The International Virus Bioinformatics Meeting 2023

The 2023 International Virus Bioinformatics Meeting was held in Valencia, Spain, from 24–26 May 2023, attracting approximately 180 participants worldwide. The primary objective of the conference was to establish a dynamic scientific environment conducive to discussion, collaboration, and the generation of novel research ideas. As the first in-person event following the SARS-CoV-2 pandemic, the meeting facilitated highly interactive exchanges among attendees. It served as a pivotal gathering for gaining insights into the current status of virus bioinformatics research and engaging with leading researchers and emerging scientists. The event comprised eight invited talks, 19 contributed talks, and 74 poster presentations across eleven sessions spanning three days. Topics covered included machine learning, bacteriophages, virus discovery, virus classification, virus visualization, viral infection, viromics, molecular epidemiology, phylodynamic analysis, RNA viruses, viral sequence analysis, viral surveillance, and metagenomics. This report provides rewritten abstracts of the presentations, a summary of the key research findings, and highlights shared during the meeting

De novo genome assembly resolving repetitive structures enables genomic analysis of 35 European Mycoplasmopsis bovis strains

Abstract Mycoplasmopsis (M.) bovis, the agent of mastitis, pneumonia, and arthritis in cattle, harbors a small genome of approximately 1 Mbp. Combining data from Illumina and Nanopore technologies, we sequenced and assembled the genomes of 35 European strains and isolate DL422_88 from Cuba. While the high proportion of repetitive structures in M. bovis genomes represent a particular challenge, implementation of our own pipeline Mycovista (available on GitHub www.github.com/sandraTriebel/mycovista ) in a hybrid approach enabled contiguous assembly of the genomes and, consequently, improved annotation rates considerably. To put our European strain panel in a global context, we analyzed the new genome sequences together with 175 genome assemblies from public databases. Construction of a phylogenetic tree based on core genes of these 219 strains revealed a clustering pattern according to geographical origin, with European isolates positioned on clades 4 and 5. Genomic data allowing assignment of strains to tissue specificity or certain disease manifestations could not be identified. Seven strains isolated from cattle with systemic circular condition (SCC), still a largely unknown manifestation of M. bovis disease, were located on both clades 4 and 5. Pairwise association analysis revealed 108 genomic elements associated with a particular clade of the phylogenetic tree. Further analyzing these hits, 25 genes are functionally annotated and could be linked to a M. bovis protein, e.g. various proteases and nucleases, as well as ten variable surface lipoproteins (Vsps) and other surface proteins. These clade-specific genes could serve as useful markers in epidemiological and clinical surveys

Interpolation by vector-valued analytic functions, with applications to controllability

In this paper, norm estimates are obtained for the problem of minimal-norm tangential interpolation by vector-valued analytic functions, expressed in terms of the Carleson constants of related scalar measures. Applications are given to the controllability properties of linear semigroup systems with a Riesz basis of eigenvectors

The International Virus Bioinformatics Meeting 2023

Peer reviewed: TrueAcknowledgements: The conference organizers thank all speakers, poster presenters, chairs and participants for creating a highly interactive scientific environment and making the meeting a success. The conference organisers acknowledge sponsorship from Promega Biotech Ibérica SL. We thank Milena Žarković, Ruben Rose, Christina Martínez Christophersen, Lea Paltzow, Mohsen M. Hegab, Anna Wansorra, Akash Srivastava, Andi Krumbholz, Pablo A. Gutiérrez, João M.F. Silva, Juan C. Muñoz-Sánchez, Maria J. Olmo-Uceda, José A. Oteo and Carlos P. Garay, Yanhua Xu, Dominik Wojtczak, Matthew Baylis, Joaquin Mould-Quevedo, Markus Braun, Gibran Rubio Quintanares, Pauline Santos, Erica Margiotta, Janice Brückmann, Csaba Miskey, Johannes Blümel, Renate König, Liam Childs, Frank O. Aylward, Alexander Lukashev, Artem Orlov, Celia Jakob, Hardin Bolte, Christian Höner zu Siederdissen, Martin Schwemmle.Funder: VirBio 01KI2106Funder: The Pandemic Institute & CSL Seqirus Influenza Research Partnership (LB)Funder: LPIThe 2023 International Virus Bioinformatics Meeting was held in Valencia, Spain, from 24–26 May 2023, attracting approximately 180 participants worldwide. The primary objective of the conference was to establish a dynamic scientific environment conducive to discussion, collaboration, and the generation of novel research ideas. As the first in-person event following the SARS-CoV-2 pandemic, the meeting facilitated highly interactive exchanges among attendees. It served as a pivotal gathering for gaining insights into the current status of virus bioinformatics research and engaging with leading researchers and emerging scientists. The event comprised eight invited talks, 19 contributed talks, and 74 poster presentations across eleven sessions spanning three days. Topics covered included machine learning, bacteriophages, virus discovery, virus classification, virus visualization, viral infection, viromics, molecular epidemiology, phylodynamic analysis, RNA viruses, viral sequence analysis, viral surveillance, and metagenomics. This report provides rewritten abstracts of the presentations, a summary of the key research findings, and highlights shared during the meeting