Okullarda Kara Tahta dönemini sona erdiren Akıllı Tahtanın yabancı dil hazırlık sınıflarında kullanımı ve karşılaştırılması

Akıllı tahta sistemi piyasaya 1997 yılında çıkmasına karşın, Türkiye?de okullarda son 4 yıldır yaygın olarak kullanılmaya başlanmıştır. Amerika Birleşik Devletleri ve Avrupa Birliği ülkelerinde uzun zamandır çok yaygın bir şekilde kullanılmaktadır. Ülkemizde, nitelikli eğitimi hayata geçirmek, eğitimde fırsat eşitliğini sağlamak, ders işlerken teknolojiden verimli bir şekilde yararlanmak amacıyla 2010 yılının Kasım ayında Milli Eğitim Bakanlığı ile Ulaştırma Bakanlığı birlikte “FATİH projesini” başlatmıştır. Günümüzde bilgi ve iletişim teknolojilerinin kullanımı hızla yayılmakta ve bu yeni teknolojiler geniş uygulama alanları bulabilmektedir. Bu gelişmelere bağlı olarak, öğretme ve öğrenme sürecine yönelik beklentiler artmakta ve yeni yaklaşımlar ortaya çıkmaktadır. İngilizce “Smartboard” ifadesinden hareketle dilimize “Akıllı Tahta” olarak çevrilen bu teknoloji harikası aygıt sayesinde tahtalar etkileşimli bir bilgisayar ekranına dönüşmektedir. Bununla birlikte, akıllı tahtaların ne yazık ki öğretme ve öğrenme sürecine sağladığı yararlarla ilgili bilimsel alandadeneysel/uygulamalı olarak gerçekleştirilmiş son derece az sayıda araştırma bulunmaktadır. Bu araştırma projesi ile yabancı dil öğrenimi ve öğretimi sürecinde, özellikle de yabancısözcük öğreniminde, akıllı tahta kullanımının öğrencinin öğrenme becerisine herhangi bir katkı sağlayıp sağlamayacağı saptanmaya çalışılmıştır. Araştırma boyunca elde edilen saha çalışması verileri, SPSS bilgisayar programı (Statistical Package for the Social Sciences) yardımıyla çözümlenmiş, bu alanda az sayıdaki inceleme-araştırma çalışmalarınakatkıda bulunmak ve yeni araştırmalara örnek teşkil etmek hedeflenmiştir.Although “Smart Board” system has been on the market since 1997, it has been used in the schools of Turkey since the last 4 years. Moreover, it has been widely used in United States of America and European Union for a long time. In our country, in order to take advantage of qualified education, to ensure the opportunity of equality in education, to take efficiently advantage of the course technology both Ministry of National Education and Ministry of Communication signed Fatih project and announced it to the public in November 2010. Nowadays, the use of information and communication technologies spread rapidly and these new technologies can lead to a wide field of applications. Expectations in the process of teaching and learning have been increasing and new approaches are emerging. Thanks to this English term “Smart board” translated as “Akıllı Tahta” to our language, the boards are transformed to an interactive computer screen. Yet, unfortunately, there is very little experimental research in the literature about its benefits on the process of teaching and learning. This project intends to identify whether the use of smart board could provide any contribution to the students learning skills or not in the process of foreign language learning-teaching, specifically vocabulary learning. It is aimed to contribute to the literature which is thought to be insufficient with the findings gathered via SPSS computer program (Statistical Package for the Social Sciences)

Position Statement:Emerging genetic therapies for rare disorders

Emerging genetic therapies for rare disorders at high cost, cannot realistically address the global burden of disease. Stakeholders must develop new pathways to ensure safe, fair and sustainable provision of such therapies

The TREAT-NMD DMD Global Database: analysis of more than 7,000 Duchenne muscular dystrophy mutations.

Analyzing the type and frequency of patient-specific mutations that give rise to Duchenne muscular dystrophy (DMD) is an invaluable tool for diagnostics, basic scientific research, trial planning, and improved clinical care. Locus-specific databases allow for the collection, organization, storage, and analysis of genetic variants of disease. Here, we describe the development and analysis of the TREAT-NMD DMD Global database (http://umd.be/TREAT_DMD/). We analyzed genetic data for 7,149 DMD mutations held within the database. A total of 5,682 large mutations were observed (80% of total mutations), of which 4,894 (86%) were deletions (1 exon or larger) and 784 (14%) were duplications (1 exon or larger). There were 1,445 small mutations (smaller than 1 exon, 20% of all mutations), of which 358 (25%) were small deletions and 132 (9%) small insertions and 199 (14%) affected the splice sites. Point mutations totalled 756 (52% of small mutations) with 726 (50%) nonsense mutations and 30 (2%) missense mutations. Finally, 22 (0.3%) mid-intronic mutations were observed. In addition, mutations were identified within the database that would potentially benefit from novel genetic therapies for DMD including stop codon read-through therapies (10% of total mutations) and exon skipping therapy (80% of deletions and 55% of total mutations)

HGP NÖROLOJİK HASTALIKLARA YAKLAŞIMIMIZI NASIL ETKİLEDİ ?

İnsan genomu projesinin, 1990' lı yıllardan başlayarak nörolojik hastalıkların tanınması ve tedavisinde çok önemli katkısı olmaktadır

Current Outline of Exon Skipping Trials in Duchenne Muscular Dystrophy

Molecular treatments for Duchenne muscular dystrophy (DMD) are already in clinical practice. One particular means is exon skipping, an approach which has more than 15 years of background. There are several promising clinical trials based on earlier works. The aim is to be able to initiate the production of enough dystrophin to change the rate of progression and create a clinical shift towards the better. Some of these molecules already have received at least conditional approval by health authorities; however, we still need new accumulating data

Gestational Outcomes Of Pregnant Women Who Have Had Invasive Prenatal Testing For The Prenatal Diagnosis Of Duchenne Muscular Dystrophy

Aim . To show the importance of prenatal diagnosis of Duchenne Muscular Dystrophy (DMD) and to demonstrate the effect of DMD gene mutations on gestational outcomes. Materials and Methods . We retrospectively evaluated 89 pregnancies in 81 individuals who were referred to Hacettepe University for prenatal diagnosis of DMD between January 2000 and December 2015. Prenatal diagnostic methods (chorionic villus sampling (CVS): 66, amniocentesis (AC): 23) were compared for test results, demographic features, and obstetric outcomes of pregnancies. The female fetuses were divided into two groups according to the DMD status (healthy or carrier) to understand the effect of DMD gene mutations on obstetric outcomes. Results . Eight prenatally diagnosed disease-positive fetuses were terminated. There was no statistically significant difference between the CVS and AC groups in terms of study variables. There were 46 male fetuses (51.6%) and 43 female fetuses (48.4%). Fifteen of the female fetuses were carriers (34.8%). Median birthweight values were statistically insignificantly lower in the carrier group. Conclusion . Pregnancies at risk for DMD should be prenatally tested to prevent the effect of disease on families and DMD carrier fetuses had obstetric outcomes similar to DMD negative female fetuses.PubMedScopu