fish, and Colorectal Cancer Risk: The European Prospective Investigation into Cancer and Nutrition
Proceedings of the 2nd annual symposium of the German Society for Paleo Nutrition held in 2014
We present the scientific abstracts of the 2nd Annual Symposium of the German Society for Paleo Nutrition (Deutsche Gesellschaft für Paläoernährung e.V.) which was held on November 8th 2014 in Schweinfurt, Germany. The topics presented had a great variety that included (i) a discussion of specific foods (one talk addressed the potential problems associated with cow’s milk consumption and one talk dealt with the staple foods of the Hadzda hunter-gatherers); (ii) the emerging role of ketogenic diets in the treatment of neurodegenerative diseases and cancer; (iii) an overview of intermittend fasting and its effects on health and performance; (iv) an extension of evolutionary principles beyond nutrition and their incorporation into everyday life in a way we term the paleo concept