139 research outputs found
Outcome of COVID-19 in hospitalised immunocompromised patients:An analysis of the WHO ISARIC CCP-UK prospective cohort study
- Author
- Aston Stephen
- Baillie J. Kenneth
- Davis Christopher
- de Silva Thushan I.
- Docherty Annemarie B.
- Drake Thomas M.
- Hardwick Hayley E.
- Harrison Ewen M.
- Ho Antonia
- ISARIC4C investigators
- Law Andy
- Leeming Gary
- Openshaw Peter J.M.
- Palmieri Carlo
- Richter Alex
- Russell Clark D.
- Scott Janet T.
- Semple Malcolm G.
- Swets Maaike
- Thorpe Mathew
- Turtle Lance
- Wootton Daniel G.
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background:
Immunocompromised patients may be at higher risk of mortality if hospitalised with Coronavirus Disease 2019 (COVID-19) compared with immunocompetent patients. However, previous studies have been contradictory. We aimed to determine whether immunocompromised patients were at greater risk of in-hospital death and how this risk changed over the pandemic.
Methods and findings:
We included patients > = 19 years with symptomatic community-acquired COVID-19 recruited to the ISARIC WHO Clinical Characterisation Protocol UK prospective cohort study. We defined immunocompromise as immunosuppressant medication preadmission, cancer treatment, organ transplant, HIV, or congenital immunodeficiency. We used logistic regression to compare the risk of death in both groups, adjusting for age, sex, deprivation, ethnicity, vaccination, and comorbidities. We used Bayesian logistic regression to explore mortality over time. Between 17 January 2020 and 28 February 2022, we recruited 156,552 eligible patients, of whom 21,954 (14%) were immunocompromised. Approximately 29% (n = 6,499) of immunocompromised and 21% (n = 28,608) of immunocompetent patients died in hospital. The odds of in-hospital mortality were elevated for immunocompromised patients (adjusted OR 1.44, 95% CI [1.39, 1.50], p < 0.001). Not all immunocompromising conditions had the same risk, for example, patients on active cancer treatment were less likely to have their care escalated to intensive care (adjusted OR 0.77, 95% CI [0.7, 0.85], p < 0.001) or ventilation (adjusted OR 0.65, 95% CI [0.56, 0.76], p < 0.001). However, cancer patients were more likely to die (adjusted OR 2.0, 95% CI [1.87, 2.15], p < 0.001). Analyses were adjusted for age, sex, socioeconomic deprivation, comorbidities, and vaccination status. As the pandemic progressed, in-hospital mortality reduced more slowly for immunocompromised patients than for immunocompetent patients. This was particularly evident with increasing age: the probability of the reduction in hospital mortality being less for immunocompromised patients aged 50 to 69 years was 88% for men and 83% for women, and for those >80 years was 99% for men and 98% for women. The study is limited by a lack of detailed drug data prior to admission, including steroid doses, meaning that we may have incorrectly categorised some immunocompromised patients as immunocompetent.
Conclusions:
Immunocompromised patients remain at elevated risk of death from COVID-19. Targeted measures such as additional vaccine doses, monoclonal antibodies, and nonpharmaceutical preventive interventions should be continually encouraged for this patient group.
Trial registration:
ISRCTN 66726260
The Sorcerer II Global Ocean Sampling Expedition: Northwest Atlantic through Eastern Tropical Pacific
- Author
- Aaron L Halpern
- Bao Tran
- Clare Stewart
- Cynthia Andrews-Pfannkoch
- David M Karl
- Dongying Wu
- Douglas B Rusch
- Eldredge Bermingham
- Germán Bonilla-Rosso
- Giselle Tamayo-Castillo
- Granger Sutton
- Hamilton Smith
- Holly Baden-Tillson
- J. Craig Venter
- Jason Freeman
- Jeff M Hoffman
- John F Heidelberg
- Jonathan A Eisen
- Joseph E Venter
- Joyce Thorpe
- Karen Beeson
- Karin Remington
- Karla B Heidelberg
- Kelvin Li
- Kenneth Nealson
- Luis E Eguiarte
- Luisa I Falcón
- Marvin Frazier
- Michael R Ferrari
- Nancy A Moran
- Robert Friedman
- Robert L Strausberg
- Saul Kravitz
- Shannon Williamson
- Shibu Yooseph
- Shubha Sathyendranath
- Terry Utterback
- Trevor Platt
- Valeria Souza
- Victor Gallardo
- Yu-Hui Rogers
- Publication venue
- Public Library of Science
- Publication date
- 01/03/2007
- Field of study
The world's oceans contain a complex mixture of micro-organisms that are for the most part, uncharacterized both genetically and biochemically. We report here a metagenomic study of the marine planktonic microbiota in which surface (mostly marine) water samples were analyzed as part of the Sorcerer II Global Ocean Sampling expedition. These samples, collected across a several-thousand km transect from the North Atlantic through the Panama Canal and ending in the South Pacific yielded an extensive dataset consisting of 7.7 million sequencing reads (6.3 billion bp). Though a few major microbial clades dominate the planktonic marine niche, the dataset contains great diversity with 85% of the assembled sequence and 57% of the unassembled data being unique at a 98% sequence identity cutoff. Using the metadata associated with each sample and sequencing library, we developed new comparative genomic and assembly methods. One comparative genomic method, termed “fragment recruitment,” addressed questions of genome structure, evolution, and taxonomic or phylogenetic diversity, as well as the biochemical diversity of genes and gene families. A second method, termed “extreme assembly,” made possible the assembly and reconstruction of large segments of abundant but clearly nonclonal organisms. Within all abundant populations analyzed, we found extensive intra-ribotype diversity in several forms: (1) extensive sequence variation within orthologous regions throughout a given genome; despite coverage of individual ribotypes approaching 500-fold, most individual sequencing reads are unique; (2) numerous changes in gene content some with direct adaptive implications; and (3) hypervariable genomic islands that are too variable to assemble. The intra-ribotype diversity is organized into genetically isolated populations that have overlapping but independent distributions, implying distinct environmental preference. We present novel methods for measuring the genomic similarity between metagenomic samples and show how they may be grouped into several community types. Specific functional adaptations can be identified both within individual ribotypes and across the entire community, including proteorhodopsin spectral tuning and the presence or absence of the phosphate-binding gene PstS
The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe
- Author
- Adams Corey
- Adams David
- Akiri Tarek
- Alion Tyler
- Anderson Kris
- Andreopoulos Costas
- Andrews Mike
- Anghel Ioana
- Anjos João Carlos Costa dos
- Antonello Maddalena
- Arrieta-Diaz Enrique
- Artuso Marina
- Asaadi Jonathan
- Bai Xinhua
- Baibussinov Bagdat
- Baird Michael
- Balantekin Baha
- Baller Bruce
- Baptista Brian
- Barker D'Ann
- Barker Gary
- Barletta William A.
- Barr Giles
- Bartoszek Larry
- Bashyal Amit
- Bass Matt
- Bellini Vincenzo
- Benetti Pietro Angelo
- Berger Bruce E.
- Bergevin Marc
- Berman Eileen
- Berns Hans-Gerd
- Bernstein Adam
- Bernstein Robert
- Bhandari Babu
- Bhatnagar Vipin
- Bhuyan Bipul
- Bian Jianming
- Bishai Mary
- Blake Andrew
- Blaszczyk Flor
- Blaufuss Erik
- Bleakley Bruce
- Blucher Edward
- Blusk Steve
- Bocean Virgil
- Boffelli F.
- Boissevain Jan
- Bolton Timothy
- Bonesini Maurizio
- Boyd Steve
- Brandt Andrew
- Breedon Richard
- Bromberg Carl
- Brown Ralph
- Brunetti Giullia
- Buchanan Norman
- Bugg Bill
- Busenitz Jerome
- Calligarich E.
- Camilleri Leslie
- Carminati Giada
- Carr Rachel
- Castromonte Cesar
- Cavanna Flavio
- Centro Sandro
- Chen Alex
- Chen Hucheng
- Chen Kai
- Cherdack Daniel
- Chi Cheng-Yi
- Childress Sam
- Choudhary Brajesh Chandra
- Christodoulou Georgios
- Christofferson Cabot-Ann
- Church Eric
- Cline David
- Coan Thomas
- Cocco Alfredo
- Coelho Joao
- Coleman Stephen
- Conrad Janet M.
- Convery Mark
- Corey Robert
- Corwin Luke
- Cranshaw Jack
- Cronin-Hennessy Daniel
- Curioni A.
- da Motta Helio
- Davenne Tristan
- Davies Gavin S.
- Dazeley Steven
- de Geronimo Gianluigi
- de Gouvea Andre
- de Jong Jeffrey K.
- De Kaushik
- Demuth David
- Densham Chris
- Diwan Milind
- Djurcic Zelimir
- Dolfini R.
- Dolph Jeffrey
- Drake Gary
- Dye Stephen
- Dyuang Hongue
- Edmunds Daniel
- Elliott Steven
- Elnimr Muhammad
- Eno Sarah
- Enomoto Sanshiro
- Escobar Carlos O.
- Evans Justin
- Falcone A.
- Falk Lisa
- Farbin Amir
- Farnese Christian
- Fava Angela
- Felde John
- Fernandes S.
- Ferroni Fernando
- Feyzi Farshid
- Fields Laura
- Finch Alex
- Fitton Mike
- Fleming Bonnie
- Fowler Jack
- Fox Walt
- Friedland Alex
- Fuess Stu
- Fujikawa Brian
- Gallagher Hugh
- Gandhi Raj
- Garvey Gerald
- Gehman Victor M.
- Gibin Daniele
- Gill Ronald
- Gomes Ricardo A.
- Goodman Maury C.
- Goon Jason
- Graf Nicholas
- Graham Mathew
- Gran Rik
- Grant Christopher
- Grant Nick
- Greenlee Herbert
- Greenler Leland
- Grullon Sean
- Guardincerri Elena
- Guarino Victor
- Guarnaccia Evan
- Guedes Germano
- Guenette Roxanne
- Guglielmi Alberto
- Guzzo Marcelo M.
- Habig Alec T.
- Hackenburg Robert W.
