The Effect of Childhood Economic Deprivation on Physical and Psychological health Status

This paper investigates the effects of childhood deprivation on health at the later stages of the working age. The results indicate that there is an effect of childhood socioeconomic conditions on later adulthood overall health profile and second on the likelihood of suffering from a number of medical conditions. The risk of frail health is higher among adult respondents of the age between 50 to 65 who grew up in unfavourable socioeconomic circumstances, after controlling for their genetic risk traits, and their current educational and wealth status

Fundamental parameters of Be stars located in the seismology fields of COROT

In preparation for the COROT space mission, we determined the fundamental parameters (spectral type, temperature, gravity, vsini) of the Be stars observable by COROT in its seismology fields (64 Be stars). We applied a careful and detailed modeling of the stellar spectra, taking into account the veiling caused by the envelope, as well as the gravitational darkening and stellar flattening due to rapid rotation. Evolutionary tracks for fast rotators were used to derive stellar masses and ages. The derived parameters will be used to select Be stars as secondary targets (i.e. observed for 5 consecutive months) and short-run targets of the COROT mission. Furthermore, we note that the main part of our stellar sample is falling in the second half of the main sequence life time, and that in most cases the luminosity class of Be stars is inaccurate in characterizing their evolutionary status.Comment: 25 pages, 9 figures, Accepted for publication in A&

Non-western immigrants' satisfaction with the general practitioners' services in Oslo, Norway

<p>Abstract</p> <p>Background</p> <p>Over the last few years the number of immigrants from the non-western parts of the world living in Oslo, has increased considerably. We need to know if these immigrants are satisfied with the health services they are offered. The aim of this study was to assess whether the immigrants' level of satisfaction with visits to general practitioners was comparable with that for ethnic Norwegians.</p> <p>Methods</p> <p>Two population-based surveys, the Oslo Health Study and the Oslo Immigrant Health Study, were performed on selected groups of Oslo citizens in 2000 and 2002. The response rates were 46% and 33%, respectively. In all, 11936 Norwegians and 1102 non-western immigrants from the Oslo Health Study, and 1774 people from the Oslo Immigrant Health Study, were included in this analysis. Non-western immigrants' and ethnic Norwegians' level of satisfaction with visits to general practitioners were analysed with respect to age, gender, health, working status, and use of translators. Bivariate (Chi square) and multivariate analyses (logistic regression) were performed.</p> <p>Results</p> <p>Most participants were either moderately or very satisfied with their last visit to a general practitioner. Non-western immigrants were less satisfied than Norwegians. Dissatisfaction among the immigrants was associated with young age, a feeling of not having good health, and coming from Turkey, Iran, Pakistan, or Vietnam as compared to Sri Lanka. The attendance rates in the surveys were rather low and lowest among the non-western immigrants.</p> <p>Conclusion</p> <p>Although the degree of satisfaction with the primary health care was relatively high among the participants in these surveys, the non-western immigrants in this study were less satisfied than ethnic Norwegians with their last visit to a general practitioner. The rather low response rates opens for the possibility that the degree of satisfaction may not be representative for all immigrants.</p

Interaction effects of region-level GDP per capita and age on labour market transition rates in Italy

Abstract The aim of this paper is to measure the effect of the interaction between age for the population of males and females aged 18 to 74 and region-level GDP per capita on labour market transition probabilities in Italy. We compare different occupational states in a sample of males and females who remained in their region of residence at two points in time (12 months apart). We estimate the transition probabilities using a flexible hierarchical logit model with interaction effects between worker age and region-level GDP per capita. We apply this model using longitudinal data from the Italian Labour Force Survey that cover the 2004–2013 period. We find empirical support for the assumption that people in the same age cohort have different labour market opportunities based on the level of GDP per capita in their region of residence. These differences are particularly relevant among younger workers

Mental Health of Parents and Life Satisfaction of Children: A Within-Family Analysis of Intergenerational Transmission of Well-Being

