14 research outputs found
A Genetic Screen for Dihydropyridine (DHP)-Resistant Worms Reveals New Residues Required for DHP-Blockage of Mammalian Calcium Channels
- Author
- A Hohaus
- A Schuster
- AR Burns
- AV Chobanian
- BP Bean
- BZ Peterson
- BZ Peterson
- BZ Peterson
- BZ Peterson
- C Shi
- DB Halling
- E Wappl
- EA Mathews
- GH Hockerman
- GH Hockerman
- Guillermo Selman
- H Glossmann
- H Ito
- I Splawski
- I Splawski
- J Mitterdorfer
- J Mitterdorfer
- JB Lansman
- JE Sulston
- K Hui
- Kwokyin Hui
- L Lacinova
- LE Waggoner
- LR Garcia
- M Grabner
- MJ Berridge
- MJ Sinnegger
- Nicole Ricker
- NM Soldatov
- NT Bech-Hansen
- Peter John Roy
- RY Lee
- S Berjukow
- S Sonkusare
- S Tang
- S Yamaguchi
- S Yamaguchi
- TC Kwok
- Trevor C. Y. Kwok
- WA Catterall
- WA Catterall
- Wayne N. Frankel
- Wojciech Kostelecki
- X Wang
- Zhong-Ping Feng
- ZP Feng
- Publication venue
- Public Library of Science
- Publication date
- 01/05/2008
- Field of study
Dihydropyridines (DHPs) are L-type calcium channel (Cav1) blockers prescribed to treat several diseases including hypertension. Cav1 channels normally exist in three states: a resting closed state, an open state that is triggered by membrane depolarization, followed by a non-conducting inactivated state that is triggered by the influx of calcium ions, and a rapid change in voltage. DHP binding is thought to alter the conformation of the channel, possibly by engaging a mechanism similar to voltage dependent inactivation, and locking a calcium ion in the pore, thereby blocking channel conductance. As a Cav1 channel crystal structure is lacking, the current model of DHP action has largely been achieved by investigating the role of candidate Cav1 residues in mediating DHP-sensitivity. To better understand DHP-block and identify additional Cav1 residues important for DHP-sensitivity, we screened 440,000 randomly mutated Caenorhabditis elegans genomes for worms resistant to DHP-induced growth defects. We identified 30 missense mutations in the worm Cav1 pore-forming (α1) subunit, including eleven in conserved residues known to be necessary for DHP-binding. The remaining polymorphisms are in eight conserved residues not previously associated with DHP-sensitivity. Intriguingly, all of the worm mutants that we analyzed phenotypically exhibited increased channel activity. We also created orthologous mutations in the rat α1C subunit and examined the DHP-block of current through the mutant channels in culture. Six of the seven mutant channels examined either decreased the DHP-sensitivity of the channel and/or exhibited significant residual current at DHP concentrations sufficient to block wild-type channels. Our results further support the idea that DHP-block is intimately associated with voltage dependent inactivation and underscores the utility of C. elegans as a screening tool to identify residues important for DHP interaction with mammalian Cav1 channels
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
- Buckner Randy L
- Budson Andrew E
- Buimer Elizabeth E L
- Buitelaar Jan K
- Burke Anna
- Burns Jeffrey M
- Bustillo Juan R
- Bülow Robin
- Bülow Robin
- Bürger Christian
- Bÿchel Christian
- Cabrera Yuliana
- Cahn Wiepke
- Cairns Murray J
- Cairns Nigel J
- Calhoun Vince
- Cannon Dara M
- Capote Horacio
- Carlsson Cynthia M
- Carmichael Owen
- Carr Vaughan J
