慢性蕁麻疹における屋内塵ダニ中のヤケヒョウダニとコナヒョウダニの相関について

One hundred and thirty-eight patients with chronic urticaria were tested intradermally with Dermatophagodes pteronyssinus and Dermatophagoides farinae allergens. None had any past history of other atopic diseases. The percentage of cases which gave positive skin reactions to these mite allergens was larger in chronic urticarial patients than in normal healthy subjects. A significant correlation was observed between the magnitude of skin reactions to D. pteronyssinus and to D. farinae. The results suggest that D. pteronyssinus and D. farinae may play a role in chronic urticaria and that there may be cross allergenicity between D. pteronyssinus and D. farinae

Interobserver Reliability of the Endoscopic Ultrasound Criteria for the Diagnosis of Early Chronic Pancreatitis: Comparison between the 2009 and 2019 Japanese Diagnostic Criteria

In 2009, diagnostic criteria for early chronic pancreatitis (DCECP2009) were proposed by the Japan Pancreas Society. This study aimed to evaluate the interobserver reliability (IOR) of endoscopic ultrasound (EUS) criteria for diagnosis of early chronic pancreatitis (ECP) between DCECP2009 and 2019 diagnostic criteria for ECP (DCECP2019) to assess the validity of the revision from the perspective of EUS findings. Among patients who underwent a detailed observation of the pancreas by EUS at our institution between January 2018 and March 2019, EUS images of 97 patients were extracted. Images were reviewed by 12 gastrointestinal endoscopy experts (eight pancreatologists, group A and four nonpancreatologists, group B). The overall kappa (K)-values for the IOR of the DCECP2009 EUS criteria were 0.424 and 0.563:0.231 for groups A:B, whereas the overall K-values for the DCECP2019 criteria were 0.618, and 0.733:0.442 for groups A:B. Regarding changes in the final diagnosis of ECP based on clinical features and EUS findings, 20 cases were definite ECP, 53 were probable ECP, and 24 were normal according to DCECP2009. In contrast, seven were definite ECP, 19 were probable ECP, and 71 were normal according to DECEP2019. IOR of DCECP2019 was higher than that of DCECP2009, which indicates an improvement in precision