- Hadavand Haleh
- Hahn Alan
- Haigh Martin
- Haines Todd
- Handler Thomas
- Hans Sunej
- Hartnell Jeff
- Harton John
- Hatcher Robert
- Hatzikoutelis Athans
- Hays Steven
- Hazen Eric
- Headley Mike
- Heavey Anne
- Heeger Karsten
- Heise Jaret
- Hellauer Robert
- Hewes Jeremy
- Himmel Alexander
- Hogan Matthew
- Holanda Pedro
- Holin Anna
- Horton-Smith Glenn
- Howell Joe
- Hurh Patrick
- Huston Joey
- Hylen James
- Imlay Richard
- Insler Jonathan
- Introzzi G.
- Isvan Zeynep
- Jackson Chris
- Jacobsen John
- Jaffe David E.
- James Cat
- Jen Chun-Min
- Johnson Marvin
- Johnson Randy
- Johnson Robert
- Johnson Scott
- Johnston William
- Johnstone John
- Jones Ben J. P.
- Jostlein H.
- Junk Thomas
- Kadel Richard
- Kaess Karl
- Karagiorgi Georgia
- Kaspar Jarek
- Katori Teppei
- Kayser Boris
- Kearns Edward
- Keener Paul
- Kemp Ernesto
- Kettell Steve H.
- Kirby Mike
- Klein Joshua
- Koizumi Gordon
- Kopp Sacha
- Kormos Laura
- Kropp William
- Kudryavtsev Vitaly A.
- Kumar Ashok
- Kumar Jason
- Kutter Thomas
- La Zia Franco
- Lande Kenneth
- Lane Charles
- Lang Karol
- Lanni Francesco
- Lanza Richard
- Latorre Tony
- LBNE Collaboration
- Learned John
- Lee David
- Lee Kevin
- Li Qizhong
- Li Shaorui
- Li Yichen
- Li Zepeng
- Libo Jiang
- Linden Steve
- Ling Jiajie
- Link Jonathan
- Littenberg Laurence
- Liu Hu
- Liu Qiuguang
- Liu Tiankuan
- Losecco John
- Louis William
- Lundberg Byron
- Lundin Tracy
- Lundy Jay
- Machado Ana Amelia
- Maesano Cara
- Magill Steve
- Mahler George
- Malon David
- Malys Stephen
- Mammoliti Francesco
- Mandal Samit Kumar
- Mann Anthony
- Mantsch Paul
- Marchionni Alberto
- Marciano William
- Mariani Camillo
- Maricic Jelena
- Marino Alysia
- Marshak Marvin
- Marshall John
- Matsuno Shiegenobu
- Mauger Christopher
- Mavrokoridis Konstantinos
- Mayer Nate
- McCauley Neil
- McCluskey Elaine
- McDonald Kirk
- McFarland Kevin
- McKee David
- McKeown Robert
- McTaggart Robert
- Mehdiyev Rashid
- Mei Dongming
- Menegolli A.
- Meng Guang
- Meng Yixiong
- Mertins David
- Messier Mark
- Metcalf William
- Milincic Radovan
- Miller William
- Mills Geoff
- Mishra Sanjib R.
- Mokhov Nikolai
- Montanari Claudio
- Montanari David
- Moore Craig
- Morfin Jorge
- Morgan Ben
- Morse William
- Moss Zander
- Moura Célio A.
- Mufson Stuart
- Muller David
- Musser Jim
- Naples Donna
- Napolitano Jim
- Newcomer Mitch
- Nichol Ryan
- Nicholls Tim
- Niner Evan
- Norris Barry
- Nowak Jaroslaw
- O'Keeffe Helen
- Oliveira Roberto
- Olson Travis
- Page Brian
- Pakvasa Sandip
- Palamara Ornella
- Paley Jon
- Paolone Vittorio
- Papadimitriou Vaia
- Park Seongtae
- Parsa Zohreh
- Partyka Kinga
- Paulos Bob
- Pavlovic Zarko
- Peeters Simon
- Perch Andy
- Perkin Jon D.
- Petti Roberto
- Petukhov Andre
- Pietropaolo Francesco
- Plunkett Robert
- Polly Chris
- Pordes Stephen
- Potekhin Maxim
- Potenza Renato
- Prakash Arati
- Prokofiev Oleg
- Qian Xin
- Raaf Jennifer L.
- Radeka Veljko
- Rakhno Igor
- Ramachers Yorck
- Rameika Regina
- Ramsey John
- Rappoldi A.
- Raselli G. L.
- Ratoff Peter
- Ravindra Shreyas
- Rebel Brian
- Reichenbacher Juergen
- Reitzner Dianne
- Rescia Sergio
- Richardson Martin
- Rielage Kieth
- Riesselmann Kurt
- Robinson Matt
- Rochester Leon
- Ronquest Michael
- Rosen Marc
- Rossella M.
- Rubbia Carlo
- Rucinski Russ
- Sahijpal Sandeep
- Sahoo Himansu
- Sala Paola
- Salmiera Delia
- Samios Nicholas
- Sanchez Mayly
- Scaramelli Alberto
- Schellman Heidi
- Schmitt Richard
- Schmitz David
- Schneps Jack
- Scholberg Kate
- Segreto Ettore
- Seibert Stanley
- Sexton-Kennedy Liz
- Shaevitz Mike
- Shanahan Peter
- Sharma Rahul
- Shaw Terri
- Simos Nikolaos
- Singh Venktesh
- Sinnis Gus
- Sippach William
- Skwarnicki Tomasz
- Smy Michael
- Sobel Henry
- Soderberg Mitch
- Sondericker John
- Sondheim Walter
- Sousa Alexandre
- Spooner Neil J. C.
- Stancari Michelle
- Stancu Ion
- Stefan Dorota
- Stefanik Andy
- Stewart James
- Stone Sheldon
- Strait James
- Strait Matthew
- Striganov Sergei
- Sullivan Gregory
- Sun Yujing
- Suter Louise
- Svenson Andrew
- Svoboda Robert
- Szczerbinska Barbara
- Szelc Andrzej
- Szydagis Matthew
- Söldner-Rembold Stefan
- Talaga Richard
- Tamsett Matthew
- Tariq Salman
- Tayloe Rex
- Taylor Charles
- Taylor David
- Teymourian Artin
- Themann Harry
- Thiesse Matthew
- Thomas Jenny
- Thompson Lee F.
- Thomson Mark
- Thorn Craig
- Thorpe Matt
- Tian Xinchun
- Tiedt Doug
- Toki Walter
- Tolich Nikolai
- Torti M.
- Toups Matt
- Touramanis Christos
- Tripathi Mani
- Tropin Igor
- Tsai Yun-Tse
- Tull Craig
- Tzanov Martin
- Urheim Jon
- Usman Shawn
- Vagins Mark
- Valdiviesso Gustavo
- Van Berg Rick
- Van de Water Richard
- Van Gemmeren Peter
- Varanini Filippo
- Varner Gary
- Vaziri Kamran
- Velev Gueorgui
- Ventura Sandro
- Vignoli Chiara
- Viren Brett
- Wahl Dan
- Waldron Abby
- Walter Christopher W.
- Wang Hanguo
- Wang Wei
- Warburton Karl
- Warner David
- Wasserman Ryan
- Watson Blake
- Weber Alfons
- Wei Wenzhao
- Wells Douglas
- Wetstein Matthew
- White Andy
- White Hywel
- Whitehead Lisa
- Whittington Denver
- Willhite Joshua
- Wilson Robert J.
- Winslow Lindley
- Wood Kevin
- Worcester Elizabeth
- Worcester Matthew
- Xin Tian
- Yarritu Kevin
- Ye Jingbo
- Yeh Minfang
- Yu Bo
- Yu Jae
- Yuan Tianlu
- Zani A.
- Zeller Geralyn P.
- Zhang Chao
- Zhang Chao
- Zimmerman Eric D.
- Zwaska Robert
- Publication venue
- Publication date
- 28/07/2013
- Field of study
The preponderance of matter over antimatter in the early Universe, the
dynamics of the supernova bursts that produced the heavy elements necessary for
life and whether protons eventually decay --- these mysteries at the forefront
of particle physics and astrophysics are key to understanding the early
evolution of our Universe, its current state and its eventual fate. The
Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed
plan for a world-class experiment dedicated to addressing these questions. LBNE
is conceived around three central components: (1) a new, high-intensity
neutrino source generated from a megawatt-class proton accelerator at Fermi
National Accelerator Laboratory, (2) a near neutrino detector just downstream
of the source, and (3) a massive liquid argon time-projection chamber deployed
as a far detector deep underground at the Sanford Underground Research
Facility. This facility, located at the site of the former Homestake Mine in
Lead, South Dakota, is approximately 1,300 km from the neutrino source at
Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino
charge-parity symmetry violation and mass ordering effects. This ambitious yet
cost-effective design incorporates scalability and flexibility and can
accommodate a variety of upgrades and contributions. With its exceptional
combination of experimental configuration, technical capabilities, and
potential for transformative discoveries, LBNE promises to be a vital facility
for the field of particle physics worldwide, providing physicists from around
the globe with opportunities to collaborate in a twenty to thirty year program
of exciting science. In this document we provide a comprehensive overview of
LBNE's scientific objectives, its place in the landscape of neutrino physics
worldwide, the technologies it will incorporate and the capabilities it will
possess.Comment: Major update of previous version. This is the reference document for
LBNE science program and current status. Chapters 1, 3, and 9 provide a
comprehensive overview of LBNE's scientific objectives, its place in the
landscape of neutrino physics worldwide, the technologies it will incorporate
and the capabilities it will possess. 288 pages, 116 figure
Gut Microbiome Dysbiosis in Antibiotic-Treated COVID-19 Patients is Associated with Microbial Translocation and Bacteremia
- Author
- Anastasio Kelly
- Askenase Michael H.
- Axelrad Jordan E.
- Batsu Maria
- Bernard-Raichon Lucie
- Brito Anderson
- Brower Kristina
- Cadwell Ken
- Campbell Melissa
- Casanovas-Massana Arnau
- Courchaine Edward
- Deluliis Giuseppe
- Dittmann Meike
- Fauver Joseph R.
- Gago Juan
- Geng Bertie
- Glick Laura
- Harden Christina
- Hussey Grant A.
- Iwasaki Akiko
- Jensen Cole
- Kalinich Chaney
- Kim Daniel
- Klein Jon
- Knaggs Lynda
- Ko Albert I.