- Carrillo Maria
- Carroll Maria
- Carson Richard E
- Carter Raina
- Casaceli Cynthia
- Casalin Paola
- Caseras Xavier
- Caspell Chelsea
- Caspers Svenja
- Catafau Ana
- Cavalleri Gianpiero L
- Cedarbaum Jesse
- Cellar Janet S
- Celmins Dzintra
- Cendes Fernando
- Chahine Lama
- Chakravarty Mallar
- Chalker Alison
- Chao Steven
- Chen Kewei
- Chen Qiang
- Chertkow Howard
- Cheung Joshua W
- Chiang Gloria
- Ching Christopher R K
- Chowdhury Munir
- Chowdhury Sohini
- Chu Congying
- Cichon Sven
- Clark Christopher M
- Clark David
- Coffey Christopher
- Coleman Edward
- Colodro-Conde Lucía
- Comery Thomas
- Conrad Gary
- Conrod Patricia
- Consortium CHARGE
- Consortium Enhancing NeuroImaging Genetics through Meta-Analysis
- Consortium EPIGEN
- Consortium IMAGEN
- Consortium SYS
- Correia Stephen
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crawford Karen
- Creech Mary L
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Curran Joanne E
- D'Agostino Daniel
- Daedelow Laura
- Daiello Lori A
- Dale Anders M
- Dale Anders M
- Dalley Jeffrey
- Dalrymple-Alford John C
- Dalvie Shareefa
- Dang Mimi
- Dannlowski Udo
- Darin Abigail
- Davies Gareth E
- Davies Peter
- de Araujo Tânia K
- de Geus Eco J C
- de Zubicaray Greig I
- de Zwarte Sonja M C
- Deary Ian J
- Deary Ian J
- Debette Stephanie
- Debette Stephanie
- Decarli Charles
- DeCarli Charles
- Deeley Cheryl
- Degenhardt Franziska
- Delanty Norman
- DeMarco Kathryn
- den Braber Anouk
- Dennis Michelle F
- Depondt Chantal
- Desrivieres Sylvane
- Desrivières Sylvane
- Dietsche Bruno
- Djurovic Srdjan
- Doan Nhat Trung
- Doherty Colin P
- Dohm Katharina
- Dolen Sara
- Donohoe Gary
- Donohue Michael
- Doody Rachelle S
- Dooley Eoin
- Doraiswamy P Murali
- Drost Dick
- Duara Ranjan
- Dubow Jordan S
- Dunlop Becky
- Egebjerg Jan
- Ehrlich Stefan
- El Khouli Riham
- Engelbrecht Hannah-Ruth
- Erk Susanne
- Espay Alberto
- Espay Kristy
- Espeseth Thomas
- Espiritu Ryan
- Faber Kelley
- Factor Stewart
- Fan Chun Chieh
- Fargher Kristin
- Farlow Martin R
- Fatica Parianne
- Fedko Iryna O
- Feldman Howard
- Fernandez Hubert
- Fernández Guillén
- Figurski Michal
- Filippi Irina
- Fillit Howard
- Fillmer Ariane
- Finger Elizabeth
- Fisher Simon E
- Flashman Laura A
- Fleisher Adam
- Fletcher Evan
- Flor Herta
- Flor Herta
- Foley Sonya F
- Fontaine Deborah
- Fontoura Paulo
- Ford Judith M
- Fornage Myriam
- Fornage Myriam
- Foroud Tatiana
- Foroud Tatiana M
- Forstner Andreas J
- Foster Eric
- Foster Norm
- Fox Nick
- Francks Clyde
- Frank Richard
- Frank Samuel
- Franke Barbara
- Franklin Erin
- Franz Carol E
- Frasier Mark
- Frouin Vincent
- Fröhner Juliane
- Fukunaga Masaki
- Gaikwad Mrunalini
- Galasko Douglas
- Garavan Hugh
- Garijo Daniel
- Garrett Melanie E
- Gauss Katharina
- Ge Tian
- Geldmacher David
- Gessert Devon
- Ghanbari Mohsen
- Giddaluru Sudheer
- Gigliotti Christina
- Gil Yolanda
- Gillespie Nathan A
- Glahn David C
- Gloer Katherine
- Goldman Aaron L
- Goldstein Bonnie S
- Goldstein David B
- Gollub Randy L
- Gowland Penny
- Gowland Penny A
- Grabe Hans J
- Grabe Hans Jörgen
- Grachev Igor D
- Graff-Radford Neill R
- Grasby Katrina L
- Green Davis Robert C
- Green Melissa J
- Green Robert C
- Green Robert C
- Greig-Custo Maria T
- Griffith Randall
- Grimmer Yvonne
- Groenewold Nynke A
- Grossman Hillel
- Grotegerd Dominik
- Gruber Oliver
- Gudnason Vilmundur