This paper addresses the extent to which there is an intergenerational transmission of mental health and subjective well-being within families. Specifically it asks whether parents’ own mental distress influences their child’s life satisfaction, and vice versa. Whilst the evidence on daily contagion of stress and strain between members of the same family is substantial, the evidence on the transmission between parental distress and children’s well-being over a longer period of time is sparse. We tested this idea by examining the within-family transmission of mental distress from parent to child’s life satisfaction, and vice versa, using rich longitudinal data on 1,175 British youths. Results show that parental distress at year t-1 is an important determinant of child’s life satisfaction in the current year. This is true for boys and girls, although boys do not appear to be affected by maternal distress levels. The results also indicated that the child’s own life satisfaction is related with their father’s distress levels in the following year, regardless of the gender of the child. Finally, we examined whether the underlying transmission correlation is due to shared social environment, empathic reactions, or transmission via parent-child interaction

Detection of Elements at All Three r-process Peaks in the Metal-Poor Star HD 160617

We report the first detection of elements at all three r-process peaks in the metal-poor halo star HD 160617. These elements include arsenic and selenium, which have not been detected previously in halo stars, and the elements tellurium, osmium, iridium, and platinum, which have been detected previously. Absorption lines of these elements are found in archive observations made with the Space Telescope Imaging Spectrograph onboard the Hubble Space Telescope. We present up-to-date absolute atomic transition probabilities and complete line component patterns for these elements. Additional archival spectra of this star from several ground-based instruments allow us to derive abundances or upper limits of 45 elements in HD 160617, including 27 elements produced by neutron-capture reactions. The average abundances of the elements at the three r-process peaks are similar to the predicted solar system r-process residuals when scaled to the abundances in the rare earth element domain. This result for arsenic and selenium may be surprising in light of predictions that the production of the lightest r-process elements generally should be decoupled from the heavier r-process elements.Comment: Published in the Astrophysical Journal (22 pages, 12 figures

The chemical abundance analysis of normal early A- and late B-type stars

Modern spectroscopy of early-type stars often aims at studying complex physical phenomena. Comparatively less attention is paid to identifying and studying the "normal" A- and B-type stars and testing how the basic atomic parameters and standard spectral analysis allow one to fit the observations. We wish to stablish whether the chemical composition of the solar photosphere can be regarded as a reference for early A- and late B-type stars. We have obtained optical high-resolution, high signal-to-noise ratio spectra of three slowly rotating early-type stars (HD 145788, 21 Peg and pi Cet) that show no obvious sign of chemical peculiarity, and performed a very accurate LTE abundance analysis of up to 38 ions of 26 elements (for 21 Peg), using a vast amount of spectral lines visible in the spectral region covered by our spectra. We provide an exhaustive description of the abundance characteristics of the three analysed stars with a critical review of the line parameters used to derive the abundances. We compiled a table of atomic data for more than 1100 measured lines that may be used in the future as a reference. The abundances we obtained for He, C, Al, S, V, Cr, Mn, Fe, Ni, Sr, Y, and Zr are compatible with the solar ones derived with recent 3D radiative-hydrodynamical simulations of the solar photosphere. The abundances of the remaining studied elements show some degree of discrepancy compared to the solar photosphere. Those of N, Na, Mg, Si, Ca, Ti, and Nd may well be ascribed to non-LTE effects; for P, Cl, Sc and Co, non-LTE effects are totally unknown; O, Ne, Ar, and Ba show discrepancies that cannot be ascribed to non-LTE effects. The discrepancies obtained for O (in two stars) and Ne agree with very recent non-LTE abundance analysis of early B-type stars in the solar neighbourhood.Comment: Accepted for publication on Astronomy and Astrophysic

Photochemical internalisation of chemotherapy potentiates killing of multidrug-resistant breast and bladder cancer cells

