A Pre-registered Meta-analysis Based on Three Empirical Studies Reveals No Association Between Prenatal (Amniotic) Cortisol Exposure and Fluctuating Asymmetry in Human Infants

Developmental instability (DI) reflects an organism’s inability to develop an ideal phenotype when challenged by genetic and environmental insults. DI can be estimated via the proxy measure of fluctuating asymmetry (FA), i.e., the small random deviations from perfect bilateral symmetry observed in the morphology of paired traits. The mechanisms involved in the genesis of FA in human populations are relatively unknown, though animal research indicates that hormonal processes may be involved. As maternal stress during pregnancy is detrimental to various developmental processes, elevated prenatal cortisol may represent a causal factor in the subsequent emergence of an asymmetrical phenotype. The main purpose of this pre-registered meta-analysis based on three empirical studies was to investigate whether mid-trimester amniotic cortisol levels predict subsequent FA in finger lengths of infants from Germany, Portugal, and the UK. No statistically significant relationships were observed, and meta-analytic combination of the effect size estimates yielded a null result. We did, however, detect significant positive correlations between the cortisol present in the amniotic fluid and maternal plasma in the Portuguese cohort, and observed that FA in the German cohort was significantly lower at 70-months than at either 9- or 20-months. Taken together, the current findings run contrary to animal research showing that elevated prenatal corticosterone exposure leads to increased FA. However, this may be because a single cortisol assay obtained via amniocentesis is an inadequate proxy for average gestational exposure, and/or that prenatal cortisol levels at an earlier (i.e., first rather than second trimester) stage of pregnancy is what explains variance in subsequent FA.publishersversionpublishe

Indoor air quality improvement using nature-based solutions: Design proposals to greener cities

Low indoor air quality is an increasingly important problem due to the spread of urbanization. Because people spend most of their time inside, poor indoor air quality causes serious human health issues, resulting in significant economic losses. In this work, the current state of affairs is presented and analyzed, focusing on the current problems and the available solutions to improve the quality of indoor air, and the use of nature-based solutions. These involve the cultivation of microalgae in closed photobioreactors. In these systems, photosynthetic organisms can capture CO2 and other pollutants generated in indoor environments, which they use to grow and develop biomass. Several possible layouts for the implementation of microalgae-based indoor air cleaning systems are presented, taking into account the systems that are currently available at a commercial scale. A critical analysis of the microalgae indoor purification systems is presented, highlighting their advantages and disadvantages, and suggesting potential improvements and future lines of research and development in the area. (c) 2021 by the authors. Licensee MDPI, Basel, Switzerland

Indoor Air Quality: A Review of Cleaning Technologies

Aims: Indoor air quality (IAQ) has attracted increased attention with the emergence of COVID-19. Ventilation is perhaps the area in which the most changes have been proposed in response to the emergency caused by this virus. However, other strategies are possible, such as source control and the extraction of pollutants. The latter incorporates clean technologies, an emergent area with respect to IAQ. Method: Various air treatment technologies can be used to control contaminants, which are reviewed and discussed in this work, including physicochemical technologies (e.g., filtration, adsorption, UV-photocatalytic oxidation, ultraviolet disinfection and ionization) and biological technologies (e.g., plant purification methods and microalgae-based methods). Results and interpretation: This work reviews currently available solutions and technologies for “cleaning” indoor air, with a focus on their advantages and disadvantages. One of the most common problems in this area is the emission of pollutants that are sometimes more dangerous to human health than those that the technologies were developed to remove. Another aspect to consider is the limitation of each technology in relation to the type of pollutants that need to be removed. Each of the investigated technologies works well for a family of pollutants with similar characteristics, but it is not applicable to all pollutant types. Thus, the optimal solution may involve the use of a combination of technologies to extend the scope of application, in addition to the development of new materials, for example, through the use of nanotechnology

Importância da actividade física em doentes submetidos a transplante renal e hepático

A transplantação de órgãos tem-se desenvolvido cada vez mais nos últimos anos, tendo como objectivo a reintegração do indivíduo na comunidade onde vivia de forma produtiva e com qualidade de vida. Objectivos do estudo: obter algum conhecimento sobre alterações dos estilos de vida destes doentes, no que concerne a hábitos de sedentarismo e/ou actividade; estabelecer algumas linhas orientadoras para aconselhamento desta população quanto à prática de estilos de vida saudáveis

High mountain lakes: extreme habitats and witnesses of environmental changes.

33 páginas, 14 figuras, 3 tablas.[EN]High mountain lakes offer research opportunities beyond what could be expected from their quantitative relevance in the Earth system. In this article we present a brief summary of the research carried out in the lakes of the Pyrenees in the last twenty years by the group of limnology of the Centre for High Mountain Research (CRAM) of the University of Barcelona. The studies can be included in three main topics: life in extreme conditions, catchment-lake relationships and environmental changes.[ES]Los lagos de montaña ofrecen oportunidades de estudio que van mucho más allá de lo que su disposición en el territorio y abundancia pudieran sugerir. En este artículo presentamos un breve resumen de los temas que hemos abordado a lo largo de poco más de veinte años de investigación en los lagos de los Pirineos por parte del grupo de limnología del Centro de Investigaciones de Alta Montaña (CRAM) de la Universidad de Barcelona. Los estudios se enmarcan fundamentalmente en tres líneas generales: la vida en condiciones extremas, las relaciones cuenca-lago y los cambios ambientales.Peer reviewe

Choosing wisely: practical considerations on treatment efficacy and safety of asthma in the elderly.

