The consolidation and effectiveness of matrix support in mental health in Brazil - bottlenecks and challenges

Passados dez anos da implementação do apoio matricial nas redes de saúde por meio dos Núcleos de Apoio à Saúde da Família, ainda sente-se a falta de dados consistentes quanto à consolidação e efetividade desse arranjo. Nesse sentido, este estudo teve como objetivo revisar a bibliografia nacional dos últimos dez anos a fim de identificar os impasses e desafios vivenciados no apoio matricial em saúde mental na Atenção Primária, classificando-os a partir de uma reconstrução teórico-conceitual e fazendo uma articulação destes com os desafios pontuados em congêneres internacionais do apoio matricial. Entre os principais pontos levantados pelo estudo, destacou-se a necessidade de delineamentos claros para prática de matriciamento; investimento maciço em formação e capacitação dos profissionais; e criação de espaços institucionalizados com encontros sistemáticos dos profissionais para discussão dos casos e avaliação conjunta do andamento das atividades23COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESsem informaçãoTen years on from the introduction of matrix support in health networks through the creation of Family Health Support Centers, there is still a lack of consistent data to measure the success of consolidation and effectiveness of this arrangement. With this in mind, we conducted a literature review of national articles produced over the last ten years to identify the bottlenecks and challenges faced by matrix support in mental health in Primary Care. The problems were classified using a theoretical and conceptual reconstruction and drawing on similar experiences with matrix support in other countries. The following key points emerged from the review: the need to provide clear guidelines for matrix support; the need for major investment in training and capacity building; and the need to create institutionalized spaces to foster systematic communication between professionals to discuss cases and promote joint evaluation of the progress of activitie

Produção de biogás por digestão em fase sólida de cama de frango.

RESUMO: A cama de frango é um resíduo da atividade avícola, que é gerado em grandes quantidades, e quando mal manuseado tem elevado potencial poluidor. No entanto, é possível aproveitar este resíduo para geração de biogás, contudo este substrato apresenta desafios devido a baixa umidade e composição química. Diante deste contexto, a digestão em fase sólida se destaca como um processo promissor pelo fato de evitar o manejo ou póstratamento da água derivada do processo. O objetivo do presente estudo foi avaliar a eficiência da produção de biogás de cama de frango em um reator anaeróbio de fase sólida (RDFS) operado em batelada. Ao realizar o processo de digestão em fase sólida, verificouse que este sistema apresentou um rendimento de biogás de 90,30 mLNbiogás.gSVadic -1 ,quando comparado ao valor de referência do teste do potencial bioquímico de biogás que foi de 281 mLNbiogás.gSVadic -1 , a eficiência foi de 32 % após 30 dias de digestão. No entanto, o teor de sólidos totais que o RDFS pode operar é de 30 %, enquanto que a digestão úmida a concentração de sólidos totais é em média de 10%. Neste caso utilizando o RDFS estaremos economizando líquido para diluição do substrato, e este é um sistema robusto, de fácil monitoramento que pode ser utilizado pelos avicultores, podendo ainda ser otimizado para melhoria do sistema e assim aumentar a eficiência de produção de biogás. ABSTRACT: The poultry litter is a residue from poultry activity, which is generated in large quantities and, when poorly handled, presents a high polluting potential. It is possible to take advantage of this residue to generate biogas, however this substrate consists in a challenging material due to its humidity and chemical composition. In this context, solid-state digestion stands out as a promising process because it prevents the handling or post-treatment of water derived from the process. The goal of the present study was to evaluate the efficiency of production of poultry litter biogas in a solid phase anaerobic reactor operated in batch. When carrying out the solid phase digestion process, it was verified that this system presented a biogas production of 90,30 mLNbiogas.gSVadd -1 . When comparing this to the reference value of the biochemical potential of biogas test, which is 281 mLNbiogas.gSVadd -1 , the efficiency attained was 32% at the 30-day of digestion However, the total solids content that the RDFS can operate is 30%, while the wet digestion at the total solids concentration is on average 10%. In this case using the RDFS we will be saving liquid for dilution of the substrate, and this is a robust system, easy to monitor that can be used by poultry farmers and can be optimized for system improvement and thus increase biogas production efficiency

A method of estimation of the dynamical age of FR II-type radio sources from multifrequency data

We propose a new approach in determining ages of FR II type radio sources. We apply the assumed dynamical model of Kaiser et al. (1997) to a number of FR II type radio galaxies observed at different radio frequencies, and fit - for each frequency separately - the model free parameters to the observed sources' quantities. Such a procedure, using enlarged in fact a number of observables, enables us to determine relatively precise ages and other crucial characteristics of the analyzed sources. The resulting age estimates agree very well with those obtained by means of `classical' spectral ageing method for objects not older than 10 Myr, for which good-quality spectral data are available. The presented method is however also applicable in the case of the sources older than this, and/or the ones for which the only available low-resolution radio data do not allow for detailed spectral ageing studies. Our analysis indicates that the main factor precluding precise age determination for FR II type radio galaxies regards the poorly known shape of the initial electron energy distribution injected by the jet terminal shocks to the expanding lobes/cocoons. We briefly consider this issue, and conclude that the broad-band single power-law form assumed here may be accurate enough for the presented estimates, although most likely it does not strictly correspond to some well-defined realistic particle acceleration process. Instead, it should be considered as a simplest model approximation of the initial electron continuum, averaged over a very broad energy range and over the age of the source, with the effective spectral index which may be different for different sources.Comment: 15 pages, 9 figures included. Accepted for publication in A&