- Kuang Maxine
- Kudo Eriko
- Lim Joseph
- Linehan Melissa
- Littman Dan R.
- Lu-Culligan Alice
- Martin Anjelica
- Matos Irene
- McDonald David
- Minasyan Maksym
- Nakahata Maura
- Naushad Nida
- Nelson Allison
- Nouws Jessica
- Noval Maria G.
- Nunez Angela
- Obaid Abeer
- Park Hong-jai
- Petrone Mary
- Pironti Alejandro
- Putzel Gregory
- Rahming Harold
- Rose Kadi-Ann
- Schluter Jonas
- Sewanan Lorenzo
- Sharma Lokesh
- Shepard Denise
- Shopsin Bo
- Silva Erin
- Simonov Michael
- Smolgovsky Mikhail
- Song Eric
- Sonnert Nicole
- Stapleford Kenneth A.
- Sullivan Alexis P.
- Thorpe Lorna E.
- Todeasa Codruta
- Torres Victor J.
- Valdez Jordan
- Valero-Jimenez Ana M.
- Venzon Mericien
- Watkins Annie
- White Elizabeth B.
- Wilder Evan
- Yale IMPACT Research Team
- Zhang Chenzhen
- Publication venue
- DigitalCommons@UNMC
- Publication date
- 01/01/2022
- Field of study
Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that gut microbiome dysbiosis is associated with translocation of bacteria into the blood during COVID-19, causing life-threatening secondary infections. We first demonstrate SARS-CoV-2 infection induces gut microbiome dysbiosis in mice, which correlated with alterations to Paneth cells and goblet cells, and markers of barrier permeability. Samples collected from 96 COVID-19 patients at two different clinical sites also revealed substantial gut microbiome dysbiosis, including blooms of opportunistic pathogenic bacterial genera known to include antimicrobial-resistant species. Analysis of blood culture results testing for secondary microbial bloodstream infections with paired microbiome data indicates that bacteria may translocate from the gut into the systemic circulation of COVID-19 patients. These results are consistent with a direct role for gut microbiome dysbiosis in enabling dangerous secondary infections during COVID-19
International Factors and the 1964 Election
- Author
- Ashton Nigel
- Bartlett C. J.
- Benn Tony
- Busch Peter
- Butler D. E.
- Butler R. A.
- Craig F. W. S.
- Denver David
- Ellis Sylvia
- Griffiths Peter
- Heath Anthony
- Home Lord
- Howard Anthony
- Hughes Emrys
- John W. Young
- Jones Matthew
- Kaiser Wolfram
- Layton-Henry Zig
- Morgan Austen
- Noel G. E.
- Ovendale Ritchie
- Pearce Robert
- Pickering Jeffrey
- Pieragostini Karl
- Pimlott Ben
- Reynolds David
- Rose Richard
- Roth Andrew
- Sanders David
- Sigham A. W.
- Thorpe D. R.
- Tomlinson Jim
- Wilson Harold
- Wilson Harold
- Windrich Elaine
- Young J. W.
- Young Kenneth
- Ziegler Philip
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/09/2007
- Field of study
International issues are not usually seen as having been significant to the 1964 general election result. Harold Wilson made only limited references to foreign policy and defence during the campaign, while opinion polls showed that voters saw domestic questions as being far more important. Traditionally, international issues have had only a limited impact upon British general elections. But the 1964 election was one of the most closely run in history and this article argues that, interpreted broadly, international questions did have a real effect on the contest. The sitting prime minister Sir Alec Douglas-Home focused on the future of the nuclear deterrent for much of the campaign, while considerations about the country's relative decline in the world, reflected in chronic balance of payment problems, helped Labour's case that it was ‘time for a change’ at the top. Besides, the mid-1960s was a significant point for the country's global position: the post-war policy of ‘three circles’—in which Britain played a major role in Europe, maintained a global empire and influenced US policy via the ‘special relationship’—was being called into question. The question deserves to be asked, therefore, why there was not a more intense debate between the political leaders about Britain's international role
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
- B Hopkins
- B Johnston
- B Lenagh
- B Masunda
- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
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- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Measurement of the inclusive isolated-photon cross section in pp collisions at √s = 13 TeV using 36 fb−1 of ATLAS data
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- Zhang G.
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- Zhang J.
- Zhang L.
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- Zhang M.
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- Zhang X.
- Zhang Y.
- Zhang Z.
- Zhang Z.
- Zhao P.
- Zhao Y.
- Zhao Z.
- Zhemchugov A.
- Zheng Z.
- Zhong D.
- Zhou B.
- Zhou C.
- Zhou M.
- Zhou M. S.
- Zhou N.
- Zhou Y.
- Zhu C. G.
- Zhu H.
- Zhu H. L.
- Zhu J.
- Zhu Y.
- Zhuang X.
- Zhukov K.
- Zhulanov V.
- Zieminska D.
- Zimine N. I.
- Zimmermann S.
- Zinonos Z.
- Ziolkowski M.
- Zobernig G.
- Zoccoli A.
- Zoch K.
- Zorbas T. G.
- Zou R.
- Zwalinski L.
- Álvarez Piqueras D.
- Åkesson T. P. A.
- Šforza F.
- Ženiš T.
- Živković L.
- Publication venue
- Institute of Physics Publishing
- Publication date
- 01/01/2019
- Field of study
The differential cross section for isolated-photon production in pp collisions is measured at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC using an integrated luminosity of 36.1 fb. The differential cross section is presented as a function of the photon transverse energy in different regions of photon pseudorapidity. The differential cross section as a function of the absolute value of the photon pseudorapidity is also presented in different regions of photon transverse energy. Next-to-leading-order QCD calculations from Jetphox and Sherpa as well as next-to-next-to-leading-order QCD calculations from Nnlojet are compared with the measurement, using several parameterisations of the proton parton distribution functions. The predictions provide a good description of the data within the experimental and theoretical uncertainties. [Figure not available: see fulltext.
The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy
- Author
- Aawsaj Yousif
- Abayomi Michael
- Acharya Vikas
- Aggarwal Smeer Kumar
- Ahmad Anwar
- Ahmed Irfan
- Ahmed Jamil
- Ahmed Javed
- Ahmed Talat
- Ainley Paul
- Akhtar Mansoor
- Al Amari Khalid
- Al-Abed Yahya A.
- Al-Akash Musallam
- Al-Bahrani Ahmed Z.
- Al-Khyatt Waleed
- Al-Muhktar Ahmed
- Al-Sarireh Bilal
- Al-Taan Omer
- Alagaratnam Swethan
- Alam Imran
- Alberts Justin
- Alderson Derek
- Aldridge Roland C.
- Aleksandrov Danail
- Ali Haythem
- Ali Shahda
- Amin Khalid
- Andrew David R.
- Appleton Shaun
- Arhi Chanpreet
- Aroori Somaiah
- Aryal Kamal
- Asad Mehek
- Aseem Rabiya
- Asprou Fotini M.
- Awan Altaf
- Ayaani Soofiyah
- Aymon null
- Babu Benoy I.
- Bajwa Dalvir S.
- Bajwa Farrukh M.
- Baker Andrew L.
- Balfe Paul
- Ball William R.
- Ballance Laura
- Banwell Victoria
- Barnes James
- Barrie Jenifer
- Bartlett Francis
- Basheer Mohammed
- Bashir Gareth
- Basra Melvinder
- Basu Sanjoy
- Basynat Pradeep
- Batt Jeremy
- Bausbacher Harald
- Bawa Sadiq
- Beasley William D.
- Belding Rowena
- Bellini Maria Irene
- Bennett Stephen P.
- Bhandari Santosh
- Bharamgoudar Reshma
- Bhattacharya Vish
- Blane Christine
- Blazeby Jane M.
- Boal Matthew
- Boddy Alexander
- Boland Michael
- Bond-Smith Giles
- Booth Michael I.
- Borowski David W.
- Bowen Laura
- Boyce Kathryn M.
- Boyd Alan T.
- Bradley Donal
- Bradley Neil
- Brennan Stephen
- Brett Daniel
- Broadhurst Jack
- Brooke Eleanor
- Brown Timothy H.
- Bryant Alice
- Buchan Joanna
- Bullen Naomi
- Bunnell Catherine
- Bunting David M.
- Burke Paul
- Byrne James P.
- Byrnes Colman K.
- Campbell William
- Carney Kate
- Carney Kate
- Carroll Paul
- Carter C. Ross
- Carter Nicholas C.
- Carty Nick
- Cassidy John T.
- Chambers Adam
- Chambers Alice
- Chambers Alice
- Chan Wei Ming
- Chang Jessica
- Charalabopoulos Alexandros
- Chauhan Neal
- Cheung Melanie
- Chhabra Alok
- Chishti Imran A.
- Chitre Vivek
- Choy Alfred
- Cieplucha Krzysztos
- Clements Joshua M.
- Coats Maria
- Cockbain Andrew J.
- Coe Peter O.
- Connelly Martin
- Cooke Fiachra
- Courtney Michael J.
- Cowley Jonathan B.
- Cross Keith S.
- Cuming Tamzin
- Cunha Pedro
- Dalgaty Faith
- Dar Farooq
- Date Ravindra
- Dave Rajiv V.
- Davey Phil
- Davies James
- Dawson Suzanne
- De Marchi Joshua A.
- de Siqueira Jonathan
- Deguara Jean
- Delisle Theo G.
- Dennison A. R.
- Derbyshire Laura
- Devoto Laurence
- Dhillon Ajit
- Diamond Tom
- Dickson-Lowe Richard
- Digney Ruairi
- Dindyal Shiva
- Dobbins Brian
- Doe Matthew
- Dorrian Emmet
- Doulias Triantafyllos
- Downing Justine
- Drake Benjamin
- Driscoll Peter J.
- Duke Diana
- Durkin Damien
- Dwerryhouse Simon J.
- D’Costa Conrad
- Ebdewi Hamdi
- Ebied Husam
- Eisawi Abdalla
- El-Dhuwaib Yesar
- El-Hasani Shamsi S.
- Elkheir Natalie
- Elmasry Mohamed
- Elsayed Mohammed
- Elshaer Mohamed
- Emesih Sophie
- Farag Sameh F.
- Farooq Ansar
- Farouk Marwan
- Fasih Tani
- Fawole Adeshina S.
