Arte e Moda em devir

This work aims to break with the traditional processes of academic research and writing, through the presentation of a course of studies in art and fashion. It seeks to bring to the surface what is implicit in the final results – carved – of the usual researches that integrate monographs, dissertations and theses, constructing an essay that finds grounds in the exposition of the trivialities, these, common to the universe of every researcher, from the beginners to the most experienced. We work on the construction of an "artist's monograph", seeking to crosslink text and image in the organization and presentation of information about affection and attitude towards art/fashion. In the final stage of the project development we concluded that the attitude studied is performative, in the sense of a subject who lives de art/fashion relationship in his daily life in a very unique way, and art near life breaks the barriers of the ordinary, of the expected, promoting a process of wandering. So, this attitude is corroborated and exercised through a poetic photo-essay and an artistic performance (to be presented at the time of oral presentation of the work), both in connection.Este trabalho visa à ruptura com os processos tradicionais de pesquisa e escrita acadêmicas, por meio da exposição de um percurso de estudos em arte e moda. Busca-se trazer à tona o que fica implícito nos resultados finais – burilados – das usuais pesquisas que integram monografias, dissertações e teses, construindo-se um ensaio que encontra fundamento na exposição das trivialidades, estas, comuns ao universo de todo pesquisador, desde os iniciantes aos mais experientes. Trabalhamos na construção de uma “monografia de artista”, buscando entrecruzar texto e imagem na organização e apresentação de informações sobre afeto e atitude diante da arte/moda. Na etapa final do desenvolvimento do projeto tomamos consciência de que a atitude estudada é performativa, no sentido de um sujeito que vive a relação arte/moda em seu cotidiano de uma maneira muito singular, e a arte perto da vida quebra as barreiras do comum, do esperado, promovendo um processo de errância. Esta atitude é então corroborada e exercitada por meio da realização de um fotoensaio poético e de uma performance artística (a ser apresentada na defesa), ambos em conexão

Resistencia de cultivares de frijol (Phaseolus vulgaris) a Spodoptera frugiperda (Lepidoptera: Noctuidae).

Spodoptera frugiperda (Lepidoptera: Noctuidae) es una plaga que provoca daños en los cultivos de fríjol al reducir el área foliar y destruir las estructuras reproductivas. Este trabajo tuvo como objetivo evaluar los tipos y niveles de resistencia de cultivares de frijol a S. frugiperda. Los cultivares evaluados fueron: BRS Ametista, Pérola, BRS Notável, BRS Realce, Jalo Precoce, BRS Campeiro, BRS Agreste, BRS Cometa, BRS Executivo y BRS Pitanga, en el Laboratorio de Entomología Agrícola del Instituto Federal Goiano, Campus de Urataí, Brasil. Antixenosis, a libre y no libre escogencia y antibiosis se evaluaron en laboratorio (25 ± 2 °C, 70 ± 10 % HR y fotoperiodo 14 h). Los cultivares BRS Pitanga, BRS Executivo, BRS Notável y BRS Campeiro presentaron antixenosis y BRS Realce antibiosis a S. frugiperda. Sin embargo, no se sabe si los niveles de resistencia, exhibidos en el laboratorio, son suficientemente altos que representen un valor económico de campo para los agricultores. Por lo tanto, el próximo paso es evaluar, en condiciones de campo, los cultivares que mostraron mayor resistencia en las pruebas de laboratorio. Si las evaluaciones de campo indican niveles de resistencia suficientes, para tener un valor práctico, estos cultivares pueden utilizarse como fuentes en el programa de mejoramiento o ser utilizados directamente por los agricultores

Diretriz da Sociedade Brasileira de Cardiologia sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas

This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.  Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities.   Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.  The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.  The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.     Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou. A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica. Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas. A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica. A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.    Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.&nbsp

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Resistencia de cultivares de frijol (Phaseolus vulgaris) a Spodoptera frugiperda (Lepidoptera: Noctuidae).

Spodoptera frugiperda (Lepidoptera: Noctuidae) es una plaga que provoca daños en los cultivos de fríjol al reducir el área foliar y destruir las estructuras reproductivas. Este trabajo tuvo como objetivo evaluar los tipos y niveles de resistencia de cultivares de frijol a S. frugiperda. Los cultivares evaluados fueron: BRS Ametista, Pérola, BRS Notável, BRS Realce, Jalo Precoce, BRS Campeiro, BRS Agreste, BRS Cometa, BRS Executivo y BRS Pitanga, en el Laboratorio de Entomología Agrícola del Instituto Federal Goiano, Campus de Urataí, Brasil. Antixenosis, a libre y no libre escogencia y antibiosis se evaluaron en laboratorio (25 ± 2 °C, 70 ± 10 % HR y fotoperiodo 14 h). Los cultivares BRS Pitanga, BRS Executivo, BRS Notável y BRS Campeiro presentaron antixenosis y BRS Realce antibiosis a S. frugiperda. Sin embargo, no se sabe si los niveles de resistencia, exhibidos en el laboratorio, son suficientemente altos que representen un valor económico de campo para los agricultores. Por lo tanto, el próximo paso es evaluar, en condiciones de campo, los cultivares que mostraron mayor resistencia en las pruebas de laboratorio. Si las evaluaciones de campo indican niveles de resistencia suficientes, para tener un valor práctico, estos cultivares pueden utilizarse como fuentes en el programa de mejoramiento o ser utilizados directamente por los agricultores