The prevalence of asthma in the most advanced ages is similar to that of younger ages. However, the concept that older individuals may suffer from allergic asthma has been largely denied in the past, and a common belief attributes to asthma the definition of "rare" disease. Indeed, asthma in the elderly is often underdiagnosed or diagnosed as COPD, thus leading to undertreatment of improper treatment. This is also due to the heterogeneity of clinical and functional presentations of geriatric asthma, including the partial loss of reversibility and the lower occurrence of the allergic component in this age range. The older asthmatic patients are also characterized the coexistence of comorbid conditions that, in conjunction with age-associated structural and functional changes of the lung, may contribute to complicate the management of asthma. The current review addresses the main issues related to the management of allergic asthma in the geriatric age. In particular, the paper aims at revising current pharmacological and non pharmacological treatments for allergic asthmatics of advanced ages, primarily focusing on their safety and efficacy, although most behaviors are an arbitrary extrapolation of what has been tested in young ages. In fact, age has always represented an exclusion criterion for eligibility to clinical trials. Experimental studies and real life observations specifically testing the efficacy and safety of therapeutic approaches in allergic asthma in the elderly are urgently needed

Combined intermittent hypoxia and surface muscle electrostimulation as a method to increase peripheral blood progenitor cell concentration

Background: Our goal was to determine whether short-term intermittent hypoxia exposure, at a level well tolerated by healthy humans and previously shown by our group to increase EPO and erythropoiesis, could mobilizehematopoietic stem cells (HSC) and increase their presence in peripheral circulation. Methods: Four healthy male subjects were subjected to three different protocols: one with only a hypoxic stimulus (OH), another with a hypoxic stimulus plus muscle electrostimulation (HME) and the third with only muscle electrostimulation (OME). Intermittent hypobaric hypoxia exposureconsisted of only three sessions of three hours at barometric pressure 540 hPa (equivalent to an altitude of 5000 m) for three consecutive days, whereas muscular electrostimulation was performed in two separate periods of 25 min in each session. Blood samples were obtained from an antecubital vein on three consecutive days immediately before the experiment and 24 h, 48 h, 4 days and 7 days after the last day of hypoxic exposure. Results: There was a clear increase in the number of circulating CD34+ cells after combined hypobaric hypoxia and muscular electrostimulation. This response was not observed after the isolated application of the same stimuli. Conclusion: Our results open a new application field for hypobaric systems as a way to increase efficiency in peripheral HSC collection

Mobile Technology in Allergic Rhinitis : Evolution in Management or Revolution in Health and Care?

Smart devices and Internet-based applications (apps) are largely used in allergic rhinitis and may help to address some unmet needs. However, these new tools need to first of all be tested for privacy rules, acceptability, usability, and cost-effectiveness. Second, they should be evaluated in the frame of the digital transformation of health, their impact on health care delivery, and health outcomes. This review (1) summarizes some existing mobile health apps for allergic rhinitis and reviews those in which testing has been published, (2) discusses apps that include risk factors of allergic rhinitis, (3) examines the impact of mobile health apps in phenotype discovery, (4) provides real-world evidence for care pathways, and finally (5) discusses mobile health tools enabling the digital transformation of health and care, empowering citizens, and building a healthier society. (C) 2019 American Academy of Allergy, Asthma & ImmunologyPeer reviewe

UCRAID (Ukrainian Citizen and refugee electronic support in Respiratory diseases, Allergy, Immunology and Dermatology) action plan.

Eight million Ukrainians have taken refuge in the European Union. Many have asthma and/or allergic rhinitis and/or urticaria, and around 100,000 may have a severe disease. Cultural and language barriers are a major obstacle to appropriate management. Two widely available mHealth apps, MASK-air® (Mobile Airways Sentinel NetworK) for the management of rhinitis and asthma and CRUSE® (Chronic Urticaria Self Evaluation) for patients with chronic spontaneous urticaria, were updated to include Ukrainian versions that make the documented information available to treating physicians in their own language. The Ukrainian patients fill in the questionnaires and daily symptom-medication scores for asthma, rhinitis (MASK-air) or urticaria (CRUSE) in Ukrainian. Then, following the GDPR, patients grant their physician access to the app by scanning a QR code displayed on the physician's computer enabling the physician to read the app contents in his/her own language. This service is available freely. It takes less than a minute to show patient data to the physician in the physician's web browser. UCRAID-developed by ARIA (Allergic Rhinitis and its Impact on Asthma) and UCARE (Urticaria Centers of Reference and Excellence)-is under the auspices of the Ukraine Ministry of Health as well as European (European Academy of Allergy and Clinical immunology, EAACI, European Respiratory Society, ERS, European Society of Dermatologic Research, ESDR) and national societies