- Gunter Jeff
- Gurholt Tiril P
- Guthrie Stephanie
- Gutman Boris A
- Hake Ann Marie
- Hansell Narelle K
- Hardy Peter
- Hariri Ahmad R
- Harlan Sherry
- Harless Kelly
- Harris Mat
- Harris Mathew A
- Harrison Marc B
- Hart David
- Hartman Catharina A
- Harvey Danielle
- Hashimoto Ryota
- Haswell Courtney C
- Hauser Michael
- Hauser Robert
- Hawkins Keith A
- Hefti Franz
- Heidebrink Judith L
- Heindel Walter
- Heinz Andreas
- Heinz Andreas
- Heinzen Erin L
- Henskens Frans A
- Hergesheimer Lindsey
- Herms Stefan
- Hernando Raymundo
- Herring Scott
- Heslenfeld Dirk J
- Hetelle Joel
- Hewitt David L
- Heyn Chris Chinthaka
- Hibar Derrek P
- Hillegers Manon H J
- Himali Jayandra J
- Ho Beng-Choon
- Ho New Fei
- Hoehn David
- Hoekstra Pieter J
- Hofer Edith
- Hofer Edith
- Hoffmann Per
- Hoffmann Wolfgang U
- Hofman Albert
- Hogarth Penelope
- Hohmann Sarah
- Holleran Laurena
- Holmes Avram J
- Holsboer Florian
- Holtzman David
- Homuth Georg
- Hong L Elliot
- Honig Lawrence S
- Hoogman Martine
- Hopkins William D
- Hosein Chris
- Hosten Norbert
- Hottenga Jouke-Jan
- Hsiao John
- Hsiung Ging-Yuek Robin
- Hu Shu-Ching
- Hulshoff Pol Hilleke E
- Hunter Christine
- Hynes Mary L
- Häusler Alexander N
- Håberg Asta K
- Ihlenfeld Albrecht
- Ikeda Masashi
- Ikram M Arfan
- Ikram M Arfan
- Ing Alex
- Initiative Alzheimer’s Disease Neuroimaging
- Initiative Parkinson’s Progression Markers
- Iranzo Alex
- Isaacson Stuart
- Isensee Corinna
- Ismail M Saleem
- Ittermann Bernd
- Jack Clifford R
- Jack Clifford R
- Jagust William
- Jahanshad Neda
- James Angela
- James Olga
- James Raymond
- Jang MiHyun
- Jankovic Joseph
- Janowitz Deborah
- Jansen Andreas
- Jansen Iris E
- Jennings Danna
- Jernigan Terry L
- Jia Tianye
- Jia Tianye
- Jian Xueqiu
- Jiang Jiyang
- Jicha Greg
- Jimenez Gustavo
- Jockwitz Christiane
- Johnson Kathleen
- Johnson Keith A
- Johnson Kris
- Johnson Nancy
- Johnson Patricia Lynn
- Johnson Sterling
- Jones David
- Jönsson Erik G
- Kahn René S
- Kanai Ryota
- Kantarci Kejal
- Karama Sherif
- Karama Sherif
- Karlawish Jason H
- Kasperaviciute Dalia
- Kass Joseph S
- Kataki Maria
- Kaufmann Tobias
- Kaye Jeffrey A
- Kelly Sinead
- Keltz Melanie
- Kennedy Martin A
- Kertesz Andrew
- Kerwin Diana
- Khachaturian Zaven
- Kieburtz Karl
- Kielb Stephanie
- Kikuchi Masataka
- Killiany Ronald
- Kim Sungeun
- Kimbrel Nathan A
- Kircher Tilo T J
- Kittur Smita
- Kiyasova Vera
- Klein Marieke
- Knapp Michael
- Knodt Annchen R
- Knol Maria J
- Knopman David
- Kochunov Peter
- Koeppe Robert A
- Koleva Hristina
- Kolskår Knut
- Koops Sanne
- Kopil Catherine
- Korecka Magdalena
- Kowalksi Nancy
- Kowall Neil
- Kremen Sarah
- Kremen William S
- Krug Axel
- Krämer Bernd
- Kuller Lew
- Kwok John B
- Kwok John B J
- Lah James J
- Lam Max
- Lamar Melissa
- Lamb Ashley
- Lancaster Thomas M
- Landau Susan
- Lane Barton
- Lasch Shirley
- Launer Lenore
- Le Hellard Stephanie
- Leach Christi
- Leary Laura
- Lee Athena
- Lee Phil H
- Lee T-Y
- Lee Virginia
- Lemaitre Hervé
- Lenahan Art
- Leonard Gabriel
- Lerner Alan
- Lethbridge Emma
- Lett Tristram A
- Leverenz James
- Levey Allan I
- Lewis Lindsay
- Lewis Lindsay B
- Li Shuo
- Liang Grace
- Lim Kelvin O
- Lin Honghuang
- Lin Michael
- Lind Betty
- Lind Penelope A
- Linder Carly
- Lipowski Kristine
- Loeffler Markus
- Logovinsky Veronika
- Logue Mark
- Longstreth W. T.