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies

PMCID: PMC3581439This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Atmospheric Muon Flux at Sea Level, Underground, and Underwater

The vertical sea-level muon spectrum at energies above 1 GeV and the underground/underwater muon intensities at depths up to 18 km w.e. are calculated. The results are particularly collated with a great body of the ground-level, underground, and underwater muon data. In the hadron-cascade calculations, the growth with energy of inelastic cross sections and pion, kaon, and nucleon generation in pion-nucleus collisions are taken into account. For evaluating the prompt muon contribution to the muon flux, we apply two phenomenological approaches to the charm production problem: the recombination quark-parton model and the quark-gluon string model. To solve the muon transport equation at large depths of homogeneous medium, a semi-analytical method is used. The simple fitting formulas describing our numerical results are given. Our analysis shows that, at depths up to 6-7 km w. e., essentially all underground data on the muon intensity correlate with each other and with predicted depth-intensity relation for conventional muons to within 10%. However, the high-energy sea-level data as well as the data at large depths are contradictory and cannot be quantitatively decribed by a single nuclear-cascade model.Comment: 47 pages, REVTeX, 15 EPS figures included; recent experimental data and references added, typos correcte

E-Cadherin Acts as a Regulator of Transcripts Associated with a Wide Range of Cellular Processes in Mouse Embryonic Stem Cells

We have recently shown that expression of the cell adhesion molecule E-cadherin is required for LIF-dependent pluripotency of mouse embryonic stem (ES) cells.In this study, we have assessed global transcript expression in E-cadherin null (Ecad-/-) ES cells cultured in either the presence or absence of LIF and compared these to the parental cell line wtD3.We show that LIF has little effect on the transcript profile of Ecad-/- ES cells, with statistically significant transcript alterations observed only for Sp8 and Stat3. Comparison of Ecad-/- and wtD3 ES cells cultured in LIF demonstrated significant alterations in the transcript profile, with effects not only confined to cell adhesion and motility but also affecting, for example, primary metabolic processes, catabolism and genes associated with apoptosis. Ecad-/- ES cells share similar, although not identical, gene expression profiles to epiblast-derived pluripotent stem cells, suggesting that E-cadherin expression may inhibit inner cell mass to epiblast transition. We further show that Ecad-/- ES cells maintain a functional β-catenin pool that is able to induce β-catenin/TCF-mediated transactivation but, contrary to previous findings, do not display endogenous β-catenin/TCF-mediated transactivation. We conclude that loss of E-cadherin in mouse ES cells leads to significant transcript alterations independently of β-catenin/TCF transactivation

Non-Redundant Selector and Growth-Promoting Functions of Two Sister Genes, buttonhead and Sp1, in Drosophila Leg Development

The radically distinct morphologies of arthropod and tetrapod legs argue that these appendages do not share a common evolutionary origin. Yet, despite dramatic differences in morphology, it has been known for some time that transcription factors encoded by the Distalless (Dll)/Dlx gene family play a critical role in the development of both structures. Here we show that a second transcription factor family encoded by the Sp8 gene family, previously implicated in vertebrate limb development, also plays an early and fundamental role in arthropod leg development. By simultaneously removing the function of two Sp8 orthologs, buttonhead (btd) and Sp1, during Drosophila embryogenesis, we find that adult leg development is completely abolished. Remarkably, in the absence of these factors, transformations from ventral to dorsal appendage identities are observed, suggesting that adult dorsal fates become derepressed when ventral fates are eliminated. Further, we show that Sp1 plays a much more important role in ventral appendage specification than btd and that Sp1 lies genetically upstream of Dll. In addition to these selector-like gene functions, Sp1 and btd are also required during larval stages for the growth of the leg. Vertebrate Sp8 can rescue many of the functions of the Drosophila genes, arguing that these activities have been conserved, despite more than 500 million years of independent evolution. These observations suggest that an ancient Sp8/Dlx gene cassette was used in an early metazoan for primitive limb-like outgrowths and that this cassette was co-opted multiple times for appendage formation in multiple animal phyla

Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Interferon Alpha

Work carried out by JM was funded by the National Institutes of Health (NIH). NIH contract number is HHSN272201000039I/HHSN27200001/ A19

New limit on neutrinoless double β decay in ^(136)Xe with a time projection chamber

A xenon time projection chamber with an active volume of 207 L has been built to study neutrinoless double β decay in ^(136)Xe. Data were taken in the Gotthard Underground Laboratory, with 5 atm of xenon enriched to 62.5% in ^(136)Xe. From 3380 h of data, no evidence has been found for the 0ν 0^(+)→0^(+) transition. Half-life limits of T_(1/2)^(0ν)>2.5(4.9)×10^(23) yr in the mass-mechanism mode and T_(1/2)^(0ν)>1.7(3.2)×10^(23) yr in the right-handed-current mode, at the 90(68)% C.L., were derived. An upper limit for the Majorana neutrino mass parameter was deduced