A relevância da Enfermagem de Reabilitação no Serviço de Urgência: Focus Group

Introduction: The profession's regulatory instruments declare the need to include in the emergency services rehabilitation nurses. In this context, an attempt was made to understand the relevance of the contribution of rehabilitation nurses in the current context in emergency services. Methodology: Qualitative, exploratory and descriptive study, using a focus group as a data collection technique, in an intentional sample of eight expert nurses, four of them in the urgency area and four rehabilitation nurses. Results: Two categories emerge: organization of care, with greater relevance attributed to the subcategories teams and organization of the emergency services, with a weight of 18.0% and 12.8%, respectively, in the totality of the discourse; and provision of care, with greater relevance attributed to the subcategories prevention of complications and training of the person / caregiver for discharge, with a weight of 11.9% and 11.6%, respectively. Discussion: Corroborating the findings of this study, evidence highlights the relevance of rehabilitation nursing in the domains of leadership and interprofessional care, with gains also perceived at respiratory and motor levels. Conclusion: The participants identify gains from the integration of rehabilitation nurses in emergency services in the organization of the service and in the provision of care, highlighting the complementarity of common and specific competences, thus meeting the profession's references on the need to provide these contexts for these professionals.Introducción: Los instrumentos normativos de la profesión declaran la necesidad de incluir en los servicios de emergencia (SE) Enfermeros Especializados en Enfermería de Rehabilitación (EEER). En este contexto, se intentó comprender la relevancia de la contribución del EEER en el contexto actual de SE. Metodología: Estudio cualitativo, exploratorio y descriptivo, utilizando un grupo focal como técnica de recolección de datos, en una muestra intencional de ocho enfermeras expertas, cuatro de ellas en el área de urgencia y cuatro EEER. Resultados: Surgen dos categorías: organización del cuidado, con mayor relevancia atribuida a las subcategorías equipos y organización de los SE, con un peso de 18,0% y 12,8% respectivamente en la totalidad del discurso; y prestación de cuidados, con mayor relevancia atribuida a las subcategorías prevención de complicaciones y formación de la persona / cuidador para el alta, con un peso de 11,9% y 11,6%, respectivamente. Discusión: Corroborando los hallazgos de este estudio, la evidencia destaca la relevancia en los dominios de liderazgo y atención interprofesional, percibiéndose también ganancias a nivel respiratorio y motor. Conclusión: Los participantes identifican los beneficios de la integración de una EEER en los SE en la organización del servicio y en la prestación asistencial, destacando la complementariedad de competencias comunes y específicas, cumpliendo así los referentes de la profesión sobre la necesidad de dotar de estos contextos a estos profesionales.Introdução: Os instrumentos reguladores da profissão declaram a necessidade de se incluirem nos serviço de urgência (SU) Enfermeiros Especialistas em Enfermagem de Reabilitação (EEER). Neste contexto procurou-se compreender a relevância do contributo do EEER no contexto atual nos SU. Metodologia: Estudo qualitativo, exploratório e descritivo, com recurso a focus group como técnica de recolha de dados, numa amostra intencional de oito enfermeiros peritos, quatro deles na área da urgência e quatro EEER. Resultados: Duas categorias emergem: organização dos cuidados, com maior relevância atribuída às subcategorias equipas e organização dos SU, com um peso 18,0% e 12,8% respetivamente na totalidade do discurso; e prestação dos cuidados, com maior relevância atribuída às subcategorias prevenção de complicações e capacitação da pessoa/cuidador para a alta, com um peso 11,9% e 11,6% respetivamente. Discussão: Corroborando os achados deste estudo, a evidência salienta a relevância nos domínios da liderança e cuidados interprofissionais, havendo igualmente ganhos percebidos a nível respiratório e motor. Conclusão: Os participantes identificam ganhos da integração do EEER no SU na organização do serviço e na prestação de cuidados, evidenciando a complementaridade entre competências comuns e específicas, indo assim ao encontro dos referenciais da profissão sobre a necessidade de dotar estes contextos destes profissionais

Abnormal thyroid hormone status differentially affects bone mass accrual and bone strength in C3H/HeJ mice: a mouse model of type I deiodinase deficiency