- Longstreth William T
- Lopes-Cendes Iscia
- Lopez Oscar L
- Lopez Oscar L
- Lord Joanne L
- Loughland Carmel M
- Love Marissa Natelson
- Lu Po H
- Luciano Michelle
- Luciano Michelle
- Luykx Jurjen J
- Lyons Michael J
- Macciardi Fabio
- Maillard Pauline
- Maingault Sophie
- Makino Kelly M
- Malferrari Giulia
- Malloy Paul
- Marek Kenneth
- Mari Zoltan
- Marquand Andre F
- Marshall Gad A
- Marson Daniel
- Martin Kim
- Martin Nicholas G
- Martinot Jean-Luc
- Martinot Jean-Luc
- Martinot Marie-Laure Paillère
- Mason Sara S
- Mathalon Daniel H
- Mather Karen A
- Mather Karen A
- Mathews Dana
- Mathias Samuel R
- Mathis Chet
- Mattay Venkata S
- Matthews Brandy R
- Matthews Sarah
- Mayoral Van Son Jaqueline
- Mazoyer Bernard
- Mazoyer Bernard
- McCoy Arita
- McDonald Colm
- McEwen Sarah C
- McMahon Katie L
- McMahon Mary Agnes B
- Medland Sarah E
- Melle Ingrid
- Melzer Tracy R
- Mendick Susan
- Mesulam M Marcel
- Mesulam Marek-Marsel
- Meyer Javier Villanueva
- Meyer-Lindenberg Andreas
- Michie Patricia T
- Milaneschi Yuri
- Millenet Sabina
- Miller Bruce L
- Miller Delwyn D
- Miller Sarah
- Minton Mark
- Mintun Mark A
- Mintz Akiva
- Mintzer Jacobo
- Miranda Ruben
- Mirza-Schreiber Nazanin
- Mishra Aniket
- Mitsis Effie
- Mollenhauer Brit
- Monahan Nancy
- Montine Tom
- Moreira Jose C V
- Morey Rajendra A
- Morris Derek W
- Morris John
- Morris John C
- Mosley Thomas H
- Mosley Thomas H
- Mota Nina Roth
- Mowry Bryan
- Mudge Benita
- Mueller Bryon A
- Muglia Pierandrea
- Mule Jennifer
- Muni Donna
- Mühleisen Thomas W
- Müller-Myhsok Bertram
- Najt Pablo
- Nakahara Soichiro
- Nam Ki Won
- Nauck Matthias
- Neale Michael C
- Nees Frauke
- Neu Scott
- Nho Kwangsik
- Nho Kwangsik
- Niessen Wiro J
- Norbash Alexander
- Nordvik Jan E
- Nyberg Lars
- Nöthen Markus M
- O'Leary Daniel S
- Oakley MaryAnn
- Oates Elizabeth
- Obisesan Thomas O
- Obradov Sanja
- Ogrocki Paula
- Ogunlana Olu
- Olde Loohuis Loes M
- Olichney John
- Oliver Angela
- Onyike Chiadi
- Oosterlaan Jaap
- Opel Nils
- Ophoff Roel A
- Orfanos Dimitri Papadopoulos
- Ostrowizki Suzanne
- Ott Brian R
- Ottmann Ruth
- Oyonumo Ntekim E
- Pacini Nathaniel
- Paillere Marie-Laure
- Painter Jodie N
- Panizzon Matthew S
- Pantelis Christos
- Papadopoulos Dimitri
- Parfitt Francine
- Pasternak Stephen
- Paul Steven
- Paus Tomas
- Paus Tomáš
- Pausova Zdenka
- Pausova Zdenka
- Pavese Nicola
- Pavlik Valory
- Pavlosky William
- Pawluczyk Sonia
- Pearlson Godfrey D
- Pearson John F
- Penninx Brenda W J H
- Pentilla Jani
- Perron Michel
- Perry David
- Petersen Ronald
- Petrella Jeffrey R
- Pierce Aimee
- Pike G Bruce
- Pike G Bruce
- Pirpamer Lukas
- Pitcher Toni L
- Pizzagalli Fabrizio
- Poewe Werner
- Poki-Walker Kim
- Polderman Tinca J C
- Poline Jean-Baptiste
- Pomara Nunzio
- Porsteinsson Anton P
- Portillo Alicia
- Posthuma Danielle
- Potkin Steven
- Potter William
- Poustka Luise
- Preda Adrian
- Psaty Bruce M
- Pütz Benno
- Quiceno Mary
- Quidé Yann
- Quinlan Erin B
- Quinlan Erin Burke
- Quinn Joseph
- Rachinsky Irina
- Radtke Rodney
- Ragothaman Anjanibhargavi
- Raichle Marc
- Rainka Michelle
- Raj Balebail Ashok
- Ranola Madelaine
- Rapp Michael
- Rashid Faisal M
- Rasser Paul E
- Ratnakar Varun
- Ravdin Lisa
- Ravina Bernard
- Rawlins Ashlee
- Reay William R
- Redlich Ronny
- Reeder Stephanie
- Rees Linda
- Reiman Eric M
- Reinbold Céline S
- Reith Alastair D
- Relkin Norman
- Reppermund Simone
- Repple Jonathan
- Reynolds Brigid
- Richard Geneviève
- Richard Irene
- Richer Louis
- Riedel Brandalyn C
- Rietschel Marcella
- Riordan Cheryl
- Risacher Shannon L
- Robbins Trevor
- Robert Gabriel
- Rocha Cristiane S
- Rodriguez Rosemarie
- Roffman Joshua L
- Rogalski Emily
- Rogers John
- Rosen Allyson
- Rosen Howard J
