Search for a Heavy Top-Like Quark in p\bar{p} Collisions at {\surd}s = 1.96 TeV

We present the results of a search for pair production of a heavy top-like (t') quark decaying to Wq final states using data corresponding to an integrated luminosity of 5.6 fb-1 collected by the CDF II detector in pp collisions at {\surd}s = 1.96 TeV. We perform parallel searches for t' \to Wb and t' \to Wq (where q is a generic down-type quark) in events containing a lepton and four or more jets. By performing a fit to the two-dimensional distribution of total transverse energy versus reconstructed t quark mass, we set upper limits on the t \bar{t} production cross section and exclude a standard model fourth-generation t' quark decaying to W b (W q) with mass below 358 (340) GeV/c2 at 95% CL

Novel endoperoxide antimalarials: Synthesis, heme binding, and antimalarial activity

Copyright © 2004 American Chemical SocietyWe report the synthesis of a series of novel epoxy endoperoxide compounds that can be prepared in high yields in one to three steps from simple starting materials. Some of these compounds inhibit the growth of Plasmodium falciparum in vitro. Structure-activity studies indicate that an endoperoxide ring bisubstituted with saturated cyclic moieties is the pharmacophore. To study the molecular basis of the action of these novel antimalarial compounds, we examined their ability to interact with oxidized and reduced forms of heme. Some of the compounds interact with oxidized heme in a fashion similar to chloroquine and other 4-aminoquinolines, while some of the compounds interact with reduced heme. However, the level of antimalarial potency is not well correlated with these activities, suggesting that some of the endoperoxides may exert their antimalarial activities by a novel mechanism of action.Dennis K. Taylor, Thomas D. Avery, Ben W. Greatrex, Edward R. T. Tiekink, Ian G. Macreadie, Peter I. Macreadie, Adam D. Humphries, Martha Kalkanidis, Emma N. Fox, Nectarios Klonis and Leann Tille