Multidrug resistance (MDR) is the major confounding factor in adjuvant solid tumour chemotherapy. Increasing intracellular amounts of chemotherapeutics to circumvent MDR may be achieved by a novel delivery method, photochemical internalisation (PCI). PCI consists of the co-administration of drug and photosensitiser; upon light activation the latter induces intracellular release of organelle-bound drug. We investigated whether co-administration of hypericin (photosensitiser) with mitoxantrone (MTZ, chemotherapeutic) plus illumination potentiates cytotoxicity in MDR cancer cells. We mapped the extent of intracellular co-localisation of drug/photosensitiser. We determined whether PCI altered drug-excreting efflux pump P-glycoprotein (Pgp) expression or function in MDR cells. Bladder and breast cancer cells and their Pgp-overexpressing MDR subclones (MGHU1, MGHU1/R, MCF-7, MCF-7/R) were given hypericin/MTZ combinations, with/without blue-light illumination. Pilot experiments determined appropriate sublethal doses for each. Viability was determined by the 3-[4,5-dimethylthiazolyl]-2,5-diphenyltetrazolium bromide assay. Intracellular localisation was mapped by confocal microscopy. Pgp expression was detected by immunofluorescence and Pgp function investigated by Rhodamine123 efflux on confocal microscopy. MTZ alone (0.1–0.2 μg ml−1) killed up to 89% of drug-sensitive cells; MDR cells exhibited less cytotoxicity (6–28%). Hypericin (0.1–0.2 μM) effects were similar for all cells; light illumination caused none or minimal toxicity. In combination, MTZ /hypericin plus illumination, potentiated MDR cell killing, vs hypericin or MTZ alone. (MGHU1/R: 38.65 and 36.63% increase, P<0.05; MCF-7/R: 80.2 and 46.1% increase, P<0.001). Illumination of combined MTZ/hypericin increased killing by 28.15% (P<0.05 MGHU1/R) compared to dark controls. Intracytoplasmic vesicular co-localisation of MTZ/hypericin was evident before illumination and at serial times post-illumination. MTZ was always found in sensitive cell nuclei, but not in dark resistant cell nuclei. In illuminated resistant cells there was some mobilisation of MTZ into the nucleus. Pgp expression remained unchanged, regardless of drug exposure. Pgp efflux was blocked by the Pgp inhibitor verapamil (positive control) but not impeded by hypericin. The increased killing of MDR cancer cells demonstrated is consistent with PCI. PCI is a promising technique for enhancing treatment efficacy

A Study of Pi Aquarii During a Quasi-normal Star Phase: Refined Fundamental Parameters and Evidence for Binarity

We present the results of recent multicolor photometric and high-resolution spectroscopic observations of the bright Be star Pi Aquarii. Observational data collected from the literature were used to study the star's variations over the last four decades. The star is identified with the IR sources F22227+0107 in the IRAS Faint Point Source catalog and MSX5_G066.0066-44.7392 in the MSX catalog. The variations in near-IR brightness of Pi Aqr are found to be among the largest reported for Be stars. Since 1996, the star has shown only weak signs of circumstellar emission, which has allowed us to refine the fundamental stellar parameters: A_V=0.15 mag., T_eff=24000K, log g=3.9, and M_V=-2.95 mag. A weak emission component of the H-alpha line has been detected during the recent quasi-normal star phase. From analysis of the H-alpha line profiles, we find anti-phased radial velocity variations of the emission component and the photospheric absorption, with a period of 84.1 days and semi-amplitudes of 101.4 and 16.7 km/s, respectively. This result suggests that Pi Aqr may be a binary system consisting of stars with masses of M_1 sin^{3}i = 12.4 M_sun, M_2 sin^{3}i = 2.0 M_sun. We also estimate the orbital inclination angle to be between 50 and 75 degrees. We suggest that the photometric, spectroscopic, and polarimetric variations observed during the second half of the 20th century may be due to variable mass transfer between the binary components.Comment: 26 pages (including 8 figs, 2 tables), accepted by Ap