Analyse des antécédents de la résistance favorable au changement organisationnel durant la crise de COVID

The spread of the coronavirus in 2020 and the pandemic declared by the WHO has had several impacts on businesses around the world. Industry, services and even other mining and agricultural activities have been interrupted. This has affected the economy in general and businesses in particular. The government tried to contain the spread of the virus while maintaining business activities. However, some businesses have had to change their way of operating and adapt to the current situation. Different working methods have been introduced, including teleworking, staff rotation, digitalisation of procedures, etc. As a result, employees in all Moroccan companies have been affected. Companies have been able to trace the impact of these changes on the work of their employees. To do this, they started to analyze the performance indicators of their employees to see if there were problems with these changes. In this article, we will try to analyze the context that allows a favourable resistance to change (acceptance of change). We have chosen the banking sector for this purpose because the widespread use of COVID has led to some changes in this sector. We apply structural equation modeling to understand the impact of certain variables on favourable resistance to change. This study was conducted among employees of a Moroccan bank. We were able to collect 99 responses which were used to test the impact of the explanatory variables. The results show that favourable resistance to change during a crisis, in particular the COVID19 crisis we are witnessing today, is determined by employees' perceptions of the benefits of change and flexibility. However, given the insignificant impact of the organisational involvement variable on the variables to be explained, this was not supported in this analysis. The results of this study could help organisations to better adapt to the changes that the current situation in Morocco and, in particular, the global health situation may bring. However, this study should be complemented by a qualitative analysis of managers and change agents to obtain a more detailed understanding of the disruptions caused by the current crisis.   JEL Classification : M12 Paper type: Empirical researchLa propagation du coronavirus en 2020 et la pandémie déclarée par l'OMS ont eu plusieurs impacts sur les entreprises du monde entier. L'industrie, les services et même d'autres activités minières et agricoles ont été interrompus. Cela a affecté l'économie en général et les entreprises en particulier. Les pouvoirs publics ont tenté de contenir la propagation du virus tout en maintenant les activités commerciales. Pourtant, certaines entreprises ont dû changer leur mode de fonctionnement et s'adapter à la situation actuelle. Différentes méthodes de travail ont été introduites, notamment le télétravail, la rotation du personnel, la digitalisation des procédures, etc. Par conséquent, les employés de toutes les entreprises marocaines ont été touchés. Des entreprises ont pu retracer l'impact de ces changements sur le travail de leurs employés. Pour cela, elles ont commencé à analyser les indicateurs de performance de leurs employés pour voir si ces changements posaient des problèmes. Dans cet article, nous allons essayer d'analyser le contexte qui permet une résistance favorable au changement (acceptation du changement). Nous avons choisi le secteur bancaire à cette fin, car l'utilisation généralisée de COVID a conduit à certains changements dans ce secteur. Nous appliquons une modélisation par équations structurelles pour comprendre l'impact de certaines variables sur la résistance favorable au changement. Cette étude a été réalisée auprès des employés d'une banque marocaine. Nous avons pu recueillir 99 réponses qui ont été utilisées pour tester l'impact des variables explicatives. Les résultats montrent qu'une résistance favorable au changement pendant une crise, en particulier la crise COVID19 à laquelle nous assistons aujourd'hui, est déterminée par les perceptions des avantages du changement et de la flexibilité des employés. Cependant, étant donné l'impact non significatif de la variable d’implication organisationnelle sur les variables à expliquer, ceci n'a pas été soutenu dans cette analyse. Les résultats de cette étude pourraient aider les organisations à mieux s'adapter aux changements que pourrait entraîner la situation actuelle au Maroc et, en particulier, la situation sanitaire mondiale. Toutefois, cette étude devrait être complétée par une analyse qualitative des responsables et des agents de changement afin d'obtenir une compréhension plus détaillée des perturbations causées par la crise actuelle     Classification JEL:  M12 Type de l’article : Recherche appliqué

Distribution of prostate cancer recurrences on gallium-68 prostate-specific membrane antigen (68Ga-PSMA) positron-emission/computed tomography after radical prostatectomy with pathological node-positive extended lymph node dissection

Objectives: To examine the anatomical distribution of prostate cancer (PCa) recurrence on gallium-68 prostate-specific membrane antigen (68Ga-PSMA) positron-emission tomography (PET)/computed tomography (CT) in patients with biochemical recurrence (BCR) after undergoing radical prostatectomy (RP) with pathological lymph node metastasis (pN1) in their extended pelvic lymph node dissection (ePLND), and to compare the location of PCa recurrence with the location of the initial lymph node metastasis at ePLND. Materials and Methods: We retrospectively reviewed 100 patients with BCR (PSA 0.05–5.00 ng/mL) after RP with pN1 ePLND who underwent 68Ga-PSMA PET/CT to guide salvage therapy. Clinical and pathological features and anatomical locations of PCa recurrence on 68Ga-PSMA PET/CT were obtained, and managemen

Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential

El pdf del artículo es el manuscrito de autor.-- PubMed: PMCID:PMC2670444Cathepsins have been best characterized in tumorigenesis and cell death and implicated in liver fibrosis; however, whether cathepsins directly regulate hepatic stellate cell (HSC) activation and proliferation, hence modulating their fibrogenic potential, is largely unknown. Here, we show that expression of cathepsin B (CtsB) and cathepsin D (CtsD) is negligible in quiescent HSCs but parallels the increase of -smooth muscle actin and transforming growth factor- during in vitro mouse HSC activation. Both cathepsins are necessary for HSC transdifferentiation into myofibroblasts, because their silencing or inhibition decreasedHSC proliferation and the expression of phenotypicmarkers ofHSC activation, with similar results observed with the human HSC cell line LX2. CtsB inhibition blunted AKT phosphorylation in activated HSCs in response to platelet-derived growth factor.Moreover, during in vivo liver fibrogenesis caused by CCl4 administration, CtsB expression increased in HSCs but not in hepatocytes, and its inactivation mitigated CCl4-induced inflammation, HSC activation, and collagen deposition. Conclusion: These findings support a critical role for cathepsins inHSC activation, suggesting that the antagonismof cathepsins inHSCsmay be of relevance for the treatment of liver fibrosis.Financial support: The work was supported by CIBEREHD and grant PI070193 (Instituto de Salud Carlos III); by grant SAF2006-06780 (Plan Nacional de I+D), Spain; and by grant P50-AA-11999 (Research Center for Liver and Pancreatic Diseases, US National Institute on Alcohol Abuse and Alcoholism).Peer reviewe

