573 research outputs found
Polysorbate 80 Inhibition of Pseudomonas aeruginosa Biofilm Formation and Its Cleavage by the Secreted Lipase LipA
Surface-associated bacterial communities known as biofilms are an important source of nosocomial infections. Microorganisms such as Pseudomonas aeruginosa can colonize the abiotic surfaces of medical implants, leading to chronic infections that are difficult to eradicate. Our study demonstrates that polysorbate 80 (PS80), a surfactant commonly added to food and medicines, is able to inhibit biofilm formation by P. aeruginosa on a variety of surfaces, including contact lenses
Skin manifestations among GATA2-deficient patients
International audienceGATA2 mutations have been identified in various diseases, such as MonoMAC syndrome, Emberger syndrome, familial myelodysplastic syndrome, acute myeloid leukaemia and dendritic cell, monocyte, B-cell and natural killer-cell deficiency. These syndromes present a wide range of clinical features, dominated by severe infections and haematological disorders such as myelodysplastic syndrome. Up to 70% of patients with GATA2 mutations have dermatological features, mainly genital or extragenital warts, panniculitis or erythema nodosum and lymphoedema. We report three patients presenting with common dermatological and haematological features leading to the diagnosis of GATA2 deficiency, but also with skin manifestations that have not been previously described gingival hypertrophy, macroglossitis and glossitis and granulomatous lupoid facial lesions. Dermatologists can encounter patients with GATA2 mutations and should recognize this disorder
Oscillation frequencies and mode lifetimes in alpha Centauri A
We analyse our recently-published velocity measurements of alpha Cen A
(Butler et al. 2004). After adjusting the weights on a night-by-night basis in
order to optimize the window function to minimize sidelobes, we extract 42
oscillation frequencies with l=0 to 3 and measure the large and small frequency
separations. We give fitted relations to these frequencies that can be compared
with theoretical models and conclude that the observed scatter about these fits
is due to the finite lifetimes of the oscillation modes. We estimate the mode
lifetimes to be 1-2 d, substantially shorter than in the Sun.Comment: Accepted by Ap
Activity of florfenicol for Actinobacillus pleuropneumoniae and Pasteurella multocida using standardised versus non-standardised methodology
Reactive oxygen species and cyclooxygenase 2-derived thromboxane A2 reduce angiotensin II type 2 receptor vasorelaxation in diabetic rat resistance arteries
Angiotensin II has a key role in the control of resistance artery tone and local blood flow. Angiotensin II possesses 2 main receptors. Although angiotensin II type 1 receptor is well known and is involved in the vasoconstrictor and growth properties of angiotensin II, the role of the angiotensin II type 2 receptor (AT2R) remains much less understood. Although AT2R stimulation induces vasodilatation in normotensive rats, it induces vasoconstriction in pathological conditions involving oxidative stress and cyclooxygenase 2 expression. Thus, we studied the influence of cyclooxygenase 2 on AT2R-dependent tone in diabetes mellitus. Mesenteric resistance arteries were isolated from Zucker diabetic fatty (ZDF) and lean Zucker rats and studied using in vitro using wire myography. In ZDF rats, AT2R-induced dilation was lower than in lean rats (11% versus 21% dilation). Dilation in ZDF rats returned to the control (lean rats) level after acute superoxide reduction (Tempol and apocynin), cyclooxygenase 2 inhibition (NS398), or thromboxane A(2) synthesis inhibition (furegrelate). Cyclooxygenase 2 expression and superoxide production were significantly increased in ZDF rat arteries compared with arteries of lean rats. After chronic treatment with Tempol, AT2R-dependent dilation was equivalent in ZDF and lean rats. Chronic treatment of ZDF rats with NS398 also restored AT2R-dependent dilation to the control (lean rats) level. Plasma thromboxane B(2) (thromboxane A(2) metabolite), initially high in ZDF rats, was decreased by chronic Tempol and by chronic NS398 to the level found in lean Zucker rats. Thus, in type 2 diabetic rats, superoxide and thromboxane A(2) reduced AT2R-induced dilation. These findings are important to take into consideration when choosing vasoactive drugs for diabetic patients
Fourier Analysis of Gapped Time Series: Improved Estimates of Solar and Stellar Oscillation Parameters
Quantitative helio- and asteroseismology require very precise measurements of
the frequencies, amplitudes, and lifetimes of the global modes of stellar
oscillation. It is common knowledge that the precision of these measurements
depends on the total length (T), quality, and completeness of the observations.
Except in a few simple cases, the effect of gaps in the data on measurement
precision is poorly understood, in particular in Fourier space where the
convolution of the observable with the observation window introduces
correlations between different frequencies. Here we describe and implement a
rather general method to retrieve maximum likelihood estimates of the
oscillation parameters, taking into account the proper statistics of the
observations. Our fitting method applies in complex Fourier space and exploits
the phase information. We consider both solar-like stochastic oscillations and
long-lived harmonic oscillations, plus random noise. Using numerical
simulations, we demonstrate the existence of cases for which our improved
fitting method is less biased and has a greater precision than when the
frequency correlations are ignored. This is especially true of low
signal-to-noise solar-like oscillations. For example, we discuss a case where
the precision on the mode frequency estimate is increased by a factor of five,
for a duty cycle of 15%. In the case of long-lived sinusoidal oscillations, a
proper treatment of the frequency correlations does not provide any significant
improvement; nevertheless we confirm that the mode frequency can be measured
from gapped data at a much better precision than the 1/T Rayleigh resolution.Comment: Accepted for publication in Solar Physics Topical Issue
"Helioseismology, Asteroseismology, and MHD Connections
Bisphenol A in Thermal Paper Receipts: Taylor et al. Respond
We agree with Schwartz and Landrigan that there is a need for change in the regulatory system for chemicals used in products in the United States. Bisphenol A (BPA) is one of thousands of chemicals of concern, but it provides a striking example of what happens when there is no requirement for premarket testing
The non-detection of oscillations in Procyon by MOST: is it really a surprise?
We argue that the non-detection of oscillations in Procyon by the MOST
satellite reported by Matthews et al. (2004) is fully consistent with published
ground-based velocity observations of this star. We also examine the claims
that the MOST observations represent the best photometric precision so far
reported in the literature by about an order of magnitude and are the most
sensitive data set for asteroseismology available for any star other than the
Sun. These statements are not correct, with the most notable exceptions being
observations of oscillations in alpha Cen A that are far superior. We further
disagree that the hump of excess power seen repeatedly from velocity
observations of Procyon can be explained as an artefact caused by gaps in the
data. The MOST observations failed to reveal oscillations clearly because their
noise level is too high, possibly from scattered Earthlight in the instrument.
We did find an excess of strong peaks in the MOST amplitude spectrum that is
inconsistent with a simple noise source such as granulation, and may perhaps
indicate oscillations at roughly the expected level.Comment: 6 pages, accepted for publication in A&A Letter
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