Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk

Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored. Methods: We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium. Results: Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P = 2.51 × 10−4; OR, 1.04; 95% confidence interval (CI), 1.02–1.07] and rs77928427 (P = 1.86 × 10−4; OR, 1.04; 95% CI, 1.02–1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r2 ≥ 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, TET2. Both variants are located in DNase I hypersensitivity and transcription factor–binding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of TET2 in breast normal and tumor tissue. Conclusion: Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of TET2. Impact: Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk

Test of the exponential decay law at short decay times using tau leptons

Contains fulltext : 124607.pdf (publisher's version ) (Open Access

Measurement of emission angle anisotropy via long-range angular correlations with high pTp_T hadrons in d+d+Au and p+pp+p collisions at sNN=200\sqrt{s_{_{NN}}}=200 GeV

International audienceWe present measurements of two-particle angular correlations between high-transverse-momentum (2<pT<11 GeV/c) π0 observed at midrapidity (|η|<0.35) and particles produced either at forward (3.1<η<3.9) or backward (−3.7<η<−3.1) rapidity in d+Au and p+p collisions at sNN=200 GeV. The azimuthal angle correlations for particle pairs with this large rapidity gap in the Au-going direction exhibit a characteristic structure that persists up to pT≈6 GeV/c and which strongly depends on collision centrality, which is a similar characteristic to the hydrodynamical particle flow in A+A collisions. The structure is absent in the d-going direction as well as in p+p collisions, in the transverse-momentum range studied. The results indicate that the structure is shifted in the Au-going direction toward more central collisions, similar to the charged-particle pseudorapidity distributions