Multiple partial nephrectomy for multifocal synchronous renal cancer in a solitary kidney

Introduction & Objectives: multifocal synchronous renal cancer on a solitary kidney represent a challenging clinical scenario. The complexity of imperative nephron-sparring surgery in this setting resides in ensuring complete excision of cancer with the maximal preservation of renal function. We aim to present a case of multiple partial nephrectomy (MPN) for multifocal synchronous renal cancer in a patient with a solitary kidney and discuss our experience of imperative partial in this setting. Materials & Methods: We present a case of a 76 years old man with a past medical history of hypertension, chronic obstructive pulmonary disease, peripheral vascular disease, left radical nephrectomy for renal mass (2006) and a right renal artery stent placement for renal artery stenosis. During his surveillance, computerized axial tomography (CAT) scan showed 3 enhancing renal masses (2.2cm, 1.5cm and 1cm, respectively). Biopsy of the largest mass was consistent in clear cell renal cell carcinoma (ccRCC). Preoperative level of creatinine was 1.4mg/dL and estimated glomerular filtration rate (eGFR) 50ml/min/1,73m2. After ablative therapy was deemed unsafe, a MPN was planned

Intermittent hypoxia increases kidney tumor vascularization in a murine model of sleep apnea

We investigate the effects of intermittent hypoxia (IH), a characteristic feature of obstructive sleep apnea (OSA), on renal cancer progression in an animal and cell model. An in vivo mouse model (Balb/c, n = 50) of kidney cancer was used to assess the effect of IH on tumor growth, metastatic capacity, angiogenesis and tumor immune response. An in vitro model tested the effect of IH on RENCA cells, macrophages and endothelial cells. Tumor growth, metastatic capacity, circulating vascular endothelial growth factor (VEGF) and content of endothelial cells, tumor associated macrophages and their phenotype were assessed in the tumor. In vitro, VEGF cell expression was quantified.Although IH did not boost tumor growth, it significantly increased endothelial cells (p = 0.001) and circulating VEGF (p<0.001) in the in vivo model. Macrophages exposed to IH in vitro increased VEGF expression, whereas RENCA cells and endothelial cells did not. These findings are in keeping with previous clinical data suggesting that OSA has no effect on kidney cancer size and that the association observed between OSA and higher Fuhrman grade of renal cell carcinoma may be mediated though a proangiogenic process, with a key role of macrophages

Effects of three-times-per-week versus on-demand tadalafil treatment on erectile function and continence recovery following bilateral nerve sparing radical prostatectomy: Results of a prospective, randomized, and single-center study

AbstractErectile dysfunction (ED) and urinary incontinence after bilateral nerve-sparing radical prostatectomy (BNSRP) still remain major causes of morbidity. Phosphodiesterase type 5 inhibitors (PDE5-Is) have a role in the treatment of ED after BNSRP. Several studies in patients with ED and lower urinary tract symptoms demonstrated that PDE5-Is could improve both erectile function and urinary symptoms. The aim of this study was to compare the efficacies of two dosing regimens of 20 mg tadalafil (on-demand and 3 times per week) and to assess the role of tadalafil in recovery of erectile function and continence after BNSRP. We conducted a single-center, prospective, randomized controlled trial of three times per week versus on-demand tadalafil 20 mg and a control group after BNSRP. A total of 129 preoperatively potent and continent patients were included in the study. The patients were evaluated at 6 weeks and 12 months postoperatively for erectile function and continence status. There was no significant difference between all three groups with respect to erectile function at 6 weeks after the surgery. Twelve months after the surgery, the International Index of Erectile Function score was significantly higher in the group using tadalafil 20 mg three times per week. However, there was no significant difference between the treated groups and the control group with respect to the continence status at 12 months after the surgery. There was no correlation between incontinence and ED after the surgery in all groups. Tadalafil 20 mg three times per week is an efficacious and well-tolerated treatment option for ED after BNSRP. Treatment with 20 mg tadalafil either three times per week or on demand cannot improve continence recovery after BNSRP compared with the control group

How do you know if you are any good? A surgeon performance feedback system for the outcomes of radical prostatectomy

Surgery remains a mainstay of initial treatment for prostate cancer, with an estimated 85,000 operations per year in the US. Radical prostatectomy is associated with important risks of erectile dysfunction, urinary incontinence and, naturally, cancer recurrence. Given the possible consequences, it would be reassuring were it known that urologic surgeons offer uniformly high-quality care. Unfortunately, the data suggest that this is far from the case. There is copious evidence that surgeons with greater case volume or total lifetime experience have better outcomes. For example, low volume surgeons have complication rates 6 to 8% greater than their higher volume counterparts; in studies on the learning curve, the risk of recurrence is about 7% higher for a typical patient treated by an inexperienced surgeon than if treated by a more experienced surgeon There are also data that differences in outcome go over and above characteristics such as volume or experience, with large variations between surgeons even within volume categories, with one study reporting a five-fold variation in potency rates between surgeons at a single institution