Dense gas and HII regions in the starburst galaxy NGC 253

The energetic activity in the nuclear barred region of NGC 253 is attributable to a burst of star formation. NGC 253 is in many ways a twin of the prototypical starburst galaxy M82; the strong non-thermal radio continuum, high far-infrared luminosity, and bright molecular emission of the central 1 Kpc parallel the morphology of the M82 starburst. Furthermore, the filamentary low ionization optical emission and extended x ray emission along the minor axis in NGC 253 is similar to a scaled down version of the well developed galactic bipolar wind in M82. The infrared luminosity of NGC 253, 3(exp 10) solar luminosity, is comparable to M82 but is emitted from a smaller region (Telesco and Harper 1980). This suggests that the NGC 253 starburst may be more intense and at an earlier evolutionary stage than M82. However, the presence of a non-stellar AGN in NGC 253 may complicate the comparison (Turner and Ho, 1985). Researchers used the Hat Creek millimeter interferometer to map emission from the J = 1 to 0 transitions of HCN and HCO(+) as well as 3 mm continuum emission, toward the nuclear region of NGC 253. The HCO(+) and continuum observations are sensitive to spatial scales from 6 to 45 seconds. The 2 minute field of view comfortably includes the entire starburst region (about 40 seconds; 650 pc). Because the longer baseline HCN observations are not yet complete, they are only sensitive to spatial scales from 15 to 45 seconds

Thermal kinetic inductance detectors for ground-based millimeter-wave cosmology

We show measurements of thermal kinetic inductance detectors (TKID) intended for millimeter wave cosmology in the 200-300 GHz atmospheric window. The TKID is a type of bolometer which uses the kinetic inductance of a superconducting resonator to measure the temperature of the thermally isolated bolometer island. We measure bolometer thermal conductance, time constant and noise equivalent power. We also measure the quality factor of our resonators as the bath temperature varies to show they are limited by effects consistent with coupling to two level systems.Comment: 8 pages, 4 figures. Submitted to Journal of Low Temperature Physic

Dynamic plantar loading index detects altered foot function in individuals with rheumatoid arthritis but not changes due to orthotic use

Background Altered foot function is common in individuals with rheumatoid arthritis. Plantar pressure distributions during gait are regularly assessed in this patient group; however, the association between frequently reported magnitude-based pressure variables and clinical outcomes has not been clearly established. Recently, a novel approach to the analysis of plantar pressure distributions throughout stance phase, the dynamic plantar loading index, has been proposed. This study aimed to assess the utility of this index for measuring foot function in individuals with rheumatoid arthritis.Methods Barefoot plantar pressures during gait were measured in 63 patients with rheumatoid arthritis and 51 matched controls. Additionally, 15 individuals with rheumatoid arthritis had in-shoe plantar pressures measured whilst walking in standardized footwear for two conditions: shoes-only; and shoes with prescribed custom foot orthoses. The dynamic plantar loading index was determined for all participants and conditions. Patient and control groups were compared for significant differences as were the shod and orthosis conditions.Findings The patient group was found to have a mean index of 0.19, significantly lower than the control group's index of 0.32 (p > 0.001, 95% CI [0.054, 0.197]). No significant differences were found between the shoe-only and shoe plus orthosis conditions. The loading index was found to correlate with clinical measures of structural deformity.Interpretation The dynamic plantar loading index may be a useful tool for researchers and clinicians looking to objectively assess dynamic foot function in patients with rheumatoid arthritis; however, it may be unresponsive to changes caused by orthotic interventions in this patient group.</p

Photoreceptor Cell Rescue at Early and Late RPE-Cell Transplantation Periods During Retinal Disease in RCS Dystrophic Rats

Maximal PRC rescue was affected by RPE-cell transplantation in retinas of RCS dystrophic rats at early stages of the retinal disease, while little or no rescue was detected when transplantation was performed at late time periods

Angular Momentum Transport by MHD Turbulence in Accretion Disks: Gas Pressure Dependence of the Saturation Level of the Magnetorotational Instability

