Trend analysis for daily rainfall series of Barcelona

Frequency analysis of hydrological series is a key point to acquire an in-depth understanding of the behaviour of hydrologic events. The occurrence of extreme hydrologic events in an area may imply great social and economical impacts. A good understanding of hazardous events improves the planning of human activities.Peer ReviewedPostprint (published version

Effectiveness of vancomycin plus cloxacillin compared with vancomycin, cloxacillin and daptomycin single therapies in the treatment of methicillin-resistant and methicillin-susceptible Staphylococcus aureus in a rabbit model of experimental endocarditis

Objectives: To investigate if the addition of cloxacillin to vancomycin enhances the activity of both monotherapies for treating MSSA and MRSA experimental endocarditis (EE) in rabbits. Methods: Vancomycin plus cloxacillin was compared with the respective monotherapies and daptomycin. In vitro time-kill studies were performed using standard (105 cfu) and high (108 cfu) inocula of five MRSA, one glycopeptide-intermediate (GISA) and five MSSA strains. One MSSA (MSSA-678) and one MRSA (MRSA-277) strain were selected to be used in the in vivo model. A human-like pharmacokinetics model was applied and the equivalents of cloxacillin 2 g/4 h IV and daptomycin 6 mg/kg/day IV were administered. To optimize vancomycin activity, dosage was adjusted to achieve an AUC/MIC ≥400. Results: Daptomycin sterilized significantly more vegetations than cloxacillin (13/13, 100% versus 9/15, 60%; P = 0.02) and showed a trend of better activity than vancomycin (10/14, 71%; P = 0.09) and vancomycin plus cloxacillin (10/14, 71%; P = 0.09) against MSSA-678. Addition of cloxacillin to vancomycin (13/15, 87%) was significantly more effective than vancomycin (8/16, 50%; P = 0.05) and showed similar activity to daptomycin (13/18, 72%; P = 0.6) against MRSA-277. In all treatment arms, the bacterial isolates recovered from vegetations were re-tested and showed the same daptomycin susceptibility as the original strains. Conclusions: Vancomycin plus cloxacillin proved synergistic and bactericidal activity against MRSA. Daptomycin was the most efficacious option against MSSA and similar to vancomycin plus cloxacillin against MRSA. In settings with high MRSA prevalence, vancomycin plus cloxacillin might be a good alternative for empirical therapy of S. aureus IE

(el caso del Macizo de Caroig)

Se estudian los regímenes selvícolas más adecuados para la utilización energética y maderable de las masas de pino carrasco (Pinus halepensis) del Macizo del Caroig, partiendo de los datos de un inventario LIDAR y de una revision bibliográfica amplia sobre la especie. Se proporcionan datos sobre los sistemas de aprovechamiento más adecuados, sus rendimientos y costes estimados para los distintos tipos de masas forestales inventariadas, se estudia la influencia de esos tratamientos sobre el riesgo de incendios forestales y se recomiendan prácticas para reducir su incidencia y gravedad a través de selvicultura preventiva e infraestructuras de defensa optimizadas mediante algoritmos basados en lógica fuzzy. Se proporcionan también datos sobre transformación energética y características de los combustibles

Highly active and stable OER electrocatalysts derived from Sr2MIrO6 for proton exchange membrane water electrolyzers

Proton exchange membrane water electrolysis is a promising technology to produce green hydrogen from renewables, as it can efficiently achieve high current densities. Lowering iridium amount in oxygen evolution reaction electrocatalysts is critical for achieving cost-effective production of green hydrogen. In this work, we develop catalysts from Ir double perovskites. Sr2CaIrO6 achieves 10 mA cm−2 at only 1.48 V. The surface of the perovskite reconstructs when immersed in an acidic electrolyte and during the first catalytic cycles, resulting in a stable surface conformed by short-range order edge-sharing IrO6 octahedra arranged in an open structure responsible for the high performance. A proton exchange membrane water electrolysis cell is developed with Sr2CaIrO6 as anode and low Ir loading (0.4 mgIr cm−2). The cell achieves 2.40 V at 6 A cm−2 (overload) and no loss in performance at a constant 2 A cm−2 (nominal load). Thus, reducing Ir use without compromising efficiency and lifetim

European Society of Cardiology Quality Indicators for the care and outcomes of cardiac pacing:developed by the Working Group for Cardiac Pacing Quality Indicators in collaboration with the European Heart Rhythm Association of the European Society of Cardiology

Aims: To develop a suite of quality indicators (QIs) for the evaluation of the care and outcomes for adults undergoing cardiac pacing. Methods and results: Under the auspice of the Clinical Practice Guideline Quality Indicator Committee of the European Society of Cardiology (ESC), the Working Group for cardiac pacing QIs was formed. The Group comprised Task Force members of the 2021 ESC Clinical Practice Guidelines on Cardiac Pacing and Cardiac Resynchronization Therapy, members of the European Heart Rhythm Association, international cardiac device experts, and patient representatives. We followed the ESC methodology for QI development, which involved (i) the identification of the key domains of care by constructing a conceptual framework of the management of patients receiving cardiac pacing, (ii) the development of candidate QIs by conducting a systematic review of the literature, (iii) the selection of the final set of QIs using a modified-Delphi method, and (iv) the evaluation of the feasibility of the developed QIs. Four domains of care were identified: (i) structural framework, (ii) patient assessment, (iii) pacing strategy, and (iv) clinical outcomes. In total, seven main and four secondary QIs were selected across these domains and were embedded within the 2021 ESC Guidelines on Cardiac Pacing and Cardiac Resynchronization therapy. Conclusion: By way of a standardized process, 11 QIs for cardiac pacing were developed. These indicators may be used to quantify adherence to guideline-recommended clinical practice and have the potential to improve the care and outcomes of patients receiving cardiac pacemakers

Bayesian trend analysis for daily rainfall series of Barcelona

A Point-Over-Threshold approach using a reparameterization of the Generalized Pareto Distribution (GPD) has been used to assess changes in the daily rainfall Barcelona series (1854–2006). A Bayesian approach, considering the suitable scale and physical features of the phenomenon, has been used to look for these alterations. Two different models have been assessed: existence of abrupt changes in the new GPD parameters due to modifications of the observatory locations and trends in these GPD parameters, pointing to a climate change scenario

Trend analysis for daily rainfall series of Barcelona

Frequency analysis of hydrological series is a key point to acquire an in-depth understanding of the behaviour of hydrologic events. The occurrence of extreme hydrologic events in an area may imply great social and economical impacts. A good understanding of hazardous events improves the planning of human activities.Peer Reviewe

Bayesian trend analysis for daily rainfall series of Barcelona

A Point-Over-Threshold approach using a reparameterization of the Generalized Pareto Distribution (GPD) has been used to assess changes in the daily rainfall Barcelona series (1854–2006). A Bayesian approach, considering the suitable scale and physical features of the phenomenon, has been used to look for these alterations. Two different models have been assessed: existence of abrupt changes in the new GPD parameters due to modifications of the observatory locations and trends in these GPD parameters, pointing to a climate change scenario