- Fenwick Stephen
- Ferguson Graeme
- Ferris Paul
- Finch David
- Finch J. G.
- Finlay Ian
- Fleming Katie
- Fletcher Ted
- Fordham Imogen J.
- Forouzanfar Amir
- Forrest Craig R.
- Forster Luke
- Fothergill Laura
- Frame Richard J.
- Francombe James
- Frank Lucinda
- Fusai Guiseppe
- Galanopoulos Giorgios
- Gallagher Paul V.
- Garcea Giuseppe
- Gardner-Thorpe James
- Geoghegan Justin G.
- Geogloma Ileana
- Gerakopoulos Stratos
- Ghareeb Essam
- Ghazanfar Mudassar A.
- Gibson Simon
- Giles Mathew
- Giovinazzo Francesco
- Giwa Lola
- Goh Yan Li
- Gopalswamy Sivakumar
- Goscimski Andrzej
- Gossage James A.
- Gough Martin
- Gould Laura
- Gould Laura
- Grant Alan J.
- Gravante Gianpiero
- Griffiths Ewen
- Griffiths Ewen A.
- Gull Sadaf
- Gunasekera Rohan T.
- Gurung Kabita
- Guthrie Graeme J. K.
- Guy Finch J.
- Hafiz Shazia
- Halkias Constantine
- Hall Claire
- Hamady Zayed
- Hamdan Alhafidz
- Hamdan Mohammed F.
- Hamilton Emma
- Hancorn Kate
- Haque Manzarul
- Haque Samer Ul
- Hardy Thomas J.
- Hargreaves Anita
- Harilingam Mohan
- Harris Andrew
- Harrison Ewen
- Hawkins Helen
- Heath Jonathan
- Hebbar Madhusoodhana
- Henderson Lucy T.
- Henley Natasha
- Heshaishi Mohamed
- Hewes James
- Hewes James C.
- Heywood Nick
- Higgs Simon M.
- Hill Arnold D. K.
- Hindley Caroline
- Hirst Natalie A.
- Hisham Elzanati
- Ho Wei-Min
- Hoban Jennifer R.
- Hodgkins Kathryn A.
- Hodson James
- Holroyd David J.
- Hooks Gareth
- Hopwood Benjamin
- Hornby Steve T.
- Hornsby Jane
- Hosie Kenneth B.
- Hosie Kenneth B.
- Hossack Martin R.
- Hossain Tanvir
- Hoti Emir
- Hou David
- Hrycaiczuk Alex
- Hughes Michael
- Hunter David I.
- Hussain Abdulzahra A.
- Hussain Adnan
- Hussain Anwar
- Hussain Najam
- Iftikhar Syed Yusuf
- Iqbal Nusrat
- Iskandar Edrin
- Issa Eyad
- Ivanovski Ivan
- Jackson Andrew
- Jackson Claire
- Jafferbhoy Sadaf F.
- Jambulingam Periyathambi
- Jamdar Saurabh
- Jamel Sara
- Janeczko Adam
- Jaunoo Shameen
- Jayanthi Naga V. G.
- Jelley Clare
- Jennings Neil A.
- Joel Abraham
- Johnpulle Michelle A.
- Johnston Dorothy
- Johnstone Marianne
- Johnstone Marianne
- Joji Nikita
- Jones Claire
- Jones Elinor
- Jones Gareth H.
- Jones M. Angharad
- Jones Michael J.
- Jones Robert P.
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- Kadhim Abbas
- Kadirkamanathan Sritharan
- Kallaway Charlotte
- Kanakala Venkatesh
- Kanavati Osama
- Kansal Nisheeth
- Kaptanis Sarantos
- Karavadra Babu
- Karim Lawen
- Karunakaran Priyadarssini
- Kaur Parminder
- Kausar Ambareen
- Kelly Michael E.
- Kendal Chris
- Kennedy David
- Kenny Ross
- Keogh Ken
- Khalil Ahmed M.
- Khan Amarah
- Khan Mohammad A.
- Khan Muhammad A. S.
- Khan Raja Basit
- Khan Shabuddin
- Khan Shahab
- Khawaja Amir
- Khawaja Zechan
- Khogali Elmoataz
- Kimble Adam
- Kinghorn Alison
- Kirkham Amanda J.
- Knight Benjamin
- Knight Katrina
- Kourkulos Michail
- Krysztopik Richard
- Kumar Pradeep
- Kynaston James
- Kyriakidis Dimitrios
- Lalla Kushik
- Lambert Joel
- Lammy Simon
- Lane Risha
- Larkin David
- Law Jennifer
- Lawther Roger
- Lazim Taha
- Lee Kathryn
- Lee Matthew
- Leeder Paul
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- Lim Henry C. C.
- Lim Pei J.
- Lindsay David
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- Madanipour Suroosh
- Madbak Khaliel
- Madurska Marta
- Magee Conor J.
- Maguire Donal
- Maharaj Geta
- Majeed Ali
- Malcolm Cathy
- Malde Deep
- Malik Nabeela S.
- Mallik Mekhlola
- Mansour Sami
- Manu Mangta
- Manzelli Antonio
- Marriott Paul
- Martin Jack
- Martin Sean T.
- Martin Serena
- Marudanayagam Ravi
- Mason Denise
- Mathur Pawan
- Mawhinney Abi
- Mbuvi James
- McAree Barry
- McCain Stephen
- McCallum Iain J. D.
- McClarey Andrew
- McCune Ken
- McDermott Frank
- McEntee Gerry P.
- McGlone Emma R.
- McGuigan Andrew
- McIlmunn Colin
- McKay Damian
- McKenzie Stephen
- McNair Angus G. K.
- Mealy Ken
- Menzies Donald
- Mercer Stuart J.
- Milburn James
- Mirza Ahmed K.
- Mirza Darius
- Miu Victor
- Mockford Justine Downing Katherine A.
- Mohamed Sarah
- Mohan Helen M.
- Mok Kam Wa Jessica
- Monk David
- Morcous Paul
- Morrison Tamsin E. M.
- Mothe Bhavani Sidhartha
- Mowbray Nicholas
- Mozolowski Kirsty L.
- Mukherjee Dipankar
- Murphy James O.
- Murtaza Ghulam
- Nally Deirdre M.
- Napetti Sara
- Nassar Ahmad H.
- Naumann David
- Nedujchelyn Yuwaraja
- Needham Paul J.
- Newton Katy
- Newton Richard C.
- Ngu Wee Sing
- Nicholson Gary A.
- Nicholson James
- Nicholson James A.
- Nicol Laura
- Nicolay Christopher R.
- Nieto Tom
- Nijjar Rajwinder S.
- Nilsen-Nunn April
- Nilsson Frida
- Noble Fergus
- Nofal Emma
- Noor Nigel
- Nunes Quentin M.
- Obeidallah Mohd Rami
- Ogedegbe Arikoge
- Old Oliver J.
- Orchard Philippa
- Orizu Mavis N.
- O’Dwyer Patrick
- O’Neill Maeve A.
- O’Neill Stephen
- O’Reilly Derek A.
- O’shea Kathryn M.
- O’Sullivan Adrian W.
- Packer Jessica R.
- Padwick Robert
- Pannu Arslan
- Panteleimonitis Sofoklis
- Parappally Ciny P.
- Parmar J.
- Pasquali Sandro
- Patel Abhilasha
- Patel Krashna
- Patel Shakira
- Pati Pradeep
- Pearce Belinda
- Pearson Katherine L.
- Peirce Colin
- Pellen Mike
- Peter Mark B.
- Peterson Mark
- Pezzuto Roberto
- Photi Evangelos
- Phull Manraj
- Pinho-Gomes Ana C.
- Pollock Sarah
- Popplewell Matthew
- Pore Naresh
- Porter Jonathan
- Prasad Abheesh R.
- Prasad Raj
- Preston Shaun R.
- Preziosi Giuseppe
- Prince Sarah
- Psica Alicja
- Puig Sonia
- Puntis Daniel J.
- Puri Yogesh
- Qandeel Haitham
- Rabie Mohamed
- Radwan Rami
- Rae David M.
- Rahman Saquib
- Rajaganeshan Rajasundaram
- Rajendran Ilayaraja
- Ramage Michael I.
- Rao Sudhindra T. V.
- Rate Anthony J.
- Raza Soulat
- Read Edward
- Reddy Marcus
- Reece-Bolton Obuobi
- Reed Joanna
- Reid Alistair
- Rengifo Carla
- Rhys Thomas
- Richards Colin H.
- Riera Manel
- Ritchie Judith
- Robb William
- Roberts Geoffrey P.
- Robinson Sarah
- Robinson Steven J.
- Robinson Stuart
- Rodriguez Dan
- Rodriguez Daniel Urriza
- Roebuck Amanda
- Rogers Paul N.
- Rolph Rachel C.
- Roy Sudipta
- Rutherford Claire L.
- Sadat Mohammed M.
- Sakai Naomi
- Sampat Keerthika
- Samuel Nehemiah
- Sarmah Piyush B.
- Sarvananthan Kas
- Sarveswaran Janahan
- Satheesan Steve
- Saunders Michael
- Sayegh Mazin
- Segaran Ashvina
- Sekhar Hema
- Sen Gourab
- Seymour Keith
- Shabo Wael
- Shah Nayab
- Shah Reena
- Shahin Yousef
- Sheel Andrea R. G.
- Shenoy Hrishikesh
- Shetty Vinutha
- Shier David
- Shingler Guy M.
- Shiwani Muhammad Hanif
- Shrestha Ashish Kiran
- Siddiqi Najaf
- Siddiqui Midhat N.
- Siddiqui Zohaib
- Sillo Toritseju O.
- Silva Michael
- Simpson Duncan J.
- Singh Shailendra
- Singh-Ranger Deepak
- Sinha Sidhartha
- Skelly Brendan L.
- Slavin John P.
- Slawinski Corinna
- Sloane Jake
- Smith Stella R.
- Smith Stella R.
- Sonsale Aniket
- Spearman John
- Spence Gary
- Spreadborough Philip
- Spreadborough Philip
- Starmer Benjamin Z.
- Stevenson Thomas E. J.
- Stewart Duncan J.
- Stirland E.
- Subramanium Dhivya
- Sufi Pratik A.
- Sukha Anisha
- Sutcliffe Robert
- Suttie Stuart
- Sutton Cherith M. L. R.