The saturation level of the magnetorotational instability (MRI) is investigated using three-dimensional MHD simulations. The shearing box approximation is adopted and the vertical component of gravity is ignored, so that the evolution of the MRI is followed in a small local part of the disk. We focus on the dependence of the saturation level of the stress on the gas pressure, which is a key assumption in the standard alpha disk model. From our numerical experiments it is found that there is a weak power-law relation between the saturation level of the Maxwell stress and the gas pressure in the nonlinear regime; the higher the gas pressure, the larger the stress. Although the power-law index depends slightly on the initial field geometry, the relationship between stress and gas pressure is independent of the initial field strength, and is unaffected by Ohmic dissipation if the magnetic Reynolds number is at least 10. The relationship is the same in adiabatic calculations, where pressure increases over time, and nearly-isothermal calculations, where pressure varies little with time. Our numerical results are qualitatively consistent with an idea that the saturation level of the MRI is determined by a balance between the growth of the MRI and the dissipation of the field through reconnection. The quantitative interpretation of the pressure-stress relation, however, may require advances in the theoretical understanding of non-steady magnetic reconnection.Comment: 45 pages, 5 tables, 17 figures, accepted for publication in Ap

Statistical methods for automated drug susceptibility testing: Bayesian minimum inhibitory concentration prediction from growth curves

Determination of the minimum inhibitory concentration (MIC) of a drug that prevents microbial growth is an important step for managing patients with infections. In this paper we present a novel probabilistic approach that accurately estimates MICs based on a panel of multiple curves reflecting features of bacterial growth. We develop a probabilistic model for determining whether a given dilution of an antimicrobial agent is the MIC given features of the growth curves over time. Because of the potentially large collection of features, we utilize Bayesian model selection to narrow the collection of predictors to the most important variables. In addition to point estimates of MICs, we are able to provide posterior probabilities that each dilution is the MIC based on the observed growth curves. The methods are easily automated and have been incorporated into the Becton--Dickinson PHOENIX automated susceptibility system that rapidly and accurately classifies the resistance of a large number of microorganisms in clinical samples. Over seventy-five studies to date have shown this new method provides improved estimation of MICs over existing approaches.Comment: Published in at http://dx.doi.org/10.1214/08-AOAS217 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

Financial consequences of competitive set choice

This study examines the financial consequences of competitive set choice using a sample of 312 hotels in a major metropolitan area in the United States. We document existence of asymmetric competitor monitoring, finding just 55% of monitoring is reciprocal; that is, about half of managers “agree,” by virtue of monitoring one another, on being direct competitors. Monitoring reciprocity is positively associated with performance through average daily rates. With total revenue unchanged, profits are higher through lower occupancy and lower total costs. We examine alternative competitive sets formed using strategic groups- and customer-based approaches, comparing these to actual compsets. We found that performance declines when managers deviate from these alternative sets. Post-hoc analyses provide insight on how overlapping compsets impact rates, occupancy and revenue. Our study is of value to academics and practitioners, providing evidence on the financial impact of competitive monitoring, and insights for managers who choose competitive sets

Microwave Continuum Emission and Dense Gas Tracers in NGC 3627: Combining Jansky VLA and ALMA Observations

We present Karl G. Jansky Very Large Array (VLA) Ka band (33 GHz) and Atacama Large Millimeter Array (ALMA) Band 3 (94.5 GHz) continuum images covering the nucleus and two extranuclear star-forming regions within the nearby galaxy NGC 3627 (M 66), observed as part of the Star Formation in Radio Survey (SFRS). Both images achieve an angular resolution of $\lesssim$2\arcsec, allowing us to map the radio spectral indices and estimate thermal radio fractions at a linear resolution of $\lesssim$90 pc at the distance of NGC 3627. The thermal fraction at 33 GHz reaches unity at and around the peaks of each HII region; we additionally observed the spectral index between 33 and 94.5 GHz to become both increasingly negative and positive away from the peaks of the HII regions, indicating an increase of non-thermal extended emission from diffusing cosmic-ray electrons and the possible presence of cold dust, respectively. While the ALMA observations were optimized for collecting continuum data, they also detected line emission from the $J=1\rightarrow0$ transitions of HCN and HCO$^{+}$. The peaks of dense molecular gas traced by these two spectral lines are spatially offset from the peaks of the 33 and 94.5 GHz continuum emission for the case of the extranuclear star-forming regions, indicating that our data reach an angular resolution at which one can spatially distinguish sites of recent star formation from the sites of future star formation. Finally, we find trends of decreasing dense gas fraction and velocity dispersion with increasing star formation efficiency among the three regions observed, indicating that the dynamical state of the dense gas, rather than its abundance, plays a more significant role in the star formation process.Comment: 9 pages, 5 figures, accepted for publication in Ap

Black carbon physical and optical properties across northern India during pre-monsoon and monsoon seasons