- Roshchupkin Gennady V
- Roshchupkin Gennady V
- Rotter Jerome I
- Rountree Susan
- Rowe Dominic
- Rowland Laura M
- Rudolph Alice
- Ruggeri Barbara
- Russell David
- Saba Barbara
- Saba Yasaman
- Sachdev Perminder S
- Sachdev Perminder S
- Sadowski Martin
- Sadowsky Carl
- Salazar Jennifer
- Salloway Stephen
- Salminen Lauren
- Samuels Patricia
- Santulli Robert B
- Saremi Arvin
- Sarrael Antero
- Satizabal Claudia L
- Satizabal Claudia L
- Saykin Andrew J
- Saykin Andrew J
- Schall Ulrich
- Scharre Douglas W
- Schlag Fenja
- Schmaal Lianne
- Schmidt Helena
- Schmidt Reinhold
- Schmidt Reinhold
- Schneider Lon S
- Schneider Stacy
- Schofield Peter R
- Schofield Peter R
- Scholz Markus
- Schuff Norbert
- Schultz Susan K
- Schumann Gunter
- Schumann Gunter
- Scott Rodney J
- Secolin Rodrigo
- Seibyl John
- Seiler Stephan
- Seltzer Marc
- Senjem Matt
- Seppi Klaus
- Seshadri Sudha
- Seshadri Sudha
- Shah Bina
- Shah Raj C
- Shapland Chin Yang
- Shatokhina Natalia
- Shaw Leslie M
- Sheikh Mohammed O
- Shen Li
- Shen Li
- Sherer Todd
- Shianna Kevin
- Shibley Victoria
- Shill Holly
- Shim Hyungsub
- Shin Jean
- Shumskaya Elena
- Siderowf Andrew
- Silbert Lisa C
- Silverman Daniel H S
- Silverstein Rebecca
- Sim Kang
- Simpson Donna M
- Simuni Tanya
- Singleton Andrew
- Singleton-Garvin Jamika
- Sink Kaycee M
- Sirrel Sherye A
- Sisodiya Sanjay M
- Smith Amanda
- Smith Charles D
- Smith Karen Ekstam
- Smolka Michael
- Smoller Jordan W
- Snyder Peter
- Snyder Peter J
- Soares Holly
- Sommer Iris E
- Sorensen Greg
- Sosa Elizabeth
- Sossi Vesna
- Spann Bryan M
- Sperling Reisa A
- Spicer Kenneth
- Sprenger Fabienne
- Sprooten Emma
- St Pourcain Beate
- Standaert David
- Steen Vidar M
- Stefanovic Bojana
- Stein Dan J
- Stein Jason L
- Stern Matthew
- Stern Yaakov
- Strike Lachlan T
- Stringaris Argyris
- Swerdlow Russell H
- Sämann Philipp G
- Sønderby Ida E
- Tanner Caroline
- Tansey Katherine E
- Tarawneh Rawan
- Tariot Pierre
- Tatsuoka Curtis
- Taylor Joy L
- Taylor Peggy
- Taylor-Reinwald Lisa
- Teng Edmond
- Teodoro Liberty
- Tetrud James
- Teumer Alexander
- Teumer Alexander
- Thai Gaby
- Thal Leon
- Thalamuthu Anbupalam
- Thalamuthu Anbupalam
- Thomas Cathi-Ann
- Thomopoulos Sophia I
- Thompson Paul
- Thompson Paul M
- Tingus Kathleen
- Tinklenberg Jared
- Todd Gretchen
- Toga Arthur
- Toga Arthur W
- Toga Arthur W
- Tolosa Eduardo
- Tooney Paul A
- Tordesillas-Gutiérrez Diana
- Torres Fábio R
- Tran Baochan
- Tremont Geoffrey
- Trncic Nadira
- Trojanowki John Q
- Trollor Julian
- Trollor Julian N
- Turner Jessica A
- Turner Raymond Scott
- Tzourio Christophe
- Uhlmann Anne
- Uitterlinden André G
- Ulysse Anaztasia
- Umek Robert
- Uribe Liz
- Vaishnavi Sanjeev
- Vallerga Costanza Ludovica
- van 't Ent Dennis
- van der Brug Marcel
- van der Lee Sven J
- van der Meer Dennis
- Van der Wee Nic J A
- van Donkelaar Marjolein M J
- van Duijn Cornelia M
- van Dyck Christopher H
- van Eijk Liza
- van Erp Theo G M
- van Haren Neeltje E M
- van Noort Betteke
- van Rooij Daan
- van Tol Marie-José
- Vanderswag Helen
- Varma Pradeep
- Veillette Suzanne
- Veldink Jan H
- Veltman Dick J
- Vemuri Prashanthi
- Venkov Heli
- Verhoef Ellen
- Vernooij Meike W
- Villena Teresa
- Villringer Arno
- Voyvodic James T
- Völker Uwe
- Völzke Henry
- Walter Henrik
- Walter Henrik
- Walter Sarah
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Ward Chad
- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
- Weiner Michael
- Weiner Michael W
- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
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- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
- Author
- Aanniz Tarek
- Abar Aden Elmi
- Abbad Anass
- Abdelfattah May
- Abdelhamid W.