C3H/HeJ (C3H) mice are deficient of type I deiodinase (D1), an enzyme that activates thyroid hormone (TH), converting thyroxine (T4) to triiodothyronine (T3). Nevertheless, C3H mice present normal serum T3 and a gross euthyroid phenotype. To investigate if a global D1 deficiency interferes in the TH effects on bone, we compared bone growth, bone mass accrual and bone strength of C3H and C57BL/6J (B6) mice under abnormal TH status. Four-week-old female mice of both strains were grouped as Euthyroid, Hypothyroid (pharmacologically-induced), 1xT4 and 10xT4 (hypothyroid animals receiving 1- or 10-fold the physiological dose of T4 /day/16 weeks). Hypothyroidism and TH excess similarly impaired body weight (BW) gain and body growth in both mice strains. In contrast, whereas hypothyroidism only slightly impaired bone mineral density (BMD) accrual in B6 mice, it severely impaired BMD accrual in C3H mice. No differences were observed in serum and bone concentrations of T3 between hypothyroid animals of both strains. Interestingly, treatment with 10xT4 was less deleterious to BMD accrual in C3H than in B6 mice and resulted in less elevated T3 serum levels in B6 than in C3H mice, which is probably explained by the lower D1 activity in C3H mice. In addition, hypothyroidism decreased bone strength only in C3H but not in B6 mice, while TH excess decreased this parameter in both strains. These findings indicate that D1 deficiency contributes to the TH excess-induced differences in bone mass accrual in C3H vs. B6 mice and suggest that deiodinase-unrelated genetic factors might account for the different skeleton responses to hypothyroidism between strains

Chemical structure and biological activity of the (1 → 3)-linked β-D-glucan isolated from marine diatom Conticribra weissflogii

Several polysaccharides are considered to be "biological response modifiers" (BRM) - these refer to biomolecules that augment immune responses and can be derived from a variety of sources. Microalgae produce a diverse range of polysaccharides and could be an excellent source of BRM. Here, we describe the chemical structure and biological activity of water-soluble polysaccharide isolated from the marine diatom Conticribra weissflogii. Using chemical and NMR spectroscopic methods, the polysaccharide was identified as a (1 → 3)-linked β-D-glucan with a low proportion of C-6 substitution by single β-glucose units. The biological activity of this low molecular weight β-glucan (11.7 kDa) was investigated with respect to glioblastoma cell lines (U87 MG and U251) and macrophages (RAW 264.7). We observed that this β-D-glucan did not exhibit cytotoxic activity against glioblastoma cells, but did enhance the phagocytic activity of macrophages, suggesting that it possesses immunomodulatory properties.</p

A Deep Learning Neural Network to Classify Obesity Risk in Portuguese Adolescents Based on Physical Fitness Levels and Body Mass Index Percentiles: Insights for National Health Policies

The increasing prevalence of overweight and obesity among adults is a risk factor for many chronic diseases and death. In addition, obesity among children and adolescents has reached unprecedented levels and studies show that obese children and adolescents are more likely to become obese adults. Therefore, both the prevention and treatment of obesity in adolescents are critical. This study aimed to develop an artificial intelligence (AI) neural network (NNET) model that identifies the risk of obesity in Portuguese adolescents based on their body mass index (BMI) percentiles and levels of physical fitness. Using datasets from the FITescola® project, 654 adolescents aged between 10–19 years old, male: 334 (51%), female: n = 320 (49%), age 13.8 ± 2 years old, were selected to participate in a cross-sectional observational study. Physical fitness variables, age, and sex were used to identify the risk of obesity. The NNET had good accuracy (75%) and performance validation through the Receiver Operating Characteristic using the Area Under the Curve (ROC AUC = 64%) in identifying the risk of obesity in Portuguese adolescents based on the BMI percentiles. Correlations of moderate effect size were perceived for aerobic fitness (AF), upper limbs strength (ULS), and sprint time (ST), showing that some physical fitness variables contributed to the obesity risk of the adolescents. Our NNET presented a good accuracy (75%) and was validated with the K-Folds Cross-Validation (K-Folds CV) with good accuracy (71%) and ROC AUC (66%). According to the NNET, there was an increased risk of obesity linked to low physical fitness in Portuguese teenagers.This project was supported by the National Funds through the FCT—Portuguese Foundation for Science and Technology (project UIDB/04045/2021).info:eu-repo/semantics/publishedVersio

