Quantum key distribution without alternative measurements

Entanglement swapping between Einstein-Podolsky-Rosen (EPR) pairs can be used to generate the same sequence of random bits in two remote places. A quantum key distribution protocol based on this idea is described. The scheme exhibits the following features. (a) It does not require that Alice and Bob choose between alternative measurements, therefore improving the rate of generated bits by transmitted qubit. (b) It allows Alice and Bob to generate a key of arbitrary length using a single quantum system (three EPR pairs), instead of a long sequence of them. (c) Detecting Eve requires the comparison of fewer bits. (d) Entanglement is an essential ingredient. The scheme assumes reliable measurements of the Bell operator.Comment: REVTeX, 5 pages, 2 figures. Published version with some comment

``Plug and play'' systems for quantum cryptography

We present a time-multiplexed interferometer based on Faraday mirrors, and apply it to quantum key distribution. The interfering pulses follow exactly the same spatial path, ensuring very high stability and self balancing. Use of Faraday mirrors compensates automatically any birefringence effects and polarization dependent losses in the transmitting fiber. First experimental results show a fringe visibility of 0.9984 for a 23km-long interferometer, based on installed telecom fibers.Comment: LaTex, 6 pages, with 2 Postscript figures, Submitted to Applied Physics Letter

HYPERION: An open-source parallelized three-dimensional dust continuum radiative transfer code

HYPERION is a new three-dimensional dust continuum Monte-Carlo radiative transfer code that is designed to be as generic as possible, allowing radiative transfer to be computed through a variety of three-dimensional grids. The main part of the code is problem-independent, and only requires an arbitrary three-dimensional density structure, dust properties, the position and properties of the illuminating sources, and parameters controlling the running and output of the code. HYPERION is parallelized, and is shown to scale well to thousands of processes. Two common benchmark models for protoplanetary disks were computed, and the results are found to be in excellent agreement with those from other codes. Finally, to demonstrate the capabilities of the code, dust temperatures, SEDs, and synthetic multi-wavelength images were computed for a dynamical simulation of a low-mass star formation region. HYPERION is being actively developed to include new features, and is publicly available (http://www.hyperion-rt.org).Comment: Accepted for publication in Astronomy & Astrophysics. HYPERION is being prepared for release at the start of 2012, but you can already sign up to the mailing list at http://www.hyperion-rt.org to be informed once it is available for downloa

Low-light-level nonlinear optics with slow light

Electromagnetically induced transparency in an optically thick, cold medium creates a unique system where pulse-propagation velocities may be orders of magnitude less than $c$ and optical nonlinearities become exceedingly large. As a result, nonlinear processes may be efficient at low-light levels. Using an atomic system with three, independent channels, we demonstrate a quantum interference switch where a laser pulse with an energy density of $\sim23$ photons per $\lambda^2/(2\pi)$ causes a 1/e absorption of a second pulse.Comment: to be published in PR

Quantum cryptography using balanced homodyne detection

We report an experimental quantum key distribution that utilizes balanced homodyne detection, instead of photon counting, to detect weak pulses of coherent light. Although our scheme inherently has a finite error rate, it allows high-efficiency detection and quantum state measurement of the transmitted light using only conventional devices at room temperature. When the average photon number was 0.1, an error rate of 0.08 and "effective" quantum efficiency of 0.76 were obtained.Comment: Errors in the sentence citing ref.[20] are correcte

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. © 2018 The Author(s).Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. © 2018 The Author(s).Peer reviewe