- Abdella Saro
- Abdellah Faouzi
- Abdelmjid El Oualid
- Abdelmoula Fatma
- Abdelmoulah F.
- Abderrahmane Maaroufi
- Abderrazak Rfaki
- Abdillahi Idil Salah
- Abdissa Alemseged
- Abdo I.
- Abdoelraheem Mohamed Hassan
- Abe Haruka
- Abebe Markos
- Abechi Priscilla
- Abera Adugna
- Abi Rachid
- Abias Abe G.
- Abichu Getachew
- Abid N.
- Abid Nabil
- Abid Salma
- Abilio Nuro
- Abimbola Sharon
- Abo Shama Noura M
- Abosede O.
- Aboubaker Mohamed Houmed
- Abouelhoda Mohamed
- Abouelnaga S.
- Abualas Elamin
- Abubeker Ramalia Chabi
- Abuelenein Ehab Abdelkader
- Abuzaid Nadir
- Abworo Edward O.
- Ada Diosdado Odjama Nseng
- Addidle Michael
- Adegbola Richard
- Adegnika Akim A.
- Adegnika Ayola Akim
- Adel Abd Monaem
- Adeniji Johnson A.
- Adepetun Tomiwa
- Adesegun A.
- Adesuyi Omoare
- Adetifa Ifedayo M. O.
- Adewumi Olubusuyi M.
- Adewumi Oluwatimilehin
- Adewumi Praise
- Adeyemi Kayode T.
- Adhikari Bishwo N.
- Adil El Hamouchi
- Adjiratou Aissatou B. A.
- Adnew Bethlehem
- Adu Bright
- Adu Eric
- Adusei-Poku Mildred
- Agbenyo Seyram Bless
- Agbodzi B.
- Ageez A.M.
- Agoti Charles N.
- Aguenaou Hassan
- Agwa Sara Hassan
- Agweyu Ambrose
- Ahmed El Bara
- Ahmed Elhadi A.
- Ahmed Hatem
- Ahmed M.
- Ahmed O. S.
- Ahmed Rahma
- Ahmed Shymaa S.
- Ahmed Side Mohamed
- Ahmed Yahaya Ali
- Ahouidi Ambroise
- Ahuka-Mundeke Steve
- Ahumibe Anthony
- Ahyong Vida
- Aissam El Aliani
- Ajayi Nnennaya A.
- Ajibaye Solomon
- Ajili F.
- Ajogbasile F.V.
- Ajogbasile Fehintola V.
- Akanbi Olusola Anuoluwapo
- Akenji Blaise MBoringong
- Akhoud Youssef
- Akinola Monilade
- Akogbeto Petas
- Akoua-Koffi Chantal G.
- Akpede George O.
- Al Onifade Fattah
- Alain Etoundi Mballa
- Alaoui Afaf
- Alaoui-Amine Sanaa
- Alarif Ahlam
- Alaruusi A. M.
- Albert Mélanie
- AlEmam Adba Alfatih
- Alemayehu Dawit Hailu
- Alemu Fekadu
- Algheriani Raiva
- Ali Abraham
- Ali M.A.
- Ali Mohamed Ahmed
- Ali Mushal
- Ali Wael
- Alkarim Mona O.A.
- Allam Loubna
- Allam Mushal
- Allam Mushal
- Altamura Settimia
- Amar Narjis
- Amenga-Etego Lucas N.
- Amer K. E.
- Amer Khaled
- Amira Souissi
- Amoako Daniel G.
- Amoo Olufemi Samuel
- Amoth Patrick
- Amougou Marie
- Ampofo William K.
- Amuri Adrienne A.
- Amuzu Dominic S. Y.
- Amzazi Saaïd
- Anang Abraham Kwabena
- Anas Abbad
- Andeko Julia C.
- Andersen Kristian
- Andersson Hana Sofia
- Andika Brian
- Andres Moreira-Soto
- Andriam Soa Fy
- Andriamandimby Soa Fy
- Anga Latifa
- Ange Dossou
- Angelov Angel
- Anna-Lena Sander
- Annajr B.
- Anoh Etilé A.
- Anscombe Catherine
- Antwerpen Markus H.
- Anu Campbell
- Anyaneji Ugochukwu J.
- Anyika Chinyere
- Aouni M.
- Appiah Vincent
- Appiah-Kubi Joyce
- Arena Fabio
- Arjaquah Augustina
- Arjarquah A.
- Armand Edang-Minko
- Armanious Riad Mounir
- Armoo Samuel
- Arnaldo Paulo
- Arnold Catherine E.
- Arrouchi Housna
- Artesi Maria
- Aryeetey Sherihane
- Asamoah Jesse Addo
- Asante Ivy A.
- Asare K.M.