Resistance of common bean (Phaseolus vulgaris) cultivars to Spodoptera frugiperda (Lepidoptera: Noctuidae)

Spodoptera frugiperda (Lepidoptera: Noctuidae) es una plaga que provoca daños en los cultivos de fríjol al reducir el área foliar y destruir las estructuras reproductivas. Este trabajo tuvo como objetivo evaluar los tipos y niveles de resistencia de cultivares de frijol a S. frugiperda. Los cultivares evaluados fueron: BRS Ametista, Pérola, BRS Notável, BRS Realce, Jalo Precoce, BRS Campeiro, BRS Agreste, BRS Cometa, BRS Executivo y BRS Pitanga, en el Laboratorio de Entomología Agrícola del Instituto Federal Goiano, Campus de Urataí, Brasil. Antixenosis, a libre y no libre escogencia y antibiosis se evaluaron en laboratorio (25 ± 2 °C, 70 ± 10 % HR y fotoperiodo 14 h). Los cultivares BRS Pitanga, BRS Executivo, BRS Notável y BRS Campeiro presentaron antixenosis y BRS Realce antibiosis a S. frugiperda. Sin embargo, no se sabe si los niveles de resistencia, exhibidos en el laboratorio, son suficientemente altos que representen un valor económico de campo para los agricultores. Por lo tanto, el próximo paso es evaluar, en condiciones de campo, los cultivares que mostraron mayor resistencia en las pruebas de laboratorio. Si las evaluaciones de campo indican niveles de resistencia suficientes, para tener un valor práctico, estos cultivares pueden utilizarse como fuentes en el programa de mejoramiento o ser utilizados directamente por los agricultores.Spodoptera frugiperda (Lepidoptera: Noctuidae) damages bean crops, resulting in decreased leaf area and destruction of reproductive structures. This study aimed to evaluate the types and levels of resistance of bean cultivars to S. frugiperda. The bean cultivars evaluated were: BRS Ametista, Pérola, BRS Notável, BRS Realce, Jalo Precoce, BRS Campeiro, BRS Agreste, BRS Cometa, BRS Executivo and BRS Pitanga, in the Laboratory of Agricultural Entomology of the Goiano Federal Institute, Urutaí Campus, Brazil. Tests to identify levels of antixenosis, in free-choice and no-choice tests, and antibiosis were performed in the laboratory (25 ± 2 °C, 70 ± 10 % R. H. and photophase of 14 h). The cultivars BRS Pitanga, BRS Executivo, BRS Notável and BRS Campeiro presented antixenosis and BRS Realce antibiosis to S. frugiperda. However, it is not known whether the levels of resistance exhibited in the laboratory are sufficiently high to be of any economic value to agriculture. Therefore, the next step is to evaluate, under field conditions, the cultivars showing the most resistance in laboratory tests. If field evaluations indicate sufficient levels of resistance to be of practical value, these cultivars may be used as donor sources in the breeding program or may be used directly by farmers

Resistance of corn genotypes to fall armyworm Spodoptera frugiperda (Lepidoptera: Noctuidae)

The objective of this study was to evaluate resistance mechanisms in 12 corn genotypes (transgenic hybrids: 30A91 PW, 20A78 HX, Impacto VIP 3, 20A55 HX, NS90 PRO 2, Maximus VIP 3, BX 1293YG, RB 9004 PRO, Feroz VIP 3, LG 6036 PRO; conventional: AG 1051 and variety: AL Bandeitante). Attractiveness, aversion to feeding, and antibiosis were evaluated via free and no choice tests in the laboratory. Attractiveness was evaluated at 1, 5, 10, 15 and 30 min and 1, 2, 6, 12 and 24 h by counting the number of larvae that fed on each genotype. The preference for feeding was determined by quantifying the leaf area of each genotype consumed. Antibiosis was determined by assessing biological parameters of the fed caterpillars in relation to each genotype. The biological parameters evaluated were (a) Larval stage: the viability of the larval stage and weight of larvae at ten days; and (b) pupal stage: the viability and weight of pupae at 24 h of age. After emergence, the moths were fed and evaluated to assess the longevity of the adults and the total life cycle. The transgenic genotypes NS90 PRO2, Maximus VIP 3, Feroz VIP 3 and Maximus VIP 3 elicited an aversion and/or an antibiosis reaction from fall armyworm (FAW). The transgenic genotypes HX 20A55, 30A91 PW, LG 6036 PRO, 20A78 HX and BR 9004 PRO showed a moderate resistance to FAW. The conventional genotypes AG 1051 and AL Bandeirante were highly susceptible to FAW and the transgenic genotype BX 1293 YG was susceptible to FAW.Keywords: Integrated pest management, transgenic crop, plant resistance to insects, Zea may

Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023

Note: These guidelines are for information purposes and should not replace the clinical judgment of a physician, who must ultimately determine the appropriate treatment for each patient