Concentrated Poverty Increased in Both Rural and Urban Areas Since 2000, Reversing Declines in the 1990s

In this brief, authors Brian Thiede, Hyojung Kim, and Matthew Valasik discuss changes in poverty levels among U.S. counties using data from the 2000 U.S. Decennial Census and the 2005–2009 and 2011-2015 American Community Surveys. They report that the share of rural counties with high poverty rates (20 percent or more) increased from 20.6 percent in 2000 to 32.5 percent in the aggregate 2011–2015 data, and the share of high-poverty urban counties increased from 6.7 to 15.6 percent. The share of the population living in these high-poverty counties nearly doubled in both rural and urban areas during this period. Substantial increases in concentrated poverty occurred in rural areas both before and after the Great Recession, but increases in urban areas primarily occurred in years during and after the downturn. In rural areas, increases in concentrated poverty were greatest among micropolitan counties with small cities, which had historically been characterized by lower poverty rates than more sparsely populated and isolated areas. Increases in the population exposed to concentrated poverty were greater among the rural non-Hispanic white and black populations than among rural Hispanics. The authors conclude that the overall resurgence of concentrated poverty since 2000 should be of concern to policy makers and other stakeholders since areas with very high poverty rates face many social, economic, and health challenges

Locating refractive index variations with bistatic radar

Refractivity variations measured by use of radar antennas at both ends of wave propagation pat

Working poverty is a widespread but under-analyzed and poorly-measured problem in the US

Data and statistics are integral to policymakers in government trying to tackle problems such as working poverty. And yet, estimates of the proportion of working poor in the US vary from 2 to 19 percent. In new research, Brian C. Thiede, Daniel T. Lichter, and Scott R. Sanders seek to explain the variation in statistics around those in working poverty. They write that estimates about the magnitude of working poverty, and on its incidence among racial and ethnic groups can be sensitive to the often technical choices, often based on assumptions about how people get into poverty, made by those who are doing the estimating

Buchbesprechungen / Book Reviews

Lüdecke, C., Fritzsche, D., Dullo, C., Thiede, J., Salewski, C. (2016): Book Reviews. Zoological Journal of the Linnean Society 176: 224-225, DOI: 10.2312/polarforschung.86.1.72, URL: http://dx.doi.org/10.2312/polarforschung.86.1.7

Fluvial Sediment Aggradation and Incision in NW Sub-Himalaya

Abstract HKT-ISTP 2013 A

Exhumation history of the Higher Himalayan Crystalline along Dhauliganga-Goriganga river valleys, NW India: new constraints from fission track analysis

New apatite and zircon fission track data collected from two transects along the Dhauliganga and Goriganga rivers in the NW Himalaya document exhumation of the Higher Himalayan Crystalline units. Despite sharing the same structural configuration and rock types and being separated by only 60 km, the two study areas show very different patterns of exhumation. Fission track (FT) data from the Dhauliganga section show systematic changes in age (individual apatite FT ages range from 0.9 ± 0.3 to 3.6 ± 0.5 Ma, r 2 = 0.82) that record faster exhumation across a zone that extends from the Main Central Thrust to north of the Vaikrita thrust. By contrast, FT results from the Goriganga Valley show a stepwise change in ages across the Vaikrita thrust that suggests Quaternary thrust sense displacement. Footwall samples yield a weighted mean apatite age of 1.6 ± 0.1 Ma compared to 0.7 ± 0.04 Ma in the hanging wall. A constant zircon fission track age of 1.8 ± 0.4 Ma across both the footwall and hanging wall shows the 0.9 Ma difference in apatite ages is due to movement on the Vaikrita thrust that initiated soon after ∼1.8 Ma. The Goriganga section provides clear evidence for >1 Ma of tectonic deformation in the brittle crust that contrasts with previous exhumation studies in other areas of the high Himalaya ranges; these studies have been unable to decouple the role of climate erosion from tectonics. One possibility why there is a clear tectonic signal in the Goriganga Valley is that climate erosion has not yet fully adjusted to the tectonic perturbation

Expression and mutational analysis of Nm23-H1 in liver metastases of colorectal cancer.

It has been proposed that nm23-H1, a candidate suppressor gene for metastasis, plays an important role in metastasis formation of human tumours. In order to investigate its role in the progression of colorectal cancer, we analysed 22 liver metastases of this malignancy with respect to mutational changes, loss of heterozygosity and expression levels of nm23-H1. Although genetic alterations in nm23-H1 have recently been described in those colorectal adenocarcinomas which give rise to distant metastases, we were unable to detect any mutation in the coding sequence of nm23-H1 in the metastatic tissue itself. We further analysed the metastases with respect to allelic deletions at the chromosomal locus of nm23. However, no loss of heterozygosity could be detected in ten informative cases. Moreover, the mRNA expression levels of nm23-H1 in the metastatic tissues were not significantly different from those in normal colon mucosa. Thus, although nm23-H1 might be involved in metastasis suppression of certain tumour types, in colorectal tumour progression its role remains to be determined

Poor Metacomprehension Accuracy as a Result of Inappropriate Cue Use

Two studies attempt to determine the causes of poor metacomprehension accuracy, and then, in turn, to identify interventions that circumvent these difficulties to support effective comprehension monitoring performance. The first study explored the cues that both at-risk and typical college readers use as a basis for their metacomprehension judgments in the context of a delayed summarization paradigm. Improvement was seen in all readers, but at-risk readers did not reach the same level of metacomprehension accuracy as a sample of typical college readers. Further, while few readers reported using comprehension-related cues, more at-risk readers reported using surface-related cues as the basis for their judgments. To support the use of more predictive cues among the at-risk readers, a second study employed a concept map intervention, which was intended to make situation model-level representations more salient. Concept mapping improved both the comprehension and metacomprehension accuracy of at-risk readers. The results suggest that poor metacomprehension accuracy can result from a failure to use appropriate cues for monitoring judgments, and that especially less-able readers need interventions that direct them to predictive cues for comprehension

An RNAi-based system for loss-of-function analysis identifies Raf1 as a crucial mediator of BCR-ABL - Driven leukemogenesis

Genetic loss-of-function studies in murine tumor models have been essential in the analysis of downstream mediators of oncogenic transformation. Unfortunately, these studies are frequently limited by the availability of genetically modified mouse strains. Here we describe a versatile method allowing the efficient expression of an oncogene and simultaneous knockdown of targets of interest (TOI) from a single retroviral vector. Both oncogene and TOI-specific miR30-based shRNA are under the control of the strong viral long terminal repeat promoter, resulting in a single shared RNA transcript. Using this vector in a murine syngeneic BM transplantation model for BCR-ABL - induced chronic myeloid leukemia, we find that oncogene expression andtargetknockdownin primary hematopoietic cells with this vector is efficient both in vitro and in vivo, and demonstrate that Raf1, but not BRAF, modulates BCR-ABL - dependent ERK activation and transformation of hematopoietic cells. This expression system could facilitate genetic loss-of-function studies and allow the rapid validation of potential drug targets in a broad range of oncogene-driven murine tumor models. © 2011 by The American Society of Hematology