- Szentpali Karoly
- Tang Cheuk-Bong
- Tanner Nicola
- Tate Sophie
- Tayeh Salim
- Taylor Christopher
- Taylor Greg W.
- Teasdale Rebecca L.
- Templeton Alexa
- Terrace John
- Thakkar Rohan
- Thomas George
- Thompson Ronald L. E.
- Tilston Michael P.
- Toh Simon K. C.
- Tolofari Sotonye
- Tomlinson Mark A.
- Trevatt Alexander E. J.
- Trotter Martin
- Tsang Andrew
- Tsavellas George
- Tuck Liz
- Turner Paul
- Tutton Matthew G.
- Ullah Muhammad Fahad
- Upchurch Emma A.
- Urbonas Tomas
- Varghase Joseph
- Vass David G.
- Vaughan Elizabeth M.
- Vijay Vardhini
- Vijayan Deepak
- Vijayanand Dhakshinamoorthy
- Villatoro Eduardo
- Virupaksha Suvi
- Vitone Louis J.
- Vohra Ravinder S.
- Wadley Martin
- Wainwright Denise
- Wajed Saj
- Wallace Tom
- Wardle Stacy
- Warren Conor
- Watkin Helen
- Watson Angus J. M.
- Watson Nicholas F.
- Wayman John
- Weaver Simon
- Weber Beatrix
- Weber Beatrix
- Weerasinghe Chamindri
- Welbourn Hannah
- Wheatley Kevin
- White Timothy J.
- Wijetunga Imeshi
- Wild Jonathan R. L.
- Wilkinson Marc D.
- Williams Sophie V.
- Williamson Tracey K.
- Willson Peter D.
- Wilson Michael S. J.
- Wilson Timothy R.
- Winter Des C.
- Winter Hannah
- Wood Christopher P. J.
- Wood Peter
- Wood Simon
- Woodman Thomas
- Yahya Salama
- Yao Caroline
- Yeldham Geoffrey
- Yoganathan Thusidaran
- Youssef Haney
- Zafar Sara
- Zafrani Zakhi
- Zarsadias Prizzi
- Zeeshan Saquib
- Zhang Catherine
- Ziprin Paul
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations.
Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves.
Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p 90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score.
Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care
Observation of Cosmic Ray Anisotropy with Nine Years of IceCube Data
- Author
- Abbasi Rasha
- Ackermann Markus
- Adams Jenni
- Aguado Timothy
- Aguilar Juanan
- Ahlers M.
- Ahrens Maryon
- Alispach Cyril Martin
- Alves Junior Antonio Augusto
- Amin Najia Moureen Binte
- An Rui
- Andeen Karen
- Anderson Tyler
- Anton Gisela
- Arguelles Carlos
- Ashida Yosuke
- Axani Spencer
- Bai Xinhua
- Balagopal V. Aswathi
- Barbano Anastasia Maria
- Barwick S. W.
- Bastian Benjamin
- Basu Vedant
- Baur Sebastian
- Bay R. C.
- Beatty J. J.
- Becker Tjus Julia
- Becker K.-H.
- Bellenghi Chiara
- BenZvi Segev
- Berley D.
- Bernardini Elisa
- Besson D. Z.
- Binder Gary
- Bindig Daniel
- Blaufuss E.
- Blot Summer
- Boddenberg Matthias
- Bontempo Federico
- Borowka Jurgen
- Boser S.
- Botner Olga
- Bottcher Jakob
- Bourbeau Etienne
- Bradascio Federica
- Braun J.
- Bron Stephanie
- Brostean-Kaiser Jannes
- Browne Sally-Ann
- Burgman Alexander
- Burley Ryan
- Busse Raffaela
- Campana Michael
- Carnie-Bronca Erin
- Chen Chujie
- Chirkin Dmitry
- Choi Koun
- Clark Brian
- Clark Kenneth
- Classen Lew
- Coleman Alan
- Collin Gabriel
- Conrad J. M.
- Coppin Paul
- Correa Pablo
- Cowen D. F.
- Cross R.
- Dappen Christian
- Dave Pranav
- DE CLERCQ Catherine
- De Ridder Sam
- De With Meike
- DeLaunay James
- Dembinski Hans
- Deoskar Kunal
- Desai Abhishek
- Desiati Paolo
- DeYoung Tyce
- Dharani Sukeerthi
- Diaz Alejandro
- Diaz-Velez Juan Carlos
- Dittmer Markus
- Dujmovic Hrvoje
- Dunkman Matt
- DuVernois Michael
- Dvorak Emily
- Ehrhardt Thomas
- Eijndhoven Nick van
- Eller Philipp
- Engel Ralph
- Erpenbeck Hannah
- Evans John
- Evenson P. A.
- Fan Kwok Lung
- Fazely A. R.
- Fiedlschuster Sebastian
- Fienberg Aaron
- Filimonov Kirill
- Finley Chad
- Fischer Leander
- Fox Derek B.
- Franckowiak Anna
- Friedman Elizabeth
- Fritz Alexander
- Furst Philipp
- Gaisser T. K.
- Gallagher Jay
- Ganster Erik
- Garcia Alfonso
- Garrappa Simone
- Gerhardt L.
- Ghadimi Ava
- Glaser Christian
- Glauch Theo
- Glusenkamp Thorsten
- Goldschmidt A.
- Gonzalez Javier
- Goswami Sreetama
- Grant Darren
- Griswold Spencer
- Gruchot Katherine
- Grégoire Timothée
- Gunduz Mehmet
- Günther Christoph
- Ha Minh Martin
- Haack Christian
- Hallgren Allan
- Halliday R.
- Halve L.
- Halzen F.
- Hanson Kael
- Hardin John
- Harnisch Alexander A.
- Haungs Andreas
- Hauser Simon
- Hebecker Dustin
- Helbing K.
- Henningsen Felix
- Hettinger Emma C.
- Hickford Stephanie
- Hignight Joshua
- Hill Colton
- Hill G. C.
- Hoffman Kara
- Hoffmann Ruth
- Hoinka Tobias
- Hokanson-Fasig Benjamin
- Hoshina K.
- Huang Feifei
- Huber Matthias
- Huber Thomas
- Hultqvist Klas
- Hunnefeld Mirco
- Hussain Raamis
- In Seongjin
- Iovine Nadège
- Ishihara Aya
- Jansson Matti
- Japaridze George
- Jeong Minjin
- Jones Ben
- Kang Donghwa
- Kang Woosik
- Kang Xinyue
- Kappes Alexander
- Kappesser David
- Karg Timo
- Karl Martina
- Karle A.
- Katz U.
- Kauer M.
- Kellermann Moritz
- Kelley J. L.
- Kheirandish Ali
- Kin Ken\u27ichi
- Kintscher Thomas
- Kiryluk Joanna
- Klein Spencer
- Koirala Ramesh
- Kolanoski Hermann
- Kontrimas Tomas
- Kopke Lutz
- Kopper Claudio
- Kopper Sandro
- Koskinen D. J.
- Koundal Paras
- Kovacevich Michael
- Kowalski Marek
- Kozynets Tetiana
- Kun Emma
- Kurahashi Naoko
- Lad Neha
- Lagunas Gualda Cristina
- Lanfranchi Justin
- Larson Michael J.
- Lauber Frederik Hermann
- Lazar Jeffrey
- Lee Jiwoong
- Leonard Kayla
- Leszczyńska Agnieszka
- Li Yijia
- Lincetto Massimiliano
- Liu Qinrui
- Liubarska Maria
- Lohfink Elisa
- Lozano Mariscal Cristian Jesus
- Lu Lu
- Lucarelli Francesco
- Ludwig Andrew
- Luszczak William
- Lyu Yang
- Ma Wing Yan
- Madsen James
- Mahn Kendall
- Makino Yuya
- Mancina Sarah
- Maris Ioana Codrina
- Maruyama Reina H.
- Mase K.
- McElroy Thomas
- McNally Frank
- Mead James Vincent
- Meagher K.
- Medina Andres
- Meier Maximilian
- Meighen-Berger Stephan
- Micallef Jessie
- Mockler Daniela
- Montaruli Teresa
- Moore Roger
- Morse R.
- Moulai Marjon
- Moy Andrew
- Naab Richard
- Nagai Ryo
- Naumann Uwe
- Necker Jannis
- Nguyen Le Viet
- Niederhausen Hans
- Nisa Mehr
- Nowicki Sarah
- Nygren Dave
- O\u27Sullivan Erin
- Obertacke Pollmann Anna
- Oehler Marie
- Olivas A.
- Pandya Hershal
- Pankova Daria
- Park Nahee
- Parker Grant
- Paudel Ek Narayan
- Paul Larissa
- Perez de los Heros Carlos
- Peters Lilly
- Peterson Josh
- Philippen Saskia
- Pieloth Damian
- Pieper Sarah
- Pittermann Martin
- Pizzuto A.
- Plum M.
- Popovych Yuiry
- Porcelli Alessio
- Prado Rodriguez Maria
- Price P. Buford
- Pries Brandom
- Przybylski Gerald
- Raab Christoph
- Raissi Amirreza
- Rameez Mohamed
- Rawlins K.
- Rea Immacolata Carmen
- Rehman Abdul
- Reichherzer Patrick
- Reimann René
- Renzi Giovanni
- Resconi Elisa
- Reusch Simeon
- Rhode Wolfgang
- Richman Mike
- Riedel Benedikt
- Roberts Ella
- Robertson Sally
- Roellinghoff Gerrit
- Rongen Martin
- Rott Carsten
- Ruhe Tim
- Ryckbosch Dirk
- Rysewyk Cantu Devyn
- Safa Ibrahim
- Saffer Julian
- Sanchez Herrera Sebastian
- Sandrock Alexander
- Sandroos Joakim
- Santander Marcos
- Santen Jakob van
- Sarkar Sourav
- Sarkar Subir
- Satalecka Konstancja
- Scharf Maximilian Karl
- Schaufel Merlin
- Schieler Harald
- Schindler Sebastian
- Schlunder P.
- Schmidt Torsten
- Schneider Austin
- Schneider Judith
- Schröder Frank G.
- Schumacher Lisa Johanna
- Schwefer Georg
- Sclafani Steve
- Seckel D.
- Seunarine Surujhdeo
- Sharma Ankur
- Shefali Shefali
- Silva Manuel
- Simmons Alexander
- Skrzypek Barbara
- Smithers Ben
- Snihur Robert
- Soedingrekso Jan
- Soldin Dennis
- Spannfellner Christian
- Spiczak Glenn
- Spiering Christian
- Stachurska Juliana
- Stamatikos Michael
- Stanev T.
- Stein Robert
- Stettner Joeran
- Steuer A.
- Stezelberger T.
- Sturwald Timo
- Stuttard Thomas
- Sullivan G. W.
- Taboada I.
- Tenholt Frederik
- Ter-Antonyan Samvel
- Thorpe Andrew
- Tilav S.
- Tischbein Franziska
- Tollefson Kirsten
- Tomankova Lenka
- Toscano Simona
- Tosi Delia
- Trettin Alexander
- Tselengidou Maria
- Tung Chunfai
- Turcati Andrea
- Turcotte Roxanne
- Turley Colin
- Twagirayezu Jean Pierre
- Ty Bunheng
- Tönnis Christoph
- Unland Elorrieta Martin
- Valtonen-Mattila Nora
- Vandenbroucke Justin
- Vannerom David
- Verpoest Stef
- Vraeghe Matthias
- Vries Krijn de
- Walck C.
- Wasseige Gwenhaël de
- Watson Timothyblake
- Weaver Chris
- Weigel Philip
- Weindl Andreas
- Weiss Matthew
- Weldert Jan
- Wendt Chris
- Werthebach Johannes
- Weyrauch Mark
- Whitehorn Nathan
- Wiebusch C. H.
- Williams Dawn
- Wolf Martin
- Woodward Hannah
- Woschnagg Kurt
- Wrede Gerrit
- Wulff Johan
- Xu Xianwu
- Xu Yiqian
- Yanez Juan Pablo
- Yoshida S.
- Yu Shiqi
- Yuan Tianlu
- Zhang Zelong
- Publication venue
- Scuola Internazionale Superiore di Studi Avanzati
- Publication date
- 04/10/2021
- Field of study
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
- Bolton Christel
- Bolund Lars
- Bondoc Marnel
- Bonfield James
- Bonnett Ralph
- Bonnin David
- Border Richard
- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
- Brottier Philippe
- Brown Andrew
- Brown Clive
- Brown Jacqui
- Brown Margaret
- Brown Mary
- Brown Mary J.
- Brown Michael
- Brown Nancy C.
- Bruce David D.
- Bruce Robert
- Bruno William J.
- Bruskiewich Richard
- Bryant Jackie
- Bryant Jennifer E.
- Bryant Nathaniel P.
- Brüls Thomas
- Buatsi Delali
- Buck David
- Buckingham Judith M.
- Buckle Veronica
- Buczek Donald
- Budd Claire
- Buhay Christian J.
- Bulbul Kerem
- Buller Sarah
- Bunker Nathan
- Burberry Jill
- Burch Paula Ellen
- Burford Deborah
- Burgess Joanne
- Burgin Matt
- Burkett Carrie E.
- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
- Burton Christine
- Burton John
- Butcher Phil
- Butler Adam
- Butler Jon
- Butler Paul
- Caenepeel Sean
- Cahill Patrick
- Cai Tianjing
- Cai Zhen
- Cairns Murray
- Calderon Eliana
- Callen David F.
- Camarata Jody
- Camire David
- Camm Nick
- Campbell Christopher
- Campbell Connie S.
- Campbell Evelyn W.
- Campbell Mary I.
- Campbell Mary L.
- Campo Kevin
- Canning Bruno
- Cao Ting
- Cao Yuzhu
- Caoile Chenier
- Cardenas Faviola
- Cardenas Lolo
- Cardenas Veronica
- Carder Carol
- Carder Paul
- Carpenter Kelly
- Carrano Anthony V.
- Carriere Jason
- Carter Jason
- Carter Kelvin
- Carter Nigel
- Caruso Lauren
- Casias Kristal
- Cattolico Laurence
- Cavanna Tamara
- Cavazos Iracema
- Cavazos Sandra R.
- Ceasar Heather
- Cedroni Maria
- Cepeda Mario
- Chacko Joseph
- Chain Patrick
- Chalk Shani
- Challacombe Jean F.
- Chan Ka
- Chan Sheryl N.
- Chan Yee Man
- Chang Jean L.
- Chapman Jarrod
- Chapman Joanna
- Chapple Jeffrey
- Charles Rachel
- Chasteen Leslie A.
- Chavarria Simeon
- Chazaro Bruno
- Chen Baoxian
- Chen Bin
- Chen Chira
- Chen Chong
- Chen Chong
- Chen Chun-Nan
- Chen Cong
- Chen Ellson
- Chen Hsiu-Chuan
- Chen Jianlong
- Chen Jie
- Chen Jin
- Chen Junbao
- Chen Lihong
- Chen Lixia
- Chen Ray
- Chen Shu
- Chen Tong
- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
- Chissoe Stephanie
- Chiu Sally
- Chothia Tom
- Christensen Mari
- Christopoulos Constantine
- Chu Joseph
- Chui Connie
- Chung A
- Cinkowsky Michael J.
- Citroen Mieke
- Clack Rob
- Clamp Michele
- Clark Anthea
- Clark Graham
- Clark Kevin
- Clark Lynn
- Clark Lynn M.
- Clark Richard
- Clark Sarah
- Clark Sue
- Clarke Adrian
- Clarke Betty
- Clarke Eddie
- Clarke Kay
- Clarke Laura
- Clawson Hiram
- Clee Chris
- Clegg Shelia
- Clerc Blankenburg Kerstin Petra
- Cleveland David
- Clifford Karen
- Clifton Sandra W.
- Coates Julia
- Cobley Victoria
- Cockrell Raynard
- Coffey Alison
- Cofield Jackie
- Coggill Penelope
- Cohn Judith D.
- Colayco Rick
- Cole Lotte
- Collier Rachael
- Collings Simon
- Collins Francis S.
- Collins John
- Collins Philip
- Collymore Al
- Colman Louise
- Combs Jessie
- Comstock Robin
- Cong Bin
- Conner Richard
- Connolly Anthony
- Connolly Karen
- Conquer Jennie
- Conrad Ansgar
- Conroy Donald
- Considine Tony
- Constance Doug
- Cook April
- Cook Leanna
- Cooke Patrick
- Cooper Jonathan
- Cooper Rachel
- Cooper Robert
- Copeland Alex
- Coppola Maria
- Copsey Teresa
- Corby Nicole
- Cordes Matt
- Cordray Rebecca
- Cornell Christine
- Cornell Earl
- Cornell Linda
- Cornell Ruth
- Corum Ben
- Cottage Amanda
- Cotton Sara
- Coulson Alan
- Couronne Olivier
- Courtney Laura P.
- Coville Gez
- Cox Anthony
- Cox Caroline D.
- Cox Tony
- Coxhill Robert
- Coyle Marcus D.
- Craig Matthew
- Crane Tom
- Crawford Amanda L.
- Crawley Matt
- Cree Andrew
- Crespeau Hervé
- Crew Victor
- Critchlow Terrance
- Critz Paul
- Cruaud Corinne
- Cuff James
- Cui Hongjuan
- Cui Jinhui
- Cui Peng
- Cui Peng
- Culley Karl
- Cummings Auli
- Cummings Kirsti
- Cummings Paul
- Cummings Stephanie
- Cuomo Christina A.
- Curran Adam
- Curwen Valery
- Cutts Jeffrey
- Czubayko Martin
- D\u27Souza Lisa Marie
- Da Silva Corinne
- Dai Li
- Dalin Eillen
- Dang Michelle
- Danganan Linda
- Daniels Rachael
- Dathorne Stephanie R.
- Daum Christopher
- David Robert
- Davidson Lucy
- Davidson Stuart
- Davies Jonathon
- Davies Joy
- Davies Nicholas
- Davies Robert
- Davila Mary Louise
- Davis Candi Mon\u27et
- Davis Cheryl
- Davis Clay
- Davis Jayne
- Davis John
- Davis Matthew
- Davy-Carroll Latarsha
- Dawoe Tenzin
- Dawson Elisabeth
- De Anda Claudia
- De Latorre Andrea
- Deadman Rebecca
- Dean Peter
- Dear Simon
- Dearden Frances
- DeArellano Kurt
- Deaven Larry I.
- Deaven Larry L.
- Deere Kerry
- DeGray Stewart
- Degusta David
- Deguzman Maria
- Dehal Paramvir
- Delgado Marcos
- Delgado Oliver
- Delhaunty Kimberley
- Deloukas Panos
- Deng Yajun
- Dennis Janet
- Denson Shawn
- Denys Mirian
- Deramo Christine
- Desai Anu
- Detter John C.
- Devlin Laurie
- Dewar Ken
- Dhami Pawandeep
- Dhongsar Chemey
- Dias Jennifer
- Dias Victoria
- Dibartolo Genevieve
- Dibling Catherine
- Dickson Mark
- Diekhans Mark
- Dietz-Band Jeanne
- Digennaro Richard
- Dilts Karen
- Dimitrijevic-Bussod Mira
- Ding Hao
- Ding Keyue
- Ding Li
- Ding Yan
- Dinh Huyen H.
- Dixon Kami
- Do Long
- Dobbs Ruth
- Dobson Richard
- Dockree Catherine
- Doddington Daniel
- Dodsworth Steven
- Doggett Norman
- Doggett Norman A.
- Dong Hui
- Dong Kimberly
- Dong Wei
- Dong Wei
- Dong Xiaojia
- Donlin Jeremy E.
- Dooley Kathy
- Dooling David
- Dorje Passang
- Dorjee Kunsang
- Dorris Lester
- Dorsett Victor
- Doucette-Stamm Lynn
- Douthwaite Karen J.
- Down Thomas
- Draper Heather
- Du Feiyu
- Du Hui
- Du Yutao
- Duarte Suzanne
- Dubchak Inna
- Duffy Noah
- Dugan-Rocha Shannon
- Dunham Andrew
- Dunham Ian
- Dunn Adam M.
- Dunn Anne
- Dunn Matthew
- Dunwell Erin
- Dupes Alan
- Durbin Kenneth J.
- Durbin Richard
- Durham Jillian
- Dutta Ireena
- Dwyer Ruth
- Dyer Lauren
- Dziuda Darius
- Earnhardt Christopher D.
- Earthrowl Mark
- Eastham Emma
- Eastham Timothy
- Eaves Kristy A.
- Eckenberg Ralph
- Edgar Darren
- Edionwe Susan Omwanghe Osayanro
- Edwards Carol
- Edwards Jennifer
- Edwards Karen
- Egan Amy
- Eichler Evan
- Eichler Evan
- Ejima Fumio
- Elkin Chris
- Ellington Andrew
- Elliot David
- Elliot Glendoria
- Elliot Jeffrey
- Ellwood Matthew
- Emberson Becky
- Emelianenko Natalia
- Emery-Cohen Alexandra J.
- Endrizzi Matthew
- Engh Ger van den
- Engle David
- Erickson Jeffery
- Erler Anne Marie
- Errington Helen
- Escobar Julio
- Escotto Michael
- Eugene Craig S.
- Evans Gareth
- Evans John
- Evans Katie
- Evans Richard
- Eveleth Gerald
- Eyras Eduardo
- Fan Hongyuan
- Fan Keke
- Fang Jianqiu
- Farina Abderrahim
- Faro Susan
- Faulkner Louisa
- Fawcett Joseph J.
- Fechtel Kim
- Fellingham Charlotte
- Felming Claire
- Felsenfeld Adam
- Feltwell Theresa
- Feng Guodong
- Feng Haiyan
- Feng Jie
- Feng Xiaoli
- Fennell Stephen
- Ferguson Alicia
- Fernandez Sonia
- Fernandez-Suarez Xose
- Fernando Pushpa Ranjani
- Ferriera Pat
- Fertitta Anne
- Fey Jim
- Fidel Patrick
- Fields Elizabeth
- Fink Marie
- Finley Maria C.
- Finn Robert
- Fischer Heather
- Fischer Laurice
- Fisher Shelia
- Fitch Pat
- Fitzgerald Mike
- Flack Tina
- Flagg Nicole
- Flanagan J.
- Fleming Kerry
- Flint Jonathan
- Flint Mark
- Flowers Dave
- Floyd Yvonne
- Foley Karen
- Folta Peg
- Fong Jonathan
- Fonknechten Núrua
- Footman Simon
- Forbes Lisa D.
- Ford Amanda F.
- Foster Myre J.
- Fotopulos Dea
- Fourcade Matthew
- Fowler John
- Fox Jessica
- Frame Deborah
- Francis Matthew
- Francis Stephen
- Frankel Ken
- Frankish Adam
- Frankland John
- Fraser Audrey
- Fraser David
- Frazier Marvin
- French Lisa
- Fricker David
- Fridlyand Jane
- Fronick Catrina
- Frost Carole
- Frost Daniel
- Frost Jackie
- Frost Lorna
- Fu Gang
- Fu Gang
- Fu Gang
- Fu Qiushi
- Fujioka Michiru
- Fujiyama Asao
- Fukawa Rintaro
- Fuller Liam
- Fuller Sharin
- Fullerton Kathryn
- Fulton Lucinda A.
- Fulton Robert S.
- Furey Terrence S.
- Furuhashi Mie
- Förste Silke
- Gabisi Abdul M.
- Gage Diane
- Gaige Tony
- Galgoczy Petra
- Gallegos Celsa
- Galvez Michael
- Gammon Stuart
- Gao Anwu
- Gao Jimei
- Gao Quan
- Gao Yang
- Gao Yimei
- Garcia Carmen
- Garcia Emilio
- Garcia Marvin
- Garcia Ricardo M, III
- Garcia-Martinez Antonio
- Gardner Alison
- Gardner Alison
- Garduno Consuelo
- Gardyna Steph
- Garner Patrick
- Garner Toni T.
- Garnes Jeffrey A.
- Garnett Jane
- Garza Melissa
- Gatewood Joseph M.
- Gatland Leigh
- Gatland Lindsay
- Gattung Stacie
- Gay Laura
- Gearin Gary
- Gebreyesus Binyam
- Gelein Cynthia
- Gelpke Maartin
- Gench Stephanie L.
- Geng Jianing
- Georgescu Anca
- Geotina Amy
- Ghori Jilur
- Ghose Sayantan
- Gibbs Ben
- Gibbs Richard A.
- Gibson Diane
- Gibson Elizabeth
- Gifford Mary
- Gil Isaias
- Gilbert James
- Gilby Lisa
- Gill Rachel
- Gillet Will
- Gillson Christopher
- Gilna Paul
- Gimmel Verena
- Gingrich Jeff
- Giovanelli Kira
- Glavina Tijana
- Glithero Rebecca
- Glöckner Gernot
- Gnerre Sante
- Gnirke Andreas
- Gold Darren
- Golinveaux Kristen
- Gomez Maria
- Gong Guanghui
- Gong Jinying
- Gonzales Eidelyn
- Gonzalez Guillermo B.
- Gooderham April
- Goodstadt Leo
- Goodstein David
- Goodwin Lynne A.
- Gordon Catherine
- Gordon Laurie A.
- Gordon Seth
- Gorton Matthew
- Gorvad Ann
- Gould Christine
- Goyea Ernest
- Goyette Audra
- Grady Deborah I.
- Grady Michelle L.
- Grafham Darren
- Graham Joe
- Grandbois Edward
- Grant Jennifer
- Grant Michael
- Grant Susan
- Graves Tina A.
- Gray Bruce
- Gray Emma
- Gray Lain
- Green Lisa
- Greenhalgh James
- Greenhill Joe
- Gregg Philippa
- Gregory Simon
- Grewal Nennu
- Gribble Susan
- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
- Griffiths Mark
- Griffiths-Jones Sam
- Grigoriev Igor
- Grimwood Jane
- Grocock Russell
- Groza Matthew
- Gu Jingli
- Gu Jun
- Gu Jun
- Gu Wenyi
- Gu Wenyi
- Gu Xiaochang
- Guan Qiaoning
- Guarin Hannibal
- Guel Metzalli
- Guerra William
- Guevara Whitney V.
- Gui Qi
- Gunaratne Preethi
- Gunning Kate
- Guo Daorong
- Guo Jane
- Guo Lili
- Gustafson Erik
- Guthrie Ian
- Guyer Mark
- Gwilliam Rhian
- Gyaltsen Kunsang
- Gyapay Gábor
- Görlich Yvonne
- Ha Chi
- Hafez Nabil
- Haglund Krista
- Hagopian Daniel
- Hagos Birhane
- Haim Allen
- Hajek Patrick
- Hall Brett Lynn
- Hall Brittany
- Hall Jennifer
- Hall Rebekah
- Hall-Tamly Gretta
- Halls Karen
- Hallsworth-Pepin Kym
- Hamada Junko
- Hamilton Cerissa
- Hamilton Keelan A.
- Hamilton Matt
- Hamlett John
- Hamlett John
- Hammon Nancy
- Hammond Martin
- Hammond Sha
- Hammond Sian
- Hamza Khalid
- Han Guiqing
- Han Shunsheng
- Han Xurong
- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
- Harley Joanne
- Harper David
- Harper Georgina
- Harper Patrik
- Harradence Grant
- Harris Anthony
- Harrison Charlene-Lou
- Harrison Elliot
- Harrison Ruth
- Hart Elizabeth
- Hasegawa Tomoko
- Hashimoto Etsuko
- Hashimoto Wakako
- Hassan Daniel
- Hatcher Beath
- Hattori Masahira
- Haugen Eric
- Haussler David
- Havlak Paul
- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
- Hawkins Trevor
- Hawley Kellie
- Haydu Lauren
- Hayes Kerry
- He Fengying
- He Jiaying
- He Lin
- Heaford Andrew
- Heath Paul
- Heathcott Rosemary
- Heilig Roland
- Heiner Cheryl
- Heinze Ivonne
- Heitmann Katja
- Helfenbein Keven
- Heller Andrew
- Hellsten Uffe
- Hembry Cathy
- Henderson Carl
- Henderson Nicholas
- Henderson Nina
- Hendrix David
- Hennig Steffen
- Henning Karla
- Hepa Victor
- Herd Tim
- Herman Charles
- Hernandez Judith
- Hernandez Omar
- Herseim Allyson
- Hewitt Stephen
- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
- Hillier LaDeana
- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
- Holden Jane
- Holdgate Janet
- Hollaway Mara
- Hollins Barbara
- Holloway Ele
- Holmes Andrea
- Holmes Ian
- Holmes Sarah
- Holroyd Simon
- Holtz Ann
- Holtzer Caleb
- Homsi Deana K.
- Homsi Farah J.
- Honan Tracy
- Hood Leroy
- Hooper Alison
- Hopewell Lucy
- Hopkins Ben
- Horne Jennifer
- Hornett Gary
- Hornischer Klaus
- Hornsby Amber
- Hornsby Geoff
- Hornsby Tony
- Horsley Sharon
- Horton Roger
- Hosage-Norman Catherine
- Hosoda Kei
- Hosono Katsuhiro
- Hosseini Roya
- Hou Shunfang
- Hou Xiaodi
- Houde Nathan
- Howard Philip
- Howard Stephanie R.
- Howden Philip
- Howe Kevin
- Howell Gareth
- Howell Latoya Lynette
- Howells Sally Lucinda
- Hsu Fan
- Hu George
- Hu Jie
- Hu Songnian
- Huang Fang
- Huang Guyang
- Huang Katherine
- Huang Mei
- Huang Wayne
- Huang Wei
- Huang Wei
- Huang Wei
- Huang Zhengping
- Hubbard Timothy
- Huber James W.
- Huckle Elizabeth
- Hue Heather
- Hughes Jaime
- Hughes Jennifer
- Hughes Lee
- Hughes-Hull Hillary
- Hull Louisa
- Hulme Bill
- Hulyk Steven
- Hume Jennifer
- Hummeric Holger
- Humphray Sean
- Humphries David
- Humphries Matthew
- Hunt Adrienne
- Hunt Michael
- Hunt Paul
- Hunt Sarah
- Hunter Giselle
- Hunter Rov, II
- Hupman Matt
- Huynh Sandy
- Hyde David
- Hynds Christopher
- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
- Inagaki Naomi
- Ince Michael
- Ingram Drew
- Inoue Shuuji
- Isak Amber
- Isherwood Judith
- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
- Isozaki Emi
- Israni Sanjay
- Ito Fumiaki
- Ito Noriko
- Itoh Takehiko
- Iwakawa Shinobu
- Iwatate Mariko
- Iwatsu Mikiko
- Iyer Vivek
- Izatt Janet
- Izmajlowicz Monica
- Izumiyama Tomohiro
- Jacintho Mark
- Jackson Laronda R.
