Impeded inverse energy transfer in the Charney--Hasegawa--Mima model of quasi-geostrophic flows

The behaviour of turbulent flows within the single-layer quasi-geostrophic (Charney-Hasegawa-Mima) model is shown to be strongly dependent on the Rossby deformation wavenumber lambda (or free-surface elasticity). Herein, we derive a bound oil the inverse energy transfer, specifically on the growth rate dl/dt of the characteristic length scale e representing the energy centroid. It is found that dl/dt = l(s) >> lambda(-1)) the inverse energy transfer is strongly impeded, in the sense that under the usual time scale no significant transfer of energy to larger scales occurs. The physical implication is that the elasticity of the free surface impedes turbulent energy transfer in wavenumber space, effectively rendering large-scale vortices long-lived and inactive. Results from numerical simulations of forced-dissipative turbulence confirm this prediction.Publisher PDFPeer reviewe

Revisiting Batchelor's theory of two-dimensional turbulence

Recent mathematical results have shown that a central assumption in the theory of two-dimensional turbulence proposed by Batchelor (Phys. Fluids, vol. 12, 1969, p. 233) is false. That theory, which predicts a X-2/3 k(-1) enstrophy spectrum in the inertial range of freely-decaying turbulence, and which has evidently been successful in describing certain aspects of numerical simulations at high Reynolds numbers Re, assumes that there is a finite, non-zero enstrophy dissipation X in the limit of infinite Re. This, however, is not true for flows having finite vorticity. The enstrophy dissipation in fact vanishes. We revisit Batchelor's theory and propose a simple modification of it to ensure vanishing X in the limit Re -> infinity. Our proposal is supported by high Reynolds number simulations which confirm that X decays like 1/ln Re, and which, following the time of peak enstrophy dissipation, exhibit enstrophy spectra containing an increasing proportion of the total enstrophy (omega(2))/2 in the inertial range as Re increases. Together with the mathematical analysis of vanishing X, these observations motivate a straightforward and, indeed, alarmingly simple modification of Batchelor's theory: just replace Batchelor's enstrophy spectrum X(2/3)k(-1) with (omega(2))k(-1)(In Re)(-1).Publisher PDFPeer reviewe

TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis

Truncating mutations in the tumor suppressor gene adenomatous polyposis coli (APC) are the initiating step in the vast majority of sporadic colorectal cancers, and they underlie familial adenomatous polyposis (FAP) syndromes. Modeling of APC- driven tumor formation in the mouse has contributed substantially to our mechanistic understanding of the associated disease, but additional models are needed to explore therapeutic opportunities and overcome current limitations of mouse models. We report on a novel and penetrant genetic cancer model in Xenopus tropicalis, an aquatic tetrapod vertebrate with external development, diploid genome and short life cycle. Tadpoles and froglets derived from embryos injected with TAL effector nucleases targeting the apc gene rapidly developed intestinal hyperplasia and other neoplasms observed in FAP patients, including desmoid tumors and medulloblastomas. Bi-allelic apc mutations causing frame shifts were detected in the tumors, which displayed activation of the Wnt/β-catenin pathway and showed increased cellular proliferation. We further demonstrate that simultaneous double bi-allelic mutation of apc and a non-relevant gene is possible in the neoplasias, opening the door for identification and characterization of effector or modifier genes in tumors expressing truncated apc. Our results demonstrate the power of modeling human cancer in Xenopus tropicalis using mosaic TALEN-mediated bi-allelic gene disruption

Shared larval rearing environment, sex, female size and genetic diversity shape Ae. albopictus bacterial microbiota

The Asian tiger mosquito Aedes albopictus became of public health concern as it can replicate and transmit viral and filarial pathogens with a strong invasive success over the world. Various strategies have been proposed to reduce mosquito population's vectorial capacity. Among them, symbiotic control of mosquito borne disease offers promising perspectives. Such method is likely to be affected by the dynamics of mosquito-associated symbiotic communities, which might in turn be affected by host genotype and environment. Our previous study suggested a correlation between mosquitoes' origin, genetic diversity and midgut bacterial diversity. To distinguish the impact of those factors, we have been studying the midgut bacterial microbiota of two Ae. albopictus populations from tropical (La Re A union) and temperate (Montpellier) origins under controlled laboratory conditions. the two populations experienced random mating or genetic bottleneck. Microbiota composition did not highlight any variation of the alpha and beta-diversities in bacterial communities related to host's populations. However, sizes of the mosquitoes were negatively correlated with the bacterial a-diversity of females. Variations in mosquito sex were associated with a shift in the composition of bacterial microbiota. The females' mosquitoes also exhibited changes in the microbiota composition according to their size and after experiencing a reduction of their genetic diversity. These results provide a framework to investigate the impact of population dynamics on the symbiotic communities associated with the tiger mosquito.Peer reviewe

Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids

BACKGROUND:Because Plasmodium falciparum displays increase tolerance against the recommended artemisinin combination therapies (ACT), new classes of anti-malarial drugs are urgently required. Previously synthesized artemisinin-aminoquinoline hybrids were evaluated to ascertain whether the potent low nanomolar in vitro anti-plasmodial activity would carry over in vivo against Plasmodium vinckei. A snapshot pharmacokinetic analysis was carried out on one of the hybrids to obtain an indication of the pharmacokinetic properties of this class of anti-malarial drugs. METHODS: In vitro activity of hybrids 2 and 3 were determined against the 3D7 strain of P. falciparum. Plasmodium vinckei-infected mice were treated with hybrids 1 - 3 for four days at a dosage of 0.8mg/kg, 2.5mg/kg, 7.5mg/kg or 15mg/kg intraperitoneally (ip), or orally (per os) with 2.7mg/kg, 8.3mg/kg, 25mg/kg or 50mg/kg. Artesunate was used as reference drug. A snapshot oral and IV pharmacokinetic study was performed on hybrid 2. RESULTS: Hybrids 1 - 3 displayed potent in vivo anti-malarial activity with ED50 of 1.1, 1.4 and <0.8mg/kg by the ip route and 12, 16 and 13mg/kg per os, respectively. Long-term monitoring of parasitaemia showed a complete cure of mice (without recrudescence) at 15mg/kg via ip route and at 50mg/kg by oral route for hybrid 1 and 2, whereas artesunate was only able to provide a complete cure at 30mg/kg ip and 80mg/kg per os. CONCLUSIONS: These compounds provide a new class of desperately needed anti-malarial drug. Despite a short half-life and moderate oral bioavailability, this class of compounds was able to cure malaria in mice at very low dosages. The optimum linker length for anti-malarial activity was found to be a diaminoalkyl chain consisting of two carbon atoms either methylated or unmethylated

Interacting Galaxies in the A901/902 Supercluster with STAGES

We present a study of galaxy mergers and the influence of environment in the Abell 901/902 supercluster at z~0.165. We use HST ACS F606W data from the STAGES survey, COMBO-17, Spitzer 24um, and XMM-Newton X-ray data. Our analysis utilizes both a visual classification system, and quantitative CAS parameters to identify systems which show evidence of a recent or ongoing merger of mass ratio >1/10. Our results are: (1) After visual classification and minimizing the contamination from false projection pairs, we find that the merger fraction f_merge is 0.023+/-0.007. The estimated fractions of likely major mergers, likely minor mergers, and ambiguous cases are 0.01+/-0.004, 0.006+/-0.003, and 0.007+/-0.003, respectively. (2) The mergers lie outside the cluster core of radius R < 0.25 Mpc: the lack of mergers in the core is likely due to the large galaxy velocity dispersion in the core. Mergers populate the region (0.25 Mpc < R <= 2 Mpc) between the core and outskirt. In this region, the estimated frequency of mergers is similar to those seen at typical group overdensities. This suggests ongoing growth of the clusters via accretion of group and field galaxies. (3) We compare our observed merger fraction with those reported in other clusters and groups out to z~0.4. Existing data points on the merger fraction for L<= L* galaxies in clusters allow for a range of evolutionary scenarios. (4) The fraction of mergers, which lie on the blue cloud is 80%+/-18% versus 34%+/-7% for non-interacting galaxies, implying that interacting galaxies are preferentially blue. (5) The average SFR, based on UV or UV+IR data, is enhanced by a factor of ~1.5 to 2 in mergers compared to non-interacting galaxies. However, mergers in the clusters contribute only a small fraction (between 10% and 15%) of the total SFR density.(Abridged)Comment: Accepted for publication in ApJ. 34 pages, 16 figures. Version with full resolution figures available at: http://www.as.utexas.edu/~alh/apj/int/ ; updated abridged abstrac

The Growth of Massive Galaxies Since z=2

We study the growth of massive galaxies from z=2 to the present using data from the NEWFIRM Medium Band Survey. The sample is selected at a constant number density of n=2x10^-4 Mpc^-3, so that galaxies at different epochs can be compared in a meaningful way. We show that the stellar mass of galaxies at this number density has increased by a factor of ~2 since z=2, following the relation log(M)=11.45-0.15z. In order to determine at what physical radii this mass growth occurred we construct very deep stacked rest-frame R-band images at redshifts z=0.6, 1.1, 1.6, and 2.0. These image stacks of typically 70-80 galaxies enable us to characterize the stellar distribution to surface brightness limits of ~28.5 mag/arcsec^2. We find that massive galaxies gradually built up their outer regions over the past 10 Gyr. The mass within a radius of r=5 kpc is nearly constant with redshift whereas the mass at 5-75 kpc has increased by a factor of ~4 since z=2. Parameterizing the surface brightness profiles we find that the effective radius and Sersic n parameter evolve as r_e~(1+z)^-1.3 and n~(1+z)^-1.0 respectively. The data demonstrate that massive galaxies have grown mostly inside-out, assembling their extended stellar halos around compact, dense cores with possibly exponential radial density distributions. Comparing the observed mass evolution to the average star formation rates of the galaxies we find that the growth is likely dominated by mergers, as in-situ star formation can only account for ~20% of the mass build-up from z=2 to z=0. The main uncertainties in this study are possible redshift-dependent systematic errors in the total stellar masses and the conversion from light-weighted to mass-weighted radial profiles.Comment: Accepted for publication in the Astrophysical Journal. 26 pages, 13 figures in main tex