Black carbon (BC) is known to have major impacts on both climate and human health and is therefore of global importance, particularly in regions close to large populations that have strong sources. The size-resolved mixing state of BC-containing particles was characterised using a single-particle soot photometer (SP2). The study focusses on the Indo-Gangetic Plain (IGP) during the pre-monsoon and monsoon seasons. Data presented are from the UK Facility for Airborne Atmospheric Measurements BAe-146 research aircraft that performed flights during the pre-monsoon (11 and 12 June) and monsoon (30 June to 11 July) seasons of 2016. Over the IGP, BC mass concentrations were greater (1.95 µg m−3) compared to north-west India (1.50 µg m−3) and north-east India (0.70 µg m−3) during the pre-monsoon season. Across northern India, two distinct BC modes were recorded; a mode of small BC particles (core diameter <0.16 µm and coating thickness <50 nm) and a mode of moderately coated BC (core diameter <0.22 µm and coating thickness of 50–200 nm). The IGP and north-east India locations exhibited moderately coated black carbon particles with enhanced coating thicknesses, core sizes, mass absorption cross sections, and scattering enhancement values compared to much lower values present in the north-west. The coating thickness and mass absorption cross section increased with altitude (13 %) compared to those in the boundary layer. As the monsoon arrived across the region, mass concentration of BC decreased over the central IGP and north-east locations (38 % and 28 % respectively), whereas for the north-west location BC properties remained relatively consistent. Post-monsoon onset, the coating thickness, core size, mass absorption cross section, and scattering enhancement values were all greatest over the central IGP much like the pre-monsoon season but were considerably reduced over both north-east and north-west India. Increases in mass absorption cross section through the atmospheric column were still present during the monsoon for the north-west and central IGP locations, but less so over the north-east due to lack of long-range transport aerosol aloft. Across the Indo-Gangetic Plain and north-east India during the pre-monsoon and monsoon seasons, solid-fuel (wood burning) emissions form the greatest proportion of BC with moderately coated particles. However, as the monsoon develops in the north-east there was a switch to small uncoated BC particles indicative of traffic emissions, but the solid-fuel emissions remained in the IGP into the monsoon. For both seasons in the north-west, traffic emissions form the greatest proportion of BC particles. Our findings will prove important for greater understanding of the BC physical and optical properties, with important consequences for the atmospheric radiative forcing of BC-containing particles. The findings will also help constrain the regional aerosol models for a variety of applications such as space-based remote sensing, chemistry transport modelling, air quality, and BC source and emission inventories

Targeted interventions for patellofemoral pain syndrome (TIPPS): classification of clinical subgroups

Introduction Patellofemoral pain (PFP) can cause significant pain leading to limitations in societal participation and physical activity. An international expert group has highlighted the need for a classification system to allow targeted intervention for patients with PFP; we have developed a work programme systematically investigating this. We have proposed six potential subgroups: hip abductor weakness, quadriceps weakness, patellar hypermobility, patellar hypomobility, pronated foot posture and lower limb biarticular muscle tightness. We could not uncover any evidence of the relative frequency with which patients with PFP fell into these subgroups or whether these subgroups were mutually exclusive. The aim of this study is to provide information on the clinical utility of our classification system. Methods and analysis 150 participants will be recruited over 18 months in four National Health Services (NHS) physiotherapy departments in England. Inclusion criteria: adults 18–40 years with PFP for longer than 3 months, PFP in at least two predesignated functional activities and PFP elicited by clinical examination. Exclusion criteria: prior or forthcoming lower limb surgery; comorbid illness or health condition; and lower limb training or pregnancy. We will record medical history, demographic details, pain, quality of life, psychomotor movement awareness and knee temperature. We will assess hip abductor and quadriceps weakness, patellar hypermobility and hypomobility, foot posture and lower limb biarticular muscle tightness. The primary analytic approach will be descriptive. We shall present numbers and percentages of participants who meet the criteria for membership of (1) each of the subgroups, (2) none of the subgroups and (3) multiple subgroups. Exact (binomial) 95% CIs for these percentages will also be presented. Ethics and dissemination This study has been approved by National Research Ethics Service (NRES) Committee North West—Greater Manchester North (11/NW/0814) and University of Central Lancashire (UCLan) Built, Sport, Health (BuSH) Ethics Committee (BuSH 025). An abstract has been accepted for the third International Patellofemoral Pain Research Retreat, Vancouver, September 2013