REE geochemistry of neogene–holocene sediments of La Fontanilla Cove (Tinto Estuary, SW Spain)

The Tinto and Odiel rivers (SW Spain) drain from a vast sulfide mining district and join at a 20-km-long estuary that enters the Atlantic Ocean. In this work, the contents of rare earth elements (REE) and fractionation in Neogene–Holocene sediment cores from La Fontanilla cove (Tinto estuary) were studied. The sediments were collected from a depth of 18 m at different distances from the recent river flow and were analyzed for new information on the temporal development of the REE load in the sediment column. Results show that the ∑ REE is higher in the finer sediments and during periods of mining activity from prehistoric to recent times. Marine influence appears to increase the light REE (LREE) relative to the heavy REE (HREE). The REE patterns of these estuarine sediments show convex curvatures in the MREE relative to the LREE and HREE, indicating the presence of acid-mixing processes between the fluvial waters affected by acid mine drainage (AMD) and seawater, as well as the precipitation of poorly crystalline mineral phases. Significant positive Eu anomalies were found in ebb-tide channels and marsh deposits, which can reflect the mineralogical composition and/or a strong localized salinity gradient combined with organic matter degradation. Sedimentological characteristics of the deposits appear to play the main role in accumulation and fractionation of the RE

A comprehensive assessment of the transcriptome of cork oak (Quercus suber) through EST sequencing

Background: Cork oak (Quercus suber) is one of the rare trees with the ability to produce cork, a material widely used to make wine bottle stoppers, flooring and insulation materials, among many other uses. The molecular mechanisms of cork formation are still poorly understood, in great part due to the difficulty in studying a species with a long life-cycle and for which there is scarce molecular/genomic information. Cork oak forests are of great ecological importance and represent a major economic and social resource in Southern Europe and Northern Africa. However, global warming is threatening the cork oak forests by imposing thermal, hydric and many types of novel biotic stresses. Despite the economic and social value of the Q. suber species, few genomic resources have been developed, useful for biotechnological applications and improved forest management. Results: We generated in excess of 7 million sequence reads, by pyrosequencing 21 normalized cDNA libraries derived from multiple Q. suber tissues and organs, developmental stages and physiological conditions. We deployed a stringent sequence processing and assembly pipeline that resulted in the identification of ~159,000 unigenes. These were annotated according to their similarity to known plant genes, to known Interpro domains, GO classes and E.C. numbers. The phylogenetic extent of this ESTs set was investigated, and we found that cork oak revealed a significant new gene space that is not covered by other model species or EST sequencing projects. The raw data, as well as the full annotated assembly, are now available to the community in a dedicated web portal at http://www.corkoakdb.org. Conclusions: This genomic resource represents the first trancriptome study in a cork producing species. It can be explored to develop new tools and approaches to understand stress responses and developmental processes in forest trees, as well as the molecular cascades underlying cork differentiation and disease response.Peer Reviewe

Protocolos em Medicina Interna - Serviço de Medicina lnterna do Hospital Central do Funchal

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Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Les droits disciplinaires des fonctions publiques : « unification », « harmonisation » ou « distanciation ». A propos de la loi du 26 avril 2016 relative à la déontologie et aux droits et obligations des fonctionnaires

The production of tt‾ , W+bb‾ and W+cc‾ is studied in the forward region of proton–proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98±0.02 fb−1 . The W bosons are reconstructed in the decays W→ℓν , where ℓ denotes muon or electron, while the b and c quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions.The production of $t\overline{t}$, $W+b\overline{b}$ and $W+c\overline{c}$ is studied in the forward region of proton-proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98 $\pm$ 0.02 \mbox{fb}^{-1}. The $W$ bosons are reconstructed in the decays $W\rightarrow\ell\nu$, where $\ell$ denotes muon or electron, while the $b$ and $c$ quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions