Pregeometric Concepts on Graphs and Cellular Networks as Possible Models of Space-Time at the Planck-Scale

Starting from the working hypothesis that both physics and the corresponding mathematics have to be described by means of discrete concepts on the Planck-scale, one of the many problems one has to face is to find the discrete protoforms of the building blocks of continuum physics and mathematics. In the following we embark on developing such concepts for irregular structures like (large) graphs or networks which are intended to emulate (some of) the generic properties of the presumed combinatorial substratum from which continuum physics is assumed to emerge as a coarse grained and secondary model theory. We briefly indicate how various concepts of discrete (functional) analysis and geometry can be naturally constructed within this framework, leaving a larger portion of the paper to the systematic developement of dimensional concepts and their properties, which may have a possible bearing on various branches of modern physics beyond quantum gravity.Comment: 16 pages, Invited paper to appear in the special issue of the Journal of Chaos, Solitons and Fractals on: "Superstrings, M, F, S ... Theory" (M.S. El Naschie, C. Castro, Editors

Ship resistance when operating in floating ice floes: a combined CFD&DEM approach

Whilst climate change is transforming the Arctic into a navigable ocean where small ice floes are floating on the sea surface, the effect of such ice conditions on ship performance has yet to be understood. The present work combines a set of numerical methods to simulate the ship-wave-ice interaction in such ice conditions. Particularly, Computational Fluid Dynamics is applied to provide fluid solutions for the floes and it is incorporated with the Discrete Element Method to govern ice motions and account for ship-ice/ice-ice collisions, by which, the proposed approach innovatively includes wave effects in the interaction. In addition, this work introduces two algorithms that can implement computational models with natural ice-floe fields, which takes randomness into consideration thus achieving high-fidelity modelling of the problem. Following validation against experiments, the model is shown accurate in predicting the ice-floe resistance of a ship, and then a series of simulations are performed to investigate how the resistance is influenced by ship speed, ice concentration, ice thickness and floe diameter. This paper presents a useful approach that can provide power estimates for Arctic shipping and has the potential to facilitate other polar engineering purposes.Comment: 26 pages 18 figures, submitted journal pape

Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing

Gene silencing mediated by small interfering RNA (siRNA) is a novel approach in the development of new cancer therapeutics. Polycations used for nucleic acid delivery still remain heterogeneous compounds, despite continuous progress in polymer synthetic technologies. Here we report the development of a structural defined folic acid polyethylene glycol (PEG) siRNA conjugate accessible via click chemistry yielding a monodisperse ligand-PEG-siRNA conjugate. The folic acid targeting ligand was synthesized by solid phase supported peptide chemistry. The conjugate was shown to be specifically internalized into folic acid receptor expressing cells. When combined with a structurally defined polycation, again synthesized with the precision of solid phase chemistry, efficient receptor specific gene silencing is achieved

Numerical simulation of hydroelastic waves along a semi-infinite ice floe

With the increasing demand for Arctic Engineering purposes, Squire suggests current theories may have oversimplified the sea ice hydroelasticity, indicating the need to develop numerical models to obtain more realistic solutions. Numerical models have been reported capable of achieving a full coupling between waves and rigid floating ice. When an ice floe is relatively small to wavelength, it is valid for the floe to be considered as rigid, thus no need to solve ice deformations. However, in order to model the sea ice hydroelasticity, a Fluid-Structure Interaction (FSI) approach is required to obtain the structural solution of ice deformation and couple it with the solution of surrounding fluid domain, which requires further development of above models. To fill this gap, an FSI approach was developed based on the open-source code, OpenFOAM, and it has been validated in the case of wave interaction with a finite ice floe. In this work, the developed model is extended to a very long ice floe to study the semi-infinite scenario. Simulations are performed to present the wave-induced ice deformation, with the attenuation of hydroelastic waves along the ice floe investigated

Computational universes

Suspicions that the world might be some sort of a machine or algorithm existing ``in the mind'' of some symbolic number cruncher have lingered from antiquity. Although popular at times, the most radical forms of this idea never reached mainstream. Modern developments in physics and computer science have lent support to the thesis, but empirical evidence is needed before it can begin to replace our contemporary world view.Comment: Several corrections of typos and smaller revisions, final versio

Photoionization Dynamics of the Tetraoxo Complexes OsO4 and RuO4

The photoionization dynamics of OsO4 and RuO4, chosen as model systems of small-size mononuclear heavy-metal complexes, has been theoretically studied by the time-dependent density functional theory (TDDFT). Accurate experimental measurements of photoionization dynamics as a benchmarking test for the theory are reported for the photoelectron asymmetry parameters of outer valence ionizations of OsO4, measured in the 17-90 eV photon energy range. The theoretical results are in good agreement with the available experimental data. The observed dynamical behavior of partial cross sections and asymmetry parameters has been related to both the coupling to the continuum of discrete excited states, giving strong modulations in the photon energy dependency, and the atomic composition of the initial ionized states, which determines the rate of decay of ionization probability for increasing excitation energies. Overall, an extensive analysis of the photoionization dynamics for valence and core orbitals is presented, showing good agreement with all the available experimental data. This provides confidence for the validity of the TDDFT approach in describing photoionization of heavy transition element compounds, with the perspective of being used for larger systems. Further experimental work is suggested for RuO4 to gather evidence of the sensitivity of the theoretical method to the nature of the metal atom

Hydrothermal Alteration of Ultramafic Rocks in Ladon Basin, Mars—Insights From CaSSIS, HiRISE, CRISM, and CTX

The evolution of the Ladon basin has been marked by intense geological activity and the discharge of huge volumes of water from the Martian highlands to the lowlands in the late Noachian and Hesperian. We explore the potential of the ExoMars Trace Gas Orbiter/Color and Stereo Surface Imaging System color image data set for geological interpretation and show that it is particularly effective for geologic mapping in combination with other data sets such as HiRISE, Context, and Compact Reconnaissance Imaging Spectrometer for Mars. The study area displays dark lobate flows of upper Hesperian to early Amazonian age, which were likely extruded from a regional extensional fault network. Spectral analysis suggests that these flows and the underlying rocks are ultramafic. Two distinct altered levels are observed below the lobate flows. The upper, yellow-orange level shows hundreds of structurally controlled narrow ridges reminiscent of ridges of listwanite, a suite of silicified, fracture-controlled silica-carbonate rocks derived from an ultramafic source and from serpentine. In addition to serpentinite, the detected mineral assemblages may include chlorite, carbonates, and talc. Kaolin minerals are detected in the lower, white level, which could have formed by groundwater alteration of plagioclase in the volcanic pile. Volcanism, tectonics, hydrothermal activity, and kaolinization are interpreted to be coeval, with hydrothermal activity and kaolinization controlled by the interactions between the aquifer and the hot, ultramafic lobate flows. Following our interpretations, East Ladon may host the first listwanite ridges described on Mars, involving a hydrothermal system rooted in a Hesperian aquifer and affecting ultramafic rocks from a magmatic source yet to be identified

Systematic review and meta-analysis of the risk of severe and life-threatening thromboembolism in cancer patients receiving anti-EGFR monoclonal antibodies (cetuximab or panitumumab)

Cancer-associated thromboembolism is a substantial problem in clinical practice. An increase in the level of fibrinopeptide A (a substance associated with hypercoagulable states) has been observed in humans exposed to fluorouracil. Anti-EGFR monoclonal antibodies cetuximab and panitumumab, which are now widely used in patients with metastatic colorectal cancer, could prolong the uncovering of endothelial structures resulting from flouorouracil or other co-administered agents, thus favouring several factors leading to thromboembolism. We performed a systematic review and meta-analysis of randomised, controlled trials assessing whether cancer patients receiving anti-EGFR monoclonal antibodies cetuximab and panitumumab are at increased risk of thromboembolic events. We searched electronic databases (Medline, Embase, Web of Science, Central) and reference lists. Phase II/III randomised, controlled trials comparing standard anti-cancer regimens with or without anti-EGFR monoclonal antibodies and reporting serious venous thromboembolic events were included in the analysis. Seventeen studies (12,870 patients) were considered for quantitative analysis. The relative risk (RR) for venous thromboembolism (18 comparisons) was 1.46 (95% CI 1.26 to 1.69); the RR of pulmonary embolism, on the basis of eight studies providing nine comparisons, was 1.55 (1.20 to 2.00). Cancer patients receiving anti-EGFR monoclonal antibodies-containing regimens are approximately 1.5 times more likely to experience venous or pulmonary embolism, compared to those treated with the same regimens without anti-EGFR monoclonal antibodies. Clinicians should consider patient's baseline thromboembolic risk when selecting regimens that include cetuximab or panitumumab. Potential non-reporting of these important adverse events remains a concern. PROSPERO registration number is CRD42014009165

Liquid marble interaction gate for collision-based computing

© 2017 Elsevier Ltd Liquid marbles are microliter droplets of liquid, encapsulated by self-organized hydrophobic particles at the liquid/air interface. They offer an efficient approach for manipulating liquid droplets and compartmentalizing reactions in droplets. Digital fluidic devices employing liquid marbles might benefit from having embedded computing circuits without electronics and moving mechanical parts (apart from the marbles). We present an experimental implementation of a collision gate with liquid marbles. Mechanics of the gate follows principles of Margolus’ soft-sphere collision gate. Boolean values of the inputs are given by the absence (FALSE) or presence (TRUE) of a liquid marble. There are three outputs: two outputs are trajectories of undisturbed marbles (they only report TRUE when just one marble is present at one of the inputs), one output is represented by trajectories of colliding marbles (when two marbles collide they lose their horizontal momentum and fall), this output reports TRUE only when two marbles are present at inputs. Thus the gate implements AND and AND-NOT logical functions. We speculate that by merging trajectories representing AND-NOT output into a single channel one can produce a one-bit half-adder. Potential design of a one-bit full-adder is discussed, and the synthesis of both a pure nickel metal and a hybrid nickel/polymer liquid marble is reported

Mapping outcomes of liquid marble collisions

© 2019 The Royal Society of Chemistry. Liquid marbles (LMs) have many promising roles in the ongoing development of microfluidics, microreactors, bioreactors, and unconventional computing. In many of these applications, the coalescence of two LMs is either required or actively discouraged, therefore it is important to study liquid marble collisions and establish parameters which enable the desired collision outcome. Recent reports on LM coalescence have focused on either two mobile LMs colliding, or an accelerating LM hitting a sessile LM with a backstop. A further possible scenario is the impact of a mobile LM against a non-supported static LM. This paper investigates such a collision, using high-speed videography for single-frame analysis. Multiple collisions were undertaken whilst varying the modified Weber number (We∗) and offset ratios (X∗). Parameter ranges of 1.0 0.25, and We∗ 1.55 resulted in 100% non-coalescence. Additionally, observations of LMs moving above a threshold velocity of 0.6 m s -1 have revealed a new and unusual deformation. Comparisons of the outcome of collisions whilst varying both the LM volume and the powder grain size have also been made, revealing a strong link. The results of this work provide a deeper understanding of LM coalescence, allowing improved control when designing future collision experiments