David R. Dillon of Savannah

There have probably been few, if any, men whom by virtue of their colorful life style and philanthropy managed to capture the hearts of Savannahians to the extent as did our subject David R. Dillon. Sportsman, Banker, Realtor, Boat Captain and owner, Civic Leader and Philanthropist were titles that were quite apropos for David R, Dillonhttps://digitalcommons.georgiasouthern.edu/sav-bios-lane/1047/thumbnail.jp

Going to the Zoo: Using Tags to Create Measures for Animal Health, Well-being and Welfare in a Managed Care Setting

This PhD investigates how animal-attached motion-sensitive electronic tags might create behavioural biomarkers for animal ‘state’. Such biomarkers could indicate good health, disease, and injuries as well as positive and negative affective states. Success could have widespread implications for the well-being of numerous species in managed care by optimising welfare practices. This work primarily involved loggerhead sea turtles, Caretta caretta, in different states of health at the Arca del Mar rehabilitation centre, Oceanogràfic, Valencia, Spain, however the potential of tags for various aquatic, aerial and terrestrial species is also considered. Initially, the concept of tag-derived behavioural biomarkers for health (TDBBs) was established, examining data from ‘healthy’ and ‘unhealthy’ rehabilitating sea turtles to identify potentially useful metrics for specific injuries and/or diseases. Then, potential TDBBs for ‘healthy’ turtles and those with gas emboli were created, with variance in body attitude, number of 45° turns per hour and mean angular velocity per hour showing the most promise to differentiate the two groups. TDBBs were also explored for welfare, giving ‘healthy’ turtles nutritional enrichment, demonstrating that enrichment procedures do not always affect captive animal behaviour. To consider welfare implications of captivity, the movement behaviour of free-living and managed-care loggerheads was compared to determine wild-type and captive behaviour overlap. Findings revealed significant differences in the variance in pitch, heading and absolute angular velocity as well as the number of turns per hour. The final research topic considered trajectory step length data (the distances travelled in between turns), derived from tags deployed on nine wild species, for informing enclosure size for captive animals. The findings revealed that existing enclosure size guidelines regularly only permitted animals to undertake a very small percentage (often less than 3 %) of the step lengths recorded from free-living conspecifics. Last, the potential of TDBBs is reviewed, with limitations and future research discussed

Discourse, Narrative and Agency: A Contribution of Local Stories to Disability Theory, Research and Professional Practice

The impetus for this study arose from a realisation that the post-structural concept of agency was relevant to disability studies. In locating this study as a contribution to the knowledge of disability and disablement, the initial chapters explore the theoretical genealogy of disability studies and the methodology for the study. In broad terms this has been a discursive and narrative research project, which sought to explore how discourse constituted the lives of six people with impairments and/or illness. Within this examination, specific attention was paid to those occasions in which the participants were able to take up alternative and preferred subject positions when they had been positioned in ways that removed or reduced their agency on account of their having an impairment and/or illness. The six people who participated in the study are introduced at the end of Chapter Four and the next three chapters provide an account of their accounts. Overall, the participants’ accounts of their experiences told how medical discourse positioned them in ways that removed their agency but not exclusively so. In contrast to medical discourse, disability rights discourses offered alternative subject positions because disablement is not constructed as an inevitable consequence of having an impairment and/or illness. In regard to the benefit of disability rights discourses for disabled people, two of the participants had been advantaged by the career opportunities available to them within the disability sector that arguably had been created by disability rights discourses. However, generally speaking, the participants’ accounts of their experiences showed that disability rights discourses were not the only discursive option for them. On those occasions in which the participants took up subject positions that afforded them agency, they were often calling on more than one discursive idea or practice, typically beyond both medical or disability rights discourse. The participants’ lives were more diverse and complex than the reproduction of any one singular discourse. Hence, even between just six people’s accounts, there was significant difference between how each person called on and negotiated discourse so as to take up subject positions that offered them agency. In considering the participants’ accounts, a number of generic storylines have been generated from the research process. In particular, these were: the negative impact of deficit discourse on disabled people’s lives, the advantages and limitations of disability rights discourses, the complex and person-specific processes of taking up subject positions that afford agency for the person, and the experience of silenced, subjugated and contradictory subject positions. These quite specific understandings about the processes of disablement for people who have impairments and/or illnesses, and their corresponding actions of agency, are discussed in more detail in the concluding chapter in regards to implications for future research, theory and professional practice

Fourth and Eighth Grade Students\u27 Conceptions of Energy Flow through Ecosystems

This mixed methods status study examined 32 fourth grade students’ conceptual understandings of energy flow through ecosystems prior to instruction and 40 eighth grade students’ conceptual understandings of the same topic after five years of daily standards-based instruction in science. Specific ecological concepts assessed related to: 1) roles of organisms; 2) the sun as the original energy source for most ecosystems; and 3) interdependency of organisms. Fourth and eighth grade students were assessed using the same three-tiered forced-choice instrument, with accompanying tasks for students to defend their forced-choice selections and rate their level of confidence in making the selections. The instrument was developed for the study by a team of researchers and was based on similar tasks presented in the research literature. Distractor options were embedded in each assessment task using common non-scientific ideas also reported in the research literature. Cronbach’s alpha values at or greater than .992 for each task indicated inter-rater consistency of task answers, and Rasch analysis was employed to establish the reliability of the instrument. Qualitative and quantitative analyses were employed to assess the data. Constant comparative methods were employed to analyze students’ written responses, which were coded and grouped into emerging themes. These themes were further developed to characterize students’ conceptual understandings. Student open responses also were scored and coded by a team of researchers using a rubric to identify level of scientific understanding. Quantitative analyses included Rasch analysis used to normalize survey data. Independent samples t-tests were then employed to compare students’ forced-choice responses to their written responses and to the confidence ratings, as well as to compare fourth and eighth grade students’ responses. Findings indicated that eighth grade students generally outperformed the fourth grade on both the forced-choice and written responses, but both groups demonstrated conceptual difficulties in all three topics assessed. Thus, results from the current study support the assertion that students’ understanding of concepts related to energy flow in ecosystems is not at the expected level according to national science education standards and frameworks. Conceptual difficulties identified in the study are discussed along with implications and curricular recommendations

Application of Empirical Orthogonal Function Models to Analyze Shoreline Change at Bangkalan Madura

Bangkalan’s shoreline, especially on the opposite side of Surabaya, has been evaluated to determine the morphological changes due to wave attack, near-shore current, long-shore sediment transport and coastal configuration. This research aims to determine the dominant patterns of variation of Bangkalan’s shoreline change, expressed by Eigen-function in empirical orthogonal function (EOF) models. That was started with data collection such as oceanographic data (wave and tidal), bathymetry and topographic map and sediment data. All data was used for forecasting two-monthly shoreline. Coordinate of two-monthly shoreline was used as input of EOF model. The first Eigen mode is a profile of shoreline equilibrium. The second Eigen mode shows pivot point that separates the different behaviors, which indicates a positive balance of shoreline from the direction of the dominant force. The models execution based on 1986’s shoreline show the shoreline change significantly at some cells e.g. around Suramadu bridge (cell 1-40), Batuporon (cell 70-100), Jungdima (cell 142-170) and at Kamal port (cell 230-250). The model of shoreline change using EOF was validated with the One-line model and data of 1995’s map’s shoreline. The E.O.F. value of model RMSE, 0.02, is less than the root mean square error (RMSE) value of One-line model, 0.04, which shows that the EOF model performance better than One-line models

Keratinocyte EGF signalling dominates in atopic dermatitis lesions: A comparative RNAseq analysis

Atopic dermatitis (AD) remains a highly heterogenous disorder with a multifactorial aetiology. Whilst keratinocytes are known to play a fundamental role in AD, their contribution to the overall immune landscape in moderate‐to‐severe AD is still poorly understood. In order to design new therapeutics, further investigation is needed into common disease pathways at the molecular level. We used publicly available whole‐tissue RNAseq data (4 studies) and single‐cell RNAseq keratinocyte data to identify genes/pathways that are involved in keratinocyte responses in AD and after dupilumab treatment. Transcripts present in both keratinocytes (single‐cell) and whole‐tissue, referred to as the keratinocyte‐enriched lesional skin (KELS) genes, were analysed using functional/pathway analysis. Following statistical testing, 2049 genes (16.8%) were differentially expressed in KELS. Enrichment analyses predicted increases in not only type‐1/type‐2 immune signalling and chemoattraction, but also in EGF‐dominated growth factor signalling. We identified complex crosstalk between keratinocytes and immune cells involving a dominant EGF family signature which converges on keratinocytes with potential immunomodulatory and chemotaxis‐promoting consequences. Although keratinocytes express the IL4R, we observed no change in EGF signalling in KELS after three‐month treatment with dupilumab, indicating that this pathway is not modulated by dupilumab immunotherapy. EGF family signalling is significantly dysregulated in AD lesions but is not associated with keratinocyte proliferation. EGF signalling pathways in AD require further study