- Ashton Philip
- Ashton Phillip
- Asiedu Ernest
- Asiedu-Bekoe Franklyn Egbe
- Asiimwe Stephen
- Askander Omar
- Asmamaw Kominist
- Assane Hamadi
- Assoumou Samira Zoa
- Atiga N.
- Attiku Keren Okyerebea
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- Ayivor-Djanie Reuben
- Aymane Bouzidi
- Ayo-Ale B.
- Ayoade F.
- Ayoola Joy
- Ayouba Ahidjo
- Aziz Ramy Karam
- Aziza Amuri
- Azman Andrew
- Aïssi Melchior A. Joël
- Ba-Diallo Awa
- Babatunde Sunday
- Baboo S. B.
- Badjo Ange
- Badou Yvette
- Bagaya Bernard Ssentalo
- Bah Mamadou Saliou
- Bahadoor B. S.
- Bahnassy A.A.
- Bajjou Tahar
- Baker David
- Baker Noah
- Bakhash Shah Mohamed
- Bakry U.
- Balde Aladje
- Balde Aladje
- Balm Michelle
- Bamourou Diané
- Banda R.
- Bane S.
- Barasa Edwine
- Barbet Marion
- Bareng Ontlametse T.
- Barilar Ivan
- Barkat Amina
- Barnes Kayla
- Barreh Guedi Ali
- Bashein Abdulla
- Bassène Hubert
- Batchi-Bouyou Armel L.
- Batchi-Bouyou Armel L.
- Bates Matthew
- Batra Dhwani
- Batra R.
- Bauer Peter
- Baxter Cheryl
- Bayih Abebe Genetu
- Bbosa Nicholas
- Bedford Trevor
- Bediako Yaw
- Bedié
- Bedri Shahinaz.A.
- Behillil Sylvie
- Bejon Philip
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- Djomsi Dowbiss Meta
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- Fares Wasfi
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- Gevao Sahr
- Gharmaz Hamza
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- Ghita Amalou
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- Hosch Salome
- Houda Harmak
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- Hounkanrin Gildas
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- Howard Julia
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- Iwalokun Bamidele
- Iyanu Fred-Akintunwa
- Jain Komal
- Jalal D.
- Jalal Nourlil
- Jalloh Simbirie
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- James Ayorinde Babatunde
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- Jefferies Sarah
- Jegede-Williams Anu
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- Johane Shirley
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- Joseph Rageema
- Jouali Farah
- Jumaa A.B.
- Juru Agnes
- Kabamba Gabriel
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- Kabatesi Francisca
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- Kandeil Ahmed
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- Kane Mouhamed
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- Laatiris Abdelkader
- Ladhari Hafsia
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- Lahlou Amine Idriss
- Lahlou Idriss-Amine
- Lahlou Kitane Driss
- Lako Richard Lino Loro
- Lalemi Mary
- Lambisia Arnold W.
- Lamboni Lallepak
- Lamiae Belayachi
- Langat Sombo
- Laraqui Abdelilah
- Laryea Dennis
- Latif Elwaleed M. Elamin Sara A.I
- Latifa Anga
- Layibo Yasser
- Le Viet Thanh
- Le-Viet Thanh
- Lee Justin
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- Leendertz Fabian
- Lefrançois Louise
- Lekana-Douki Bernard
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- Lell Bertrand
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- Leta D.
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- Liberator Paul
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- Lima Mendonça Maria da Luz
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- Lo Gora
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- Maiga Mamoudou
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- Manangazira Portia
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- Manneh Jarra
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- Marais Gert
- Marcello Alessandro
- Mareka Mathabo
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- Massinga Arsenia
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- Matshaba Mogomotsi
- Matsheka Maitshwarelo I.
- Maufrais Corinne
- Mavingui Patrick
- Mayaphi Sim
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- Mbanne Maimouna
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- Mbegnan Coulibaly
- Mbembo Guy Paterne Malonga
- Mbhele Nokuzola
- Mbondoukwe Noé Patrick
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- Micelli Loris
- Micheli Valeria
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- Mohammed Khadija Said
- Mohammed Oumaima Ait Si
- Mohammed Youbi
- Mohktar Quaneeta
- Mohr Vanessa
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- Mouallif Mustapha
- Mouangala Davy Leger
- Mouhssine Hemlali
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- Mulonga Kangwa
- Mulu Andargachew
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- Mveang-Nzoghe Amandine
- Mvula Bernard
- Mwangi Milkah
- Mwangi Sarah Wambui
- Mwangomba W.
- Mwebesa Henry
- Mwenda Mulenga
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- Werno Anja
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- Wuduri Zara
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- Xavier Joicymara S.
- Xiang Zuzheng
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- Yadouleton Anges
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- Yakout Mostfa
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- Yang Qi
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- Yatassaye Bouna
- Yeboah C.
- Yeboah Richmond
- Yeboah-Manu Dorothy
- Yemi Bright K.
- Yiaba Cyrus
- Yiaba Warren Cyrus
- Yu Popova A.