- Jackson Terri
- Jacob Leni Susan
- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
- James Kent W.
- Jareborg Niclas
- Jarek Michael
- Jassal Bijay
- Jeffery Grant
- Jeffery Kim
- Jeffrey Colin
- Jekosch Kerstin
- Jenkins Lee
- Jett Jamie
- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
- Jia Xingchang
- Jiang Lu
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- Jones Myrna D.
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- Kelly Shayna P.
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- Kershaw Joanna
- Kettleborough Ross
- Keys David
- Khan Arsi
- Khan Umer F.
- Khan Ziad Mohid
- Khine Susu
- Khurama Divya
- Kidd Cathy
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- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
- Kremitzki Colin
- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
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- Landers Tom
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- Lewis Keith
- Lewis Lakeshia C.
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- Longmire Johnathan L.
- Lopez Frederick
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- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
- Loveland Jane
- Lovell Jamie
- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
- Lu Tao
- Lu Xiuhua
- Lu Yongxiang
- Lu Yontao T.
- Lu Yue
- Lucas Robert
- Lucas Susan
- Lucier Alice
- Lucier Raymond L.
- Ludeman Thom
- Lui Annie
- Lundgren Lyndsey
- Luo Chunqing
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- Lv Gang
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- Machrus Migdad
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- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
- Maeda Hideto
- Maglott Donna
- Maheshwari Manjula
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- Mahnke Ryan
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- Malfatti Stephanie
- Malloy Kevin
- Maltbie Mary I.
- Mangum Brian
- Manning Jonathan
- Manohar Chitra
- Mapua Patricia
- Marabella Dick
- Mardis Elaine R.
- Mareth David
- Mariano Marisa
- Marinelli Lisa
- Mark Graham A.
- Marquis-Homeyer Catherine
- Marr Thomas G.
- Marra Marco
- Marriott Neil
- Marrone Anne
- Marroquin Christian
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- Matthews Charles D.
- Matthews Lucy
- Matthews Nick
- Matthews Paul
- Matthews Sterling D.
- Mauceli Evan
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- McLellan Michael D.
- McLeod Michael P.
- McMurdo John
- McMurray Amanda
- McMurray Des
- McMurray Kimberly
- McMurray Kimberly L.
- McNinch Jenny
- McPherson John
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- McVicker Graham
- McWilliams Natalie
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- Medina Catherine
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- Meidi Patrick
- Meier Elke
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- Meldrim James
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- Menuge Noel
- Mercado Christian
- Mercado George
- Mercado Iracema C.
- Mercer Simon
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- Mesirov Jill P.
- Metzker Michael Lee
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- Miller Christie
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- Miner Sheri
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- Minja Emmanuel
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- Mu Feng
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- Mungall Andy
- Munidasa Mala
- Munk A. Christine
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- Murayama Yuji
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- Nagamine Kentaro
- Nagao Syunsuke
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- Naka Maho
- Nakagawa Masayo
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- Nelson Joanne
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- Newes Christian
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- Nguyen Natalie M.
- Nguyen Ngoc Bich
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- Nordsiek Gabriele
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- Novik Karen
- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
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- Ohtsubo Masafumi
- Oinn Tom
- Okoawo Ose
- Okui Michiyo
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- Okwuonu Geoffrey O.
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- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
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- Olson Maynard V.
- Omotosho Bamidele
- Onoda Junko
- Oomori Nobuhiro
- Ooshima Kenshiro
- Oragunye Njideka
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- Ovcharenko Ivan
- Overton-Larty Emma
- Oviedo Rodolfo J.
- Ow David
- Ozawa Ritsuko
- Ozersky Philip
- Pace Araceli C.
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- Padki Anuradha
- Pahlavan Shane
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- Palazzolo Michael
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- Pan Jiaofeng
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- Parkin Christopher
- Parkin Kim
- Parks Kenya L.
- Parry-Brown Ginny
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- Pasternak Shiran
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- Patrick James
- Paul Heidie A.
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- Peng Vivian
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- Peng Yi
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- Pennacchio Len A.
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- Perez Agapito
- Perez Lesette M.
- Perito Andrew
- Perrault Isabelle
- Perrier Rene
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- Perrin William
- Pesavento Brad
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- Peterson Jane
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- Polman Jos
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- Porter Keith
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- Poundstone Pat
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- Powell Don
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- Prathalingham Radhika
- Predki Paul
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- Qiang Boqin
- Qiang Boqin
- Qiao Zhenyong
- Qin Xiang
- Quail Michael
- Quan Glenda
- Quarrie Hannah
- Quiles Miyo M.
- Quince Chris
- Quiroz Juana B.
- Qureshi Matloob
- Rabata Dina
- Rachlin Eric K.
- Rachupka Anthony
- Radionenko Maxim
- Rajagopal Mohan
- Ramasami Umadevi
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- Ray Aditya
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- Reily Amy D.
- Reinhardt Astrid
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- Richardson Kristi
- Richardson Paul
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- Ridler Kerry
- Riethman Harold
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- Riley B.E
- Rise Cecil
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- Robinson Donna L.
- Robinson Melanie
- Rochford Rebecca
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- Sasaki Takashi
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- Saunders David
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- Saurin William
- Savery Glenford G.
- Sawada Nori
- Sawhill William W.
- Saxman Eric
- Scarpelli Claude
- Scharfe Maren
- Schatzkamer Kyriena L.
- Scherer Steven Edward
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- Siddiqui Roman
- Siepel Adam C.
- Silk Richard
- Silk Richard
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- Soderlund Cari
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- Solovyev Victor
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- Sonaike Titilola
- Song Liping
- Song Liping
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- Song Xing-Zhi
- Sonnhammer Erik
- Sonnhammer Erik
- Sorelle Richard P.
- Sotheran Elizabeth
- Sougnez Carrie
- Spainhower Corey
- Sparks Anastasia L.
- Spencer Brian
- Spieth John
- Spooner William
- Spraggon Lee
- Sqaures Suzanna
- Squares Janet
- Stabenau Arne
- Stables Michael
- Stalker James
- Stalker John
- Stallings Raymond I.
- Stalvey Malinda
- Stamford Steve
- Stammers Melanie
- Standring Lisa
- Stange-Thomann Nicole
- Stavropoulos Sharon
- Steffen David
- Stege Justin T.
- Steingruber Helen
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- Stephens-Bolds Shaela
- Stetson Kevin
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- Stubbs Matthew
- Stultz Janet
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- Su Xiaohu
- Subramanian Sandhya
- Subramanian Sandhya
- Sudbrak Ralf
- Sugnet Charles W.
- Sulston John
- Summers Leslie J.
- Sun Hui
- Sun Jiajia
- Sun Jiandong
- Sun Jiu Qin
- Sun Min
- Sun Tao
- Sun Wei
- Sun Yongqiao
- Sun Yu
- Sun Yue
- Sutherland Grant R.
- Sutherland Robert D.
- Sutton Angelica E.
- Svatek Amanda F.
- Svetz Jessica
- Svetz Leah Anne
- Swainson Chris
- Swann Mark
- Swarbreck David
- Swearengen-Shahid Sharhonda
- Sycamore Neil
- Ségurens Béatrice
- Tabor Paul E.
- Tacey Kristina
- Tagett Beckie
- Tagney Matthew
- Tahara Takashi
- Takahashi Keiko
- Takano Nobuhiro
- Takaoka Tori
- Takayanagi Atsushi
- Takenaka Tracy
- Talamas Jessica
- Tam Serena
- Tamerisa Kavitha S.
- Tamirisa Aparna
- Tan Olivia
- Tan Steven
- Tan Xinyu
- Tan Xinyu
- Tang Hongli
- Tang Xiangjun
- Tansey Jennifer
- Tao Ran
- Tapia Roxanne
- Taring Elizabeth
- Tatsuyama Miho
- Tatum Owatha I.
- Taudien Stefan
- Taylor Amy
- Taylor Christina C.
- Taylor Gillian
- Taylor Kate
- Taylor Ruth
- Taylor Sam
- Taylor Susan
- Taylor Tineace R.
- Taylor Todd Duane
- Tchuinga Pierre
- Tee Louise
- Telford Ethan Brett
- Tenzin Pema
- Terada Yoriko
- Terry Astrid
- Tesfaye Senait
- Tesmer Judith G.
- Tester Julieanne
- Thayer Nina
- Theaker Andrew
- Theil James
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- Thexton David
- Thies Stephanie
- Thomas Craig
- Thomas Daniel
- Thomas Daryl J.
- Thomas Karen
- Thomas Nicole
- Thomas Paulette
- Thomas Ruth
- Thomas Shereen
- Thommai Roselin
- Thompson Linda S.
- Thorne Rachel Diane
- Thorpe Andrea
- Thorpe Karen
- Thoulutsang Yama
- Threadgold Glen
- Thurston Scott
- Tian Chaoguang
- Tian Chaoguang
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- Tian Yuqing
- Tice Hope
- Tighe Damon
- Tin-Wollam Aye M.
- Tinsley Emma
- Tochigi Miwako
- Togashi Naoko
- Tomizawa Iori
- Tomlinson Chad
- Tong Jingli
- Topham Kerri
- Torcaso Bill
- Torney David C.
- Totoki Yasushi
- Towey Sarah
- Toyoda Atsushi
- Tracey Alan
- Tran Ly Thanh
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- Trani Lee
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- Trask Barbara J.
- Travers Johnathan
- Trejos Zulma Y.
- Treuhaft Marianne
- Trevino Brenda Kaye
- Tromans Anthony
- Trong Stephan
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- Tu Yuefeng
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- Ulanovsky Levy E.
- Un Chun
- Ung Quyen
- Upson Darren
- Urban Jeremy B.
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- Ureta-Vidal Abel
- Usmani Kamran
- Ustaszewska Anna
- Uyama Nozomi
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- Wu Chungen
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- Wylie Kris
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- Xi Yan
- Xi Yingying
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- Xu Alex
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- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
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- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
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