- Yusuf Nyam Itse
- Yusuf Yacob Mohamed
- Zablon J. Matoke D.
- Zablon J.O.
- Zaher Tarek Refaat Elnagdy Raafat
- Zahra El Ansari Fatima
- Zahran Manal Hamdy
- Zekri Abdel-Rahman N.
- Zhang J.
- Zhou Pei
- Zinyowera Sekesai
- Zong Minko O.
- Zongo Arsène
- Zorgani A.
- Zouaki Amal
- Zulu P.
- Zumla Ali
- Zumla Alimuddin
- Zuze Boitumelo
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 07/10/2022
- Field of study
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
Correction: A Genetic Screen for Dihydropyridine (DHP)-Resistant Worms Reveals New Residues Required for DHP-Blockage of Mammalian Calcium Channels
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- Publication venue
- Public Library of Science
- Publication date
- 01/02/2009
- Field of study
High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans
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- AK Jones
- Al Howard
- Andrew R Burns
- Anthony Chan
- BR Stockwell
- D Kokel
- D Weinshenker
- Ed Houston
- EM Link
- JA Dent
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- JA Lewis
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- JE Sulston
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- K Evason
- Karl Johanson
- KG Miller
- M Driscoll
- M Nguyen
- ML Edgley
- MR Lackner
- P Anderson
- P Lang
- Peter J Roy
- Peter McCourt
- RK Choy
- S Brenner
- Sean R Cutler
- SR Wicks
- T Kaletta
- TC Kwok
- Trevor C Y Kwok
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Nanopore-Based Target Sequence Detection
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- A Naing
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- A Uddin
- AC Syvänen
- AJ Storm
- AO Tillmar
- AT Carlsen
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- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
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m6A RNA Methylation Controls Neural Development and Is Involved in Human Diseases
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- A Bertero
- A Klungland
- A McCloskey
- A Sobczyk-Kopciol
- AJ Ho
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- JM Fustin
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- KJ Yoon
- Kunzhao Du
- LE Rajagopalan
- Longbin Zhang
- M Bartosovic
- M Landthaler
- M Linnebacher
- M Namima
- ME Hess
- N Liu
- P Gulati
- P Knuckles
- P Narayan
- P Wang
- PJ Batista
- Q Cui
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- R Levis
- RI Gregory
- S Boissel
- S Chen-Kiang
- S Geula
- S Ke
- S Lin
- S Schwartz
- S Schwartz
- S Smemo
- S Zhang
- S Zhong
- SD Agarwala
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- T Gerken
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- TM Frayling
- Trevor Lee
- W Xiao
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- Y Nishizawa
- Y Wang
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- Z Bodi
- Z Bodi
- Z Choudhry
- Z Cienikova
- Z Xi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Observation of Gravitational Waves from the Coalescence of a 2.5−4.5 M⊙ Compact Object and a Neutron Star
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- Abac A.G
- Abbott R
- Abchouyeh M. Aghaei
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- Adkins V.K
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- Aguilar I
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- Ajith P
- Akutsu T
- Akçay S
- Al-Jodah A
- Al-Shammari S
- Albanesi S
- Alfaidi R.A
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- Amato A
- Amez-Droz L
- Amorosi A
- Amra C
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- Anderson S.B
- Anderson W.G
- Andia M
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- Andrade T
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- Andrés-Carcasona M
- Anglin J
- Ansoldi S
- Antelis J.M
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- Aoumi M
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- Zhao Yuhang
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- Zhu Z.-H
- Zimmerman A.B
- Zucker M.E
- Zweizig J
- Publication venue
- HAL CCSD
- Publication date
- 12/06/2024
- Field of study
International audienceWe report the observation of a coalescing compact binary with component masses 2.5−4.5 M⊙ and 1.2−2.0 M⊙ (all measurements quoted at the 90% credible level). The gravitational-wave signal GW230529_181500 was observed during the fourth observing run of the LIGO-Virgo-KAGRA detector network on 2023 May 29 by the LIGO Livingston Observatory. The primary component of the source has a mass less than 5 M⊙ at 99% credibility. We cannot definitively determine from gravitational-wave data alone whether either component of the source is a neutron star or a black hole. However, given existing estimates of the maximum neutron star mass, we find the most probable interpretation of the source to be the coalescence of a neutron star with a black hole that has a mass between the most massive neutron stars and the least massive black holes observed in the Galaxy. We estimate a merger rate density of 55−47+127 Gpc−3yr−1 for compact binary coalescences with properties similar to the source of GW230529_181500; assuming that the source is a neutron star-black hole merger, GW230529_181500-like sources constitute about 60% of the total merger rate inferred for neutron star-black hole coalescences. The discovery of this system implies an increase in the expected rate of neutron star-black hole mergers with electromagnetic counterparts and provides further evidence for compact objects existing within the purported lower mass gap